Incidental Mutation 'R6980:Rusc2'
| ID |
543750 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rusc2
|
| Ensembl Gene |
ENSMUSG00000035969 |
| Gene Name |
RUN and SH3 domain containing 2 |
| Synonyms |
|
| MMRRC Submission |
045088-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.158)
|
| Stock # |
R6980 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
43381979-43427088 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 43422846 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 994
(I994M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000095710
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035645]
[ENSMUST00000052829]
[ENSMUST00000098106]
[ENSMUST00000107928]
[ENSMUST00000107929]
[ENSMUST00000131668]
[ENSMUST00000149221]
[ENSMUST00000149676]
[ENSMUST00000171134]
[ENSMUST00000173682]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000035645
AA Change: I994M
PolyPhen 2
Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000038379
Gene: ENSMUSG00000035969
AA Change: I994M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000052829
|
| SMART Domains |
Protein: ENSMUSP00000058980
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
47 |
2.9e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098106
AA Change: I994M
PolyPhen 2
Score 0.351 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000095710
Gene: ENSMUSG00000035969
AA Change: I994M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
SH3
|
1457 |
1512 |
7.4e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107928
|
| SMART Domains |
Protein: ENSMUSP00000103561
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
1.3e-20 |
PFAM |
|
Pfam:DUF2475
|
212 |
251 |
6.9e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107929
|
| SMART Domains |
Protein: ENSMUSP00000103562
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
1.5e-20 |
PFAM |
|
Pfam:DUF2475
|
232 |
271 |
7.7e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131668
AA Change: I994M
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000118528
Gene: ENSMUSG00000035969
AA Change: I994M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
617 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
RUN
|
1109 |
1177 |
3.66e-21 |
SMART |
|
low complexity region
|
1235 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1289 |
1324 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1341 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149221
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000149676
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000155080
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171134
|
| SMART Domains |
Protein: ENSMUSP00000127145
Gene: ENSMUSG00000042788
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF2475
|
15 |
76 |
7.2e-21 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173682
|
| SMART Domains |
Protein: ENSMUSP00000133715
Gene: ENSMUSG00000035969
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
39 |
47 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
411 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
435 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
530 |
544 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
733 |
740 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a RUN and SH3 domain containing protein that interacts with Rab1b and Rab1-binding protein GM130. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2012]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 88 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca2 |
C |
A |
2: 25,440,866 (GRCm38) |
R1189S |
possibly damaging |
Het |
| Abcf2 |
T |
C |
5: 24,565,972 (GRCm38) |
Q594R |
probably benign |
Het |
| Abhd18 |
G |
A |
3: 40,933,780 (GRCm38) |
S353N |
probably benign |
Het |
| Adrb1 |
G |
T |
19: 56,723,614 (GRCm38) |
A415S |
probably benign |
Het |
| Art2b |
T |
C |
7: 101,580,473 (GRCm38) |
N73S |
probably benign |
Het |
| BC028528 |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
CTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTT |
3: 95,888,136 (GRCm38) |
|
probably benign |
Het |
| BC028528 |
ACTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTC |
