Incidental Mutation 'R6976:Brpf3'
ID 542480
Institutional Source Beutler Lab
Gene Symbol Brpf3
Ensembl Gene ENSMUSG00000063952
Gene Name bromodomain and PHD finger containing, 3
Synonyms
MMRRC Submission 045382-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.459) question?
Stock # R6976 (G1)
Quality Score 208.009
Status Validated
Chromosome 17
Chromosomal Location 29020088-29057763 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 29054751 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 1098 (M1098V)
Ref Sequence ENSEMBL: ENSMUSP00000004985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004985]
AlphaFold B2KF05
Predicted Effect probably damaging
Transcript: ENSMUST00000004985
AA Change: M1098V

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000004985
Gene: ENSMUSG00000063952
AA Change: M1098V

DomainStartEndE-ValueType
Pfam:EPL1 48 194 8.4e-38 PFAM
PHD 214 260 7.07e-5 SMART
PHD 324 387 4.74e-6 SMART
low complexity region 405 436 N/A INTRINSIC
Blast:BROMO 491 534 7e-21 BLAST
low complexity region 558 577 N/A INTRINSIC
BROMO 586 694 4.93e-39 SMART
low complexity region 777 792 N/A INTRINSIC
low complexity region 813 823 N/A INTRINSIC
PWWP 1073 1156 2.07e-38 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127007
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140587
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140973
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144022
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156029
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (50/50)
MGI Phenotype PHENOTYPE: Homozygous knockout does not result in any obvious neurological, behavioral, developmental, histological, hematological, survival or reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 T A 2: 155,397,929 (GRCm39) probably null Het
Adamts4 G T 1: 171,079,877 (GRCm39) probably benign Het
Adgrv1 T A 13: 81,669,116 (GRCm39) K2480M probably damaging Het
Ankhd1 A C 18: 36,781,307 (GRCm39) S2120R probably benign Het
Ash1l T A 3: 88,888,964 (GRCm39) V281E possibly damaging Het
Bdh1 G A 16: 31,256,847 (GRCm39) A35T probably benign Het
Cel G A 2: 28,446,854 (GRCm39) S439F probably damaging Het
Dnah11 T C 12: 118,162,378 (GRCm39) S64G probably benign Het
Dpp7 T C 2: 25,244,836 (GRCm39) probably null Het
Fam83c T A 2: 155,672,157 (GRCm39) Y426F possibly damaging Het
Fasn A G 11: 120,710,693 (GRCm39) I322T probably damaging Het
Glod4 A G 11: 76,134,406 (GRCm39) F22S probably damaging Het
Gm3127 A G 14: 15,432,190 (GRCm39) T231A possibly damaging Het
Gm49383 A G 12: 69,243,730 (GRCm39) S444P possibly damaging Het
Gnaz T C 10: 74,827,268 (GRCm39) S7P possibly damaging Het
Grin2b C T 6: 135,757,198 (GRCm39) S421N probably benign Het
Grm1 T C 10: 10,564,924 (GRCm39) D1128G probably benign Het
Hoxb13 A G 11: 96,087,044 (GRCm39) T284A probably benign Het
Il9r G A 11: 32,143,177 (GRCm39) Q260* probably null Het
Lrrfip1 T A 1: 91,042,737 (GRCm39) C381S probably benign Het
Mitd1 A T 1: 37,921,778 (GRCm39) D85E probably benign Het
