Incidental Mutation 'R6974:Zfp119b'
ID 542386
Institutional Source Beutler Lab
Gene Symbol Zfp119b
Ensembl Gene ENSMUSG00000062101
Gene Name zinc finger protein 119b
Synonyms BC031441
MMRRC Submission 045084-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R6974 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 56245381-56256500 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 56245564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 509 (S509P)
Ref Sequence ENSEMBL: ENSMUSP00000139791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056147] [ENSMUST00000189452]
AlphaFold Q8K0G9
Predicted Effect probably benign
Transcript: ENSMUST00000056147
AA Change: S541P

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000058300
Gene: ENSMUSG00000062101
AA Change: S541P

DomainStartEndE-ValueType
KRAB 4 56 2e-14 SMART
ZnF_C2H2 155 175 2.82e1 SMART
ZnF_C2H2 287 309 1.1e-2 SMART
ZnF_C2H2 315 337 2.24e-3 SMART
ZnF_C2H2 343 365 5.14e-3 SMART
ZnF_C2H2 371 393 4.79e-3 SMART
ZnF_C2H2 399 421 1.12e-3 SMART
ZnF_C2H2 427 449 5.14e-3 SMART
ZnF_C2H2 455 477 7.37e-4 SMART
ZnF_C2H2 483 505 4.87e-4 SMART
ZnF_C2H2 511 533 1.25e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000189452
AA Change: S509P

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000139791
Gene: ENSMUSG00000062101
AA Change: S509P

DomainStartEndE-ValueType
Blast:KRAB 1 34 8e-11 BLAST
ZnF_C2H2 123 143 1.2e-1 SMART
ZnF_C2H2 255 277 4.7e-5 SMART
ZnF_C2H2 283 305 9.1e-6 SMART
ZnF_C2H2 311 333 2.2e-5 SMART
ZnF_C2H2 339 361 2e-5 SMART
ZnF_C2H2 367 389 4.7e-6 SMART
ZnF_C2H2 395 417 2.1e-5 SMART
ZnF_C2H2 423 445 3.2e-6 SMART
ZnF_C2H2 451 473 2e-6 SMART
ZnF_C2H2 479 501 5.2e-4 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12b T A 12: 70,206,221 (GRCm39) N67K probably benign Het
Amotl1 C A 9: 14,556,216 (GRCm39) E37* probably null Het
Ap4b1 C A 3: 103,720,601 (GRCm39) Y90* probably null Het
Apc A G 18: 34,431,480 (GRCm39) E277G possibly damaging Het
Atl1 T A 12: 69,972,813 (GRCm39) H44Q probably damaging Het
Atp6v0b G A 4: 117,742,864 (GRCm39) T74M probably benign Het
Auts2 T C 5: 131,469,437 (GRCm39) T627A probably benign Het
B4galnt4 T A 7: 140,647,449 (GRCm39) I372N possibly damaging Het
B4galt2 A G 4: 117,731,148 (GRCm39) S338P probably damaging Het
Cfap43 A C 19: 47,773,717 (GRCm39) probably null Het
Col4a1 T C 8: 11,362,538 (GRCm39) probably benign Het
Col7a1 A C 9: 108,798,494 (GRCm39) I1741L possibly damaging Het
Coprs A T 8: 13,935,750 (GRCm39) S90T probably benign Het
Csrnp3 T C 2: 65,779,408 (GRCm39) V40A possibly damaging Het
Ephx1 C A 1: 180,827,287 (GRCm39) probably null Het
Erich6 C A 3: 58,526,220 (GRCm39) R594L probably benign Het
F2rl2 A T 13: 95,837,038 (GRCm39) N28Y probably damaging Het
Fbxo38 A T 18: 62,639,740 (GRCm39) N1041K possibly damaging Het
Fcgr2b C T 1: 170,790,977 (GRCm39) probably null Het
Fsip2 T A 2: 82,809,061 (GRCm39) N1793K probably damaging Het
Gatad1 T C 5: 3,693,540 (GRCm39) R210G probably benign Het
Gcnt3 A G 9: 69,942,169 (GRCm39) I133T probably damaging Het
Gm57859 A G 11: 113,578,818 (GRCm39) D71G probably benign Het
Hoxa1 T A 6: 52,135,021 (GRCm39) I61F probably damaging Het
Impact C T 18: 13,115,169 (GRCm39) L102F probably damaging Het
Ist1 A T 8: 110,404,284 (GRCm39) I196N probably damaging Het
Kcnv2 T A 19: 27,311,282 (GRCm39) S550T probably benign Het
Krt1c A T 15: 101,726,314 (GRCm39) S75T unknown Het
Krtap21-1 A G 16: 89,200,466 (GRCm39) S59P unknown Het
Lef1 A T 3: 130,905,223 (GRCm39) I35F probably damaging Het
Lpcat2 A C 8: 93,599,707 (GRCm39) N225T probably damaging Het
Lztfl1 A T 9: 123,538,649 (GRCm39) N142K probably benign Het
Mdh1b G A 1: 63,760,975 (GRCm39) H88Y probably benign Het
Mettl26 A G 17: 26,095,658 (GRCm39) D171G probably damaging Het
Mrps24 A T 11: 5,654,663 (GRCm39) M97K probably benign Het
Ms4a14 A T 19: 11,279,499 (GRCm39) C1020S probably benign Het
Mterf1a A T 5: 3,940,854 (GRCm39) I338K probably benign Het
Odad2 A T 18: 7,294,479 (GRCm39) Y45N probably benign Het
Or1e22 A G 11: 73,377,299 (GRCm39) I117T probably benign Het
Or4p20 T C 2: 88,254,156 (GRCm39) Y71C possibly damaging Het
Or52s1b T A 7: 102,822,442 (GRCm39) H134L probably damaging Het
Or7g12 T A 9: 18,899,689 (GRCm39) I135N probably damaging Het
Paqr3 T A 5: 97,256,146 (GRCm39) H76L probably damaging Het
Parp1 T A 1: 180,417,071 (GRCm39) Y618* probably null Het
Pilrb2 C T 5: 137,870,049 (GRCm39) probably benign Het
Pkm A G 9: 59,575,853 (GRCm39) N90D probably damaging Het
Pla2g4c T G 7: 13,078,459 (GRCm39) probably null Het
Plppr4 C T 3: 117,116,667 (GRCm39) V339I probably damaging Het
Pnkp T A 7: 44,510,462 (GRCm39) D304E probably damaging Het
Pnlip T C 19: 58,668,067 (GRCm39) probably null Het
Polr2a A G 11: 69,638,026 (GRCm39) C148R probably damaging Het
Ppp1r10 G A 17: 36,240,443 (GRCm39) G578S probably benign Het
Ptges2 C T 2: 32,287,683 (GRCm39) T137I possibly damaging Het
Ptpre T C 7: 135,270,877 (GRCm39) V344A possibly damaging Het
Rag1 A G 2: 101,472,137 (GRCm39) F1002L probably damaging Het
Rcn2 T A 9: 55,960,298 (GRCm39) Y188* probably null Het
Rest A G 5: 77,416,046 (GRCm39) S87G probably damaging Het
Rgsl1 C T 1: 153,675,568 (GRCm39) D913N probably damaging Het
Scp2 A G 4: 107,928,475 (GRCm39) M1T probably null Het
Slamf8 T A 1: 172,415,590 (GRCm39) N83Y probably damaging Het
Slc26a11 T A 11: 119,248,844 (GRCm39) F75Y possibly damaging Het
Slc26a5 A G 5: 22,045,570 (GRCm39) S133P probably damaging Het
Sncb A T 13: 54,910,487 (GRCm39) V83E probably damaging Het
Tmem243 A G 5: 9,151,348 (GRCm39) T11A probably damaging Het
Trim38 A G 13: 23,973,502 (GRCm39) N277D probably benign Het
Vmn1r189 C T 13: 22,286,628 (GRCm39) G70S probably damaging Het
Vmn2r-ps117 A G 17: 19,058,495 (GRCm39) R684G probably benign Het
Wdr59 T C 8: 112,187,420 (GRCm39) N792D possibly damaging Het
Wnt5a A G 14: 28,244,527 (GRCm39) D238G possibly damaging Het
Zbtb42 C A 12: 112,646,824 (GRCm39) T333K probably damaging Het
Zfp365 T A 10: 67,745,594 (GRCm39) K61N probably damaging Het
Zfp553 T C 7: 126,835,825 (GRCm39) F460S probably damaging Het
Zfp788 C T 7: 41,299,301 (GRCm39) Q594* probably null Het
Zfp984 T A 4: 147,845,707 (GRCm39) M1L possibly damaging Het
Zmiz2 T A 11: 6,347,566 (GRCm39) Y291* probably null Het
Other mutations in Zfp119b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00545:Zfp119b APN 17 56,246,270 (GRCm39) missense probably damaging 1.00
IGL01868:Zfp119b APN 17 56,246,866 (GRCm39) missense possibly damaging 0.70
IGL02623:Zfp119b APN 17 56,246,793 (GRCm39) missense probably damaging 0.96
R0377:Zfp119b UTSW 17 56,245,671 (GRCm39) missense probably damaging 1.00
R1833:Zfp119b UTSW 17 56,246,271 (GRCm39) missense probably damaging 1.00
R2177:Zfp119b UTSW 17 56,245,639 (GRCm39) missense probably damaging 1.00
R2297:Zfp119b UTSW 17 56,246,355 (GRCm39) missense possibly damaging 0.46
R4273:Zfp119b UTSW 17 56,245,926 (GRCm39) missense possibly damaging 0.79
R4801:Zfp119b UTSW 17 56,246,642 (GRCm39) missense probably damaging 0.96
R4802:Zfp119b UTSW 17 56,246,642 (GRCm39) missense probably damaging 0.96
R6525:Zfp119b UTSW 17 56,246,992 (GRCm39) missense possibly damaging 0.96
R6644:Zfp119b UTSW 17 56,246,148 (GRCm39) missense probably benign 0.21
R6950:Zfp119b UTSW 17 56,246,137 (GRCm39) missense probably damaging 1.00
R7750:Zfp119b UTSW 17 56,245,682 (GRCm39) missense probably damaging 1.00
R8882:Zfp119b UTSW 17 56,246,923 (GRCm39) missense possibly damaging 0.84
R9383:Zfp119b UTSW 17 56,246,355 (GRCm39) missense probably damaging 0.96
R9431:Zfp119b UTSW 17 56,246,536 (GRCm39) missense possibly damaging 0.78
RF020:Zfp119b UTSW 17 56,246,499 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTCTCCATTTACCTGTTTCTGAGAAAG -3'
(R):5'- TACTGGAGAGAAACCCTATGAATG -3'

Sequencing Primer
(F):5'- ACCTGTTTCTGAGAAAGTGTTACG -3'
(R):5'- GTAATCAATGTGGTAAAGCCTTTGC -3'
Posted On 2018-11-28