Incidental Mutation 'R7003:Or2f2'
ID 544660
Institutional Source Beutler Lab
Gene Symbol Or2f2
Ensembl Gene ENSMUSG00000094192
Gene Name olfactory receptor family 2 subfamily F member 2
Synonyms MOR257-5P, GA_x6K02T2P3E9-4769843-4768890, Olfr452
MMRRC Submission 045108-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.181) question?
Stock # R7003 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 42766975-42767928 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 42767399 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 142 (T142I)
Ref Sequence ENSEMBL: ENSMUSP00000151882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075468] [ENSMUST00000214465] [ENSMUST00000215719] [ENSMUST00000217701]
AlphaFold Q7TRV8
Predicted Effect probably benign
Transcript: ENSMUST00000075468
AA Change: T142I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000074914
Gene: ENSMUSG00000094192
AA Change: T142I

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.8e-52 PFAM
Pfam:7tm_1 41 290 2.3e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214465
AA Change: T142I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000215719
AA Change: T142I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000217701
AA Change: T142I

PolyPhen 2 Score 0.184 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 T A 13: 111,392,490 (GRCm39) I275N probably damaging Het
Actr3b A C 5: 26,003,461 (GRCm39) Y21S probably damaging Het
Adam6b C T 12: 113,453,662 (GRCm39) Q160* probably null Het
Adgrv1 C T 13: 81,670,223 (GRCm39) probably null Het
Akr1c6 A G 13: 4,504,514 (GRCm39) N300D probably benign Het
Alox8 T C 11: 69,082,416 (GRCm39) D170G possibly damaging Het
Amhr2 A G 15: 102,354,768 (GRCm39) N40S probably benign Het
Ap2a2 A G 7: 141,209,109 (GRCm39) N767S probably benign Het
Armc3 T C 2: 19,274,839 (GRCm39) I358T probably damaging Het
Atg2b A G 12: 105,620,508 (GRCm39) S732P probably benign Het
Atp12a A G 14: 56,610,837 (GRCm39) Y327C possibly damaging Het
Bcr T C 10: 74,897,393 (GRCm39) V179A probably benign Het
Cep104 T C 4: 154,078,018 (GRCm39) L642P probably benign Het
Clspn T A 4: 126,486,513 (GRCm39) S1302R possibly damaging Het
Cmip T C 8: 118,111,727 (GRCm39) F153L probably benign Het
Cplane1 T G 15: 8,258,246 (GRCm39) L2164R probably damaging Het
D630039A03Rik T C 4: 57,910,521 (GRCm39) D97G probably damaging Het
Dok7 A T 5: 35,236,899 (GRCm39) T396S probably benign Het
Dsel C T 1: 111,788,025 (GRCm39) V837I probably benign Het
Etl4 C T 2: 20,810,695 (GRCm39) T926I probably benign Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Gpr155 A G 2: 73,173,961 (GRCm39) I816T probably damaging Het
Hpn C T 7: 30,810,367 (GRCm39) probably benign Het
Inpp5e A G 2: 26,287,877 (GRCm39) S640P probably benign Het
Irs3 C T 5: 137,643,539 (GRCm39) V82I probably benign Het
Kif16b A C 2: 142,600,749 (GRCm39) D461E possibly damaging Het
Krba1 A G 6: 48,390,014 (GRCm39) T592A possibly damaging Het
Lgsn T A 1: 31,243,024 (GRCm39) S369T possibly damaging Het