Muc4 G A 16: 32,582,892 (GRCm39) D2556N possibly damaging Het
Nlrc4 A G 17: 74,752,934 (GRCm39) I483T probably damaging Het
Or13e8 A G 4: 43,697,170 (GRCm39) M1T probably null Het
Or2ag17 A T 7: 106,389,434 (GRCm39) M258K probably damaging Het
Or8g4 A G 9: 39,662,540 (GRCm39) N286S probably damaging Het
Pcdhb7 C A 18: 37,476,631 (GRCm39) A589E probably benign Het
Pcdhgb5 G A 18: 37,864,321 (GRCm39) E39K probably damaging Het
Pja2 T C 17: 64,615,954 (GRCm39) K314E probably damaging Het
Plcb1 A G 2: 135,104,159 (GRCm39) E276G possibly damaging Het
Ppp2r5c A G 12: 110,510,579 (GRCm39) E122G probably damaging Het
Prrc2c A T 1: 162,520,413 (GRCm39) N732K probably damaging Het
Rb1cc1 T A 1: 6,333,126 (GRCm39) D1348E probably benign Het
Sh3rf1 G T 8: 61,814,766 (GRCm39) E442* probably null Het
Snapc1 A G 12: 74,016,974 (GRCm39) D204G probably damaging Het
Sry C T Y: 2,662,938 (GRCm39) D241N unknown Het
Strn4 T A 7: 16,564,279 (GRCm39) M303K probably benign Het
Tas2r118 A G 6: 23,969,470 (GRCm39) I197T probably benign Het
Tnni3k A G 3: 154,498,413 (GRCm39) Y809H probably benign Het
Tnpo3 A T 6: 29,572,594 (GRCm39) C419* probably null Het
Trpm6 T C 19: 18,760,527 (GRCm39) S143P probably benign Het
Ttc23l A T 15: 10,537,666 (GRCm39) C201* probably null Het
Ubr4 A G 4: 139,120,388 (GRCm39) N271S probably damaging Het
Vmn1r70 T C 7: 10,367,971 (GRCm39) M134T probably benign Het
Vmn2r27 C T 6: 124,201,312 (GRCm39) W215* probably null Het
Xirp1 A T 9: 119,846,984 (GRCm39) M633K probably damaging Het
Zfp174 T C 16: 3,665,804 (GRCm39) I23T possibly damaging Het
Zfp536 T A 7: 37,179,828 (GRCm39) S926C probably damaging Het
Zfp943 T C 17: 22,209,922 (GRCm39) S65P possibly damaging Het
Other mutations in Brpf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Brpf3 APN 17 29,055,674 (GRCm39) utr 3 prime probably benign
IGL01397:Brpf3 APN 17 29,036,606 (GRCm39) missense probably benign 0.22
IGL01608:Brpf3 APN 17 29,040,491 (GRCm39) missense probably benign 0.00
IGL02073:Brpf3 APN 17 29,026,370 (GRCm39) missense probably benign
IGL02540:Brpf3 APN 17 29,047,328 (GRCm39) missense probably damaging 1.00
IGL02838:Brpf3 APN 17 29,054,758 (GRCm39) missense probably benign 0.19
IGL02888:Brpf3 APN 17 29,047,365 (GRCm39) missense probably damaging 1.00
IGL02969:Brpf3 APN 17 29,040,279 (GRCm39) missense probably benign 0.05
IGL03036:Brpf3 APN 17 29,043,022 (GRCm39) missense possibly damaging 0.89
IGL03084:Brpf3 APN 17 29,054,751 (GRCm39) missense probably damaging 0.98
R0448:Brpf3 UTSW 17 29,025,010 (GRCm39) missense probably benign 0.10
R0898:Brpf3 UTSW 17 29,025,964 (GRCm39) missense possibly damaging 0.65
R1268:Brpf3 UTSW 17 29,055,530 (GRCm39) missense probably damaging 0.98
R1639:Brpf3 UTSW 17 29,043,042 (GRCm39) critical splice donor site probably null
R1754:Brpf3 UTSW 17 29,040,297 (GRCm39) missense probably benign 0.00
R1867:Brpf3 UTSW 17 29,026,342 (GRCm39) missense probably benign
R1954:Brpf3 UTSW 17 29,025,533 (GRCm39) missense probably benign
