Incidental Mutation 'R6972:Tafa2'
ID 542310
Institutional Source Beutler Lab
Gene Symbol Tafa2
Ensembl Gene ENSMUSG00000044071
Gene Name TAFA chemokine like family member 2
Synonyms Sam2, Tafa2, Fam19a2, Tafa-2
MMRRC Submission 045082-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.231) question?
Stock # R6972 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 123099901-123577109 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 123540278 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 45 (T45A)
Ref Sequence ENSEMBL: ENSMUSP00000050199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050756]
AlphaFold Q7TPG7
Predicted Effect probably benign
Transcript: ENSMUST00000050756
AA Change: T45A

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000050199
Gene: ENSMUSG00000044071
AA Change: T45A

DomainStartEndE-ValueType
Pfam:TAFA 45 133 6.8e-51 PFAM
Meta Mutation Damage Score 0.0803 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.0%
  • 20x: 95.8%
Validation Efficiency 100% (41/41)
MGI Phenotype FUNCTION: This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased anxiety-like and fear-related behaviors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd2 A G 7: 79,003,775 (GRCm39) S285G probably benign Het
Afg1l T C 10: 42,354,370 (GRCm39) T10A probably benign Het
Akap9 A G 5: 4,096,699 (GRCm39) N2525D possibly damaging Het
B3gnt7 G A 1: 86,233,109 (GRCm39) M1I probably null Het
Bdp1 T C 13: 100,174,269 (GRCm39) E2089G probably null Het
Calcrl T G 2: 84,198,922 (GRCm39) I156L probably benign Het
Cd69 T C 6: 129,246,543 (GRCm39) S122G probably benign Het
Chek2 T C 5: 111,003,705 (GRCm39) probably null Het
Ckap5 T A 2: 91,436,658 (GRCm39) I1586K probably damaging Het
Cyp4f14 C T 17: 33,124,483 (GRCm39) A523T probably benign Het
Dcaf1 T A 9: 106,723,971 (GRCm39) C466* probably null Het
Dcdc2a A T 13: 25,304,372 (GRCm39) probably benign Het
Eml5 T C 12: 98,842,439 (GRCm39) I220V probably benign Het
Etv2 T C 7: 30,334,167 (GRCm39) N189D probably benign Het
Fuz T C 7: 44,546,755 (GRCm39) probably benign Het
Git1 T G 11: 77,390,347 (GRCm39) V64G probably damaging Het
Gpr162 C T 6: 124,838,272 (GRCm39) R126H probably damaging Het
Grm5 T C 7: 87,252,131 (GRCm39) V127A probably benign Het
Iqsec1 T C 6: 90,653,750 (GRCm39) D665G probably damaging Het
Kcnh1 A G 1: 191,959,144 (GRCm39) I233V probably damaging Het
Lmcd1 C T 6: 112,287,659 (GRCm39) T115I probably damaging Het
Mybpc1 T C 10: 88,396,223 (GRCm39) E208G possibly damaging Het
Nfic C A 10: 81,256,191 (GRCm39) A158S probably benign Het
Nos3 A T 5: 24,585,241 (GRCm39) I798L probably benign Het
Ntrk1 A T 3: 87,691,288 (GRCm39) L292Q probably damaging Het
Or2ag16 A G 7: 106,351,906 (GRCm39) S230P possibly damaging Het
Orc4 T C 2: 48,817,196 (GRCm39) Q164R probably benign Het
Pcdhb14 T A 18: 37,582,745 (GRCm39) V617E probably damaging Het
Pira1 C G 7: 3,740,319 (GRCm39) A301P probably damaging Het
Plscr3 G A 11: 69,738,784 (GRCm39) E149K probably damaging Het
Pltp A G 2: 164,688,512 (GRCm39) probably null Het
Pramel11 A G 4: 143,623,472 (GRCm39) L234P probably damaging Het
Prg2 G A 2: 84,812,617 (GRCm39) R109H probably benign Het
Ptprj G A 2: 90,410,747 (GRCm39) S62F possibly damaging Het
Resf1 T A 6: 149,227,607 (GRCm39) Y218N probably damaging Het
Skint3 T A 4: 112,116,089 (GRCm39) S240T probably damaging Het
Smarca5 A G 8: 81,431,380 (GRCm39) Y946H probably damaging Het
Taf4b T C 18: 14,946,404 (GRCm39) V409A possibly damaging Het
Trim29 T A 9: 43,238,409 (GRCm39) N504K probably benign Het
Vmn2r77 T C 7: 86,452,202 (GRCm39) Y461H probably damaging Het
Zeb2 T C 2: 44,887,330 (GRCm39) K531E probably damaging Het
Zfp687 A G 3: 94,916,688 (GRCm39) S813P possibly damaging Het
Other mutations in Tafa2
AlleleSourceChrCoordTypePredicted EffectPPH Score
dolorous UTSW 10 123,540,297 (GRCm39) missense probably damaging 1.00
Lugubrious UTSW 10 123,429,401 (GRCm39) missense possibly damaging 0.86
R0395:Tafa2 UTSW 10 123,429,497 (GRCm39) missense probably benign 0.05
R1478:Tafa2 UTSW 10 123,429,401 (GRCm39) missense possibly damaging 0.86
R2869:Tafa2 UTSW 10 123,540,270 (GRCm39) missense possibly damaging 0.63
R2869:Tafa2 UTSW 10 123,540,270 (GRCm39) missense possibly damaging 0.63
R2870:Tafa2 UTSW 10 123,540,270 (GRCm39) missense possibly damaging 0.63
R2870:Tafa2 UTSW 10 123,540,270 (GRCm39) missense possibly damaging 0.63
R2873:Tafa2 UTSW 10 123,540,270 (GRCm39) missense possibly damaging 0.63
R6537:Tafa2 UTSW 10 123,429,401 (GRCm39) missense possibly damaging 0.86
R6589:Tafa2 UTSW 10 123,540,297 (GRCm39) missense probably damaging 1.00
R9043:Tafa2 UTSW 10 123,540,294 (GRCm39) missense probably damaging 1.00
R9065:Tafa2 UTSW 10 123,429,421 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- CGCCAAGCATTTACCGATGG -3'
(R):5'- CCGATTCCAACCATGCTATTAC -3'

Sequencing Primer
(F):5'- TACCGATGGAAATGGTCTCTGCAC -3'
(R):5'- CCATGCTATTACAAAGAGCAATGG -3'
Posted On 2018-11-28