ACTGGTTCTGTGGTCTCTGGTTCTGTGGTCACTGGTTCTGTGGTCACTGGTTCTGTGGTC |
3: 95,888,139 (GRCm38) |
|
probably benign |
Het |
| BC028528 |
CACTGGTTCTGTGGT |
CACTGGTTCTGTGGTTACTGGTTCTGTGGT |
3: 95,888,168 (GRCm38) |
|
probably benign |
Het |
| Cacna1a |
A |
G |
8: 84,612,285 (GRCm38) |
M1753V |
possibly damaging |
Het |
| Cbx8 |
A |
T |
11: 119,039,461 (GRCm38) |
I102N |
possibly damaging |
Het |
| Ccdc178 |
T |
A |
18: 22,105,563 (GRCm38) |
E332D |
probably benign |
Het |
| Cfap74 |
G |
A |
4: 155,466,352 (GRCm38) |
|
probably benign |
Het |
| Chat |
A |
T |
14: 32,424,154 (GRCm38) |
M354K |
probably benign |
Het |
| Cmas |
A |
G |
6: 142,756,800 (GRCm38) |
T10A |
probably damaging |
Het |
| Cyb561d1 |
A |
T |
3: 108,200,159 (GRCm38) |
L51H |
probably benign |
Het |
| D030056L22Rik |
A |
T |
19: 18,717,265 (GRCm38) |
N128I |
probably damaging |
Het |
| D130043K22Rik |
G |
T |
13: 24,864,781 (GRCm38) |
A423S |
probably damaging |
Het |
| Dnah14 |
T |
C |
1: 181,648,230 (GRCm38) |
I1349T |
probably benign |
Het |
| Dnajb3 |
T |
G |
1: 88,205,014 (GRCm38) |
D222A |
probably damaging |
Het |
| Dtx1 |
T |
C |
5: 120,681,357 (GRCm38) |
E592G |
probably damaging |
Het |
| Dzank1 |
C |
T |
2: 144,490,136 (GRCm38) |
G427R |
possibly damaging |
Het |
| E130308A19Rik |
A |
C |
4: 59,719,991 (GRCm38) |
K508Q |
probably damaging |
Het |
| Eif4e1b |
T |
A |
13: 54,784,103 (GRCm38) |
|
probably null |
Het |
| Ell2 |
A |
G |
13: 75,756,376 (GRCm38) |
M159V |
probably null |
Het |
| Eml4 |
G |
A |
17: 83,451,017 (GRCm38) |
V377I |
probably benign |
Het |
| Fryl |
A |
T |
5: 73,050,430 (GRCm38) |
S2466T |
probably benign |
Het |
| Gfpt1 |
C |
A |
6: 87,077,089 (GRCm38) |
T426K |
probably damaging |
Het |
| Gm28710 |
T |
A |
5: 16,826,946 (GRCm38) |
V533D |
possibly damaging |
Het |
| Gm49355 |
T |
C |
14: 12,307,173 (GRCm38) |
|
probably benign |
Het |
| Gm5114 |
T |
C |
7: 39,409,200 (GRCm38) |
I332V |
probably benign |
Het |
| Gpr15 |
T |
A |
16: 58,718,742 (GRCm38) |
|
probably benign |
Het |
| Gpr179 |
T |
C |
11: 97,334,858 (GRCm38) |
E2157G |
probably benign |
Het |
| Gramd4 |
A |
G |
15: 86,131,969 (GRCm38) |
N482S |
probably benign |
Het |
| Hfm1 |
A |
T |
5: 106,880,477 (GRCm38) |
I829K |
probably benign |
Het |
| Hydin |
A |
T |
8: 110,413,284 (GRCm38) |
E728D |
possibly damaging |
Het |
| Ifngr2 |
T |
A |
16: 91,560,007 (GRCm38) |
V143E |
probably damaging |
Het |
| Ift172 |
T |
C |
5: 31,257,386 (GRCm38) |
D1390G |
probably benign |
Het |
| Kdf1 |
A |
T |
4: 133,528,827 (GRCm38) |
D285V |
probably damaging |
Het |
| Mast4 |
C |
T |
13: 102,804,647 (GRCm38) |
V301I |
probably damaging |
Het |
| Mdn1 |
G |
A |
4: 32,726,942 (GRCm38) |
|
probably null |
Het |
| Megf11 |
A |
G |
9: 64,705,850 (GRCm38) |
E1016G |
probably damaging |
Het |
| Mixl1 |
G |
A |
1: 180,696,888 (GRCm38) |
A42V |
possibly damaging |
Het |
| Mpp2 |
A |
G |
11: 102,059,328 (GRCm38) |
W567R |
probably damaging |
Het |
| Mrgpra6 |
A |
G |
7: 47,188,949 (GRCm38) |
L136P |
probably damaging |
Het |
| Mroh7 |
T |
A |
4: 106,700,237 (GRCm38) |
I759L |
probably benign |
Het |
| Nrxn2 |
A |
G |
19: 6,450,579 (GRCm38) |
D277G |
probably benign |
Het |
| Nup210l |
A |
T |
3: 90,119,927 (GRCm38) |
K205N |
probably benign |
Het |
| Olfr1040 |
A |
T |
2: 86,146,337 (GRCm38) |
Y132* |
probably null |
Het |
| Olfr1284 |
A |
G |
2: 111,379,275 (GRCm38) |
I92V |
possibly damaging |
Het |
| Olfr475-ps1 |
A |
G |
2: 88,623,595 (GRCm38) |
*97W |
probably null |
Het |
| Olfr603 |
T |
C |
7: 103,383,096 (GRCm38) |
E302G |
probably benign |
Het |
| Oxnad1 |
C |
T |
14: 32,085,619 (GRCm38) |
|
probably benign |
Het |
| Pamr1 |
C |
T |
2: 102,642,204 (GRCm38) |
T616I |
probably benign |
Het |
| Pcdhgb5 |
C |
T |
18: 37,733,539 (GRCm38) |
H796Y |
possibly damaging |
Het |
| Pdlim7 |
G |
T |
13: 55,508,228 (GRCm38) |
D126E |
probably benign |
Het |
| Pfdn2 |
C |
T |
1: 171,357,897 (GRCm38) |
|
probably benign |
Het |
| Piezo2 |
T |
A |
18: 63,082,961 (GRCm38) |
|
probably null |
Het |
| Pms2 |
A |
T |
5: 143,912,024 (GRCm38) |
I43L |
probably benign |
Het |
| Prex2 |
T |
A |
1: 11,162,263 (GRCm38) |
S851R |
probably benign |
Het |
| Ptpn4 |
T |
A |
1: 119,743,421 (GRCm38) |
E202D |
possibly damaging |
Het |
| Rnf40 |
T |
A |
