Mutagenetix > Incidental Mutation

Incidental Mutation 'R6970:Dnah11'

542208

Institutional Source

Beutler Lab

Gene Symbol

Dnah11

Ensembl Gene

ENSMUSG00000018581

Gene Name

dynein, axonemal, heavy chain 11

Synonyms

b2b598Clo, b2b1289Clo, b2b1203Clo, Dnahc11, avc4, b2b1279Clo, b2b1727Clo, lrd

MMRRC Submission

045080-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.661) question?

Stock #

R6970 (G1)

Quality Score

192.009

Status

Not validated

Chromosome

Chromosomal Location

117841717-118162778 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 118072679 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 1472 (Q1472L)

Ref Sequence

ENSEMBL: ENSMUSP00000081867 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084806]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000084806
AA Change: Q1472L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000081867
Gene: ENSMUSG00000018581
AA Change: Q1472L

Domain	Start	End	E-Value	Type
low complexity region	18	28	N/A	INTRINSIC
Pfam:DHC_N1	218	794	1.6e-162	PFAM
low complexity region	1266	1282	N/A	INTRINSIC
Pfam:DHC_N2	1297	1705	1e-130	PFAM
low complexity region	1757	1773	N/A	INTRINSIC
AAA	1869	1963	1.51e0	SMART
Pfam:AAA_5	2150	2286	1.6e-12	PFAM
AAA	2474	2619	1.48e-1	SMART
AAA	2819	2931	4.57e-1	SMART
Pfam:MT	3069	3413	3.2e-162	PFAM
Pfam:AAA_9	3434	3656	2.9e-88	PFAM
Pfam:Dynein_heavy	3790	4486	7.1e-235	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.2%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a ciliary outer dynein arm protein and is a member of the dynein heavy chain family. It is a microtubule-dependent motor ATPase and has been reported to be involved in the movement of respiratory cilia. Mutations in this gene have been implicated in causing Kartagener Syndrome (a combination of situs inversus totalis and Primary Ciliary Dyskinesia (PCD), also called Immotile Cilia Syndrome 1 (ICS1)) and male sterility. [provided by RefSeq, Mar 2013]
PHENOTYPE: Approximately half of live-born homozygous mutants show situs inversus indicating that this gene is no longer properly controlling left-right asymmetry. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadsb	T	C	7: 131,036,044 (GRCm39)	Y285H	possibly damaging	Het
Adam17	A	G	12: 21,395,669 (GRCm39)	S285P	probably benign	Het
Adcy10	A	G	1: 165,384,485 (GRCm39)	N1082S	probably benign	Het
Ahdc1	T	A	4: 132,789,656 (GRCm39)	L299Q	possibly damaging	Het
Ambra1	T	A	2: 91,602,945 (GRCm39)		probably benign	Het
Arfgef1	T	C	1: 10,223,903 (GRCm39)	Q1465R	probably damaging	Het
Arfgef1	G	T	1: 10,223,904 (GRCm39)	Q1465K	probably damaging	Het
Atp8a1	A	G	5: 67,895,805 (GRCm39)	V543A	probably damaging	Het
BC034090	T	A	1: 155,117,185 (GRCm39)	D311V	probably damaging	Het
Blnk	G	T	19: 40,950,821 (GRCm39)	P110Q	probably damaging	Het
Cc2d2a	A	G	5: 43,875,927 (GRCm39)	E968G	probably damaging	Het
Ccdc14	A	T	16: 34,529,903 (GRCm39)	E394V	probably damaging	Het
Ccdc162	A	T	10: 41,491,954 (GRCm39)	H1086Q	probably benign	Het
Ccdc85b	T	A	19: 5,507,248 (GRCm39)	I60F	probably damaging	Het
Ceacam20	T	A	7: 19,723,902 (GRCm39)	L562Q	probably damaging	Het
Cntrl	T	C	2: 35,008,149 (GRCm39)	F188L	probably benign	Het
Cplane1	T	C	15: 8,217,032 (GRCm39)	V750A	probably benign	Het
Dclk1	A	T	3: 55,374,022 (GRCm39)		probably benign	Het
Ddx20	A	T	3: 105,587,674 (GRCm39)	L434H	probably damaging	Het
Ddx51	G	A	5: 110,804,728 (GRCm39)	V547M	probably damaging	Het
Dnajb13	T	C	7: 100,156,629 (GRCm39)	E149G	probably damaging	Het
Efcab3	A	G	11: 104,667,182 (GRCm39)	E1422G	probably benign	Het
Eif1ad8	G	T	12: 87,563,388 (GRCm39)		probably benign	Het
Fat4	A	G	3: 39,035,924 (GRCm39)	N3192S	probably damaging	Het
Fat4	A	T	3: 39,050,120 (GRCm39)	D3994V	probably damaging	Het
Fcgr1	C	A	3: 96,191,936 (GRCm39)		probably null	Het
Gm12185	G	A	11: 48,798,739 (GRCm39)	R585*	probably null	Het
Gm32687	A	G	10: 81,715,304 (GRCm39)	H232R	probably benign	Het
Gm5431	G	T	11: 48,779,317 (GRCm39)	A535D	probably damaging	Het
Jarid2	C	T	13: 45,056,461 (GRCm39)	P556S	probably damaging	Het
Map3k4	C	A	17: 12,467,803 (GRCm39)	G1077V	probably damaging	Het
Mast4	C	T	13: 102,941,155 (GRCm39)	V301I	probably damaging	Het
Mlxip	A	G	5: 123,583,735 (GRCm39)	T433A	possibly damaging	Het
Ms4a20	A	G	19: 11,089,678 (GRCm39)		probably null	Het
Mus81	G	T	19: 5,535,554 (GRCm39)	H199Q	probably benign	Het
Mylk3	G	A	8: 86,085,892 (GRCm39)	T54M	probably damaging	Het
Nalcn	A	G	14: 123,551,506 (GRCm39)	F1034L	possibly damaging	Het
Nfatc1	A	C	18: 80,710,228 (GRCm39)	S513A	probably benign	Het
Ninj2	A	G	6: 120,175,092 (GRCm39)	I88V	possibly damaging	Het
Nomo1	C	T	7: 45,695,391 (GRCm39)	P277L	probably damaging	Het
Nup214	C	T	2: 31,941,810 (GRCm39)	S571L	probably damaging	Het
Or10g9b	T	A	9: 39,918,009 (GRCm39)	M79L	probably benign	Het
Or5b3	T	A	19: 13,388,792 (GRCm39)	N286K	probably damaging	Het
Or9a7	T	C	6: 40,521,590 (GRCm39)	S108G	probably benign	Het
Pcdh15	C	T	10: 74,338,519 (GRCm39)	P1005S	probably damaging	Het
Pkhd1l1	G	A	15: 44,375,070 (GRCm39)	A942T	possibly damaging	Het
Plagl1	T	C	10: 13,000,860 (GRCm39)	C34R	probably damaging	Het
Plekha2	T	C	8: 25,549,280 (GRCm39)	Q168R	probably benign	Het
Plekha6	G	A	1: 133,191,556 (GRCm39)	A146T	probably benign	Het
Plekhm3	T	G	1: 64,931,912 (GRCm39)	K564T	possibly damaging	Het
Plpp2	A	G	10: 79,366,380 (GRCm39)	V26A	possibly damaging	Het
Prdm10	T	G	9: 31,241,119 (GRCm39)	Y302*	probably null	Het
Prdm8	A	G	5: 98,332,471 (GRCm39)	E124G	probably damaging	Het
Prg4	T	G	1: 150,331,657 (GRCm39)		probably benign	Het
Qser1	A	G	2: 104,618,475 (GRCm39)	V779A	probably benign	Het
Rbm39	G	A	2: 156,009,504 (GRCm39)	R123C	probably damaging	Het
Ric1	C	T	19: 29,565,172 (GRCm39)	P640S	probably damaging	Het
Rpl14	G	A	9: 120,403,293 (GRCm39)		probably benign	Het
Rsl1d1	T	A	16: 11,011,558 (GRCm39)	D382V	probably benign	Het
Rubcn	G	T	16: 32,688,514 (GRCm39)		probably benign	Het
Sec16a	G	A	2: 26,320,498 (GRCm39)	R1361C	probably damaging	Het
Slc26a11	T	G	11: 119,247,798 (GRCm39)	V41G	probably damaging	Het
Slc41a2	A	G	10: 83,151,960 (GRCm39)	F172L	possibly damaging	Het
Slc4a4	A	C	5: 89,327,690 (GRCm39)	Y674S	probably damaging	Het
Spata31e3	A	T	13: 50,401,007 (GRCm39)	Y440N	possibly damaging	Het
Strc	A	C	2: 121,208,495 (GRCm39)	M292R	probably benign	Het
Syde2	A	G	3: 145,694,381 (GRCm39)	T210A	probably benign	Het
Tcf7l2	C	A	19: 55,743,480 (GRCm39)	A97E	probably benign	Het
Tenm3	C	T	8: 48,689,474 (GRCm39)	D2038N	probably damaging	Het
Tepsin	G	A	11: 119,986,190 (GRCm39)	T168M	probably damaging	Het
Tex15	A	T	8: 34,047,456 (GRCm39)	M178L	probably benign	Het
Tgfbr2	T	C	9: 115,939,119 (GRCm39)	N236S	probably damaging	Het
Tnrc18	A	G	5: 142,713,744 (GRCm39)	V2531A	probably damaging	Het
Ttn	T	G	2: 76,725,767 (GRCm39)		probably benign	Het
Tubgcp3	G	T	8: 12,687,000 (GRCm39)	D630E	probably damaging	Het
Ubr4	G	A	4: 139,133,839 (GRCm39)	W745*	probably null	Het
Vmn2r115	G	A	17: 23,564,989 (GRCm39)	G292D	probably benign	Het
Vmn2r38	T	A	7: 9,078,340 (GRCm39)	K681*	probably null	Het
Xrcc6	A	G	15: 81,915,375 (GRCm39)	K98E	probably benign	Het
Zfp423	A	G	8: 88,530,407 (GRCm39)	V13A	probably benign	Het
Zfp512b	A	G	2: 181,228,141 (GRCm39)	I5T	possibly damaging	Het
Zmynd8	C	T	2: 165,717,670 (GRCm39)	E14K	probably damaging	Het

Other mutations in Dnah11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Dnah11	APN	12	118,162,480 (GRCm39)	missense	probably benign	0.28
IGL00422:Dnah11	APN	12	118,031,831 (GRCm39)	missense	probably damaging	1.00
IGL00436:Dnah11	APN	12	118,000,194 (GRCm39)	missense	possibly damaging	0.56
IGL00540:Dnah11	APN	12	118,150,657 (GRCm39)	missense	probably benign	0.01
IGL00687:Dnah11	APN	12	117,885,739 (GRCm39)	splice site	probably benign
IGL00833:Dnah11	APN	12	118,143,315 (GRCm39)	missense	probably damaging	1.00
IGL00906:Dnah11	APN	12	117,874,937 (GRCm39)	missense	probably damaging	1.00
IGL00952:Dnah11	APN	12	118,160,386 (GRCm39)	missense	possibly damaging	0.56
IGL01111:Dnah11	APN	12	118,106,669 (GRCm39)	splice site	probably benign
IGL01121:Dnah11	APN	12	118,014,430 (GRCm39)	missense	probably benign	0.02
IGL01143:Dnah11	APN	12	117,976,475 (GRCm39)	missense	probably damaging	1.00
IGL01359:Dnah11	APN	12	117,946,734 (GRCm39)	missense	probably damaging	0.99
IGL01372:Dnah11	APN	12	118,156,134 (GRCm39)	missense	probably damaging	1.00
IGL01410:Dnah11	APN	12	118,010,991 (GRCm39)	nonsense	probably null
IGL01418:Dnah11	APN	12	117,951,217 (GRCm39)	nonsense	probably null
IGL01444:Dnah11	APN	12	117,983,967 (GRCm39)	missense	possibly damaging	0.91
IGL01606:Dnah11	APN	12	117,946,767 (GRCm39)	missense	probably benign	0.15
IGL01645:Dnah11	APN	12	118,150,733 (GRCm39)	missense	possibly damaging	0.90
IGL01932:Dnah11	APN	12	118,156,005 (GRCm39)	splice site	probably benign
IGL02104:Dnah11	APN	12	118,156,125 (GRCm39)	missense	probably benign
IGL02151:Dnah11	APN	12	118,023,623 (GRCm39)	splice site	probably benign
IGL02189:Dnah11	APN	12	118,046,314 (GRCm39)	missense	probably benign	0.00
IGL02417:Dnah11	APN	12	118,020,915 (GRCm39)	missense	probably damaging	1.00
IGL02421:Dnah11	APN	12	118,150,637 (GRCm39)	missense	probably damaging	1.00
IGL02444:Dnah11	APN	12	117,939,608 (GRCm39)	splice site	probably benign
IGL02474:Dnah11	APN	12	117,991,180 (GRCm39)	splice site	probably null
IGL02526:Dnah11	APN	12	118,143,353 (GRCm39)	missense	possibly damaging	0.70
IGL02887:Dnah11	APN	12	117,874,775 (GRCm39)	missense	probably damaging	1.00
IGL03011:Dnah11	APN	12	117,976,112 (GRCm39)	missense	probably benign	0.08
IGL03061:Dnah11	APN	12	117,866,856 (GRCm39)	missense	probably damaging	1.00
IGL03182:Dnah11	APN	12	117,994,026 (GRCm39)	missense	probably damaging	0.99
IGL03220:Dnah11	APN	12	118,069,720 (GRCm39)	missense	probably benign
IGL03238:Dnah11	APN	12	118,073,633 (GRCm39)	missense	probably damaging	1.00
IGL03493:Dnah11	APN	12	117,976,533 (GRCm39)	missense	probably benign	0.00
P0045:Dnah11	UTSW	12	117,994,062 (GRCm39)	missense	probably benign
R0009:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R0066:Dnah11	UTSW	12	118,090,621 (GRCm39)	missense	probably benign	0.05
R0172:Dnah11	UTSW	12	117,951,188 (GRCm39)	missense	probably damaging	1.00
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0206:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0208:Dnah11	UTSW	12	118,007,509 (GRCm39)	missense	probably damaging	0.98
R0230:Dnah11	UTSW	12	117,946,791 (GRCm39)	nonsense	probably null
R0270:Dnah11	UTSW	12	118,004,748 (GRCm39)	missense	probably damaging	1.00
R0311:Dnah11	UTSW	12	118,090,868 (GRCm39)	missense	probably benign	0.03
R0325:Dnah11	UTSW	12	117,976,074 (GRCm39)	missense	probably benign
R0370:Dnah11	UTSW	12	117,958,962 (GRCm39)	missense	probably benign
R0416:Dnah11	UTSW	12	117,874,793 (GRCm39)	missense	probably damaging	1.00
R0505:Dnah11	UTSW	12	118,070,245 (GRCm39)	missense	probably damaging	1.00
R0540:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0554:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably benign	0.01
R0607:Dnah11	UTSW	12	118,046,246 (GRCm39)	missense	probably damaging	1.00
R0620:Dnah11	UTSW	12	117,951,204 (GRCm39)	missense	probably damaging	1.00
R0635:Dnah11	UTSW	12	117,971,731 (GRCm39)	missense	probably damaging	1.00
R0755:Dnah11	UTSW	12	118,162,360 (GRCm39)	missense	probably benign	0.17
R0755:Dnah11	UTSW	12	117,918,564 (GRCm39)	missense	possibly damaging	0.95
R0789:Dnah11	UTSW	12	117,874,967 (GRCm39)	missense	probably damaging	1.00
R0833:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0835:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R0836:Dnah11	UTSW	12	118,160,397 (GRCm39)	missense	probably benign	0.01
R0846:Dnah11	UTSW	12	117,897,585 (GRCm39)	missense	probably damaging	0.97
R0865:Dnah11	UTSW	12	118,154,579 (GRCm39)	nonsense	probably null
R0928:Dnah11	UTSW	12	118,009,297 (GRCm39)	missense	probably damaging	1.00
R0939:Dnah11	UTSW	12	118,024,142 (GRCm39)	missense	probably damaging	1.00
R1203:Dnah11	UTSW	12	117,897,547 (GRCm39)	missense	possibly damaging	0.81
R1394:Dnah11	UTSW	12	117,936,099 (GRCm39)	missense	possibly damaging	0.75
R1398:Dnah11	UTSW	12	118,020,841 (GRCm39)	nonsense	probably null
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1465:Dnah11	UTSW	12	118,002,430 (GRCm39)	missense	probably damaging	1.00
R1500:Dnah11	UTSW	12	117,976,564 (GRCm39)	splice site	probably null
R1535:Dnah11	UTSW	12	117,982,465 (GRCm39)	missense	probably damaging	1.00
R1539:Dnah11	UTSW	12	117,894,991 (GRCm39)	missense	probably benign	0.01
R1554:Dnah11	UTSW	12	118,046,234 (GRCm39)	missense	possibly damaging	0.92
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1574:Dnah11	UTSW	12	118,024,052 (GRCm39)	missense	probably damaging	1.00
R1615:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R1618:Dnah11	UTSW	12	117,979,200 (GRCm39)	missense	probably damaging	0.98
R1638:Dnah11	UTSW	12	117,979,154 (GRCm39)	missense	possibly damaging	0.81
R1659:Dnah11	UTSW	12	118,084,459 (GRCm39)	missense	possibly damaging	0.94
R1671:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1678:Dnah11	UTSW	12	117,897,580 (GRCm39)	missense	possibly damaging	0.50
R1699:Dnah11	UTSW	12	118,154,603 (GRCm39)	missense	probably damaging	1.00
R1712:Dnah11	UTSW	12	118,160,379 (GRCm39)	missense	probably benign	0.32
R1728:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1729:Dnah11	UTSW	12	117,880,666 (GRCm39)	missense	probably damaging	1.00
R1764:Dnah11	UTSW	12	118,154,560 (GRCm39)	missense	probably benign	0.31
R1780:Dnah11	UTSW	12	117,991,293 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah11	UTSW	12	118,002,515 (GRCm39)	missense	probably damaging	0.99
R1800:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1863:Dnah11	UTSW	12	118,027,587 (GRCm39)	missense	possibly damaging	0.92
R1892:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R1907:Dnah11	UTSW	12	118,091,291 (GRCm39)	missense	possibly damaging	0.66
R1964:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R1967:Dnah11	UTSW	12	117,880,523 (GRCm39)	missense	probably damaging	1.00
R1997:Dnah11	UTSW	12	118,046,203 (GRCm39)	missense	possibly damaging	0.64
R2086:Dnah11	UTSW	12	118,077,606 (GRCm39)	missense	possibly damaging	0.82
R2092:Dnah11	UTSW	12	117,976,451 (GRCm39)	missense	possibly damaging	0.50
R2108:Dnah11	UTSW	12	117,984,088 (GRCm39)	missense	probably damaging	1.00
R2140:Dnah11	UTSW	12	117,972,545 (GRCm39)	missense	probably benign	0.01
R2261:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2261:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2262:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2262:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,843,760 (GRCm39)	missense	probably benign	0.06
R2263:Dnah11	UTSW	12	117,930,374 (GRCm39)	missense	probably damaging	0.99
R2328:Dnah11	UTSW	12	117,850,421 (GRCm39)	missense	probably damaging	0.98
R2352:Dnah11	UTSW	12	117,892,065 (GRCm39)	missense	probably damaging	1.00
R2410:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R2885:Dnah11	UTSW	12	117,951,162 (GRCm39)	nonsense	probably null
R3499:Dnah11	UTSW	12	117,874,758 (GRCm39)	missense	probably damaging	1.00
R3741:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3742:Dnah11	UTSW	12	118,095,076 (GRCm39)	missense	probably benign	0.05
R3779:Dnah11	UTSW	12	118,094,448 (GRCm39)	splice site	probably benign
R3785:Dnah11	UTSW	12	117,981,337 (GRCm39)	missense	probably damaging	1.00
R3883:Dnah11	UTSW	12	117,942,188 (GRCm39)	splice site	probably benign
R4014:Dnah11	UTSW	12	117,938,649 (GRCm39)	missense	probably benign	0.16
R4043:Dnah11	UTSW	12	117,843,678 (GRCm39)	missense	probably damaging	1.00
R4072:Dnah11	UTSW	12	118,070,227 (GRCm39)	missense	probably damaging	1.00
R4073:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4074:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4076:Dnah11	UTSW	12	118,009,413 (GRCm39)	missense	probably benign	0.01
R4201:Dnah11	UTSW	12	117,930,394 (GRCm39)	missense	possibly damaging	0.63
R4224:Dnah11	UTSW	12	118,094,627 (GRCm39)	missense	probably benign	0.06
R4233:Dnah11	UTSW	12	117,880,526 (GRCm39)	missense	probably damaging	1.00
R4358:Dnah11	UTSW	12	118,089,578 (GRCm39)	nonsense	probably null
R4430:Dnah11	UTSW	12	117,946,746 (GRCm39)	missense	probably benign	0.26
R4465:Dnah11	UTSW	12	117,951,186 (GRCm39)	missense	probably benign	0.09
R4489:Dnah11	UTSW	12	117,880,631 (GRCm39)	missense	probably benign	0.31
R4572:Dnah11	UTSW	12	117,973,860 (GRCm39)	missense	probably benign	0.00
R4574:Dnah11	UTSW	12	117,975,990 (GRCm39)	critical splice donor site	probably null
R4657:Dnah11	UTSW	12	118,156,162 (GRCm39)	missense	probably benign	0.02
R4709:Dnah11	UTSW	12	117,982,495 (GRCm39)	missense	probably benign	0.26
R4740:Dnah11	UTSW	12	118,084,279 (GRCm39)	missense	probably benign	0.28
R4803:Dnah11	UTSW	12	118,091,343 (GRCm39)	missense	possibly damaging	0.50
R4896:Dnah11	UTSW	12	117,958,935 (GRCm39)	missense	probably damaging	1.00
R4908:Dnah11	UTSW	12	118,090,618 (GRCm39)	missense	probably benign	0.37
R5018:Dnah11	UTSW	12	118,094,463 (GRCm39)	missense	probably benign	0.00
R5071:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5074:Dnah11	UTSW	12	118,046,188 (GRCm39)	nonsense	probably null
R5080:Dnah11	UTSW	12	118,162,565 (GRCm39)	start codon destroyed	probably null	0.01
R5097:Dnah11	UTSW	12	117,981,435 (GRCm39)	missense	probably damaging	1.00
R5131:Dnah11	UTSW	12	117,918,486 (GRCm39)	missense	probably damaging	1.00
R5215:Dnah11	UTSW	12	118,121,096 (GRCm39)	missense	probably benign	0.09
R5252:Dnah11	UTSW	12	118,089,676 (GRCm39)	missense	probably damaging	1.00
R5296:Dnah11	UTSW	12	117,847,151 (GRCm39)	missense	probably damaging	1.00
R5308:Dnah11	UTSW	12	118,049,415 (GRCm39)	missense	possibly damaging	0.60
R5368:Dnah11	UTSW	12	117,918,628 (GRCm39)	missense	probably damaging	1.00
R5383:Dnah11	UTSW	12	118,049,432 (GRCm39)	missense	probably damaging	0.99
R5499:Dnah11	UTSW	12	118,070,209 (GRCm39)	missense	possibly damaging	0.53
R5503:Dnah11	UTSW	12	117,844,186 (GRCm39)	critical splice donor site	probably null
R5546:Dnah11	UTSW	12	117,939,583 (GRCm39)	missense	possibly damaging	0.83
R5578:Dnah11	UTSW	12	117,982,537 (GRCm39)	missense	probably damaging	0.99
R5657:Dnah11	UTSW	12	117,847,352 (GRCm39)	missense	probably damaging	1.00
R5702:Dnah11	UTSW	12	118,077,642 (GRCm39)	missense	probably benign	0.04
R5706:Dnah11	UTSW	12	117,987,670 (GRCm39)	missense	probably damaging	1.00
R5727:Dnah11	UTSW	12	118,090,841 (GRCm39)	missense	probably damaging	1.00
R5737:Dnah11	UTSW	12	118,156,125 (GRCm39)	missense	probably benign
R5884:Dnah11	UTSW	12	118,141,269 (GRCm39)	missense	probably benign	0.00
R5900:Dnah11	UTSW	12	118,046,166 (GRCm39)	splice site	probably null
R5905:Dnah11	UTSW	12	117,918,659 (GRCm39)	missense	probably damaging	1.00
R5928:Dnah11	UTSW	12	117,878,371 (GRCm39)	splice site	probably null
R5973:Dnah11	UTSW	12	118,074,687 (GRCm39)	missense	probably benign	0.02
R6024:Dnah11	UTSW	12	117,994,007 (GRCm39)	missense	probably benign	0.34
R6056:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign	0.03
R6075:Dnah11	UTSW	12	118,068,586 (GRCm39)	missense	probably damaging	1.00
R6092:Dnah11	UTSW	12	117,892,191 (GRCm39)	missense	probably benign
R6191:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R6197:Dnah11	UTSW	12	118,143,482 (GRCm39)	missense	probably benign	0.03
R6262:Dnah11	UTSW	12	117,894,913 (GRCm39)	missense	probably damaging	0.98
R6321:Dnah11	UTSW	12	118,106,027 (GRCm39)	missense	possibly damaging	0.56
R6454:Dnah11	UTSW	12	117,880,590 (GRCm39)	missense	probably benign	0.01
R6614:Dnah11	UTSW	12	117,850,411 (GRCm39)	missense	possibly damaging	0.72
R6694:Dnah11	UTSW	12	118,150,617 (GRCm39)	splice site	probably null
R6712:Dnah11	UTSW	12	118,014,457 (GRCm39)	missense	probably damaging	1.00
R6720:Dnah11	UTSW	12	118,009,381 (GRCm39)	missense	probably damaging	1.00
R6742:Dnah11	UTSW	12	118,077,629 (GRCm39)	missense	possibly damaging	0.82
R6806:Dnah11	UTSW	12	117,951,411 (GRCm39)	splice site	probably null
R6895:Dnah11	UTSW	12	117,958,926 (GRCm39)	missense	probably damaging	0.99
R6939:Dnah11	UTSW	12	118,070,297 (GRCm39)	missense	probably damaging	1.00
R6940:Dnah11	UTSW	12	118,162,503 (GRCm39)	missense	probably benign
R6945:Dnah11	UTSW	12	118,024,045 (GRCm39)	missense	probably damaging	1.00
R6958:Dnah11	UTSW	12	117,897,544 (GRCm39)	missense	probably damaging	1.00
R6976:Dnah11	UTSW	12	118,162,378 (GRCm39)	missense	probably benign	0.16
R7000:Dnah11	UTSW	12	117,981,396 (GRCm39)	missense	probably damaging	1.00
R7011:Dnah11	UTSW	12	117,885,753 (GRCm39)	frame shift	probably null
R7101:Dnah11	UTSW	12	118,031,880 (GRCm39)	missense	probably benign
R7106:Dnah11	UTSW	12	117,924,884 (GRCm39)	missense	probably benign	0.15
R7203:Dnah11	UTSW	12	118,009,257 (GRCm39)	missense	possibly damaging	0.90
R7219:Dnah11	UTSW	12	118,090,624 (GRCm39)	missense	probably benign	0.00
R7219:Dnah11	UTSW	12	118,004,830 (GRCm39)	missense	possibly damaging	0.95
R7308:Dnah11	UTSW	12	117,959,010 (GRCm39)	missense	probably damaging	1.00
R7361:Dnah11	UTSW	12	117,982,477 (GRCm39)	missense	probably damaging	1.00
R7367:Dnah11	UTSW	12	117,951,177 (GRCm39)	missense	possibly damaging	0.59
R7399:Dnah11	UTSW	12	118,089,520 (GRCm39)	missense	probably damaging	1.00
R7399:Dnah11	UTSW	12	117,991,212 (GRCm39)	missense	probably benign	0.00
R7404:Dnah11	UTSW	12	118,068,543 (GRCm39)	missense	probably benign	0.36
R7473:Dnah11	UTSW	12	117,866,911 (GRCm39)	missense	probably benign	0.19
R7545:Dnah11	UTSW	12	117,894,939 (GRCm39)	missense	probably damaging	1.00
R7608:Dnah11	UTSW	12	118,104,505 (GRCm39)	splice site	probably null
R7625:Dnah11	UTSW	12	118,160,377 (GRCm39)	missense	probably benign
R7761:Dnah11	UTSW	12	117,987,648 (GRCm39)	missense	probably damaging	1.00
R7879:Dnah11	UTSW	12	118,004,744 (GRCm39)	missense	probably damaging	1.00
R7881:Dnah11	UTSW	12	117,951,237 (GRCm39)	missense	probably benign	0.04
R7904:Dnah11	UTSW	12	117,867,003 (GRCm39)	missense	possibly damaging	0.72
R8100:Dnah11	UTSW	12	117,930,368 (GRCm39)	missense	probably damaging	0.99
R8179:Dnah11	UTSW	12	117,842,284 (GRCm39)	missense	possibly damaging	0.90
R8192:Dnah11	UTSW	12	117,976,181 (GRCm39)	missense	probably benign
R8254:Dnah11	UTSW	12	117,842,259 (GRCm39)	missense	possibly damaging	0.89
R8268:Dnah11	UTSW	12	117,991,243 (GRCm39)	nonsense	probably null
R8272:Dnah11	UTSW	12	118,074,752 (GRCm39)	missense	probably benign	0.01
R8344:Dnah11	UTSW	12	118,049,466 (GRCm39)	missense	probably benign	0.00
R8515:Dnah11	UTSW	12	117,939,533 (GRCm39)	missense	probably damaging	1.00
R8528:Dnah11	UTSW	12	117,972,538 (GRCm39)	missense	probably damaging	0.96
R8557:Dnah11	UTSW	12	117,842,247 (GRCm39)	missense	probably benign
R8676:Dnah11	UTSW	12	118,154,539 (GRCm39)	missense	probably damaging	1.00
R8738:Dnah11	UTSW	12	118,049,384 (GRCm39)	critical splice donor site	probably null
R8773:Dnah11	UTSW	12	117,958,950 (GRCm39)	missense	possibly damaging	0.94
R8818:Dnah11	UTSW	12	117,874,764 (GRCm39)	missense	probably damaging	1.00
R8855:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8866:Dnah11	UTSW	12	118,156,107 (GRCm39)	missense	probably benign	0.03
R8881:Dnah11	UTSW	12	118,090,550 (GRCm39)	missense	probably benign	0.05
R8881:Dnah11	UTSW	12	118,077,647 (GRCm39)	missense	probably benign	0.00
R8920:Dnah11	UTSW	12	118,077,674 (GRCm39)	missense	probably damaging	0.99
R8944:Dnah11	UTSW	12	118,091,381 (GRCm39)	missense	possibly damaging	0.63
R8945:Dnah11	UTSW	12	117,987,718 (GRCm39)	missense	probably benign	0.36
R8962:Dnah11	UTSW	12	117,918,630 (GRCm39)	missense	probably damaging	1.00
R8962:Dnah11	UTSW	12	117,916,273 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah11	UTSW	12	118,094,578 (GRCm39)	missense	probably benign	0.00
R9155:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9162:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9164:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9171:Dnah11	UTSW	12	117,894,918 (GRCm39)	missense	probably damaging	0.99
R9186:Dnah11	UTSW	12	118,154,632 (GRCm39)	missense	probably benign
R9205:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9208:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9234:Dnah11	UTSW	12	117,951,095 (GRCm39)	missense	probably damaging	1.00
R9264:Dnah11	UTSW	12	117,991,262 (GRCm39)	missense	probably damaging	1.00
R9290:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9291:Dnah11	UTSW	12	117,991,251 (GRCm39)	missense	probably damaging	0.99
R9315:Dnah11	UTSW	12	118,143,341 (GRCm39)	missense	probably benign	0.11
R9353:Dnah11	UTSW	12	118,143,434 (GRCm39)	missense	probably benign	0.00
R9375:Dnah11	UTSW	12	117,884,703 (GRCm39)	missense	possibly damaging	0.67
R9392:Dnah11	UTSW	12	118,141,290 (GRCm39)	missense	probably benign	0.00
R9392:Dnah11	UTSW	12	118,011,055 (GRCm39)	nonsense	probably null
R9433:Dnah11	UTSW	12	117,976,007 (GRCm39)	missense	probably damaging	1.00
R9511:Dnah11	UTSW	12	117,878,352 (GRCm39)	missense	probably damaging	1.00
R9526:Dnah11	UTSW	12	118,150,711 (GRCm39)	missense	probably damaging	0.98
R9566:Dnah11	UTSW	12	117,938,728 (GRCm39)	missense	possibly damaging	0.69
R9673:Dnah11	UTSW	12	117,982,513 (GRCm39)	missense	possibly damaging	0.91
R9705:Dnah11	UTSW	12	118,094,770 (GRCm39)	missense	probably damaging	1.00
R9716:Dnah11	UTSW	12	118,024,148 (GRCm39)	missense	probably damaging	0.99
R9746:Dnah11	UTSW	12	117,842,311 (GRCm39)	nonsense	probably null
R9764:Dnah11	UTSW	12	117,884,704 (GRCm39)	missense	probably benign	0.05
RF023:Dnah11	UTSW	12	117,918,585 (GRCm39)	missense	probably damaging	1.00
RF047:Dnah11	UTSW	12	117,973,818 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,858,747 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah11	UTSW	12	117,946,704 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah11	UTSW	12	118,094,534 (GRCm39)	missense	probably damaging	0.97
Z1176:Dnah11	UTSW	12	118,090,854 (GRCm39)	missense	probably benign	0.00
Z1176:Dnah11	UTSW	12	117,894,912 (GRCm39)	missense	possibly damaging	0.81

Predicted Primers

PCR Primer
(F):5'- AGAAGACTCCTTTGTGTCATCTGC -3'
(R):5'- TCTAAGTCATGGCTGAGATATTGG -3'

Sequencing Primer
(F):5'- TTTCTGAACTACAAGTCCCCTGAGAG -3'
(R):5'- GCCCTAAATTTGATGTGGATGCAC -3'

Posted On

2018-11-28