Incidental Mutation 'R7011:Or4f14b'
ID 545000
Institutional Source Beutler Lab
Gene Symbol Or4f14b
Ensembl Gene ENSMUSG00000094747
Gene Name olfactory receptor family 4 subfamily F member 14B
Synonyms GA_x6K02T2Q125-72988111-72987173, MOR245-19P, Olfr1307
MMRRC Submission 045112-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R7011 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111774861-111775799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111775031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 257 (F257I)
Ref Sequence ENSEMBL: ENSMUSP00000097201 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099604] [ENSMUST00000099606]
AlphaFold Q7TQX1
Predicted Effect probably benign
Transcript: ENSMUST00000099604
AA Change: F257I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000097199
Gene: ENSMUSG00000094747
AA Change: F257I

DomainStartEndE-ValueType
Pfam:7tm_4 38 311 1.5e-36 PFAM
Pfam:7tm_1 49 295 6.5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099606
AA Change: F257I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000097201
Gene: ENSMUSG00000094747
AA Change: F257I

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 2.2e-42 PFAM
Pfam:7tm_1 41 287 6.7e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 96% (66/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam19 C T 11: 46,033,845 (GRCm39) P886S probably benign Het
Anapc1 C T 2: 128,490,601 (GRCm39) probably null Het
Ankrd34c C A 9: 89,611,001 (GRCm39) G447* probably null Het
Apbb1ip A T 2: 22,725,943 (GRCm39) E238D probably damaging Het
Arfgap1 T C 2: 180,613,935 (GRCm39) L110P probably damaging Het
Arhgap21 G A 2: 20,853,689 (GRCm39) T1901I possibly damaging Het
Brpf1 C A 6: 113,295,427 (GRCm39) Q679K probably benign Het
Btnl2 A G 17: 34,582,487 (GRCm39) E351G probably damaging Het
Cd209f T A 8: 4,154,859 (GRCm39) T80S probably benign Het
Cdc16 A G 8: 13,819,451 (GRCm39) E349G probably damaging Het
Cfap53 A T 18: 74,462,564 (GRCm39) D436V probably benign Het
Crhr2 A T 6: 55,076,195 (GRCm39) probably null Het
Cux1 T C 5: 136,388,887 (GRCm39) K226E probably damaging Het
Ddr2 A T 1: 169,809,672 (GRCm39) D768E probably damaging Het
Dhx8 T C 11: 101,632,346 (GRCm39) L435P probably damaging Het
Dnah11 AGGCC AGGCCGGCC 12: 117,885,753 (GRCm39) probably null Het
Eif4ebp1 G A 8: 27,763,372 (GRCm39) R55Q probably damaging Het
Fbh1 T A 2: 11,767,774 (GRCm39) D358V probably damaging Het
Fra10ac1 T A 19: 38,177,242 (GRCm39) E304D probably benign Het
Gabrb2 T C 11: 42,517,488 (GRCm39) S399P possibly damaging Het
Gpatch2l G A 12: 86,290,958 (GRCm39) R47H probably damaging Het
Gprin2 G T 14: 33,917,393 (GRCm39) H126N probably null Het
Gucy1a1 A G 3: 82,016,422 (GRCm39) S189P probably damaging Het
Htr1d T C 4: 136,170,317 (GRCm39) M182T probably benign Het
Lipc A G 9: 70,726,236 (GRCm39) F73L probably benign Het
Liph A G 16: 21,802,847 (GRCm39) I74T probably damaging Het
Lrif1 T G 3: 106,639,601 (GRCm39) Y229D probably damaging Het
Magel2 C T 7: 62,028,281 (GRCm39) T395I possibly damaging Het
Magi3 T C 3: 104,013,070 (GRCm39) N139S probably damaging Het
Man2c1 T A 9: 57,045,117 (GRCm39) V336E probably damaging Het
Mapk12 A T 15: 89,019,803 (GRCm39) Y135N probably damaging Het
Mapkapk3 C T 9: 107,166,595 (GRCm39) probably benign Het
Mast1 A T 8: 85,638,574 (GRCm39) Y653* probably null Het
Muc16 T A 9: 18,548,839 (GRCm39) H5818L probably benign Het
Muc16 T A 9: 18,548,747 (GRCm39) I5849F probably benign Het
Ndufa10 A G 1: 92,398,581 (GRCm39) S68P probably damaging Het
Nedd1 C A 10: 92,526,635 (GRCm39) L503F probably benign Het
Nr1i3 A G 1: 171,041,927 (GRCm39) M4V probably benign Het
Or12e9 G A 2: 87,202,604 (GRCm39) A243T possibly damaging Het
Or2av9 T A 11: 58,380,970 (GRCm39) I204F possibly damaging Het
Or9i2 T C 19: 13,816,403 (GRCm39) I45V probably benign Het
Pcdh18 A T 3: 49,709,231 (GRCm39) S695T probably benign Het
