Incidental Mutation 'R7009:Mob3c'
ID 544887
Institutional Source Beutler Lab
Gene Symbol Mob3c
Ensembl Gene ENSMUSG00000028709
Gene Name MOB kinase activator 3C
Synonyms MOB3C, Mobkl2c, D130076I06Rik
MMRRC Submission 045111-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R7009 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 115828092-115836185 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 115831582 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 104 (R104H)
Ref Sequence ENSEMBL: ENSMUSP00000030477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030477] [ENSMUST00000148409]
AlphaFold Q8BJG4
Predicted Effect probably benign
Transcript: ENSMUST00000030477
AA Change: R104H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000030477
Gene: ENSMUSG00000028709
AA Change: R104H

Mob1_phocein 33 207 3.04e-103 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000148409
SMART Domains Protein: ENSMUSP00000123611
Gene: ENSMUSG00000028709

Pfam:Mob1_phocein 31 90 1.3e-21 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 99% (82/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700007G11Rik A T 5: 98,784,520 (GRCm38) D193V probably damaging Het
4921517D22Rik G T 13: 59,690,810 (GRCm38) D69E possibly damaging Het
Abat A C 16: 8,602,367 (GRCm38) M177L probably benign Het
Acadvl A G 11: 70,014,791 (GRCm38) probably null Het
Adam5 T C 8: 24,806,438 (GRCm38) N331S probably benign Het
Ager A G 17: 34,600,736 (GRCm38) E372G probably damaging Het
Angpt1 T A 15: 42,523,595 (GRCm38) Q121L possibly damaging Het
Apoa4 A T 9: 46,242,880 (GRCm38) I260F possibly damaging Het
Arhgap32 A T 9: 32,245,976 (GRCm38) I90F probably damaging Het
Arhgap5 A T 12: 52,519,639 (GRCm38) Q1131L probably benign Het
Bach1 G A 16: 87,719,291 (GRCm38) R240Q probably benign Het
Cacna2d3 A T 14: 28,969,365 (GRCm38) M1K probably null Het
Ccdc18 G A 5: 108,173,862 (GRCm38) probably null Het
Ccdc42 T C 11: 68,594,616 (GRCm38) F267S probably damaging Het
Cdh23 T A 10: 60,337,306 (GRCm38) Y1700F probably damaging Het
Cenpe A T 3: 135,235,201 (GRCm38) S704C probably damaging Het
Cenpe G A 3: 135,235,202 (GRCm38) S704N probably benign Het
Cfap54 A T 10: 92,875,019 (GRCm38) S2727T unknown Het
Clu T A 14: 65,971,832 (GRCm38) V113D probably damaging Het
Cnbd2 A G 2: 156,320,034 (GRCm38) I98V probably benign Het
Copa G T 1: 172,091,000 (GRCm38) R97L probably damaging Het
Epb41l1 C A 2: 156,534,683 (GRCm38) probably null Het
Etnk1 T A 6: 143,203,154 (GRCm38) probably null Het
Fnip1 A T 11: 54,502,935 (GRCm38) K732N probably damaging Het
G6pd2 A G 5: 61,808,891 (GRCm38) E3G probably benign Het
Gal3st2 A G 1: 93,873,759 (GRCm38) T95A probably benign Het
Gapvd1 A G 2: 34,700,817 (GRCm38) S948P probably damaging Het
Ggps1 A T 13: 14,054,165 (GRCm38) Y8* probably null Het
Gria2 T C 3: 80,706,972 (GRCm38) E587G probably damaging Het
Hpse T C 5: 100,692,279 (GRCm38) E324G probably benign Het
Il16 G A 7: 83,646,388 (GRCm38) T493I probably benign Het
Ints1 T C 5: 139,768,462 (GRCm38) T652A possibly damaging Het
Ism1 A G 2: 139,757,279 (GRCm38) I391V probably damaging Het
Katnb1 A G 8: 95,098,384 (GRCm38) D598G probably damaging Het
Kif5c A G 2: 49,757,429 (GRCm38) S880G probably benign Het
Klra8 T C 6: 130,125,184 (GRCm38) N96S probably benign Het
Krt79 T A 15: 101,931,441 (GRCm38) D373V probably damaging Het
Lamtor4 G A 5: 138,259,112 (GRCm38) R92Q probably benign Het
Lce1d C A 3: 92,686,046 (GRCm38) C20F unknown Het
