Incidental Mutation 'R6988:Usp32'
ID 543098
Institutional Source Beutler Lab
Gene Symbol Usp32
Ensembl Gene ENSMUSG00000000804
Gene Name ubiquitin specific peptidase 32
Synonyms 6430526O11Rik, 2900074J03Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6988 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 84984442-85140161 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85010143 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 1084 (M1084V)
Ref Sequence ENSEMBL: ENSMUSP00000103710 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108075]
AlphaFold F8VPZ3
Predicted Effect probably benign
Transcript: ENSMUST00000000821
SMART Domains Protein: ENSMUSP00000000821
Gene: ENSMUSG00000000804

DomainStartEndE-ValueType
Pfam:UCH 32 260 4.1e-51 PFAM
Pfam:UCH_1 33 228 1.7e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000108075
AA Change: M1084V

PolyPhen 2 Score 0.348 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000103710
Gene: ENSMUSG00000000804
AA Change: M1084V

DomainStartEndE-ValueType
EFh 232 260 4.66e0 SMART
EFh 268 296 5.8e-1 SMART
Blast:EFh 318 346 5e-7 BLAST
DUSP 389 588 2.32e-16 SMART
Pfam:Ubiquitin_3 628 711 2.4e-9 PFAM
Pfam:UCH 733 1564 2.4e-83 PFAM
Pfam:UCH_1 1202 1547 2.9e-12 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T G 4: 137,454,579 (GRCm38) L15W probably damaging Het
4930550C14Rik G A 9: 53,411,756 (GRCm38) V31I possibly damaging Het
4932415D10Rik T C 10: 82,291,899 (GRCm38) D1759G possibly damaging Het
Adgre1 C T 17: 57,408,445 (GRCm38) S255F probably benign Het
Aff4 T G 11: 53,398,237 (GRCm38) S404R probably damaging Het
Akr1c19 A T 13: 4,233,758 (GRCm38) probably benign Het
Ankrd31 T A 13: 96,878,249 (GRCm38) I1342K probably damaging Het
Arhgap5 T A 12: 52,518,125 (GRCm38) D626E possibly damaging Het
Arhgef1 G A 7: 24,916,923 (GRCm38) V332I probably benign Het
AY358078 A G 14: 51,826,187 (GRCm38) E430G probably damaging Het
B4gat1 T A 19: 5,040,434 (GRCm38) I395N probably benign Het
Bub1b T A 2: 118,636,830 (GRCm38) I878N probably damaging Het
Ccdc150 C T 1: 54,355,709 (GRCm38) Q745* probably null Het
Ccl19 A T 4: 42,754,885 (GRCm38) I87N probably damaging Het
Ces2g G C 8: 104,963,908 (GRCm38) G107A probably benign Het
Chpt1 A G 10: 88,488,406 (GRCm38) V180A probably damaging Het
Col2a1 T C 15: 98,004,454 (GRCm38) T14A unknown Het
Dnah7a T C 1: 53,582,625 (GRCm38) I1114V possibly damaging Het
Dnah7c T C 1: 46,666,213 (GRCm38) I2462T possibly damaging Het
Dnah8 T C 17: 30,643,275 (GRCm38) F208S probably damaging Het
Dnhd1 A G 7: 105,714,210 (GRCm38) E3993G probably damaging Het
Erv3 C T 2: 131,855,966 (GRCm38) D158N possibly damaging Het
Exoc6 T A 19: 37,609,091 (GRCm38) F647I probably damaging Het
Fbrs G A 7: 127,479,508 (GRCm38) probably benign Het
Fgfr1op2 T C 6: 146,589,965 (GRCm38) F109L probably damaging Het
Fv1 T C 4: 147,869,271 (GRCm38) F98S possibly damaging Het
Gm436 A G 4: 144,686,325 (GRCm38) F15S probably benign Het
H2-M10.1 T C 17: 36,325,592 (GRCm38) K107E probably benign Het
Hspg2 A T 4: 137,528,890 (GRCm38) Q1436L probably damaging Het
Ighv1-74 T C 12: 115,802,763 (GRCm38) Y79C probably damaging Het
Kcnj1 G A 9: 32,396,585 (GRCm38) V102I probably benign Het
Mnt C A 11: 74,842,809 (GRCm38) probably benign Het
Mrpl15 T C 1: 4,782,660 (GRCm38) T112A probably benign Het
Ncdn T C 4: 126,747,189 (GRCm38) D506G probably benign Het
Ogdh C T 11: 6,313,806 (GRCm38) R81* probably null Het
Olfr791 T A 10: 129,526,673 (GRCm38) S149T probably benign Het
Olfr815 G C 10: 129,902,409 (GRCm38) F100L probably damaging Het
Pole G T 5: 110,329,583 (GRCm38) V1863F probably damaging Het
Pramel5 T C 4: 144,274,007 (GRCm38) probably benign Het
Rabep1 A G 11: 70,934,537 (GRCm38) K636E probably damaging Het
Rasgrf2 T A 13: 91,885,635 (GRCm38) Y1151F probably benign Het
Rrad A G 8: 104,630,636 (GRCm38) V93A probably damaging Het
Sesn3 A T 9: 14,310,257 (GRCm38) R118* probably null Het
Slc27a3 T C 3: 90,386,290 (GRCm38) N596S probably benign Het
Snx19 C A 9: 30,428,935 (GRCm38) D456E probably damaging Het
Supt20 T C 3: 54,698,597 (GRCm38) S35P probably damaging Het
Syde2 G T 3: 146,019,809 (GRCm38) R885L probably benign Het
Synm G A 7: 67,733,658 (GRCm38) L1419F probably damaging Het
Tcrg-V6 G T 13: 19,190,644 (GRCm38) G40W possibly damaging Het
Tekt2 A G 4: 126,323,443 (GRCm38) F221L probably benign Het
Ticam1 C T 17: 56,269,900 (GRCm38) E732K probably benign Het
Tmem39b A G 4: 129,693,148 (GRCm38) I90T possibly damaging Het
Trib2 A G 12: 15,815,338 (GRCm38) S79P probably damaging Het
Vmn1r181 T C 7: 23,984,847 (GRCm38) F246L probably damaging Het
Wnt16 A G 6: 22,288,511 (GRCm38) D2G probably damaging Het
Zfp462 A G 4: 55,080,716 (GRCm38) E1357G probably benign Het
Zhx3 A G 2: 160,779,868 (GRCm38) M793T probably benign Het
Other mutations in Usp32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00529:Usp32 APN 11 84,994,426 (GRCm38) missense probably damaging 1.00
IGL00701:Usp32 APN 11 85,059,125 (GRCm38) splice site probably null
IGL00848:Usp32 APN 11 85,051,181 (GRCm38) splice site probably benign
IGL00934:Usp32 APN 11 85,007,076 (GRCm38) missense probably damaging 1.00
IGL01019:Usp32 APN 11 85,039,265 (GRCm38) missense probably damaging 0.97
IGL01302:Usp32 APN 11 84,988,482 (GRCm38) missense probably benign 0.05
IGL01444:Usp32 APN 11 85,059,164 (GRCm38) missense probably damaging 0.97
IGL01575:Usp32 APN 11 85,022,802 (GRCm38) missense probably damaging 1.00
IGL01981:Usp32 APN 11 85,036,524 (GRCm38) missense probably benign 0.02
IGL02118:Usp32 APN 11 85,032,177 (GRCm38) nonsense probably null
IGL02159:Usp32 APN 11 85,005,802 (GRCm38) splice site probably null
IGL02227:Usp32 APN 11 84,986,481 (GRCm38) missense probably damaging 1.00
IGL02363:Usp32 APN 11 85,044,787 (GRCm38) missense probably benign 0.01
IGL02524:Usp32 APN 11 85,010,011 (GRCm38) nonsense probably null
IGL02613:Usp32 APN 11 85,040,070 (GRCm38) missense probably damaging 0.99
IGL02720:Usp32 APN 11 85,006,991 (GRCm38) critical splice donor site probably null
IGL02738:Usp32 APN 11 85,083,806 (GRCm38) missense probably damaging 1.00
IGL02929:Usp32 APN 11 84,988,372 (GRCm38) missense probably benign 0.01
IGL03303:Usp32 APN 11 85,022,832 (GRCm38) missense probably damaging 1.00
BB010:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
BB020:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
PIT4812001:Usp32 UTSW 11 85,010,074 (GRCm38) missense probably damaging 1.00
R0026:Usp32 UTSW 11 85,032,074 (GRCm38) missense possibly damaging 0.48
R0295:Usp32 UTSW 11 85,053,692 (GRCm38) missense probably damaging 0.98
R1320:Usp32 UTSW 11 85,017,793 (GRCm38) missense probably damaging 0.98
R1712:Usp32 UTSW 11 85,042,580 (GRCm38) missense probably benign 0.12
R1922:Usp32 UTSW 11 85,007,004 (GRCm38) nonsense probably null
R1973:Usp32 UTSW 11 85,103,931 (GRCm38) missense probably benign 0.09
R2010:Usp32 UTSW 11 85,040,004 (GRCm38) missense probably damaging 0.98
R2082:Usp32 UTSW 11 85,030,512 (GRCm38) missense probably damaging 0.99
R2355:Usp32 UTSW 11 85,005,909 (GRCm38) missense probably benign 0.34
R3147:Usp32 UTSW 11 85,029,087 (GRCm38) missense probably damaging 1.00
R3160:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3162:Usp32 UTSW 11 85,025,536 (GRCm38) missense probably damaging 0.97
R3716:Usp32 UTSW 11 85,042,563 (GRCm38) missense probably damaging 1.00
R3816:Usp32 UTSW 11 84,994,384 (GRCm38) critical splice donor site probably null
R3870:Usp32 UTSW 11 85,007,055 (GRCm38) nonsense probably null
R3871:Usp32 UTSW 11 85,081,156 (GRCm38) missense probably null 0.81
R4041:Usp32 UTSW 11 85,017,739 (GRCm38) missense probably benign 0.40
R4079:Usp32 UTSW 11 85,039,229 (GRCm38) missense probably damaging 0.98
R4332:Usp32 UTSW 11 85,103,978 (GRCm38) missense possibly damaging 0.79
R4396:Usp32 UTSW 11 85,053,975 (GRCm38) missense probably benign
R4580:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4620:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably null
R4744:Usp32 UTSW 11 84,994,393 (GRCm38) missense probably damaging 1.00
R4909:Usp32 UTSW 11 85,055,772 (GRCm38) nonsense probably null
R5056:Usp32 UTSW 11 85,026,795 (GRCm38) missense probably benign 0.07
R5111:Usp32 UTSW 11 85,077,331 (GRCm38) missense possibly damaging 0.95
R5213:Usp32 UTSW 11 85,022,259 (GRCm38) missense probably damaging 1.00
R5308:Usp32 UTSW 11 85,017,718 (GRCm38) missense probably benign 0.12
R5381:Usp32 UTSW 11 85,059,127 (GRCm38) critical splice donor site probably benign
R5538:Usp32 UTSW 11 85,017,786 (GRCm38) missense possibly damaging 0.65
R5659:Usp32 UTSW 11 85,077,414 (GRCm38) missense possibly damaging 0.94
R6006:Usp32 UTSW 11 84,992,451 (GRCm38) critical splice donor site probably null
R6011:Usp32 UTSW 11 85,032,097 (GRCm38) missense possibly damaging 0.70
R6029:Usp32 UTSW 11 85,025,582 (GRCm38) missense probably damaging 0.99
R6074:Usp32 UTSW 11 84,994,573 (GRCm38) missense probably benign 0.00
R6331:Usp32 UTSW 11 84,986,576 (GRCm38) missense possibly damaging 0.92
R6353:Usp32 UTSW 11 85,022,281 (GRCm38) missense probably benign
R6714:Usp32 UTSW 11 85,026,870 (GRCm38) missense probably damaging 0.99
R6778:Usp32 UTSW 11 85,025,686 (GRCm38) missense probably benign 0.00
R6992:Usp32 UTSW 11 85,032,088 (GRCm38) missense probably damaging 0.99
R7182:Usp32 UTSW 11 85,040,170 (GRCm38) missense probably benign 0.34
R7186:Usp32 UTSW 11 85,051,234 (GRCm38) missense probably benign 0.45
R7198:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7201:Usp32 UTSW 11 85,022,855 (GRCm38) frame shift probably null
R7469:Usp32 UTSW 11 84,988,553 (GRCm38) missense possibly damaging 0.94
R7502:Usp32 UTSW 11 85,022,898 (GRCm38) missense possibly damaging 0.48
R7513:Usp32 UTSW 11 85,027,112 (GRCm38) nonsense probably null
R7629:Usp32 UTSW 11 85,019,855 (GRCm38) frame shift probably null
R7703:Usp32 UTSW 11 85,077,327 (GRCm38) missense probably damaging 0.99
R7741:Usp32 UTSW 11 84,987,281 (GRCm38) missense probably damaging 0.99
R7765:Usp32 UTSW 11 84,994,408 (GRCm38) missense probably damaging 1.00
R7933:Usp32 UTSW 11 85,007,059 (GRCm38) missense probably damaging 1.00
R7973:Usp32 UTSW 11 85,022,808 (GRCm38) missense probably damaging 0.99
R7989:Usp32 UTSW 11 85,034,300 (GRCm38) missense
R7998:Usp32 UTSW 11 84,994,426 (GRCm38) missense probably damaging 1.00
R8292:Usp32 UTSW 11 85,077,401 (GRCm38) missense probably damaging 0.99
R8305:Usp32 UTSW 11 85,032,185 (GRCm38) missense possibly damaging 0.83
R8548:Usp32 UTSW 11 85,017,827 (GRCm38) missense possibly damaging 0.52
R8924:Usp32 UTSW 11 85,025,544 (GRCm38) missense probably damaging 0.98
R9002:Usp32 UTSW 11 85,053,951 (GRCm38) missense probably damaging 0.96
R9145:Usp32 UTSW 11 85,022,292 (GRCm38) missense probably damaging 1.00
R9209:Usp32 UTSW 11 85,040,012 (GRCm38) missense probably damaging 0.98
R9211:Usp32 UTSW 11 85,022,733 (GRCm38) missense probably damaging 1.00
R9296:Usp32 UTSW 11 85,017,652 (GRCm38) missense probably damaging 1.00
R9310:Usp32 UTSW 11 85,051,202 (GRCm38) missense probably benign 0.29
R9417:Usp32 UTSW 11 84,994,543 (GRCm38) missense probably damaging 1.00
R9514:Usp32 UTSW 11 85,022,734 (GRCm38) missense probably damaging 0.99
R9652:Usp32 UTSW 11 85,030,491 (GRCm38) missense probably damaging 0.97
R9723:Usp32 UTSW 11 85,044,710 (GRCm38) nonsense probably null
R9757:Usp32 UTSW 11 85,077,329 (GRCm38) nonsense probably null
X0028:Usp32 UTSW 11 84,992,606 (GRCm38) missense probably benign 0.05
Z1177:Usp32 UTSW 11 84,988,612 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACCTACCAATCCTGTGCATG -3'
(R):5'- AAACCTTTCTGTGGGTCTCC -3'

Sequencing Primer
(F):5'- GCATGGTTGCTAGCTTCTTGAG -3'
(R):5'- TGGGTCTCCACTTTAAATGGTAG -3'
Posted On 2018-11-28