|Institutional Source||Beutler Lab|
|Gene Name||CUGBP, Elav-like family member 4|
|Synonyms||Brunol4, Brul4, BRUNOL-4, A230070D14Rik, C130060B05Rik|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R6521 (G1)|
|Chromosomal Location||25477632-25754157 bp(-) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||T to A at 25479474 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000153258 (fasta)|
|Predicted Effect||probably null
|Coding Region Coverage||
|Validation Efficiency||100% (48/48)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Celf4||
(F):5'- AGGCCCCATTGTACACTTGC -3'
(R):5'- TTTAGGGCAGGATGCTGAACG -3'
(F):5'- GTACACTTGCCCCTGCCTG -3'
(R):5'- TGCTGAACGGGCTACATTAAAAAC -3'