Incidental Mutation 'R6996:Adamts16'
| ID |
544235 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adamts16
|
| Ensembl Gene |
ENSMUSG00000049538 |
| Gene Name |
ADAM metallopeptidase with thrombospondin type 1 motif 16 |
| Synonyms |
|
| MMRRC Submission |
045102-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6996 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
70875921-70989930 bp(-) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
C to T
at 70946157 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105316
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080145]
[ENSMUST00000080145]
[ENSMUST00000080145]
[ENSMUST00000109694]
[ENSMUST00000109694]
[ENSMUST00000109694]
[ENSMUST00000123552]
|
| AlphaFold |
Q69Z28 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000080145
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000080145
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000080145
|
| SMART Domains |
Protein: ENSMUSP00000079041
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
57 |
203 |
7.8e-34 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
2.9e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
1.2e-8 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
5.4e-32 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
3.7e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
6.4e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
TSP1
|
872 |
926 |
3.48e0 |
SMART |
|
TSP1
|
928 |
985 |
4.84e-3 |
SMART |
|
TSP1
|
987 |
1046 |
1.49e-3 |
SMART |
|
TSP1
|
1052 |
1113 |
3.19e-2 |
SMART |
|
TSP1
|
1127 |
1179 |
7.68e-6 |
SMART |
|
Pfam:PLAC
|
1188 |
1218 |
2.9e-13 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109694
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109694
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000109694
|
| SMART Domains |
Protein: ENSMUSP00000105316
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
2.2e-32 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
1.8e-13 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
7.3e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
4.6e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
4.1e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
3.3e-10 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
Pfam:ADAM_spacer1
|
744 |
856 |
1.3e-37 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123552
|
| SMART Domains |
Protein: ENSMUSP00000122031
Gene: ENSMUSG00000049538
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
36 |
N/A |
INTRINSIC |
|
Pfam:Pep_M12B_propep
|
56 |
203 |
5.9e-33 |
PFAM |
|
Pfam:Reprolysin_5
|
287 |
470 |
5.1e-14 |
PFAM |
|
Pfam:Reprolysin_4
|
289 |
489 |
2.2e-9 |
PFAM |
|
Pfam:Reprolysin
|
289 |
493 |
1.2e-33 |
PFAM |
|
Pfam:Reprolysin_2
|
306 |
483 |
1.2e-10 |
PFAM |
|
Pfam:Reprolysin_3
|
310 |
442 |
9.7e-11 |
PFAM |
|
TSP1
|
587 |
639 |
1.43e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is co-expressed with the Wilms tumor protein, Wt1, in the developing glomeruli of embryonic kidneys. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme. [provided by RefSeq, Jul 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam5 |
G |
A |
8: 25,296,517 (GRCm39) |
S310L |
probably damaging |
Het |
| Arrb1 |
C |
A |
7: 99,240,569 (GRCm39) |
D194E |
probably benign |
Het |
| Atp1a3 |
T |
C |
7: 24,697,051 (GRCm39) |
D217G |
probably damaging |
Het |
| Bcar3 |
A |
G |
3: 122,302,033 (GRCm39) |
I123V |
possibly damaging |
Het |
| Bdp1 |
G |
A |
13: 100,180,321 (GRCm39) |
L1833F |
probably damaging |
Het |
| Cdc14a |
T |
C |
3: 116,122,355 (GRCm39) |
Y155C |
probably damaging |
Het |
| Cdo1 |
C |
A |
18: 46,853,380 (GRCm39) |
R126M |
possibly damaging |
Het |
| Cfap99 |
G |
T |
5: 34,484,604 (GRCm39) |
R627L |
probably damaging |
Het |
| Efr3a |
T |
A |
15: 65,720,030 (GRCm39) |
L369* |
probably null |
Het |
| Erich6 |
A |
C |
3: 58,543,516 (GRCm39) |
F185V |
probably damaging |
Het |
| Fam186a |
T |
C |
15: 99,853,374 (GRCm39) |
D122G |
unknown |
Het |
| Fank1 |
A |
G |
7: 133,478,627 (GRCm39) |
I230M |
possibly damaging |
Het |
| Flg2 |
A |
T |
3: 93,109,977 (GRCm39) |
E668D |
unknown |
Het |
| Flg2 |
A |
C |
3: 93,110,256 (GRCm39) |
R761S |
unknown |
Het |
| Gabrr1 |
T |
C |
4: 33,158,157 (GRCm39) |
L260P |
probably damaging |
Het |
| Gfm2 |
G |
A |
13: 97,285,868 (GRCm39) |
R119K |
probably damaging |
Het |
| Gm14226 |
A |
G |
2: 154,866,357 (GRCm39) |
T105A |
probably benign |
Het |
| Gm14496 |
A |
G |
2: 181,637,997 (GRCm39) |
N357S |
probably damaging |
Het |
| Gm5916 |
G |
A |
9: 36,039,935 (GRCm39) |
L18F |
probably benign |
Het |
| Golm1 |
A |
T |
13: 59,790,058 (GRCm39) |
N247K |
probably benign |
Het |
| Gpatch2l |
G |
A |
12: 86,290,958 (GRCm39) |
R47H |
probably damaging |
Het |
| Greb1 |
C |
T |
12: 16,773,355 (GRCm39) |
A240T |
probably benign |
Het |
| Gtf3c6 |
T |
C |
10: 40,125,774 (GRCm39) |
M148V |
probably benign |
Het |
| Guca1a |
T |
C |
17: 47,706,102 (GRCm39) |
S126G |
probably benign |
Het |
| Hacl1 |
A |
T |
14: 31,337,380 (GRCm39) |
I393N |
possibly damaging |
Het |
| Hddc3 |
A |
G |
7: 79,993,498 (GRCm39) |
D68G |
possibly damaging |
Het |
| Hsfy2 |
T |
C |
1: 56,675,569 (GRCm39) |
T323A |
possibly damaging |
Het |
| Kcng2 |
T |
C |
18: 80,366,358 (GRCm39) |
|
probably benign |
Het |
| Kdm2a |
G |
T |
19: 4,395,669 (GRCm39) |
P321T |
probably benign |
Het |
| Krt31 |
A |
G |
11: 99,938,558 (GRCm39) |
V345A |
probably benign |
Het |
| Lrrc37 |
A |
T |
11: 103,509,583 (GRCm39) |
L795* |
probably null |
Het |
| Mettl1 |
T |
C |
10: 126,880,887 (GRCm39) |
S193P |
probably benign |
Het |
| Mme |
G |
A |
3: 63,253,523 (GRCm39) |
D456N |
possibly damaging |
Het |
| Mmrn1 |
A |
G |
6: 60,954,367 (GRCm39) |
T883A |
probably benign |
Het |
| Mphosph10 |
C |
G |
7: 64,038,669 (GRCm39) |
E293Q |
probably benign |
Het |
| Muc16 |
C |
A |
9: 18,557,193 (GRCm39) |
K3033N |
unknown |
Het |
| Myo16 |
C |
T |
8: 10,619,496 (GRCm39) |
T1349M |
probably damaging |
Het |
| Myo5c |
T |
C |
9: 75,157,746 (GRCm39) |
I233T |
probably benign |
Het |
| Or4p4b-ps1 |
A |
G |
2: 88,454,189 (GRCm39) |
T181A |
unknown |
Het |
| Or52a33 |
T |
G |
7: 103,289,065 (GRCm39) |
N94T |
probably benign |
Het |
| Or52ac1 |
A |
T |
7: 104,246,018 (GRCm39) |
F123L |
probably benign |
Het |
| Or5b111 |
A |
T |
19: 13,291,036 (GRCm39) |
S204R |
probably benign |
Het |
| Or5h22 |
A |
G |
16: 58,894,555 (GRCm39) |
M296T |
probably benign |
Het |
| Or6c2 |
T |
A |
10: 129,362,732 (GRCm39) |
V212E |
probably damaging |
Het |
| Or7c70 |
C |
A |
10: 78,683,351 (GRCm39) |
V133L |
probably benign |
Het |
| Oxct2b |
A |
G |
4: 123,011,480 (GRCm39) |
I467V |
probably benign |
Het |
| Parp1 |
A |
T |
1: 180,414,936 (GRCm39) |
N425Y |
possibly damaging |
Het |
| Pcdhgc3 |
T |
A |
18: 37,939,656 (GRCm39) |
V19D |
possibly damaging |
Het |
| Pfkl |
T |
A |
10: 77,833,423 (GRCm39) |
I260F |
probably damaging |
Het |
| Pkd1l1 |
C |
T |
11: 8,799,046 (GRCm39) |
G1789R |
probably damaging |
Het |
| Pla1a |
G |
A |
16: 38,217,830 (GRCm39) |
A386V |
probably benign |
Het |
| Pml |
A |
G |
9: 58,142,169 (GRCm39) |
L221P |
probably damaging |
Het |
| Rcn2 |
C |
T |
9: 55,964,845 (GRCm39) |
Q268* |
probably null |
Het |
| Reps1 |
T |
A |
10: 17,969,603 (GRCm39) |
D235E |
probably damaging |
Het |
| Rsf1 |
CGGCGGCGG |
CGGCGGCGGGGGCGGCGG |
7: 97,229,118 (GRCm39) |
|
probably benign |
Het |
| Sap30bp |
A |
G |
11: 115,824,314 (GRCm39) |
|
probably benign |
Het |
| Scn1a |
A |
T |
2: 66,118,075 (GRCm39) |
S1433T |
probably damaging |
Het |
| Sde2 |
T |
C |
1: 180,678,754 (GRCm39) |
V6A |
probably benign |
Het |
| Sdk1 |
C |
A |
5: 142,197,769 (GRCm39) |
R2141S |
probably benign |
Het |
| Setd2 |
T |
C |
9: 110,379,640 (GRCm39) |
S1152P |
probably damaging |
Het |
| Slc26a2 |
C |
T |
18: 61,334,926 (GRCm39) |
V176I |
probably damaging |
Het |
| Snx7 |
A |
G |
3: 117,640,281 (GRCm39) |
I76T |
possibly damaging |
Het |
| Specc1l |
C |
A |
10: 75,082,113 (GRCm39) |
A520D |
probably benign |
Het |
| Spop |
A |
G |
11: 95,362,136 (GRCm39) |
T56A |
possibly damaging |
Het |
| Syne2 |
T |
A |
12: 76,074,786 (GRCm39) |
D4576E |
probably damaging |
Het |
| Tas2r134 |
A |
C |
2: 51,517,601 (GRCm39) |
M27L |
probably benign |
Het |
| Tecta |
A |
C |
9: 42,278,082 (GRCm39) |
I1142S |
probably benign |
Het |
| Timm44 |
T |
C |
8: 4,316,611 (GRCm39) |
D311G |
possibly damaging |
Het |
| Tmem123 |
C |
G |
9: 7,791,071 (GRCm39) |
T124R |
possibly damaging |