7: 127,594,677 (GRCm38) |
V455E |
probably damaging |
Het |
| Rp1l1 |
A |
G |
14: 64,028,720 (GRCm38) |
N585S |
probably benign |
Het |
| Rrp12 |
A |
G |
19: 41,890,143 (GRCm38) |
S188P |
probably damaging |
Het |
| Rsbn1l |
T |
A |
5: 20,896,484 (GRCm38) |
H686L |
probably benign |
Het |
| Runx2 |
C |
T |
17: 44,735,316 (GRCm38) |
V107I |
possibly damaging |
Het |
| Ryr1 |
T |
A |
7: 29,109,387 (GRCm38) |
D420V |
probably benign |
Het |
| Sash1 |
T |
C |
10: 8,729,848 (GRCm38) |
Q926R |
probably benign |
Het |
| Scgb3a2 |
T |
A |
18: 43,764,434 (GRCm38) |
I6N |
probably damaging |
Het |
| Sdc3 |
T |
A |
4: 130,816,922 (GRCm38) |
|
probably benign |
Het |
| Sik2 |
A |
G |
9: 50,897,455 (GRCm38) |
V658A |
probably benign |
Het |
| Slc25a39 |
A |
G |
11: 102,405,775 (GRCm38) |
V81A |
probably damaging |
Het |
| Snai2 |
T |
A |
16: 14,708,249 (GRCm38) |
S255T |
possibly damaging |
Het |
| Sorbs1 |
A |
T |
19: 40,327,616 (GRCm38) |
Y371* |
probably null |
Het |
| Spata31d1b |
A |
T |
13: 59,715,422 (GRCm38) |
H128L |
probably benign |
Het |
| Spdl1 |
A |
T |
11: 34,830,879 (GRCm38) |
M1K |
probably null |
Het |
| Tgm3 |
T |
A |
2: 130,026,777 (GRCm38) |
N211K |
probably benign |
Het |
| Tmem116 |
T |
C |
5: 121,467,987 (GRCm38) |
|
probably null |
Het |
| Tmem132e |
T |
A |
11: 82,438,386 (GRCm38) |
|
probably null |
Het |
| Tmem53 |
T |
C |
4: 117,268,508 (GRCm38) |
C251R |
probably damaging |
Het |
| Trcg1 |
A |
C |
9: 57,245,573 (GRCm38) |
D551A |
probably damaging |
Het |
| Trp63 |
T |
A |
16: 25,802,093 (GRCm38) |
F12I |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,879,057 (GRCm38) |
|
probably null |
Het |
| Tubgcp4 |
T |
C |
2: 121,195,465 (GRCm38) |
V596A |
probably benign |
Het |
| Ugt2a3 |
A |
C |
5: 87,325,632 (GRCm38) |
H475Q |
probably damaging |
Het |
| Unc79 |
G |
A |
12: 103,059,500 (GRCm38) |
R382K |
probably damaging |
Het |
| Vmn2r58 |
T |
C |
7: 41,864,238 (GRCm38) |
H327R |
possibly damaging |
Het |
| Vmn2r7 |
G |
A |
3: 64,716,566 (GRCm38) |
T111I |
possibly damaging |
Het |
| Zfp318 |
T |
A |
17: 46,397,212 (GRCm38) |
Y399N |
probably damaging |
Het |
|
| Other mutations in Rusc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01358:Rusc2
|
APN |
4 |
43,426,116 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01474:Rusc2
|
APN |
4 |
43,416,434 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01541:Rusc2
|
APN |
4 |
43,415,840 (GRCm38) |
missense |
probably benign |
0.08 |
|
IGL01628:Rusc2
|
APN |
4 |
43,425,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01969:Rusc2
|
APN |
4 |
43,415,738 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL02030:Rusc2
|
APN |
4 |
43,416,095 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02079:Rusc2
|
APN |
4 |
43,425,668 (GRCm38) |
missense |
probably benign |
|
|
IGL02115:Rusc2
|
APN |
4 |
43,426,136 (GRCm38) |
splice site |
probably benign |
|
|
IGL02122:Rusc2
|
APN |
4 |
43,421,685 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02350:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02357:Rusc2
|
APN |
4 |
43,425,351 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL02437:Rusc2
|
APN |
4 |
43,415,545 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02930:Rusc2
|
APN |
4 |
43,416,376 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03154:Rusc2
|
APN |
4 |
43,425,806 (GRCm38) |
missense |
probably benign |
0.00 |
|
P0026:Rusc2
|
UTSW |
4 |
43,415,840 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R0036:Rusc2
|
UTSW |
4 |
43,424,009 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0068:Rusc2
|
UTSW |
4 |
43,424,100 (GRCm38) |
splice site |
probably benign |
|
|
R0114:Rusc2
|
UTSW |
4 |
43,422,055 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0255:Rusc2
|
UTSW |
4 |
43,423,954 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0471:Rusc2
|
UTSW |
4 |
43,425,486 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1381:Rusc2
|
UTSW |
4 |
43,416,137 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1413:Rusc2
|
UTSW |
4 |
43,416,568 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1416:Rusc2
|
UTSW |
4 |
43,421,617 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R1731:Rusc2
|
UTSW |
4 |
43,426,046 (GRCm38) |
missense |
probably benign |
|
|
R1864:Rusc2
|
UTSW |
4 |
43,421,719 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R1897:Rusc2
|
UTSW |
4 |
43,421,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2010:Rusc2
|
UTSW |
4 |
43,415,212 (GRCm38) |
missense |
probably benign |
0.06 |
|
R2212:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2275:Rusc2
|
UTSW |
4 |
43,416,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2885:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R2886:Rusc2
|
UTSW |
4 |
43,415,456 (GRCm38) |
missense |
probably benign |
0.28 |
|
R3412:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3413:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3414:Rusc2
|
UTSW |
4 |
43,415,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3852:Rusc2
|
UTSW |
4 |
43,416,424 (GRCm38) |
missense |
probably benign |
0.45 |
|
R4135:Rusc2
|
UTSW |
4 |
43,425,563 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R4272:Rusc2
|
UTSW |
4 |
43,415,533 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4574:Rusc2
|
UTSW |
4 |
43,416,080 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4888:Rusc2
|
UTSW |
4 |
43,423,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5010:Rusc2
|
UTSW |
4 |
43,415,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5071:Rusc2
|
UTSW |
4 |
43,415,240 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5131:Rusc2
|
UTSW |
4 |
43,414,948 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5177:Rusc2
|
UTSW |
4 |
43,421,805 (GRCm38) |
splice site |
probably null |
|
|
R5540:Rusc2
|
UTSW |
4 |
43,423,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5561:Rusc2
|
UTSW |
4 |
43,415,932 (GRCm38) |
nonsense |
probably null |
|
|
R5628:Rusc2
|
UTSW |
4 |
43,425,348 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5645:Rusc2
|
UTSW |
4 |
43,425,758 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6129:Rusc2
|
UTSW |
4 |
43,424,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6362:Rusc2
|
UTSW |
4 |
43,416,416 (GRCm38) |
missense |
probably benign |
0.30 |
|
R6633:Rusc2
|
UTSW |
4 |
43,414,852 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7491:Rusc2
|
UTSW |
4 |
43,426,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7641:Rusc2
|
UTSW |
4 |
43,425,335 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R7698:Rusc2
|
UTSW |
4 |
43,414,900 (GRCm38) |
nonsense |
probably null |
|
|
R7710:Rusc2
|
UTSW |
4 |
43,416,119 (GRCm38) |
missense |
probably benign |
0.07 |
|
R8052:Rusc2
|
UTSW |
4 |
43,421,851 (GRCm38) |
missense |
probably benign |
|
|
R8061:Rusc2
|
UTSW |
4 |
43,422,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8127:Rusc2
|
UTSW |
4 |
43,423,747 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R8319:Rusc2
|
UTSW |
4 |
43,425,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8355:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8397:Rusc2
|
UTSW |
4 |
43,424,206 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8455:Rusc2
|
UTSW |
4 |
43,422,846 (GRCm38) |
missense |
probably benign |
0.35 |
|
R8553:Rusc2
|
UTSW |
4 |
43,416,508 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8725:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8725:Rusc2
|
UTSW |
4 |
43,415,396 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8727:Rusc2
|
UTSW |
4 |
43,401,351 (GRCm38) |
intron |
probably benign |
|
|
R8834:Rusc2
|
UTSW |
4 |
43,416,431 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9295:Rusc2
|
UTSW |
4 |
43,416,382 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9483:Rusc2
|
UTSW |
4 |
43,415,897 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9666:Rusc2
|
UTSW |
4 |
43,416,262 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9705:Rusc2
|
UTSW |
4 |
43,424,936 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0025:Rusc2
|
UTSW |
4 |
43,422,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
X0066:Rusc2
|
UTSW |
4 |
43,422,204 (GRCm38) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTTGTACTCAGAGCAAGCTG -3'
(R):5'- GATACGTGGCCCTCATTCACTC -3'
Sequencing Primer
(F):5'- AGCTGAGAAGGGCCTGGC -3'
(R):5'- TGGCCCTCATTCACTCAGACAC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation