Incidental Mutation 'R0608:Zmynd8'
ID 54383
Institutional Source Beutler Lab
Gene Symbol Zmynd8
Ensembl Gene ENSMUSG00000039671
Gene Name zinc finger, MYND-type containing 8
Synonyms 2010005I16Rik, ZMYND8, RACK7, 1110013E22Rik, 3632413B07Rik, Prkcbp1
MMRRC Submission 038797-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R0608 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 165784152-165899016 bp(-) (GRCm38)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 165787158 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000136211 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018050] [ENSMUST00000088113] [ENSMUST00000099084] [ENSMUST00000109266] [ENSMUST00000109269] [ENSMUST00000170272] [ENSMUST00000177633]
AlphaFold A2A484
Predicted Effect probably null
Transcript: ENSMUST00000018050
SMART Domains Protein: ENSMUSP00000018050
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
low complexity region 37 56 N/A INTRINSIC
PHD 90 131 2.23e-11 SMART
BROMO 147 254 1.77e-17 SMART
Pfam:PWWP 275 349 4e-12 PFAM
Pfam:DUF3544 412 624 9.8e-112 PFAM
internal_repeat_2 640 701 9.06e-5 PROSPERO
low complexity region 770 805 N/A INTRINSIC
low complexity region 853 868 N/A INTRINSIC
low complexity region 875 887 N/A INTRINSIC
coiled coil region 916 978 N/A INTRINSIC
Pfam:zf-MYND 988 1022 2.2e-7 PFAM
low complexity region 1055 1075 N/A INTRINSIC
low complexity region 1142 1156 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000088113
SMART Domains Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
low complexity region 43 54 N/A INTRINSIC
low complexity region 57 76 N/A INTRINSIC
PHD 85 126 2.23e-11 SMART
BROMO 142 249 1.77e-17 SMART
Pfam:PWWP 271 346 2.7e-11 PFAM
Pfam:DUF3544 408 617 2.1e-102 PFAM
internal_repeat_2 635 696 4.2e-5 PROSPERO
low complexity region 765 800 N/A INTRINSIC
low complexity region 848 863 N/A INTRINSIC
low complexity region 870 882 N/A INTRINSIC
coiled coil region 911 973 N/A INTRINSIC
low complexity region 1050 1070 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000099084
SMART Domains Protein: ENSMUSP00000096683
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
low complexity region 37 56 N/A INTRINSIC
PHD 65 106 2.23e-11 SMART
BROMO 122 229 1.77e-17 SMART
Pfam:PWWP 250 324 4.1e-12 PFAM
Pfam:DUF3544 387 599 1e-111 PFAM
internal_repeat_2 615 676 4.95e-5 PROSPERO
low complexity region 745 780 N/A INTRINSIC
low complexity region 819 844 N/A INTRINSIC
low complexity region 880 895 N/A INTRINSIC
low complexity region 902 914 N/A INTRINSIC
coiled coil region 943 1005 N/A INTRINSIC
Pfam:zf-MYND 1015 1049 2.3e-7 PFAM
low complexity region 1082 1102 N/A INTRINSIC
low complexity region 1169 1183 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000109266
SMART Domains Protein: ENSMUSP00000104889
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 6 11 N/A INTRINSIC
low complexity region 43 54 N/A INTRINSIC
low complexity region 57 76 N/A INTRINSIC
PHD 110 151 2.23e-11 SMART