Het |
| Tmem184b |
A |
T |
15: 79,246,959 (GRCm39) |
L370Q |
probably benign |
Het |
| Trim25 |
T |
A |
11: 88,890,329 (GRCm39) |
N5K |
probably benign |
Het |
| Vmn2r93 |
A |
G |
17: 18,524,903 (GRCm39) |
Y187C |
probably damaging |
Het |
| Vpreb1a |
A |
G |
16: 16,686,678 (GRCm39) |
Y71H |
probably damaging |
Het |
| Vpreb1b |
T |
C |
16: 17,798,441 (GRCm39) |
S5P |
probably benign |
Het |
| Xpo7 |
A |
T |
14: 70,906,888 (GRCm39) |
C939S |
probably benign |
Het |
| Zfp78 |
C |
A |
7: 6,381,764 (GRCm39) |
S271R |
probably benign |
Het |
| Zic5 |
A |
T |
14: 122,702,080 (GRCm39) |
M217K |
probably benign |
Het |
|
| Other mutations in Adamts16 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Adamts16
|
APN |
13 |
70,943,603 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01338:Adamts16
|
APN |
13 |
70,984,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01663:Adamts16
|
APN |
13 |
70,941,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01804:Adamts16
|
APN |
13 |
70,949,080 (GRCm39) |
nonsense |
probably null |
|
|
IGL01874:Adamts16
|
APN |
13 |
70,916,823 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL01984:Adamts16
|
APN |
13 |
70,935,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02305:Adamts16
|
APN |
13 |
70,921,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02357:Adamts16
|
APN |
13 |
70,886,704 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02429:Adamts16
|
APN |
13 |
70,935,289 (GRCm39) |
splice site |
probably benign |
|
|
IGL02450:Adamts16
|
APN |
13 |
70,984,419 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02807:Adamts16
|
APN |
13 |
70,886,897 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03356:Adamts16
|
APN |
13 |
70,901,410 (GRCm39) |
missense |
probably benign |
0.00 |
|
swap
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
switcheroo
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0046:Adamts16
|
UTSW |
13 |
70,911,579 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0201:Adamts16
|
UTSW |
13 |
70,927,763 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0326:Adamts16
|
UTSW |
13 |
70,927,730 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0336:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R0369:Adamts16
|
UTSW |
13 |
70,927,671 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0422:Adamts16
|
UTSW |
13 |
70,887,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Adamts16
|
UTSW |
13 |
70,916,766 (GRCm39) |
missense |
probably benign |
|
|
R0524:Adamts16
|
UTSW |
13 |
70,949,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0590:Adamts16
|
UTSW |
13 |
70,949,073 (GRCm39) |
missense |
probably benign |
|
|
R0734:Adamts16
|
UTSW |
13 |
70,886,600 (GRCm39) |
splice site |
probably benign |
|
|
R0787:Adamts16
|
UTSW |
13 |
70,886,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Adamts16
|
UTSW |
13 |
70,916,811 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0920:Adamts16
|
UTSW |
13 |
70,911,680 (GRCm39) |
splice site |
probably benign |
|
|
R1027:Adamts16
|
UTSW |
13 |
70,915,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Adamts16
|
UTSW |
13 |
70,984,253 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1535:Adamts16
|
UTSW |
13 |
70,939,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Adamts16
|
UTSW |
13 |
70,946,154 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1700:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1734:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1736:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1737:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1738:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R1746:Adamts16
|
UTSW |
13 |
70,927,717 (GRCm39) |
splice site |
probably null |
|
|
R1869:Adamts16
|
UTSW |
13 |
70,883,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1944:Adamts16
|
UTSW |
13 |
70,940,005 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1997:Adamts16
|
UTSW |
13 |
70,901,386 (GRCm39) |
missense |
probably benign |
0.39 |
|
R2018:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2135:Adamts16
|
UTSW |
13 |
