|Institutional Source||Beutler Lab|
|Gene Name||family with sequence similarity 19, member A2|
|Is this an essential gene?||Probably non essential (E-score: 0.109)|
|Stock #||R6972 (G1)|
|Chromosomal Location||123263996-123741204 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 123704373 bp|
|Amino Acid Change||Threonine to Alanine at position 45 (T45A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000050199 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000050756]|
|Predicted Effect||probably benign
AA Change: T45A
PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
AA Change: T45A
|Meta Mutation Damage Score||0.0803|
|Coding Region Coverage||
|Validation Efficiency||100% (41/41)|
FUNCTION: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased anxiety-like and fear-related behaviors. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fam19a2||
(F):5'- CGCCAAGCATTTACCGATGG -3'
(R):5'- CCGATTCCAACCATGCTATTAC -3'
(F):5'- TACCGATGGAAATGGTCTCTGCAC -3'
(R):5'- CCATGCTATTACAAAGAGCAATGG -3'