BROMO 167 274 1.77e-17 SMART
Pfam:PWWP 295 369 4.1e-12 PFAM
Pfam:DUF3544 432 644 1e-111 PFAM
internal_repeat_2 660 721 8.36e-5 PROSPERO
low complexity region 790 825 N/A INTRINSIC
low complexity region 873 888 N/A INTRINSIC
low complexity region 895 907 N/A INTRINSIC
coiled coil region 936 998 N/A INTRINSIC
Pfam:zf-MYND 1008 1042 2.3e-7 PFAM
low complexity region 1075 1095 N/A INTRINSIC
low complexity region 1162 1176 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000109269
SMART Domains Protein: ENSMUSP00000104892
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 27 38 N/A INTRINSIC
low complexity region 41 60 N/A INTRINSIC
PHD 94 135 2.23e-11 SMART
BROMO 151 258 1.77e-17 SMART
Pfam:PWWP 280 355 6.6e-11 PFAM
Pfam:DUF3544 417 626 2.6e-102 PFAM
internal_repeat_2 644 705 6.15e-5 PROSPERO
low complexity region 774 809 N/A INTRINSIC
low complexity region 848 873 N/A INTRINSIC
low complexity region 909 924 N/A INTRINSIC
low complexity region 931 943 N/A INTRINSIC
coiled coil region 972 1034 N/A INTRINSIC
low complexity region 1111 1131 N/A INTRINSIC
low complexity region 1198 1212 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152682
Predicted Effect probably null
Transcript: ENSMUST00000170272
SMART Domains Protein: ENSMUSP00000128680
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 23 34 N/A INTRINSIC
low complexity region 37 56 N/A INTRINSIC
PHD 65 106 2.23e-11 SMART
BROMO 122 229 1.77e-17 SMART
Pfam:PWWP 250 324 1.1e-11 PFAM
Pfam:DUF3544 387 599 1.9e-111 PFAM
internal_repeat_2 615 676 7.92e-5 PROSPERO
low complexity region 745 780 N/A INTRINSIC
low complexity region 828 843 N/A INTRINSIC
low complexity region 850 862 N/A INTRINSIC
coiled coil region 891 953 N/A INTRINSIC
Pfam:zf-MYND 963 997 1.1e-6 PFAM
low complexity region 1030 1050 N/A INTRINSIC
low complexity region 1117 1131 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000177633
SMART Domains Protein: ENSMUSP00000136211
Gene: ENSMUSG00000039671

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
low complexity region 43 54 N/A INTRINSIC
low complexity region 57 76 N/A INTRINSIC
PHD 85 126 2.23e-11 SMART
BROMO 142 249 1.77e-17 SMART
Pfam:PWWP 270 344 9.6e-12 PFAM
Pfam:DUF3544 407 619 1.8e-111 PFAM
internal_repeat_2 635 696 6.45e-5 PROSPERO
low complexity region 765 800 N/A INTRINSIC
low complexity region 848 863 N/A INTRINSIC
low complexity region 870 882 N/A INTRINSIC
coiled coil region 911 973 N/A INTRINSIC
Pfam:zf-MYND 983 1017 6.7e-7 PFAM
low complexity region 1050 1070 N/A INTRINSIC
low complexity region 1137 1151 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 99.0%
  • 10x: 97.7%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730017C20Rik A G 18: 59,062,459 (GRCm38) probably null Het
Akap11 A G 14: 78,510,753 (GRCm38) V1398A probably benign Het
Ampd3 C A 7: 110,795,790 (GRCm38) D315E probably damaging Het
Ampd3 T A 7: 110,795,791 (GRCm38) F316I probably damaging Het
Arhgef40 A C 14: 51,996,974 (GRCm38) E911D probably damaging Het
Atxn2l A G 7: 126,501,416 (GRCm38) probably null Het
BC117090 T C 16: 36,323,024 (GRCm38) probably null Het
Bckdhb T G 9: 83,953,736 (GRCm38) F98V probably damaging Het
Calhm1 C T 19: 47,143,841 (GRCm38) V112I probably benign Het
Ccdc28a G A 10: 18,224,951 (GRCm38) R90C probably damaging Het
Cdc40 A T 10: 40,848,052 (GRCm38) Y247N probably benign Het
Cds1 G A 5: 101,814,433 (GRCm38) V305M probably damaging Het
Cep128 T G 12: 90,999,535 (GRCm38) probably benign Het
Cep72 A T 13: 74,038,304 (GRCm38) H249Q probably damaging Het
Cfap70 A T 14: 20,448,563 (GRCm38) Y19N probably damaging Het
Col11a1 T C 3: 114,218,715 (GRCm38) probably benign Het
Cysltr1 A G X: 106,578,655 (GRCm38) V75A possibly damaging Het
Dnah17 G T 11: 118,090,749 (GRCm38) Y1716* probably null Het
Dnm1 T C 2: 32,335,824 (GRCm38) E383G possibly damaging Het
Dst C A 1: 34,290,356 (GRCm38) probably null Het
Edil3 T C 13: 89,184,849 (GRCm38) S375P probably damaging Het
Eme1 A G 11: 94,650,082 (GRCm38) C277R probably damaging Het
Enam T C 5: 88,493,027 (GRCm38) W183R possibly damaging Het
Fbxl6 C T 15: 76,536,753 (GRCm38) V341M probably benign Het
Fgf14 A G 14: 124,676,603 (GRCm38) S39P probably damaging Het
Fmo4 C T 1: 162,803,651 (GRCm38) R249H possibly damaging Het
Gle1 T A 2: 29,940,228 (GRCm38) D265E probably benign Het
Gml2 T C 15: 74,821,386 (GRCm38) probably null Het
Golgb1 G T 16: 36,916,330 (GRCm38) E1980* probably null Het
Hap1 A G 11: 100,349,305 (GRCm38) L555P probably damaging Het
Heca T C 10: 17,915,291 (GRCm38) D339G possibly damaging Het
Hepacam2 T C 6: 3,483,479 (GRCm38) T101A possibly damaging Het
Ift88 T C 14: 57,496,221 (GRCm38) V707A probably benign Het
Kdm3a C T 6: 71,620,046 (GRCm38) G252D probably benign Het
Klhl11 A G 11: 100,472,242 (GRCm38) Y163H probably damaging Het
Kntc1 A T 5: 123,786,074 (GRCm38) N1008Y probably damaging Het
Lrp2 G T 2: 69,486,243 (GRCm38) N2131K probably benign Het
Lrrc6 T A 15: 66,380,474 (GRCm38) M448L probably benign Het
Magi3 C G 3: 104,017,557 (GRCm38) G1092A probably damaging Het
Mef2a G T 7: 67,235,148 (GRCm38) S406* probably null Het
Mrps26 G T 2: 130,563,858 (GRCm38) R27L possibly damaging Het
Myof T C 19: 37,916,504 (GRCm38) D1624G probably damaging Het
Naif1 T C 2: 32,454,896 (GRCm38) M204T probably benign Het
Ndufb8 T C 19: 44,550,345 (GRCm38) E179G possibly damaging Het
Neb A T 2: 52,326,757 (GRCm38) D135E probably benign Het
Nlrp6 C T 7: 140,923,486 (GRCm38) Q502* probably null Het
Nploc4 A G 11: 120,413,681 (GRCm38) L238P probably damaging Het
Olfr463 G A 11: 87,893,196 (GRCm38) H243Y probably damaging Het
Parp4 T A 14: 56,602,404 (GRCm38) V523E probably damaging Het
Pdgfra T C 5: 75,163,777 (GRCm38) Y98H probably damaging Het
Plcz1 C T 6: 139,990,733 (GRCm38) R590H probably damaging Het
Pnliprp1 T A 19: 58,738,196 (GRCm38) Y328* probably null Het
Pnpla8 C T 12: 44,283,463 (GRCm38) P48L probably benign Het
Rab44 T A 17: 29,147,343 (GRCm38) probably null Het
Ranbp2 T C 10: 58,493,898 (GRCm38) I3031T probably damaging Het
Rnf219 T C 14: 104,479,527 (GRCm38) Y470C probably damaging Het
Sbno1 T C 5: 124,384,541 (GRCm38) D1072G probably damaging Het
Senp7 A G 16: 56,123,873 (GRCm38) T187A possibly damaging Het
Serpinh1 A G 7: 99,349,394 (GRCm38) C10R unknown Het
Sh2d4a A G 8: 68,346,694 (GRCm38) Y405C possibly damaging Het
Slc26a7 T C 4: 14,621,317 (GRCm38) D23G probably benign Het
Slc7a7 A G 14: 54,377,802 (GRCm38) L246P probably damaging Het
Spire1 T C 18: 67,528,875 (GRCm38) R163G probably damaging Het
Stxbp2 T A 8: 3,632,559 (GRCm38) D49E probably damaging Het
Susd2 C T 10: 75,638,235 (GRCm38) A509T probably benign Het
Sycp2 A G 2: 178,382,404 (GRCm38) F396L probably damaging Het
Syne2 T C 12: 75,963,813 (GRCm38) L2499P probably damaging Het
Syt10 C A 15: 89,826,941 (GRCm38) A130S probably benign Het
Sytl4 A T X: 133,962,187 (GRCm38) D16E probably benign Het
Tab2 C T 10: 7,920,119 (GRCm38) V126I probably damaging Het
Tecpr1 T C 5: 144,211,499 (GRCm38) T363A probably damaging Het
Terb2 A G 2: 122,186,335 (GRCm38) D16G probably benign Het
Tm2d2 A G 8: 25,020,536 (GRCm38) E137G probably benign Het
Trim30d T A 7: 104,472,485 (GRCm38) H201L probably damaging Het
Tspan3 A G 9: 56,147,385 (GRCm38) probably null Het
Ttn A T 2: 76,796,185 (GRCm38) probably null Het
Ttn A T 2: 76,787,323 (GRCm38) L16268Q probably damaging Het
Ubap2 T A 4: 41,218,319 (GRCm38) T263S probably benign Het
Vmn2r100 C A 17: 19,522,120 (GRCm38) P252Q possibly damaging Het
Zeb2 A T 2: 44,996,126 (GRCm38) M973K possibly damaging Het
Zfp229 A G 17: 21,746,634 (GRCm38) E615G probably damaging Het
Zfp655 T A 5: 145,244,057 (GRCm38) S242T possibly damaging Het
Zfp788 T A 7: 41,648,281 (GRCm38) F62I possibly damaging Het
Other mutations in Zmynd8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Zmynd8 APN 2 165,812,814 (GRCm38) missense probably damaging 1.00
IGL01311:Zmynd8 APN 2 165,805,209 (GRCm38) missense probably damaging 1.00
IGL02317:Zmynd8 APN 2 165,820,572 (GRCm38) missense possibly damaging 0.92
IGL02548:Zmynd8 APN 2 165,833,405 (GRCm38) missense probably damaging 1.00
IGL02798:Zmynd8 APN 2 165,852,150 (GRCm38) critical splice acceptor site probably null
IGL02933:Zmynd8 APN 2 165,828,318 (GRCm38) missense possibly damaging 0.65
cain UTSW 2 165,858,053 (GRCm38) critical splice donor site probably null
F5770:Zmynd8 UTSW 2 165,812,394 (GRCm38) nonsense probably null
I1329:Zmynd8 UTSW 2 165,828,225 (GRCm38) missense probably damaging 1.00
P0031:Zmynd8 UTSW 2 165,820,698 (GRCm38) splice site probably benign
R0267:Zmynd8 UTSW 2 165,828,402 (GRCm38) missense probably damaging 1.00
R1663:Zmynd8 UTSW 2 165,807,885 (GRCm38) missense probably benign 0.11
R2212:Zmynd8 UTSW 2 165,815,451 (GRCm38) missense probably damaging 1.00
R3412:Zmynd8 UTSW 2 165,815,451 (GRCm38) missense probably damaging 1.00
R3413:Zmynd8 UTSW 2 165,815,451 (GRCm38) missense probably damaging 1.00
R3749:Zmynd8 UTSW 2 165,805,198 (GRCm38) missense probably damaging 1.00