70,949,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2219:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R2228:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R3410:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3411:Adamts16
|
UTSW |
13 |
70,901,345 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3842:Adamts16
|
UTSW |
13 |
70,887,010 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4117:Adamts16
|
UTSW |
13 |
70,916,111 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4435:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4436:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4526:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4552:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4555:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4556:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4557:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4579:Adamts16
|
UTSW |
13 |
70,927,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4639:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4640:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4641:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4642:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4672:Adamts16
|
UTSW |
13 |
70,927,637 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R5350:Adamts16
|
UTSW |
13 |
70,901,315 (GRCm39) |
nonsense |
probably null |
|
|
R5464:Adamts16
|
UTSW |
13 |
70,909,868 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5613:Adamts16
|
UTSW |
13 |
70,878,253 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5667:Adamts16
|
UTSW |
13 |
70,984,494 (GRCm39) |
nonsense |
probably null |
|
|
R5735:Adamts16
|
UTSW |
13 |
70,984,337 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5762:Adamts16
|
UTSW |
13 |
70,886,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5907:Adamts16
|
UTSW |
13 |
70,877,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Adamts16
|
UTSW |
13 |
70,918,393 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Adamts16
|
UTSW |
13 |
70,984,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6665:Adamts16
|
UTSW |
13 |
70,927,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6913:Adamts16
|
UTSW |
13 |
70,877,017 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6982:Adamts16
|
UTSW |
13 |
70,916,639 (GRCm39) |
splice site |
probably null |
|
|
R7313:Adamts16
|
UTSW |
13 |
70,921,074 (GRCm39) |
nonsense |
probably null |
|
|
R7356:Adamts16
|
UTSW |
13 |
70,984,399 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7509:Adamts16
|
UTSW |
13 |
70,935,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7595:Adamts16
|
UTSW |
13 |
70,878,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7782:Adamts16
|
UTSW |
13 |
70,984,265 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7968:Adamts16
|
UTSW |
13 |
70,886,701 (GRCm39) |
missense |
probably benign |
|
|
R8231:Adamts16
|
UTSW |
13 |
70,925,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8232:Adamts16
|
UTSW |
13 |
70,941,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8470:Adamts16
|
UTSW |
13 |
70,984,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8485:Adamts16
|
UTSW |
13 |
70,886,794 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8772:Adamts16
|
UTSW |
13 |
70,984,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8916:Adamts16
|
UTSW |
13 |
70,941,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8921:Adamts16
|
UTSW |
13 |
70,939,910 (GRCm39) |
splice site |
probably benign |
|
|
R8973:Adamts16
|
UTSW |
13 |
70,886,959 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9132:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9149:Adamts16
|
UTSW |
13 |
70,883,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9159:Adamts16
|
UTSW |
13 |
70,901,408 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9312:Adamts16
|
UTSW |
13 |
70,949,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9584:Adamts16
|
UTSW |
13 |
70,949,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adamts16
|
UTSW |
13 |
70,909,892 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCATGTTGAGAATGGTGAGGAC -3'
(R):5'- AAAAGCTGGGCAGGTCTCTC -3'
Sequencing Primer
(F):5'- CATAAGTCGTAATGTTTTCATGGCC -3'
(R):5'- GGTCTCTCTTCTTCTAACATGGGAAC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation