Incidental Mutation 'R6974:Or1e22'
ID 542370
Institutional Source Beutler Lab
Gene Symbol Or1e22
Ensembl Gene ENSMUSG00000072708
Gene Name olfactory receptor family 1 subfamily E member 22
Synonyms Olfr381, GA_x6K02T2P1NL-3646409-3645474, MOR135-4
MMRRC Submission 045084-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R6974 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 73376713-73377648 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73377299 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 117 (I117T)
Ref Sequence ENSEMBL: ENSMUSP00000149355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078358] [ENSMUST00000119863] [ENSMUST00000214623] [ENSMUST00000215358]
AlphaFold Q5SSP0
Predicted Effect probably benign
Transcript: ENSMUST00000078358
AA Change: I117T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000077467
Gene: ENSMUSG00000072708
AA Change: I117T

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.3e-35 PFAM
Pfam:7tm_4 139 283 5.3e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119863
AA Change: I117T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000113846
Gene: ENSMUSG00000072708
AA Change: I117T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.2e-57 PFAM
Pfam:7tm_1 41 290 2e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214623
AA Change: I117T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215358
AA Change: I117T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12b T A 12: 70,206,221 (GRCm39) N67K probably benign Het
Amotl1 C A 9: 14,556,216 (GRCm39) E37* probably null Het
Ap4b1 C A 3: 103,720,601 (GRCm39) Y90* probably null Het
Apc A G 18: 34,431,480 (GRCm39) E277G possibly damaging Het
Atl1 T A 12: 69,972,813 (GRCm39) H44Q probably damaging Het
Atp6v0b G A 4: 117,742,864 (GRCm39) T74M probably benign Het
Auts2 T C 5: 131,469,437 (GRCm39) T627A probably benign Het
B4galnt4 T A 7: 140,647,449 (GRCm39) I372N possibly damaging Het
B4galt2 A G 4: 117,731,148 (GRCm39) S338P probably damaging Het
Cfap43 A C 19: 47,773,717 (GRCm39) probably null Het
Col4a1 T C 8: 11,362,538 (GRCm39) probably benign Het
Col7a1 A C 9: 108,798,494 (GRCm39) I1741L possibly damaging Het
Coprs A T 8: 13,935,750 (GRCm39) S90T probably benign Het
Csrnp3 T C 2: 65,779,408 (GRCm39) V40A possibly damaging Het
Ephx1 C A 1: 180,827,287 (GRCm39) probably null Het
Erich6 C A 3: 58,526,220 (GRCm39) R594L probably benign Het
F2rl2 A T 13: 95,837,038 (GRCm39) N28Y probably damaging Het
Fbxo38 A T 18: 62,639,740 (GRCm39) N1041K possibly damaging Het
Fcgr2b C T 1: 170,790,977 (GRCm39) probably null Het
Fsip2 T A 2: 82,809,061 (GRCm39) N1793K probably damaging Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gcnt3 A G 9: 69,942,169 (GRCm39) I133T probably damaging Het
Gm57859 A G 11: 113,578,818 (GRCm39) D71G probably benign Het
Hoxa1 T A 6: 52,135,021 (GRCm39) I61F probably damaging Het
Impact C T 18: 13,115,169 (GRCm39) L102F probably damaging Het
Ist1 A T 8: 110,404,284 (GRCm39) I196N probably damaging Het
Kcnv2 T A 19: 27,311,282 (GRCm39) S550T probably benign Het
Krt1c A T 15: 101,726,314 (GRCm39) S75T unknown Het
Krtap21-1 A G 16: 89,200,466 (GRCm39) S59P unknown Het
Lef1 A T 3: 130,905,223 (GRCm39) I35F probably damaging Het
Lpcat2 A C 8: 93,599,707 (GRCm39) N225T probably damaging Het
Lztfl1 A T 9: 123,538,649 (GRCm39) N142K probably benign Het
Mdh1b G A 1: 63,760,975 (GRCm39) H88Y probably benign Het
Mettl26 A G 17: 26,095,658 (GRCm39) D171G probably damaging Het
Mrps24 A T 11: 5,654,663 (GRCm39) M97K probably benign Het
Ms4a14 A T 19: 11,279,499 (GRCm39) C1020S probably benign Het
Mterf1a A T 5: 3,940,854 (GRCm39) I338K probably benign Het
Odad2 A T 18: 7,294,479 (GRCm39) Y45N probably benign Het
Or4p20 T C 2: 88,254,156 (GRCm39) Y71C possibly damaging Het
Or52s1b T A 7: 102,822,442 (GRCm39) H134L probably damaging Het
Or7g12 T A 9: 18,899,689 (GRCm39) I135N probably damaging Het
Paqr3 T A 5: 97,256,146 (GRCm39) H76L probably damaging Het
Parp1 T A 1: 180,417,071 (GRCm39) Y618* probably null Het
Pilrb2 C T 5: 137,870,049 (GRCm39) probably benign Het
Pkm A G 9: 59,575,853 (GRCm39) N90D probably damaging Het
Pla2g4c T G 7: 13,078,459 (GRCm39) probably null Het
Plppr4 C T 3: 117,116,667 (GRCm39) V339I probably damaging Het
Pnkp T A 7: 44,510,462 (GRCm39) D304E probably damaging Het
Pnlip T C 19: 58,668,067 (GRCm39) probably null Het
Polr2a A G 11: 69,638,026 (GRCm39) C148R probably damaging Het
Ppp1r10 G A 17: 36,240,443 (GRCm39) G578S probably benign Het
Ptges2 C T 2: 32,287,683 (GRCm39) T137I possibly damaging Het
Ptpre T C 7: 135,270,877 (GRCm39) V344A possibly damaging Het
Rag1 A G 2: 101,472,137 (GRCm39) F1002L probably damaging Het
Rcn2 T A 9: 55,960,298 (GRCm39) Y188* probably null Het
Rest A G 5: 77,416,046 (GRCm39) S87G probably damaging Het
Rgsl1 C T 1: 153,675,568 (GRCm39) D913N probably damaging Het
Scp2 A G 4: 107,928,475 (GRCm39) M1T probably null Het
Slamf8 T A 1: 172,415,590 (GRCm39) N83Y probably damaging Het
Slc26a11 T A 11: 119,248,844 (GRCm39) F75Y possibly damaging Het
Slc26a5 A G 5: 22,045,570 (GRCm39) S133P probably damaging Het
Sncb A T 13: 54,910,487 (GRCm39) V83E probably damaging Het
Tmem243 A G 5: 9,151,348 (GRCm39) T11A probably damaging Het
Trim38 A G 13: 23,973,502 (GRCm39) N277D probably benign Het
Vmn1r189 C T 13: 22,286,628 (GRCm39) G70S probably damaging Het
Vmn2r-ps117 A G 17: 19,058,495 (GRCm39) R684G probably benign Het
Wdr59 T C 8: 112,187,420 (GRCm39) N792D possibly damaging Het
Wnt5a A G 14: 28,244,527 (GRCm39) D238G possibly damaging Het
Zbtb42 C A 12: 112,646,824 (GRCm39) T333K probably damaging Het
Zfp119b A G 17: 56,245,564 (GRCm39) S509P probably benign Het
Zfp365 T A 10: 67,745,594 (GRCm39) K61N probably damaging Het
Zfp553 T C 7: 126,835,825 (GRCm39) F460S probably damaging Het
Zfp788 C T 7: 41,299,301 (GRCm39) Q594* probably null Het
Zfp984 T A 4: 147,845,707 (GRCm39) M1L possibly damaging Het
Zmiz2 T A 11: 6,347,566 (GRCm39) Y291* probably null Het
Other mutations in Or1e22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Or1e22 APN 11 73,377,398 (GRCm39) missense probably benign 0.22
IGL02867:Or1e22 APN 11 73,376,817 (GRCm39) missense probably damaging 1.00
IGL03202:Or1e22 APN 11 73,377,351 (GRCm39) nonsense probably null
R0207:Or1e22 UTSW 11 73,377,401 (GRCm39) missense probably benign 0.00
R0539:Or1e22 UTSW 11 73,376,889 (GRCm39) missense probably benign 0.22
R1469:Or1e22 UTSW 11 73,377,149 (GRCm39) missense possibly damaging 0.81
R1469:Or1e22 UTSW 11 73,377,149 (GRCm39) missense possibly damaging 0.81
R1835:Or1e22 UTSW 11 73,377,200 (GRCm39) missense probably benign 0.08
R2095:Or1e22 UTSW 11 73,377,420 (GRCm39) missense probably damaging 1.00
R3612:Or1e22 UTSW 11 73,376,766 (GRCm39) missense probably benign 0.23
R3983:Or1e22 UTSW 11 73,376,961 (GRCm39) missense possibly damaging 0.84
R4959:Or1e22 UTSW 11 73,376,893 (GRCm39) nonsense probably null
R4983:Or1e22 UTSW 11 73,377,623 (GRCm39) missense probably benign 0.04
R5297:Or1e22 UTSW 11 73,377,215 (GRCm39) missense probably damaging 0.99
R5447:Or1e22 UTSW 11 73,377,002 (GRCm39) missense probably benign 0.01
R5569:Or1e22 UTSW 11 73,377,518 (GRCm39) missense probably damaging 0.97
R5580:Or1e22 UTSW 11 73,377,036 (GRCm39) missense probably benign
R5711:Or1e22 UTSW 11 73,377,008 (GRCm39) missense probably damaging 1.00
R5810:Or1e22 UTSW 11 73,376,921 (GRCm39) nonsense probably null
R7383:Or1e22 UTSW 11 73,376,715 (GRCm39) makesense probably null
R7661:Or1e22 UTSW 11 73,377,426 (GRCm39) missense probably damaging 1.00
R7748:Or1e22 UTSW 11 73,376,994 (GRCm39) missense probably benign 0.03
R7913:Or1e22 UTSW 11 73,377,224 (GRCm39) missense probably benign 0.01
R9400:Or1e22 UTSW 11 73,376,807 (GRCm39) missense probably damaging 1.00
R9666:Or1e22 UTSW 11 73,376,885 (GRCm39) missense probably damaging 0.98
Z1177:Or1e22 UTSW 11 73,376,979 (GRCm39) missense probably benign 0.36
Predicted Primers PCR Primer
(F):5'- TCAGAGCAGGCCAACTTGAG -3'
(R):5'- ACACACCCATGTACTTGTTTCTCAG -3'

Sequencing Primer
(F):5'- CCAACTTGAGCAGTGCAGATATGTC -3'
(R):5'- ATGTACTTGTTTCTCAGCAACTTG -3'
Posted On 2018-11-28