Lrrc4b C T 7: 44,094,580 (GRCm39) P83S probably damaging Het
Mplkipl1 A G 19: 61,164,319 (GRCm39) S39P possibly damaging Het
Neil3 T C 8: 54,054,001 (GRCm39) T343A possibly damaging Het
Nt5e A G 9: 88,246,805 (GRCm39) Y347C probably damaging Het
Or1j1 A G 2: 36,703,047 (GRCm39) I19T possibly damaging Het
Or2d3b A T 7: 106,514,319 (GRCm39) T305S probably benign Het
Or8g26 A T 9: 39,096,239 (GRCm39) Y255F probably benign Het
P2rx5 T C 11: 73,058,800 (GRCm39) probably null Het
Phtf2 A G 5: 20,999,399 (GRCm39) V248A probably benign Het
Plekhd1 T C 12: 80,768,734 (GRCm39) C406R possibly damaging Het
Plod3 T A 5: 137,018,498 (GRCm39) N245K probably damaging Het
Polr3c G T 3: 96,630,954 (GRCm39) H155Q possibly damaging Het
Psap T A 10: 60,135,276 (GRCm39) C317S probably damaging Het
Rif1 A G 2: 51,967,001 (GRCm39) I97V probably benign Het
Rnf123 T A 9: 107,940,882 (GRCm39) probably null Het
Rnf19a G A 15: 36,254,650 (GRCm39) R303* probably null Het
Sdk1 G A 5: 142,082,489 (GRCm39) V1036I probably benign Het
Shc3 T A 13: 51,620,588 (GRCm39) Y146F probably benign Het
Skint6 A G 4: 112,963,109 (GRCm39) Y441H probably benign Het
Slc7a12 T C 3: 14,570,580 (GRCm39) I173T probably damaging Het
Spesp1 A T 9: 62,189,302 (GRCm39) S15T possibly damaging Het
Tarm1 A T 7: 3,545,939 (GRCm39) probably null Het
Tenm3 T C 8: 48,693,479 (GRCm39) Y1817C probably damaging Het
Ttc9c A T 19: 8,795,904 (GRCm39) L45Q probably damaging Het
Ube3a C T 7: 58,926,188 (GRCm39) T322I probably damaging Het
Vac14 T A 8: 111,439,430 (GRCm39) V669E probably damaging Het
Vmn1r225 A G 17: 20,723,416 (GRCm39) M286V probably null Het
Zfp658 A G 7: 43,224,172 (GRCm39) K816E possibly damaging Het
Zfp846 T C 9: 20,499,188 (GRCm39) M1T probably null Het
Other mutations in Or2f2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01097:Or2f2 APN 6 42,767,077 (GRCm39) missense probably damaging 1.00
IGL02134:Or2f2 APN 6 42,767,398 (GRCm39) missense probably benign
IGL02900:Or2f2 APN 6 42,767,808 (GRCm39) nonsense probably null
IGL03115:Or2f2 APN 6 42,767,599 (GRCm39) missense probably benign 0.07
R0441:Or2f2 UTSW 6 42,767,108 (GRCm39) missense probably damaging 0.99
R0504:Or2f2 UTSW 6 42,767,530 (GRCm39) nonsense probably null
R1191:Or2f2 UTSW 6 42,767,451 (GRCm39) missense probably benign 0.00
R1912:Or2f2 UTSW 6 42,767,411 (GRCm39) missense probably benign 0.01
R4579:Or2f2 UTSW 6 42,767,458 (GRCm39) missense probably benign 0.04
R4911:Or2f2 UTSW 6 42,767,138 (GRCm39) missense probably damaging 1.00
R7949:Or2f2 UTSW 6 42,767,588 (GRCm39) missense possibly damaging 0.79
R8420:Or2f2 UTSW 6 42,767,644 (GRCm39) missense possibly damaging 0.73
R9061:Or2f2 UTSW 6 42,767,141 (GRCm39) missense probably damaging 1.00
R9508:Or2f2 UTSW 6 42,767,928 (GRCm39) makesense probably null
X0028:Or2f2 UTSW 6 42,767,453 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTGGTGGATGCATCTTATGC -3'
(R):5'- CCATGATCACAATCTCATTGGATG -3'

Sequencing Primer
(F):5'- ATAGTCCCCCAGCTGCTG -3'
(R):5'- CTCATTGGATGAAATGTCCACACAGG -3'
Posted On 2019-05-13