Incidental Mutation 'R6979:Ccnt2'
ID 542595
Institutional Source Beutler Lab
Gene Symbol Ccnt2
Ensembl Gene ENSMUSG00000026349
Gene Name cyclin T2
Synonyms 2900041I18Rik, CycT2
MMRRC Submission 045087-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6979 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 127701901-127732574 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 127702873 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 65 (M65T)
Ref Sequence ENSEMBL: ENSMUSP00000108189 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027587] [ENSMUST00000112570]
AlphaFold Q7TQK0
Predicted Effect possibly damaging
Transcript: ENSMUST00000027587
AA Change: M65T

PolyPhen 2 Score 0.866 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000027587
Gene: ENSMUSG00000026349
AA Change: M65T

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 653 N/A INTRINSIC
low complexity region 658 664 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112570
AA Change: M65T

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000108189
Gene: ENSMUSG00000026349
AA Change: M65T

DomainStartEndE-ValueType
CYCLIN 42 141 4.27e-14 SMART
CYCLIN 154 242 4.51e0 SMART
low complexity region 531 543 N/A INTRINSIC
low complexity region 621 634 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
PHENOTYPE: Mice homozygous for a gene trap allele die prior to the 4-cell stage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac C T 3: 59,947,424 (GRCm39) T374M probably benign Het
Aspg A G 12: 112,087,378 (GRCm39) D278G possibly damaging Het
Aspm C A 1: 139,408,223 (GRCm39) A2370E probably damaging Het
Cd163 A G 6: 124,294,945 (GRCm39) T670A probably benign Het
Cpne3 G A 4: 19,533,098 (GRCm39) T279I probably benign Het
Ctdspl G A 9: 118,869,598 (GRCm39) V227M probably damaging Het
Ctnnd2 A G 15: 30,619,376 (GRCm39) E99G probably damaging Het
Dapk1 T C 13: 60,896,095 (GRCm39) S728P probably damaging Het
Dmxl2 A G 9: 54,358,163 (GRCm39) I512T possibly damaging Het
Dop1a A T 9: 86,403,695 (GRCm39) T1630S possibly damaging Het
Dqx1 A G 6: 83,037,992 (GRCm39) D460G probably damaging Het
Foxg1 T C 12: 49,431,567 (GRCm39) probably benign Het
H2-Q2 T A 17: 35,564,623 (GRCm39) probably null Het
Hes6 T C 1: 91,340,810 (GRCm39) E17G possibly damaging Het
Ighv1-42 T C 12: 114,900,848 (GRCm39) Y79C possibly damaging Het
Itfg2 T C 6: 128,388,554 (GRCm39) D311G probably damaging Het
Itgb5 T A 16: 33,740,356 (GRCm39) C489S probably damaging Het
Map4k5 A T 12: 69,869,622 (GRCm39) C488S probably damaging Het
Mark1 C T 1: 184,644,825 (GRCm39) G377D possibly damaging Het
Mat2a A G 6: 72,412,096 (GRCm39) V318A probably damaging Het
Mpp7 T G 18: 7,355,049 (GRCm39) N459T possibly damaging Het
Mrc2 C A 11: 105,239,461 (GRCm39) N1348K probably damaging Het
Mroh5 T C 15: 73,664,978 (GRCm39) K264R probably benign Het
Mtor A G 4: 148,608,930 (GRCm39) M1529V possibly damaging Het
Mtrr C T 13: 68,718,122 (GRCm39) probably null Het
Nwd1 C T 8: 73,394,288 (GRCm39) P517L probably damaging Het
Or4a27 T A 2: 88,559,528 (GRCm39) R138S probably benign Het
Or8h10 A G 2: 86,808,577 (GRCm39) S188P probably damaging Het
Polr1c A G 17: 46,557,095 (GRCm39) F63L probably damaging Het
Polrmt C T 10: 79,582,400 (GRCm39) probably null Het