Pcdha1 T C 18: 37,063,588 (GRCm39) I84T probably damaging Het
Plek T A 11: 16,944,760 (GRCm39) D90V possibly damaging Het
Ppp6r1 A G 7: 4,649,825 (GRCm39) C47R probably damaging Het
Psg27 G C 7: 18,290,798 (GRCm39) N468K probably benign Het
Ptchd4 G A 17: 42,814,759 (GRCm39) E887K probably benign Het
Rabgap1 C T 2: 37,430,492 (GRCm39) L678F probably damaging Het
Rmdn3 T C 2: 118,968,904 (GRCm39) Y429C probably damaging Het
Ros1 A T 10: 52,056,272 (GRCm39) C73S probably damaging Het
Rtkn2 G A 10: 67,815,495 (GRCm39) probably benign Het
Slc25a42 A G 8: 70,639,352 (GRCm39) S242P probably damaging Het
Smtnl1 T A 2: 84,648,753 (GRCm39) D167V probably benign Het
Smurf2 A G 11: 106,724,610 (GRCm39) L511P probably benign Het
Stbd1 A T 5: 92,752,977 (GRCm39) K156* probably null Het
Tenm4 G T 7: 96,545,342 (GRCm39) G2453* probably null Het
Tent4a C T 13: 69,648,199 (GRCm39) G489S probably damaging Het
Tpr A G 1: 150,309,523 (GRCm39) K1760E probably damaging Het
Triobp T A 15: 78,862,923 (GRCm39) L1427Q probably damaging Het
Uaca A G 9: 60,777,650 (GRCm39) E679G probably damaging Het
Ucn3 T G 13: 3,991,421 (GRCm39) H77P possibly damaging Het
Wnk2 T A 13: 49,224,567 (GRCm39) D998V probably damaging Het
Xrcc3 A G 12: 111,770,969 (GRCm39) V320A probably damaging Het
Zdbf2 A G 1: 63,345,925 (GRCm39) T1435A possibly damaging Het
Zfp36l2 G T 17: 84,493,861 (GRCm39) H259N possibly damaging Het
Zfp619 A T 7: 39,187,186 (GRCm39) H1072L probably damaging Het
Zfy2 T A Y: 2,107,127 (GRCm39) E502D possibly damaging Het
Zfyve16 G A 13: 92,658,495 (GRCm39) P472L probably benign Het
Other mutations in Or4f14b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01501:Or4f14b APN 2 111,774,863 (GRCm39) makesense probably null
IGL01947:Or4f14b APN 2 111,775,339 (GRCm39) missense probably benign 0.26
IGL02373:Or4f14b APN 2 111,775,178 (GRCm39) missense probably benign 0.01
IGL02682:Or4f14b APN 2 111,775,285 (GRCm39) missense probably damaging 1.00
R0714:Or4f14b UTSW 2 111,774,898 (GRCm39) missense probably benign 0.01
R1670:Or4f14b UTSW 2 111,775,264 (GRCm39) missense probably damaging 1.00
R1730:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R1733:Or4f14b UTSW 2 111,775,625 (GRCm39) missense probably benign 0.13
R1773:Or4f14b UTSW 2 111,775,204 (GRCm39) missense possibly damaging 0.55
R1783:Or4f14b UTSW 2 111,775,633 (GRCm39) missense probably benign 0.45
R2180:Or4f14b UTSW 2 111,775,348 (GRCm39) missense probably benign 0.39
R2197:Or4f14b UTSW 2 111,775,658 (GRCm39) missense possibly damaging 0.64
R2207:Or4f14b UTSW 2 111,775,270 (GRCm39) missense probably damaging 1.00
R2377:Or4f14b UTSW 2 111,774,988 (GRCm39) missense probably damaging 1.00
R4425:Or4f14b UTSW 2 111,775,534 (GRCm39) missense probably benign 0.00
R4595:Or4f14b UTSW 2 111,774,997 (GRCm39) missense possibly damaging 0.86
R4859:Or4f14b UTSW 2 111,775,156 (GRCm39) missense probably damaging 0.98
R4910:Or4f14b UTSW 2 111,775,423 (GRCm39) missense possibly damaging 0.69
R5167:Or4f14b UTSW 2 111,775,447 (GRCm39) missense probably damaging 1.00
R5537:Or4f14b UTSW 2 111,775,393 (GRCm39) missense probably damaging 1.00
R6328:Or4f14b UTSW 2 111,775,739 (GRCm39) missense probably null 0.41
R6877:Or4f14b UTSW 2 111,775,184 (GRCm39) missense probably benign 0.16
R7177:Or4f14b UTSW 2 111,775,501 (GRCm39) missense probably damaging 1.00
R7937:Or4f14b UTSW 2 111,774,875 (GRCm39) missense probably benign 0.00
R8792:Or4f14b UTSW 2 111,775,073 (GRCm39) missense probably damaging 1.00
R9290:Or4f14b UTSW 2 111,774,967 (GRCm39) missense possibly damaging 0.91
R9358:Or4f14b UTSW 2 111,775,429 (GRCm39) missense probably benign 0.31
Predicted Primers PCR Primer
(F):5'- CAGAAGACAGTCCATAGTACATTTAGG -3'
(R):5'- ATGTGTTGGACAGCTTCTACTG -3'

Sequencing Primer
(F):5'- AGCTGTCTGCATACTCTCT -3'
(R):5'- ACCAGCTGGAATTCATGGTC -3'
Posted On 2019-05-13