Incidental Mutation 'R6692:Stk19'
ID543505
Institutional Source Beutler Lab
Gene Symbol Stk19
Ensembl Gene ENSMUSG00000061207
Gene Nameserine/threonine kinase 19
SynonymsRP1, G11
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.418) question?
Stock #R6692 (G1)
Quality Score225.009
Status Validated
Chromosome17
Chromosomal Location34823993-34836945 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 34824794 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Serine at position 95 (G95S)
Ref Sequence ENSEMBL: ENSMUSP00000124667 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077477] [ENSMUST00000159333] [ENSMUST00000161885]
Predicted Effect silent
Transcript: ENSMUST00000077477
SMART Domains Protein: ENSMUSP00000076686
Gene: ENSMUSG00000061207

DomainStartEndE-ValueType
Pfam:Stk19 37 251 1e-37 PFAM
Predicted Effect silent
Transcript: ENSMUST00000159333
SMART Domains Protein: ENSMUSP00000125311
Gene: ENSMUSG00000061207

DomainStartEndE-ValueType
Pfam:Stk19 1 129 3.2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161885
AA Change: G95S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000162055
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (38/38)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahcyl1 C T 3: 107,675,085 G54D probably damaging Het
Aldh1b1 T C 4: 45,803,427 C322R probably damaging Het
Cdc14b T C 13: 64,215,563 I258V probably damaging Het
Cenph T C 13: 100,772,735 I55V probably benign Het
Cep290 T A 10: 100,569,144 probably null Het
Ces2b A G 8: 104,837,287 Y431C probably damaging Het
Cyp4f17 T C 17: 32,506,976 S28P possibly damaging Het
Cyp4f40 C G 17: 32,675,742 T427S possibly damaging Het
Exoc2 A G 13: 30,935,507 I137T probably benign Het
Fam168b C A 1: 34,836,741 G21V probably damaging Het
G3bp1 T A 11: 55,493,509 D168E probably benign Het
Gm765 T G 6: 98,248,208 H38P possibly damaging Het
Impg2 T A 16: 56,252,333 L376H probably damaging Het
Kdm4d A T 9: 14,463,065 M499K probably benign Het
Lonp1 C T 17: 56,619,230 V426M probably damaging Het
Lypla2 C A 4: 135,970,862 A26S probably benign Het
Map3k13 T C 16: 21,905,237 V323A possibly damaging Het
Mov10 A G 3: 104,818,044 L83P probably damaging Het
Mphosph9 G T 5: 124,260,116 A1039D probably damaging Het
Nedd1 T C 10: 92,698,337 K317R possibly damaging Het
Olfr1117-ps1 A G 2: 87,308,992 T68A possibly damaging Het
Pde3a T A 6: 141,479,346 S623T probably damaging Het
Pld1 T A 3: 28,041,199 M227K probably benign Het
Rell1 T G 5: 63,937,867 K85N probably damaging Het
Rhbdf1 T C 11: 32,215,652 T93A probably damaging Het
Sccpdh T A 1: 179,684,227 M88K possibly damaging Het
Siae T G 9: 37,642,799 probably null Het
Slc22a16 G A 10: 40,603,905 E637K unknown Het
Stpg2 G A 3: 139,522,977 probably null Het
Sult2a5 T A 7: 13,624,132 F30I probably damaging Het
Svil A G 18: 5,082,853 E748G probably damaging Het
Swap70 T A 7: 110,269,919 H306Q probably benign Het
Try10 G A 6: 41,357,821 G227D probably damaging Het
Ttn T C 2: 76,896,369 probably benign Het
Ttn T A 2: 76,919,092 H3871L probably benign Het
Vmn1r231 T C 17: 20,890,483 I57V possibly damaging Het
Vpreb1 A G 16: 16,868,802 S75P probably damaging Het
Zkscan5 A G 5: 145,221,084 probably null Het
Other mutations in Stk19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02192:Stk19 APN 17 34832158 unclassified probably benign
R0087:Stk19 UTSW 17 34836875 start codon destroyed probably null 0.53
R1613:Stk19 UTSW 17 34824598 missense probably damaging 0.99
R2166:Stk19 UTSW 17 34832510 missense possibly damaging 0.77
R3946:Stk19 UTSW 17 34824747 splice site probably benign
R4510:Stk19 UTSW 17 34832528 missense probably damaging 0.97
R4511:Stk19 UTSW 17 34832528 missense probably damaging 0.97
R4721:Stk19 UTSW 17 34823144 unclassified probably null
R4798:Stk19 UTSW 17 34822509 unclassified probably benign
R5225:Stk19 UTSW 17 34821424 unclassified probably benign
R5244:Stk19 UTSW 17 34832070 missense probably damaging 1.00
R5594:Stk19 UTSW 17 34820562 unclassified probably benign
R6332:Stk19 UTSW 17 34824598 missense probably damaging 0.99
R7529:Stk19 UTSW 17 34824656 missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGCTCTGACAAGGCAAGCTC -3'
(R):5'- GTAGCCTCTACATGCTTGTGTAC -3'

Sequencing Primer
(F):5'- AAGGCAAGCTCCCGGTACTTG -3'
(R):5'- GTGTACCTGCCCAGACAGTATATG -3'
Posted On2019-01-31