R3820:Zmynd8 UTSW 2 165,815,461 (GRCm38) nonsense probably null
R3836:Zmynd8 UTSW 2 165,858,099 (GRCm38) missense probably benign 0.05
R3957:Zmynd8 UTSW 2 165,812,475 (GRCm38) missense probably damaging 0.99
R4379:Zmynd8 UTSW 2 165,807,938 (GRCm38) splice site probably null
R4526:Zmynd8 UTSW 2 165,807,607 (GRCm38) intron probably benign
R4739:Zmynd8 UTSW 2 165,805,329 (GRCm38) missense probably damaging 1.00
R4838:Zmynd8 UTSW 2 165,840,034 (GRCm38) nonsense probably null
R4932:Zmynd8 UTSW 2 165,834,951 (GRCm38) missense possibly damaging 0.90
R4933:Zmynd8 UTSW 2 165,834,951 (GRCm38) missense possibly damaging 0.90
R4997:Zmynd8 UTSW 2 165,792,816 (GRCm38) missense probably benign 0.01
R5652:Zmynd8 UTSW 2 165,807,698 (GRCm38) missense probably damaging 1.00
R5741:Zmynd8 UTSW 2 165,840,017 (GRCm38) missense probably damaging 1.00
R6008:Zmynd8 UTSW 2 165,842,787 (GRCm38) missense possibly damaging 0.77
R6242:Zmynd8 UTSW 2 165,898,947 (GRCm38) missense possibly damaging 0.91
R6332:Zmynd8 UTSW 2 165,838,852 (GRCm38) missense probably damaging 1.00
R6394:Zmynd8 UTSW 2 165,846,023 (GRCm38) nonsense probably null
R6772:Zmynd8 UTSW 2 165,807,601 (GRCm38) missense probably benign 0.35
R6970:Zmynd8 UTSW 2 165,875,750 (GRCm38) missense probably damaging 1.00
R6986:Zmynd8 UTSW 2 165,833,415 (GRCm38) missense probably damaging 1.00
R7229:Zmynd8 UTSW 2 165,858,053 (GRCm38) critical splice donor site probably null
R7266:Zmynd8 UTSW 2 165,807,572 (GRCm38) missense possibly damaging 0.49
R7296:Zmynd8 UTSW 2 165,840,009 (GRCm38) missense probably damaging 0.98
R7642:Zmynd8 UTSW 2 165,812,426 (GRCm38) missense probably damaging 1.00
R7818:Zmynd8 UTSW 2 165,842,831 (GRCm38) missense probably damaging 0.97
R7821:Zmynd8 UTSW 2 165,881,080 (GRCm38) intron probably benign
R8135:Zmynd8 UTSW 2 165,812,426 (GRCm38) missense probably damaging 1.00
R8828:Zmynd8 UTSW 2 165,812,546 (GRCm38) missense probably benign 0.00
R9128:Zmynd8 UTSW 2 165,858,138 (GRCm38) start codon destroyed probably null
R9200:Zmynd8 UTSW 2 165,840,085 (GRCm38) missense probably benign
R9345:Zmynd8 UTSW 2 165,812,748 (GRCm38) missense possibly damaging 0.85
R9478:Zmynd8 UTSW 2 165,807,649 (GRCm38) missense probably damaging 1.00
R9626:Zmynd8 UTSW 2 165,812,348 (GRCm38) critical splice donor site probably null
R9649:Zmynd8 UTSW 2 165,838,852 (GRCm38) missense probably damaging 1.00
R9759:Zmynd8 UTSW 2 165,838,826 (GRCm38) missense possibly damaging 0.89
V7580:Zmynd8 UTSW 2 165,812,394 (GRCm38) nonsense probably null
V7581:Zmynd8 UTSW 2 165,812,394 (GRCm38) nonsense probably null
V7583:Zmynd8 UTSW 2 165,812,394 (GRCm38) nonsense probably null
Z1088:Zmynd8 UTSW 2 165,828,171 (GRCm38) missense probably benign
Z1176:Zmynd8 UTSW 2 165,828,188 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGGCTCTGAATGGCCCAACCTAC -3'
(R):5'- CACCTGTAAGCACATCCAGTCGAG -3'

Sequencing Primer
(F):5'- GCCCAACCTACAGCAGTTTG -3'
(R):5'- CAGTCGAGTGGCCTACATGAAG -3'
Posted On 2013-07-11