Incidental Mutation 'R6991:Vmn2r67'
| ID |
543841 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
045097-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.111)
|
| Stock # |
R6991 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 84804953 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Serine
at position 53
(Y53S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168730
AA Change: Y53S
PolyPhen 2
Score 0.549 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: Y53S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
T |
A |
7: 27,279,871 (GRCm39) |
V278D |
probably damaging |
Het |
| Akap12 |
G |
T |
10: 4,307,122 (GRCm39) |
E1311* |
probably null |
Het |
| Ankdd1a |
T |
A |
9: 65,415,957 (GRCm39) |
D186V |
probably benign |
Het |
| Birc6 |
A |
G |
17: 74,869,090 (GRCm39) |
E346G |
probably damaging |
Het |
| Brd10 |
A |
G |
19: 29,696,508 (GRCm39) |
L995S |
possibly damaging |
Het |
| Ccr7 |
A |
C |
11: 99,036,130 (GRCm39) |
V264G |
probably damaging |
Het |
| Col7a1 |
T |
C |
9: 108,812,987 (GRCm39) |
|
probably null |
Het |
| Coq8a |
T |
C |
1: 180,006,633 (GRCm39) |
T132A |
probably benign |
Het |
| Cplane1 |
A |
G |
15: 8,281,690 (GRCm39) |
E2843G |
unknown |
Het |
| Cyp2b10 |
G |
A |
7: 25,616,780 (GRCm39) |
S407N |
probably benign |
Het |
| Ddi2 |
A |
G |
4: 141,412,561 (GRCm39) |
V117A |
probably benign |
Het |
| Ddx42 |
G |
A |
11: 106,129,970 (GRCm39) |
V421I |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,601,896 (GRCm39) |
L285* |
probably null |
Het |
| Dip2c |
C |
T |
13: 9,684,868 (GRCm39) |
S1232F |
probably damaging |
Het |
| Dner |
T |
A |
1: 84,454,123 (GRCm39) |
R402* |
probably null |
Het |
| Dpysl3 |
A |
T |
18: 43,486,956 (GRCm39) |
I317N |
probably damaging |
Het |
| Dusp23 |
T |
A |
1: 172,459,224 (GRCm39) |
Y146F |
probably benign |
Het |
| Eef1a2 |
C |
A |
2: 180,790,421 (GRCm39) |
V412L |
possibly damaging |
Het |
| Epha7 |
C |
T |
4: 28,821,489 (GRCm39) |
T218I |
probably damaging |
Het |
| Gigyf2 |
T |
A |
1: 87,334,858 (GRCm39) |
C284S |
probably damaging |
Het |
| Golm1 |
ACTTCTTCT |
ACTTCT |
13: 59,797,390 (GRCm39) |
|
probably benign |
Het |
| Hao2 |
T |
A |
3: 98,784,068 (GRCm39) |
E327V |
probably damaging |
Het |
| Hdhd5 |
A |
G |
6: 120,487,130 (GRCm39) |
V409A |
probably damaging |
Het |
| Kif9 |
T |
C |
9: 110,323,690 (GRCm39) |
Y236H |
probably damaging |
Het |
| Kri1 |
T |
C |
9: 21,199,050 (GRCm39) |
|
probably benign |
Het |
| Lig4 |
A |
T |
8: 10,021,098 (GRCm39) |
V894E |
probably damaging |
Het |
| Lrriq1 |
T |
C |
10: 103,023,319 (GRCm39) |
N982S |
probably damaging |
Het |
| Mapk8 |
T |
C |
14: 33,132,841 (GRCm39) |
I32V |
possibly damaging |
Het |
| Mast4 |
C |
T |
13: 102,941,155 (GRCm39) |
V301I |
probably damaging |
Het |
| Mstn |
T |
C |
1: 53,101,100 (GRCm39) |
I59T |
probably benign |
Het |
| Mtrf1l |
T |
C |
10: 5,763,384 (GRCm39) |
E315G |
probably damaging |
Het |
| Notch4 |
G |
T |
17: 34,803,774 (GRCm39) |
E1515* |
probably null |
Het |
| Npw |
A |
C |
17: 24,877,029 (GRCm39) |
V124G |
probably benign |
Het |
| Nxph3 |
A |
G |
11: 95,402,244 (GRCm39) |
S57P |
probably damaging |
Het |
| Opn4 |
A |
T |
14: 34,315,864 (GRCm39) |
L390M |
probably benign |
Het |
| Or12e10 |
G |
A |
2: 87,640,787 (GRCm39) |
D208N |
possibly damaging |
Het |
| Or52e4 |
T |
C |
7: 104,705,771 (GRCm39) |
I106T |
probably damaging |
Het |
| Or5b95 |
G |
T |
19: 12,658,112 (GRCm39) |
L213F |
probably benign |
Het |
| Or5g23 |
T |
C |
2: 85,438,592 (GRCm39) |
I221V |
possibly damaging |
Het |
| Or5p68 |
T |
A |
7: 107,945,295 (GRCm39) |
N298Y |
possibly damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Pla2g2e |
G |
A |
4: 138,607,986 (GRCm39) |
C62Y |
probably damaging |
Het |
| Plcb4 |
G |
A |
2: 135,752,114 (GRCm39) |
V107M |
probably damaging |
Het |
| Pramel33 |
T |
A |
5: 93,632,233 (GRCm39) |
N107I |
probably damaging |
Het |
| Prorsd1 |
A |
C |
11: 29,464,486 (GRCm39) |
|
probably benign |
Het |
| Prox2 |
A |
G |
12: 85,134,165 (GRCm39) |
L587P |
probably benign |
Het |
| Prr22 |
A |
G |
17: 57,078,345 (GRCm39) |
D166G |
possibly damaging |
Het |
| Ptprz1 |
G |
A |
6: 23,002,686 (GRCm39) |
R1592Q |
probably benign |
Het |
| Rarg |
C |
G |
15: 102,150,350 (GRCm39) |
R74P |
probably damaging |
Het |
| Rcan1 |
A |
G |
16: 92,194,251 (GRCm39) |
V54A |
probably benign |
Het |
| Rmdn2 |
A |
G |
17: 79,928,739 (GRCm39) |
|
probably benign |
Het |
| Sec16a |
G |
A |
2: 26,320,498 (GRCm39) |
R1361C |
probably damaging |
Het |
| Serpina1a |
T |
C |
12: 103,820,092 (GRCm39) |
T385A |
probably benign |
Het |
| Slc44a3 |
T |
C |
3: 121,325,814 (GRCm39) |
Y12C |
probably benign |
Het |
| Smg1 |
C |
A |
7: 117,767,091 (GRCm39) |
|
probably benign |
Het |
| Spock3 |
A |
G |
8: 63,808,415 (GRCm39) |
*437W |
probably null |
Het |
| Sugct |
T |
A |
13: 17,728,965 (GRCm39) |
Q220H |
probably benign |
Het |
| Tesk1 |
A |
G |
4: 43,447,006 (GRCm39) |
T465A |
probably benign |
Het |
| Tnks |
C |
A |
8: 35,301,647 (GRCm39) |
R1274I |
probably damaging |
Het |
| Trp53bp1 |
C |
T |
2: 121,038,521 (GRCm39) |
R1439H |
probably damaging |
Het |
| Vmn1r16 |
G |
T |
6: 57,299,869 (GRCm39) |
S251* |
probably null |
Het |
| Vmn2r15 |
T |
A |
5: 109,441,180 (GRCm39) |
Q226L |
probably damaging |
Het |
| Vmn2r99 |
A |
G |
17: 19,598,372 (GRCm39) |
N132S |
probably benign |
Het |
| Wdr73 |
T |
G |
7: 80,541,604 (GRCm39) |
T313P |
probably benign |
Het |
| Zfp65 |
C |
T |
13: 67,856,640 (GRCm39) |
R213Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9215:Vmn2r67
|
UTSW |
7 |
84,802,008 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAAGCTCAATACCATGTGTC -3'
(R):5'- CAGGCAGATATCTTACGGACAAGG -3'
Sequencing Primer
(F):5'- CAATACCATGTGTCATTCATTCAGC -3'
(R):5'- CAGATATCTTACGGACAAGGAAAAG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation