Incidental Mutation 'R6693:Zfp971'
ID 543494
Institutional Source Beutler Lab
Gene Symbol Zfp971
Ensembl Gene ENSMUSG00000074519
Gene Name zinc finger protein 971
Synonyms Etohi1
MMRRC Submission 044811-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R6693 (G1)
Quality Score 78.0075
Status Validated
Chromosome 2
Chromosomal Location 177665077-177675815 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 177675224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 274 (K274N)
Ref Sequence ENSEMBL: ENSMUSP00000104554 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108926]
AlphaFold A2BFG8
Predicted Effect probably benign
Transcript: ENSMUST00000108926
AA Change: K274N

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000104554
Gene: ENSMUSG00000074519
AA Change: K274N

DomainStartEndE-ValueType
KRAB 4 66 1.6e-13 SMART
ZnF_C2H2 78 97 1.38e2 SMART
ZnF_C2H2 103 125 4.38e1 SMART
ZnF_C2H2 131 153 1.92e-2 SMART
ZnF_C2H2 159 181 4.79e-3 SMART
ZnF_C2H2 187 209 2.36e-2 SMART
ZnF_C2H2 215 237 2.36e-2 SMART
ZnF_C2H2 243 265 3.69e-4 SMART
ZnF_C2H2 271 293 4.87e-4 SMART
ZnF_C2H2 299 321 4.4e-2 SMART
ZnF_C2H2 327 349 4.61e-5 SMART
ZnF_C2H2 355 377 4.94e-5 SMART
ZnF_C2H2 383 405 3.21e-4 SMART
ZnF_C2H2 411 433 4.47e-3 SMART
ZnF_C2H2 439 461 5.99e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 100% (37/37)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,774,915 (GRCm39) V1368A probably benign Het
Aak1 C T 6: 86,942,497 (GRCm39) S680L unknown Het
Adam25 A T 8: 41,207,568 (GRCm39) N278I probably damaging Het
Adamtsl1 C A 4: 86,261,123 (GRCm39) H1111Q probably benign Het
Adgrg7 T A 16: 56,590,587 (GRCm39) N195Y probably damaging Het
Arhgap23 A G 11: 97,357,343 (GRCm39) N436S probably damaging Het
Cfap65 T C 1: 74,956,445 (GRCm39) I1045V probably benign Het
Chrm3 T C 13: 9,927,458 (GRCm39) N526S probably benign Het
Cpeb2 A T 5: 43,443,255 (GRCm39) D982V probably damaging Het
Fbxw27 T C 9: 109,617,112 (GRCm39) I130V probably benign Het
Glb1l T C 1: 75,185,745 (GRCm39) D61G probably damaging Het
Herc1 G A 9: 66,386,258 (GRCm39) C3737Y probably damaging Het
Kcnt2 A T 1: 140,278,965 (GRCm39) M39L probably benign Het
Kif17 C A 4: 138,013,791 (GRCm39) Q236K probably benign Het
Klhl25 T C 7: 75,516,561 (GRCm39) V184A possibly damaging Het
Lmf1 A T 17: 25,864,252 (GRCm39) M287L probably benign Het
Macf1 T C 4: 123,367,601 (GRCm39) T822A possibly damaging Het
Mmp13 A T 9: 7,280,245 (GRCm39) T392S probably benign Het
Myo6 T A 9: 80,153,013 (GRCm39) N215K probably damaging Het
Nedd1 T C 10: 92,534,199 (GRCm39) K317R possibly damaging Het
Or8g17 C T 9: 38,930,097 (GRCm39) A247T probably damaging Het
Or9m1 A G 2: 87,733,652 (GRCm39) Y123H probably damaging Het
Pax9 T A 12: 56,756,516 (GRCm39) S285T probably benign Het
Pcdhb15 A T 18: 37,607,394 (GRCm39) T209S probably benign Het
Pdpk1 A T 17: 24,330,100 (GRCm39) probably null Het
Rbak T C 5: 143,159,866 (GRCm39) K396E probably damaging Het
Rps6ka5 A G 12: 100,540,088 (GRCm39) V545A probably benign Het
Scg2 G T 1: 79,413,737 (GRCm39) Q329K probably benign Het
Shroom3 G A 5: 93,088,617 (GRCm39) A456T possibly damaging Het
Slc12a7 G T 13: 73,945,656 (GRCm39) A489S probably benign Het
Slc16a4 T C 3: 107,210,380 (GRCm39) I350T probably damaging Het
Slc25a45 T C 19: 5,930,162 (GRCm39) V44A possibly damaging Het
Sucla2 T A 14: 73,806,107 (GRCm39) L102* probably null Het
Tgif1 T A 17: 71,157,885 (GRCm39) probably benign Het
Tmem8b A G 4: 43,669,837 (GRCm39) E111G probably benign Het
Other mutations in Zfp971
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01067:Zfp971 APN 2 177,665,175 (GRCm39) critical splice donor site probably null
R1108:Zfp971 UTSW 2 177,675,463 (GRCm39) missense probably damaging 1.00
R1759:Zfp971 UTSW 2 177,675,722 (GRCm39) missense probably damaging 0.99
R2183:Zfp971 UTSW 2 177,675,533 (GRCm39) missense probably damaging 1.00
R2343:Zfp971 UTSW 2 177,674,787 (GRCm39) missense possibly damaging 0.84
R4873:Zfp971 UTSW 2 177,674,940 (GRCm39) missense probably benign 0.24
R4875:Zfp971 UTSW 2 177,674,940 (GRCm39) missense probably benign 0.24
R5263:Zfp971 UTSW 2 177,675,555 (GRCm39) missense probably damaging 1.00
R5396:Zfp971 UTSW 2 177,675,526 (GRCm39) missense probably damaging 1.00
R6150:Zfp971 UTSW 2 177,675,247 (GRCm39) missense probably benign 0.26
R6811:Zfp971 UTSW 2 177,675,674 (GRCm39) missense possibly damaging 0.62
R7427:Zfp971 UTSW 2 177,674,967 (GRCm39) missense probably damaging 1.00
R7428:Zfp971 UTSW 2 177,674,967 (GRCm39) missense probably damaging 1.00
R7594:Zfp971 UTSW 2 177,675,793 (GRCm39) missense possibly damaging 0.47
R7790:Zfp971 UTSW 2 177,675,292 (GRCm39) missense probably damaging 0.96
R7796:Zfp971 UTSW 2 177,673,403 (GRCm39) missense probably benign 0.00
R7934:Zfp971 UTSW 2 177,675,173 (GRCm39) missense probably benign
R7990:Zfp971 UTSW 2 177,675,361 (GRCm39) missense probably damaging 1.00
R8671:Zfp971 UTSW 2 177,675,730 (GRCm39) missense probably damaging 1.00
R9181:Zfp971 UTSW 2 177,674,736 (GRCm39) missense probably damaging 1.00
R9575:Zfp971 UTSW 2 177,675,303 (GRCm39) missense probably damaging 0.99
R9629:Zfp971 UTSW 2 177,675,417 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TGTCATCTCAGAATCCATAAGCGA -3'
(R):5'- TTGGAGGTCACTACTGCTTG -3'

Sequencing Primer
(F):5'- GCAGTAAGCAGTCATCTCGGAATC -3'
(R):5'- GGTCACTACTGCTTGCAAAG -3'
Posted On 2019-01-25