Limk1 T C 5: 134,672,699 (GRCm38) T117A probably benign Het
Medag A T 5: 149,427,243 (GRCm38) K61M probably benign Het
Mkrn3 T C 7: 62,419,618 (GRCm38) M142V probably benign Het
Morc1 G T 16: 48,627,070 (GRCm38) R903L possibly damaging Het
Myh6 T C 14: 54,952,292 (GRCm38) E1099G probably damaging Het
Nphp3 T G 9: 104,016,116 (GRCm38) C434G probably null Het
Npr3 C T 15: 11,905,248 (GRCm38) C131Y probably damaging Het
Oacyl C A 18: 65,722,538 (GRCm38) Y112* probably null Het
Oprl1 A G 2: 181,718,381 (GRCm38) T77A probably damaging Het
Osgep A G 14: 50,924,708 (GRCm38) V24A probably damaging Het
Otx2 T A 14: 48,658,797 (GRCm38) K260M probably damaging Het
Pdcd11 T C 19: 47,113,142 (GRCm38) L922P probably benign Het
Phldb1 A G 9: 44,694,408 (GRCm38) V375A probably damaging Het
Pip5k1b C T 19: 24,359,935 (GRCm38) probably null Het
Psmd3 G A 11: 98,682,766 (GRCm38) D13N probably benign Het
Ptprc G A 1: 138,064,553 (GRCm38) H1140Y probably damaging Het
Ranbp3l A T 15: 9,062,984 (GRCm38) H291L probably damaging Het
Rasa4 T A 5: 136,101,363 (GRCm38) D324E probably damaging Het
Rilpl1 T A 5: 124,503,692 (GRCm38) silent Het
Rin2 A C 2: 145,883,475 (GRCm38) D794A probably damaging Het
Ripk1 A G 13: 34,030,062 (GRCm38) I522M probably damaging Het
Rnf31 T C 14: 55,592,551 (GRCm38) Y143H probably benign Het
Rp1 T G 1: 4,042,068 (GRCm38) I1187L unknown Het
Rps6ka5 G A 12: 100,619,537 (GRCm38) H166Y probably damaging Het
Rrm1 T C 7: 102,460,334 (GRCm38) V455A probably damaging Het
Runx2 G A 17: 44,814,192 (GRCm38) P80L probably damaging Het
Scn5a T G 9: 119,485,930 (GRCm38) E1904A probably damaging Het
Sec16a G T 2: 26,436,002 (GRCm38) S240* probably null Het
Slc22a8 C T 19: 8,605,417 (GRCm38) T154I probably benign Het
Slc25a16 T A 10: 62,937,454 (GRCm38) V156E possibly damaging Het
Slc28a3 A T 13: 58,610,804 (GRCm38) S2T probably benign Het
Srd5a3 G A 5: 76,149,866 (GRCm38) V48I probably benign Het
Srebf1 A C 11: 60,200,526 (GRCm38) H1025Q probably damaging Het
Stard9 A G 2: 120,697,191 (GRCm38) K1310E probably benign Het
Swt1 A G 1: 151,370,630 (GRCm38) V848A possibly damaging Het
Tanc2 A T 11: 105,840,699 (GRCm38) T434S possibly damaging Het
Tcf20 G A 15: 82,854,682 (GRCm38) T856I probably benign Het
Tcf7l2 T C 19: 55,894,733 (GRCm38) probably null Het
Tmem246 A T 4: 49,586,325 (GRCm38) M281K probably benign Het
Trim45 A G 3: 100,931,879 (GRCm38) probably benign Het
Tsen2 T A 6: 115,547,972 (GRCm38) M44K possibly damaging Het
Ttc21a T A 9: 119,958,073 (GRCm38) C715* probably null Het
Vmn2r102 G A 17: 19,694,194 (GRCm38) V674I probably damaging Het
Zfp87 A G 13: 67,517,054 (GRCm38) S430P probably damaging Het
Other mutations in Mob3c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02210:Mob3c APN 4 115,833,755 (GRCm38) missense probably damaging 1.00
R1718:Mob3c UTSW 4 115,831,644 (GRCm38) missense probably benign 0.00
R1989:Mob3c UTSW 4 115,831,557 (GRCm38) missense probably damaging 1.00
R4678:Mob3c UTSW 4 115,833,771 (GRCm38) splice site probably null
R4883:Mob3c UTSW 4 115,833,731 (GRCm38) missense probably benign 0.11
R5610:Mob3c UTSW 4 115,833,681 (GRCm38) missense probably benign 0.17
R7248:Mob3c UTSW 4 115,831,684 (GRCm38) missense probably benign
R7410:Mob3c UTSW 4 115,831,587 (GRCm38) missense probably damaging 1.00
R8039:Mob3c UTSW 4 115,831,687 (GRCm38) missense probably benign 0.00
R8281:Mob3c UTSW 4 115,831,438 (GRCm38) missense probably benign 0.19
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-05-13