Incidental Mutation 'R6965:Or4a77'
ID 541926
Institutional Source Beutler Lab
Gene Symbol Or4a77
Ensembl Gene ENSMUSG00000075078
Gene Name olfactory receptor family 4 subfamily A member 77
Synonyms GA_x6K02T2Q125-51098877-51097933, MOR231-7, Olfr1250
MMRRC Submission 045075-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R6965 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 89486839-89487783 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 89487009 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 259 (P259T)
Ref Sequence ENSEMBL: ENSMUSP00000149720 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099768] [ENSMUST00000111527] [ENSMUST00000215730]
AlphaFold Q8VGM3
Predicted Effect probably damaging
Transcript: ENSMUST00000099768
AA Change: P259T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097356
Gene: ENSMUSG00000075078
AA Change: P259T

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.1e-28 PFAM
Pfam:7tm_4 137 278 1e-38 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111527
AA Change: P259T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107152
Gene: ENSMUSG00000075078
AA Change: P259T

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-50 PFAM
Pfam:7tm_1 39 285 8.1e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215730
AA Change: P259T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 C T 7: 119,882,452 (GRCm39) Q1205* probably null Het
Als2 A G 1: 59,209,716 (GRCm39) F1422S possibly damaging Het
Anapc4 T C 5: 52,993,093 (GRCm39) V68A possibly damaging Het
Atmin T C 8: 117,683,777 (GRCm39) F479S probably damaging Het
Atp7b T C 8: 22,518,101 (GRCm39) T234A probably benign Het
Bpifa1 G A 2: 153,987,581 (GRCm39) G144S probably damaging Het
Brf2 A T 8: 27,614,586 (GRCm39) M200K probably benign Het
C1ql2 G A 1: 120,268,944 (GRCm39) C33Y probably damaging Het
Cdk18 A G 1: 132,045,319 (GRCm39) V269A probably damaging Het
Clcc1 T C 3: 108,580,625 (GRCm39) V313A probably damaging Het
Cntrl A T 2: 35,052,845 (GRCm39) T1117S probably benign Het
Col15a1 G A 4: 47,247,533 (GRCm39) E236K probably damaging Het
Comp T C 8: 70,829,164 (GRCm39) L278P probably damaging Het
Csnk2a1-ps3 C T 1: 156,352,119 (GRCm39) R107* probably null Het
Dlg5 C A 14: 24,199,498 (GRCm39) D1469Y probably damaging Het
Efna1 A T 3: 89,186,782 (GRCm39) V23D probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Epb41l4b T C 4: 57,040,915 (GRCm39) Y516C probably damaging Het
Esr2 T C 12: 76,168,631 (GRCm39) D526G probably damaging Het
Fam184b T C 5: 45,712,477 (GRCm39) T514A probably benign Het
Fcmr A C 1: 130,803,724 (GRCm39) E176A possibly damaging Het
Fry T A 5: 150,339,685 (GRCm39) N1485K possibly damaging Het
Fut2 A G 7: 45,300,305 (GRCm39) C156R probably damaging Het
Gm5431 T C 11: 48,786,027 (GRCm39) Y116C probably benign Het
Gm5493 T A 17: 22,967,047 (GRCm39) V61E possibly damaging Het
Golga4 A T 9: 118,377,847 (GRCm39) Q456L probably damaging Het
Gpam T C 19: 55,063,041 (GRCm39) Y757C probably damaging Het
Iqcg C T 16: 32,851,174 (GRCm39) A266T probably benign Het
Lta4h G T 10: 93,307,759 (GRCm39) G331* probably null Het
Macf1 C A 4: 123,302,538 (GRCm39) V655F probably benign Het
