|Institutional Source||Beutler Lab|
|Gene Name||ATP-binding cassette, sub-family C (CFTR/MRP), member 12|
|Is this an essential gene?||Probably non essential (E-score: 0.076)|
|Stock #||R6518 (G1)|
|Chromosomal Location||86482260-86580686 bp(-) (GRCm38)|
|Type of Mutation|
|DNA Base Change (assembly)||A to G at 86509089 bp|
|Amino Acid Change|
|Coding Region Coverage||
|Validation Efficiency||98% (48/49)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Abcc12||
(F):5'- TAGCTTCTGAAATACCAGCAAGG -3'
(R):5'- AGCTGATGAGGGAGTCACTG -3'
(F):5'- AAGGCTCAGGACGCTGTTC -3'
(R):5'- AGGGAGTCACTGTTCCTGCTC -3'