Incidental Mutation 'R6965:Vmn2r101'
ID 541970
Institutional Source Beutler Lab
Gene Symbol Vmn2r101
Ensembl Gene ENSMUSG00000094892
Gene Name vomeronasal 2, receptor 101
Synonyms EG627576
MMRRC Submission 045075-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.124) question?
Stock # R6965 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 19797493-19832579 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19811284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 456 (T456I)
Ref Sequence ENSEMBL: ENSMUSP00000131583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171914]
AlphaFold E9PZS9
Predicted Effect probably benign
Transcript: ENSMUST00000171914
AA Change: T456I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000131583
Gene: ENSMUSG00000094892
AA Change: T456I

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 82 466 1.6e-36 PFAM
Pfam:NCD3G 509 562 6.4e-22 PFAM
Pfam:7tm_3 595 830 1.4e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 C T 7: 119,882,452 (GRCm39) Q1205* probably null Het
Als2 A G 1: 59,209,716 (GRCm39) F1422S possibly damaging Het
Anapc4 T C 5: 52,993,093 (GRCm39) V68A possibly damaging Het
Atmin T C 8: 117,683,777 (GRCm39) F479S probably damaging Het
Atp7b T C 8: 22,518,101 (GRCm39) T234A probably benign Het
Bpifa1 G A 2: 153,987,581 (GRCm39) G144S probably damaging Het
Brf2 A T 8: 27,614,586 (GRCm39) M200K probably benign Het
C1ql2 G A 1: 120,268,944 (GRCm39) C33Y probably damaging Het
Cdk18 A G 1: 132,045,319 (GRCm39) V269A probably damaging Het
Clcc1 T C 3: 108,580,625 (GRCm39) V313A probably damaging Het
Cntrl A T 2: 35,052,845 (GRCm39) T1117S probably benign Het
Col15a1 G A 4: 47,247,533 (GRCm39) E236K probably damaging Het
Comp T C 8: 70,829,164 (GRCm39) L278P probably damaging Het
Csnk2a1-ps3 C T 1: 156,352,119 (GRCm39) R107* probably null Het
Dlg5 C A 14: 24,199,498 (GRCm39) D1469Y probably damaging Het
Efna1 A T 3: 89,186,782 (GRCm39) V23D probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Epb41l4b T C 4: 57,040,915 (GRCm39) Y516C probably damaging Het
Esr2 T C 12: 76,168,631 (GRCm39) D526G probably damaging Het
Fam184b T C 5: 45,712,477 (GRCm39) T514A probably benign Het
Fcmr A C 1: 130,803,724 (GRCm39) E176A possibly damaging Het
Fry T A 5: 150,339,685 (GRCm39) N1485K possibly damaging Het
Fut2 A G 7: 45,300,305 (GRCm39) C156R probably damaging Het
Gm5431 T C 11: 48,786,027 (GRCm39) Y116C probably benign Het
Gm5493 T A 17: 22,967,047 (GRCm39) V61E possibly damaging Het
Golga4 A T 9: 118,377,847 (GRCm39) Q456L probably damaging Het
Gpam T C 19: 55,063,041 (GRCm39) Y757C probably damaging Het
Iqcg C T 16: 32,851,174 (GRCm39) A266T probably benign Het
Lta4h G T 10: 93,307,759 (GRCm39) G331* probably null Het
Macf1 C A 4: 123,302,538 (GRCm39) V655F probably benign Het
Map3k13 T A 16: 21,740,900 (GRCm39) D742E probably benign Het
Mrgprb2 G A 7: 48,202,597 (GRCm39) L43F probably damaging Het
N4bp1 T C 8: 87,571,461 (GRCm39) R846G probably damaging Het
Nbn T C 4: 15,970,863 (GRCm39) I282T probably benign Het
Ncor1 C T 11: 62,244,059 (GRCm39) probably null Het
Or4a77 G T 2: 89,487,009 (GRCm39) P259T probably damaging Het
Or4d10c A G 19: 12,066,120 (GRCm39) F12S possibly damaging Het
Or8b12 T A 9: 37,657,433 (GRCm39) M1K probably null Het
Pclo A G 5: 14,731,976 (GRCm39) probably benign Het
Pde9a G T 17: 31,662,861 (GRCm39) V97L probably benign Het
Ptch1 T C 13: 63,672,881 (GRCm39) Y771C possibly damaging Het
R3hcc1l G A 19: 42,551,284 (GRCm39) D94N probably damaging Het
Rnpep T A 1: 135,190,858 (GRCm39) K602* probably null Het
Rph3al T C 11: 75,745,276 (GRCm39) Y156C probably damaging Het
Rundc1 A T 11: 101,324,737 (GRCm39) Y481F possibly damaging Het
Serpinb9f A G 13: 33,509,859 (GRCm39) K17R possibly damaging Het
Smpd3 T C 8: 106,986,513 (GRCm39) H459R probably damaging Het
Spata31 A C 13: 65,070,648 (GRCm39) Q932P possibly damaging Het
Srgap3 C T 6: 112,700,090 (GRCm39) A963T probably damaging Het
Syne1 A T 10: 5,179,120 (GRCm39) F4451L possibly damaging Het
Tbc1d19 T A 5: 54,014,266 (GRCm39) probably null Het
Thap12 T A 7: 98,364,669 (GRCm39) V279D probably damaging Het
Tmprss6 T C 15: 78,328,328 (GRCm39) D544G probably damaging Het
Tox2 A G 2: 163,164,930 (GRCm39) *523W probably null Het
Txnrd1 T C 10: 82,717,652 (GRCm39) I212T probably benign Het
Unc80 T C 1: 66,685,725 (GRCm39) I2283T probably benign Het
Vmn1r176 A G 7: 23,535,099 (GRCm39) I18T possibly damaging Het
Vmn2r79 T A 7: 86,651,100 (GRCm39) H166Q probably benign Het
Zer1 A G 2: 29,991,059 (GRCm39) V723A possibly damaging Het
Other mutations in Vmn2r101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01121:Vmn2r101 APN 17 19,809,936 (GRCm39) missense probably damaging 0.99
IGL02125:Vmn2r101 APN 17 19,809,963 (GRCm39) missense possibly damaging 0.95
IGL02300:Vmn2r101 APN 17 19,832,199 (GRCm39) missense probably damaging 1.00
IGL02682:Vmn2r101 APN 17 19,832,507 (GRCm39) missense possibly damaging 0.82
IGL02825:Vmn2r101 APN 17 19,810,132 (GRCm39) missense probably benign 0.00
IGL02862:Vmn2r101 APN 17 19,831,867 (GRCm39) missense probably damaging 1.00
IGL02943:Vmn2r101 APN 17 19,831,666 (GRCm39) missense probably damaging 0.99
R0371:Vmn2r101 UTSW 17 19,810,394 (GRCm39) missense probably benign 0.07
R0462:Vmn2r101 UTSW 17 19,810,431 (GRCm39) missense probably benign 0.04
R0492:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R0654:Vmn2r101 UTSW 17 19,810,373 (GRCm39) missense probably benign 0.01
R1120:Vmn2r101 UTSW 17 19,797,723 (GRCm39) splice site probably benign
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1323:Vmn2r101 UTSW 17 19,832,313 (GRCm39) missense probably damaging 1.00
R1676:Vmn2r101 UTSW 17 19,832,184 (GRCm39) missense probably benign 0.00
R2023:Vmn2r101 UTSW 17 19,810,368 (GRCm39) nonsense probably null
R2149:Vmn2r101 UTSW 17 19,809,225 (GRCm39) missense probably benign 0.00
R2350:Vmn2r101 UTSW 17 19,810,045 (GRCm39) missense probably benign 0.01
R2760:Vmn2r101 UTSW 17 19,809,901 (GRCm39) missense probably benign 0.14
R3085:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3086:Vmn2r101 UTSW 17 19,809,077 (GRCm39) splice site probably null
R3719:Vmn2r101 UTSW 17 19,809,811 (GRCm39) missense possibly damaging 0.50
R3771:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R3773:Vmn2r101 UTSW 17 19,809,919 (GRCm39) missense probably benign
R4225:Vmn2r101 UTSW 17 19,831,951 (GRCm39) missense probably damaging 1.00
R4248:Vmn2r101 UTSW 17 19,809,376 (GRCm39) missense probably damaging 1.00
R4290:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4291:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4293:Vmn2r101 UTSW 17 19,832,303 (GRCm39) missense probably damaging 1.00
R4307:Vmn2r101 UTSW 17 19,810,423 (GRCm39) missense probably damaging 1.00
R4721:Vmn2r101 UTSW 17 19,832,287 (GRCm39) missense probably damaging 0.99
R4829:Vmn2r101 UTSW 17 19,832,229 (GRCm39) missense probably benign 0.03
R5022:Vmn2r101 UTSW 17 19,831,649 (GRCm39) critical splice acceptor site probably null
R5110:Vmn2r101 UTSW 17 19,831,897 (GRCm39) missense possibly damaging 0.92
R5244:Vmn2r101 UTSW 17 19,831,788 (GRCm39) missense probably damaging 1.00
R5397:Vmn2r101 UTSW 17 19,809,104 (GRCm39) missense probably damaging 1.00
R5875:Vmn2r101 UTSW 17 19,809,092 (GRCm39) missense probably damaging 0.99
R5944:Vmn2r101 UTSW 17 19,809,769 (GRCm39) missense probably benign 0.00
R6216:Vmn2r101 UTSW 17 19,811,267 (GRCm39) missense probably benign 0.00
R6334:Vmn2r101 UTSW 17 19,810,112 (GRCm39) missense possibly damaging 0.83
R6512:Vmn2r101 UTSW 17 19,809,146 (GRCm39) missense probably damaging 1.00
R6607:Vmn2r101 UTSW 17 19,832,296 (GRCm39) missense probably damaging 1.00
R7101:Vmn2r101 UTSW 17 19,809,350 (GRCm39) missense probably null 0.14
R7183:Vmn2r101 UTSW 17 19,832,440 (GRCm39) missense probably damaging 1.00
R7344:Vmn2r101 UTSW 17 19,832,059 (GRCm39) missense probably benign 0.38
R7375:Vmn2r101 UTSW 17 19,831,652 (GRCm39) missense probably damaging 1.00
R7574:Vmn2r101 UTSW 17 19,831,899 (GRCm39) missense possibly damaging 0.91
R7575:Vmn2r101 UTSW 17 19,831,654 (GRCm39) missense probably benign 0.01
R7592:Vmn2r101 UTSW 17 19,811,443 (GRCm39) splice site probably null
R7626:Vmn2r101 UTSW 17 19,832,192 (GRCm39) nonsense probably null
R7715:Vmn2r101 UTSW 17 19,832,177 (GRCm39) missense probably damaging 1.00
R7730:Vmn2r101 UTSW 17 19,831,950 (GRCm39) missense possibly damaging 0.81
R8078:Vmn2r101 UTSW 17 19,810,507 (GRCm39) missense probably benign 0.07
R8228:Vmn2r101 UTSW 17 19,811,284 (GRCm39) missense probably benign 0.00
R8283:Vmn2r101 UTSW 17 19,832,253 (GRCm39) missense probably damaging 1.00
R8712:Vmn2r101 UTSW 17 19,811,397 (GRCm39) missense probably benign 0.24
R8765:Vmn2r101 UTSW 17 19,809,245 (GRCm39) missense probably damaging 1.00
R9091:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9092:Vmn2r101 UTSW 17 19,809,807 (GRCm39) missense probably benign 0.07
R9113:Vmn2r101 UTSW 17 19,811,288 (GRCm39) missense possibly damaging 0.56
R9158:Vmn2r101 UTSW 17 19,809,161 (GRCm39) missense probably benign 0.00
R9168:Vmn2r101 UTSW 17 19,809,138 (GRCm39) missense probably damaging 1.00
R9235:Vmn2r101 UTSW 17 19,810,238 (GRCm39) missense probably damaging 0.99
R9270:Vmn2r101 UTSW 17 19,810,244 (GRCm39) missense probably benign
R9290:Vmn2r101 UTSW 17 19,811,395 (GRCm39) missense probably benign 0.05
R9296:Vmn2r101 UTSW 17 19,810,047 (GRCm39) missense probably damaging 0.98
R9602:Vmn2r101 UTSW 17 19,831,780 (GRCm39) nonsense probably null
R9706:Vmn2r101 UTSW 17 19,809,925 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r101 UTSW 17 19,809,237 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- AGTCAGTGGTCATTGATTGCTTAC -3'
(R):5'- TGTGTTACTAATACAGGCACTAAGC -3'

Sequencing Primer
(F):5'- CAGTGGTCATTGATTGCTTACTTAAG -3'
(R):5'- TGTTTACCCTGAGGAGCA -3'
Posted On 2018-11-28