Incidental Mutation 'R6990:Or11l3'
ID 543209
Institutional Source Beutler Lab
Gene Symbol Or11l3
Ensembl Gene ENSMUSG00000043880
Gene Name olfactory receptor family 11 subfamily L member 3
Synonyms MOR107-1, Olfr323, GA_x6K02T2NKPP-794386-795357
MMRRC Submission 045096-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6990 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 58515899-58516870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58516284 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 196 (E196G)
Ref Sequence ENSEMBL: ENSMUSP00000151137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070804] [ENSMUST00000203173] [ENSMUST00000214132]
AlphaFold Q5NCD0
Predicted Effect probably damaging
Transcript: ENSMUST00000070804
AA Change: E196G

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000068147
Gene: ENSMUSG00000043880
AA Change: E196G

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.4e-54 PFAM
Pfam:7tm_1 41 290 3.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203173
SMART Domains Protein: ENSMUSP00000145459
Gene: ENSMUSG00000043880

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000214132
AA Change: E196G

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T G 10: 78,902,925 (GRCm39) T464P probably damaging Het
Abca16 A G 7: 120,126,950 (GRCm39) I1214V probably benign Het
Arap2 A G 5: 62,833,860 (GRCm39) F869S probably damaging Het
Astn2 G T 4: 65,910,540 (GRCm39) H431N possibly damaging Het
Bap1 A G 14: 30,977,608 (GRCm39) T308A probably benign Het
Bcr G A 10: 74,966,868 (GRCm39) E492K possibly damaging Het
Bltp3b A G 10: 89,641,979 (GRCm39) D1050G probably benign Het
Camta1 A G 4: 151,229,501 (GRCm39) F444L probably damaging Het
Chd7 A T 4: 8,844,525 (GRCm39) T1545S probably benign Het
Dnmt1 A T 9: 20,827,110 (GRCm39) Y877* probably null Het
Fam13b A G 18: 34,630,500 (GRCm39) V86A possibly damaging Het
Gm11562 T A 11: 99,510,817 (GRCm39) R128W unknown Het
Krt86 A G 15: 101,371,714 (GRCm39) I95V probably benign Het
Mroh2b A G 15: 4,942,284 (GRCm39) T349A possibly damaging Het
Ms4a7 A T 19: 11,310,605 (GRCm39) L38Q probably damaging Het
Myo1h T C 5: 114,468,221 (GRCm39) S339P probably damaging Het
Nf2 T C 11: 4,749,944 (GRCm39) I46V probably benign Het
Nr1h4 T C 10: 89,290,792 (GRCm39) D416G probably benign Het
Oga G A 19: 45,755,915 (GRCm39) A576V probably benign Het
Or4p18 A G 2: 88,232,639 (GRCm39) M213T probably benign Het
Pde1c C G 6: 56,419,020 (GRCm39) E87Q possibly damaging Het
Peg10 T TCCA 6: 4,756,451 (GRCm39) probably benign Het
Pga5 A T 19: 10,646,779 (GRCm39) D317E probably benign Het
Pira2 T A 7: 3,844,067 (GRCm39) K568N probably damaging Het
Ppp2cb A G 8: 34,109,161 (GRCm39) D290G probably benign Het
Sall4 T C 2: 168,596,990 (GRCm39) K617E probably damaging Het
Slc7a14 G A 3: 31,277,728 (GRCm39) P626S possibly damaging Het
Speer4b A T 5: 27,702,076 (GRCm39) L228* probably null Het
Spns2 T C 11: 72,380,447 (GRCm39) T59A probably benign Het
Tbc1d5 A T 17: 51,275,260 (GRCm39) N78K probably benign Het
Tmem63a T C 1: 180,788,686 (GRCm39) V341A probably benign Het
Trpt1 A G 19: 6,975,683 (GRCm39) T146A probably benign Het
Tyrp1 T C 4: 80,753,674 (GRCm39) C122R probably damaging Het
Uchl1 A G 5: 66,839,818 (GRCm39) E120G possibly damaging Het
Ucn3 C T 13: 3,991,295 (GRCm39) R119Q possibly damaging Het
Vmn2r2 T G 3: 64,024,608 (GRCm39) I658L probably benign Het
Vmn2r96 T A 17: 18,804,082 (GRCm39) V444E probably benign Het
Wdr54 A C 6: 83,132,629 (GRCm39) probably null Het
Xcr1 A G 9: 123,685,300 (GRCm39) L154P probably benign Het
Zbtb26 T C 2: 37,326,557 (GRCm39) K160E probably benign Het
Zfp157 T G 5: 138,454,772 (GRCm39) Y323* probably null Het
Zfp850 A T 7: 27,689,801 (GRCm39) F136I probably benign Het
Other mutations in Or11l3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02995:Or11l3 APN 11 58,516,107 (GRCm39) missense possibly damaging 0.92
IGL03118:Or11l3 APN 11 58,516,269 (GRCm39) missense probably damaging 0.99
R0058:Or11l3 UTSW 11 58,516,494 (GRCm39) missense probably damaging 1.00
R0335:Or11l3 UTSW 11 58,516,566 (GRCm39) missense probably damaging 1.00
R1127:Or11l3 UTSW 11 58,516,284 (GRCm39) missense probably damaging 0.98
R2029:Or11l3 UTSW 11 58,516,319 (GRCm39) missense probably damaging 1.00
R2434:Or11l3 UTSW 11 58,515,937 (GRCm39) missense possibly damaging 0.95
R5483:Or11l3 UTSW 11 58,516,783 (GRCm39) missense possibly damaging 0.95
R6423:Or11l3 UTSW 11 58,516,189 (GRCm39) missense probably damaging 1.00
R7472:Or11l3 UTSW 11 58,516,260 (GRCm39) missense probably damaging 1.00
R7539:Or11l3 UTSW 11 58,516,782 (GRCm39) missense probably damaging 1.00
R7635:Or11l3 UTSW 11 58,515,990 (GRCm39) missense unknown
R7647:Or11l3 UTSW 11 58,516,029 (GRCm39) missense probably damaging 1.00
R8519:Or11l3 UTSW 11 58,516,800 (GRCm39) missense probably damaging 1.00
R8869:Or11l3 UTSW 11 58,515,994 (GRCm39) missense unknown
R9180:Or11l3 UTSW 11 58,516,062 (GRCm39) missense probably benign 0.36
R9262:Or11l3 UTSW 11 58,516,282 (GRCm39) missense probably benign 0.00
R9788:Or11l3 UTSW 11 58,516,692 (GRCm39) missense probably benign 0.03
Z1186:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1186:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1186:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1186:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1186:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1187:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1187:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1187:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1188:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1188:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1188:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1189:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1189:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1189:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1189:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1190:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1190:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1190:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1190:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1191:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1191:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1191:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1191:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Z1192:Or11l3 UTSW 11 58,516,588 (GRCm39) missense probably benign 0.00
Z1192:Or11l3 UTSW 11 58,516,130 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,075 (GRCm39) missense probably benign 0.16
Z1192:Or11l3 UTSW 11 58,516,732 (GRCm39) missense possibly damaging 0.87
Z1192:Or11l3 UTSW 11 58,516,619 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GACAGATGTGCATTTGGGC -3'
(R):5'- TTCTCATGAGCCCGGACAAC -3'

Sequencing Primer
(F):5'- CATTTGGGCGCACATACATG -3'
(R):5'- AACTGCGCTGCTCTGGTAAC -3'
Posted On 2018-11-28