Map3k13 T A 16: 21,740,900 (GRCm39) D742E probably benign Het
Mrgprb2 G A 7: 48,202,597 (GRCm39) L43F probably damaging Het
N4bp1 T C 8: 87,571,461 (GRCm39) R846G probably damaging Het
Nbn T C 4: 15,970,863 (GRCm39) I282T probably benign Het
Ncor1 C T 11: 62,244,059 (GRCm39) probably null Het
Or4d10c A G 19: 12,066,120 (GRCm39) F12S possibly damaging Het
Or8b12 T A 9: 37,657,433 (GRCm39) M1K probably null Het
Pclo A G 5: 14,731,976 (GRCm39) probably benign Het
Pde9a G T 17: 31,662,861 (GRCm39) V97L probably benign Het
Ptch1 T C 13: 63,672,881 (GRCm39) Y771C possibly damaging Het
R3hcc1l G A 19: 42,551,284 (GRCm39) D94N probably damaging Het
Rnpep T A 1: 135,190,858 (GRCm39) K602* probably null Het
Rph3al T C 11: 75,745,276 (GRCm39) Y156C probably damaging Het
Rundc1 A T 11: 101,324,737 (GRCm39) Y481F possibly damaging Het
Serpinb9f A G 13: 33,509,859 (GRCm39) K17R possibly damaging Het
Smpd3 T C 8: 106,986,513 (GRCm39) H459R probably damaging Het
Spata31 A C 13: 65,070,648 (GRCm39) Q932P possibly damaging Het
Srgap3 C T 6: 112,700,090 (GRCm39) A963T probably damaging Het
Syne1 A T 10: 5,179,120 (GRCm39) F4451L possibly damaging Het
Tbc1d19 T A 5: 54,014,266 (GRCm39) probably null Het
Thap12 T A 7: 98,364,669 (GRCm39) V279D probably damaging Het
Tmprss6 T C 15: 78,328,328 (GRCm39) D544G probably damaging Het
Tox2 A G 2: 163,164,930 (GRCm39) *523W probably null Het
Txnrd1 T C 10: 82,717,652 (GRCm39) I212T probably benign Het
Unc80 T C 1: 66,685,725 (GRCm39) I2283T probably benign Het
Vmn1r176 A G 7: 23,535,099 (GRCm39) I18T possibly damaging Het
Vmn2r101 C T 17: 19,811,284 (GRCm39) T456I probably benign Het
Vmn2r79 T A 7: 86,651,100 (GRCm39) H166Q probably benign Het
Zer1 A G 2: 29,991,059 (GRCm39) V723A possibly damaging Het
Other mutations in Or4a77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00938:Or4a77 APN 2 89,487,420 (GRCm39) missense probably damaging 0.98
IGL01608:Or4a77 APN 2 89,486,835 (GRCm39) utr 3 prime probably benign
IGL01913:Or4a77 APN 2 89,487,684 (GRCm39) missense probably benign 0.01
IGL02458:Or4a77 APN 2 89,487,692 (GRCm39) missense probably damaging 1.00
R0102:Or4a77 UTSW 2 89,486,999 (GRCm39) missense probably benign 0.10
R0621:Or4a77 UTSW 2 89,487,459 (GRCm39) nonsense probably null
R0826:Or4a77 UTSW 2 89,487,181 (GRCm39) missense possibly damaging 0.49
R5460:Or4a77 UTSW 2 89,487,414 (GRCm39) missense probably damaging 1.00
R5720:Or4a77 UTSW 2 89,487,299 (GRCm39) missense probably benign 0.20
R6044:Or4a77 UTSW 2 89,487,516 (GRCm39) missense probably damaging 1.00
R7069:Or4a77 UTSW 2 89,486,910 (GRCm39) missense probably benign 0.00
R7305:Or4a77 UTSW 2 89,486,846 (GRCm39) missense probably benign
R8058:Or4a77 UTSW 2 89,487,671 (GRCm39) missense probably benign 0.01
R9487:Or4a77 UTSW 2 89,487,731 (GRCm39) missense probably damaging 0.99
R9583:Or4a77 UTSW 2 89,487,005 (GRCm39) missense possibly damaging 0.96
Z1177:Or4a77 UTSW 2 89,487,278 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTACACATGTAAAACACTGTGGTC -3'
(R):5'- GTTGGCAATAATGGAGCAATGTC -3'

Sequencing Primer
(F):5'- TGTAAAACACTGTGGTCAAATAGAC -3'
(R):5'- AATGGAGCAATGTCTATAGTGGTC -3'
Posted On 2018-11-28