R2000:Brpf3 UTSW 17 29,040,531 (GRCm39) missense probably benign 0.20
R2064:Brpf3 UTSW 17 29,040,338 (GRCm39) missense probably benign
R2209:Brpf3 UTSW 17 29,047,394 (GRCm39) missense probably damaging 0.98
R2413:Brpf3 UTSW 17 29,024,924 (GRCm39) start gained probably benign
R3977:Brpf3 UTSW 17 29,026,016 (GRCm39) missense possibly damaging 0.49
R4067:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign
R4291:Brpf3 UTSW 17 29,042,949 (GRCm39) missense probably benign 0.00
R4369:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4371:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4741:Brpf3 UTSW 17 29,036,758 (GRCm39) missense possibly damaging 0.50
R4773:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign 0.00
R4824:Brpf3 UTSW 17 29,025,460 (GRCm39) missense probably benign
R5360:Brpf3 UTSW 17 29,029,536 (GRCm39) missense probably benign
R5923:Brpf3 UTSW 17 29,025,610 (GRCm39) missense possibly damaging 0.90
R6181:Brpf3 UTSW 17 29,029,555 (GRCm39) missense probably damaging 1.00
R6278:Brpf3 UTSW 17 29,040,258 (GRCm39) missense probably benign 0.00
R6702:Brpf3 UTSW 17 29,029,633 (GRCm39) missense probably benign 0.01
R6884:Brpf3 UTSW 17 29,050,324 (GRCm39) missense probably benign 0.03
R6920:Brpf3 UTSW 17 29,042,970 (GRCm39) missense probably benign 0.34
R7099:Brpf3 UTSW 17 29,025,611 (GRCm39) missense probably benign 0.06
R7108:Brpf3 UTSW 17 29,036,099 (GRCm39) missense probably benign 0.01
R7193:Brpf3 UTSW 17 29,055,665 (GRCm39) makesense probably null
R7316:Brpf3 UTSW 17 29,033,660 (GRCm39) missense probably damaging 1.00
R7326:Brpf3 UTSW 17 29,025,267 (GRCm39) missense probably benign 0.00
R7403:Brpf3 UTSW 17 29,040,330 (GRCm39) missense probably benign
R7666:Brpf3 UTSW 17 29,029,546 (GRCm39) missense possibly damaging 0.83
R7686:Brpf3 UTSW 17 29,025,908 (GRCm39) missense probably damaging 0.98
R7691:Brpf3 UTSW 17 29,025,805 (GRCm39) missense probably damaging 1.00
R8054:Brpf3 UTSW 17 29,055,571 (GRCm39) missense probably damaging 1.00
R8165:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8200:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8698:Brpf3 UTSW 17 29,037,436 (GRCm39) missense probably damaging 0.99
R8722:Brpf3 UTSW 17 29,029,510 (GRCm39) missense probably benign 0.42
R8738:Brpf3 UTSW 17 29,040,214 (GRCm39) missense probably benign
R9044:Brpf3 UTSW 17 29,025,871 (GRCm39) missense possibly damaging 0.90
R9250:Brpf3 UTSW 17 29,054,788 (GRCm39) missense probably damaging 1.00
R9349:Brpf3 UTSW 17 29,040,276 (GRCm39) missense probably benign 0.00
R9496:Brpf3 UTSW 17 29,040,453 (GRCm39) missense probably benign
R9564:Brpf3 UTSW 17 29,026,152 (GRCm39) missense probably benign
R9649:Brpf3 UTSW 17 29,037,597 (GRCm39) missense probably benign
R9720:Brpf3 UTSW 17 29,026,330 (GRCm39) missense probably benign 0.13
Z1177:Brpf3 UTSW 17 29,040,452 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AAGGATTGATTGCACAAGGCTG -3'
(R):5'- TCTTTAGGGGCAGCCACAAG -3'

Sequencing Primer
(F):5'- TTGCACAAGGCTGGGAGG -3'
(R):5'- TGACCCTGCACCTTGGC -3'
Posted On 2018-11-28