Incidental Mutation 'R6774:Mob4'
ID 543585
Institutional Source Beutler Lab
Gene Symbol Mob4
Ensembl Gene ENSMUSG00000025979
Gene Name MOB family member 4, phocein
Synonyms Prei3, 2610109B12Rik, Mobkl3
MMRRC Submission 044890-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R6774 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 55170404-55194058 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 55187588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000027122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027122] [ENSMUST00000159311] [ENSMUST00000161122] [ENSMUST00000162364] [ENSMUST00000162553]
AlphaFold Q6PEB6
Predicted Effect probably null
Transcript: ENSMUST00000027122
SMART Domains Protein: ENSMUSP00000027122
Gene: ENSMUSG00000025979

DomainStartEndE-ValueType
Pfam:Mob1_phocein 28 168 1.2e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159311
SMART Domains Protein: ENSMUSP00000124790
Gene: ENSMUSG00000025979

DomainStartEndE-ValueType
Pfam:Mob1_phocein 19 189 9.3e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161122
Predicted Effect probably benign
Transcript: ENSMUST00000162364
SMART Domains Protein: ENSMUSP00000125415
Gene: ENSMUSG00000025979

DomainStartEndE-ValueType
Mob1_phocein 42 209 1.89e-58 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162553
SMART Domains Protein: ENSMUSP00000124151
Gene: ENSMUSG00000025979

DomainStartEndE-ValueType
Pfam:Mob1_phocein 8 178 3.9e-63 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.8%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik A T 9: 57,163,908 (GRCm39) I822N probably damaging Het
9930111J21Rik1 A G 11: 48,838,143 (GRCm39) S815P possibly damaging Het
A430033K04Rik A G 5: 138,644,712 (GRCm39) Y199C probably benign Het
Adam34l T A 8: 44,078,220 (GRCm39) H668L probably benign Het
Afap1l1 A T 18: 61,888,732 (GRCm39) V113E probably benign Het
Ahnak2 C T 12: 112,740,172 (GRCm39) C494Y possibly damaging Het
Atr A T 9: 95,809,266 (GRCm39) E1981D probably benign Het
Bmp7 A G 2: 172,714,751 (GRCm39) Y353H probably damaging Het
Capn11 C T 17: 45,968,256 (GRCm39) probably benign Het
Ccdc103 T C 11: 102,773,519 (GRCm39) F47S probably damaging Het
Cmas A G 6: 142,710,147 (GRCm39) Y130C possibly damaging Het
Cntn5 T C 9: 10,144,222 (GRCm39) Y149C probably damaging Het
Col12a1 A C 9: 79,613,619 (GRCm39) S75R possibly damaging Het
Crat G A 2: 30,303,195 (GRCm39) H31Y probably damaging Het
Dnah7a A G 1: 53,737,810 (GRCm39) V41A probably benign Het
F5 C T 1: 164,014,447 (GRCm39) R573C probably damaging Het
Gcc2 A G 10: 58,117,261 (GRCm39) N1170S possibly damaging Het
Gm29666 A T 15: 84,798,260 (GRCm39) C100* probably null Het
Gm3573 A T 14: 42,009,472 (GRCm39) Y158N possibly damaging Het
Gtf3c1 G T 7: 125,240,793 (GRCm39) A1968E possibly damaging Het
Heg1 C A 16: 33,558,638 (GRCm39) T815K probably damaging Het
Herc1 TCCC TCC 9: 66,408,470 (GRCm39) probably null Het
Kif17 A G 4: 138,002,306 (GRCm39) Y170C probably damaging Het
Kti12 G A 4: 108,705,652 (GRCm39) G189R probably benign Het
Lrp4 G A 2: 91,341,849 (GRCm39) A1821T probably benign Het
Mamdc4 T C 2: 25,456,948 (GRCm39) I610V probably benign Het
Mmp1b T C 9: 7,387,914 (GRCm39) K27E probably benign Het
Myc G A 15: 61,860,128 (GRCm39) probably null Het
Myo5c A T 9: 75,196,468 (GRCm39) I1305F probably benign Het
Nprl3 A G 11: 32,187,381 (GRCm39) V292A probably damaging Het
Ntng2 T C 2: 29,087,102 (GRCm39) T373A probably damaging Het
Or1f19 T A 16: 3,410,380 (GRCm39) V40D probably damaging Het
Or4a67 C T 2: 88,598,228 (GRCm39) V144I probably benign Het
Or5p50 T A 7: 107,422,395 (GRCm39) T94S probably benign Het
Or7e171-ps1 A T 9: 19,853,070 (GRCm39) L222H unknown Het
Pard3 T C 8: 128,137,228 (GRCm39) L859P probably damaging Het
Ppcs T C 4: 119,276,285 (GRCm39) D100G probably damaging Het
Prkdc G T 16: 15,543,325 (GRCm39) probably null Het
Pwwp2b T C 7: 138,835,903 (GRCm39) V448A probably benign Het
Rapgef4 A G 2: 72,056,119 (GRCm39) K624R probably benign Het
Spata31e5 A T 1: 28,815,974 (GRCm39) I686N probably benign Het
Synj2 C T 17: 6,088,290 (GRCm39) S1447L possibly damaging Het
Tfap2a T A 13: 40,882,230 (GRCm39) N25I probably damaging Het
Tnxb C A 17: 34,928,606 (GRCm39) Y2673* probably null Het
Trim27 T A 13: 21,376,624 (GRCm39) H457Q probably damaging Het
Trim72 T G 7: 127,609,558 (GRCm39) F453L probably damaging Het
Ubr5 A T 15: 38,015,379 (GRCm39) M877K probably damaging Het
Usp10 T C 8: 120,678,711 (GRCm39) L564P probably benign Het
Usp54 A G 14: 20,627,296 (GRCm39) V454A probably damaging Het
Uspl1 T A 5: 149,150,904 (GRCm39) D701E probably benign Het
Vmn2r103 A G 17: 19,993,773 (GRCm39) H50R probably benign Het
Zfp35 G A 18: 24,136,015 (GRCm39) V120I possibly damaging Het
Zfp712 T C 13: 67,189,568 (GRCm39) T320A probably benign Het
Other mutations in Mob4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03340:Mob4 APN 1 55,175,867 (GRCm39) missense possibly damaging 0.50
Infinite UTSW 1 55,187,479 (GRCm39) nonsense probably null
Mobius UTSW 1 55,191,881 (GRCm39) nonsense probably null
R4756:Mob4 UTSW 1 55,191,855 (GRCm39) missense probably damaging 0.98
R4831:Mob4 UTSW 1 55,191,899 (GRCm39) missense probably benign 0.01
R4832:Mob4 UTSW 1 55,184,411 (GRCm39) intron probably benign
R4876:Mob4 UTSW 1 55,191,995 (GRCm39) unclassified probably benign
R4972:Mob4 UTSW 1 55,190,161 (GRCm39) missense possibly damaging 0.96
R5747:Mob4 UTSW 1 55,187,737 (GRCm39) missense probably damaging 1.00
R6717:Mob4 UTSW 1 55,175,872 (GRCm39) missense possibly damaging 0.91
R6925:Mob4 UTSW 1 55,191,881 (GRCm39) nonsense probably null
R7447:Mob4 UTSW 1 55,170,625 (GRCm39) start gained probably benign
R7721:Mob4 UTSW 1 55,187,479 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTATAAAAGGATAACCAGCTTGACC -3'
(R):5'- CTCACCTCTTTTGGAGTTTTATGAG -3'

Sequencing Primer
(F):5'- GGCAATTCTGCCTTGAACT -3'
(R):5'- TGGAGTTTTATGAGCTGCACAAAG -3'
Posted On 2019-03-13