Pomt2 T C 12: 87,177,125 (GRCm39) I287M probably damaging Het
Prkar2a T A 9: 108,610,342 (GRCm39) N190K possibly damaging Het
Prl3d3 T A 13: 27,341,545 (GRCm39) Y59N possibly damaging Het
Prl5a1 T A 13: 28,335,189 (GRCm39) F199L probably benign Het
Prpf38b A G 3: 108,818,640 (GRCm39) V40A probably benign Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Ptgs1 A G 2: 36,141,311 (GRCm39) D586G probably benign Het
Slx4 T C 16: 3,802,879 (GRCm39) K1312E probably damaging Het
Smok3c A G 5: 138,062,987 (GRCm39) D158G probably benign Het
Spen A T 4: 141,205,374 (GRCm39) D1084E unknown Het
Tcp11l1 C T 2: 104,536,784 (GRCm39) G27D probably benign Het
Tep1 A G 14: 51,076,094 (GRCm39) S1679P possibly damaging Het
Tmem259 C T 10: 79,814,391 (GRCm39) V322I possibly damaging Het
Tmpo A T 10: 90,988,359 (GRCm39) probably null Het
Ttn C A 2: 76,555,137 (GRCm39) A30623S probably damaging Het
Ube2l3 G A 16: 16,977,841 (GRCm39) probably benign Het
Unkl A G 17: 25,418,890 (GRCm39) D146G probably damaging Het
Vmn1r51 A T 6: 90,106,186 (GRCm39) H34L possibly damaging Het
Vmn2r17 A G 5: 109,576,265 (GRCm39) T379A possibly damaging Het
Zfp35 G T 18: 24,136,927 (GRCm39) G424C probably benign Het
Zfp420 T A 7: 29,575,446 (GRCm39) H555Q probably damaging Het
Other mutations in Ccnt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ccnt2 APN 1 127,725,628 (GRCm39) splice site probably benign
IGL01370:Ccnt2 APN 1 127,731,250 (GRCm39) missense possibly damaging 0.49
IGL02055:Ccnt2 APN 1 127,719,447 (GRCm39) missense possibly damaging 0.46
IGL02169:Ccnt2 APN 1 127,702,126 (GRCm39) splice site probably benign
R0526:Ccnt2 UTSW 1 127,727,182 (GRCm39) missense probably damaging 1.00
R0538:Ccnt2 UTSW 1 127,730,902 (GRCm39) missense probably damaging 0.98
R0744:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0833:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R0836:Ccnt2 UTSW 1 127,730,131 (GRCm39) missense probably benign 0.42
R1763:Ccnt2 UTSW 1 127,727,143 (GRCm39) missense possibly damaging 0.94
R2037:Ccnt2 UTSW 1 127,731,136 (GRCm39) missense probably damaging 1.00
R2159:Ccnt2 UTSW 1 127,702,891 (GRCm39) missense probably benign 0.00
R4585:Ccnt2 UTSW 1 127,730,766 (GRCm39) missense probably damaging 0.99
R5342:Ccnt2 UTSW 1 127,719,470 (GRCm39) splice site silent
R5527:Ccnt2 UTSW 1 127,730,401 (GRCm39) missense probably benign 0.00
R5698:Ccnt2 UTSW 1 127,730,965 (GRCm39) missense probably benign 0.00
R6606:Ccnt2 UTSW 1 127,730,978 (GRCm39) missense probably benign 0.00
R6821:Ccnt2 UTSW 1 127,731,072 (GRCm39) missense probably damaging 0.99
R7512:Ccnt2 UTSW 1 127,730,031 (GRCm39) missense possibly damaging 0.85
R8743:Ccnt2 UTSW 1 127,702,020 (GRCm39) missense probably damaging 1.00
R9334:Ccnt2 UTSW 1 127,723,046 (GRCm39) missense probably damaging 0.99
R9722:Ccnt2 UTSW 1 127,729,925 (GRCm39) missense probably damaging 1.00
X0019:Ccnt2 UTSW 1 127,702,877 (GRCm39) missense probably damaging 1.00
X0027:Ccnt2 UTSW 1 127,702,025 (GRCm39) missense probably damaging 0.98
Z1177:Ccnt2 UTSW 1 127,730,795 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTCTCCCTACGTAGCGTATTAG -3'
(R):5'- ACGAGGCAAAACGTTTATTGC -3'

Sequencing Primer
(F):5'- ATTTGGCATCCAGACTGATTTC -3'
(R):5'- CGAGGCAAAACGTTTATTGCATAAC -3'
Posted On 2018-11-28