Incidental Mutation 'R7012:Or2y1g'
ID 545087
Institutional Source Beutler Lab
Gene Symbol Or2y1g
Ensembl Gene ENSMUSG00000059864
Gene Name olfactory receptor family 2 subfamily Y member 1G
Synonyms Olfr1393, MOR256-24, GA_x6K02T2QP88-6154577-6153642, MOR256-67_i
MMRRC Submission 045113-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R7012 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 49169131-49173596 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 49171823 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 283 (M283L)
Ref Sequence ENSEMBL: ENSMUSP00000149358 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078932] [ENSMUST00000213323] [ENSMUST00000214170] [ENSMUST00000214598] [ENSMUST00000215861] [ENSMUST00000217275]
AlphaFold Q8VFA7
Predicted Effect probably benign
Transcript: ENSMUST00000078932
AA Change: M283L

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000077962
Gene: ENSMUSG00000059864
AA Change: M283L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.3e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 230 3e-6 PFAM
Pfam:7tm_1 41 289 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213323
AA Change: M283L

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000214170
Predicted Effect probably benign
Transcript: ENSMUST00000214598
Predicted Effect probably benign
Transcript: ENSMUST00000215861
Predicted Effect probably benign
Transcript: ENSMUST00000217275
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (49/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 T C 5: 35,769,431 (GRCm39) F686L probably benign Het
Adcy4 C T 14: 56,017,376 (GRCm39) V266I possibly damaging Het
Adgrb1 A G 15: 74,401,750 (GRCm39) T249A probably damaging Het
Adss1 A G 12: 112,600,670 (GRCm39) D213G probably benign Het
Ap1b1 T G 11: 4,980,963 (GRCm39) V453G probably damaging Het
Apold1 G A 6: 134,961,007 (GRCm39) G154R probably damaging Het
Birc5 A G 11: 117,740,262 (GRCm39) E29G probably benign Het
Clcn1 G A 6: 42,267,542 (GRCm39) R75H probably benign Het
Cngb1 T A 8: 95,984,583 (GRCm39) I868F possibly damaging Het
Cntn6 T A 6: 104,703,223 (GRCm39) V215E probably damaging Het
Cntn6 A G 6: 104,751,441 (GRCm39) I294V probably benign Het
Col6a2 A T 10: 76,450,511 (GRCm39) I140N possibly damaging Het
Cops5 A G 1: 10,100,890 (GRCm39) *147Q probably null Het
Dbr1 T A 9: 99,465,374 (GRCm39) Y317* probably null Het
Dock5 A C 14: 68,060,035 (GRCm39) V468G probably damaging Het
F13b A G 1: 139,444,096 (GRCm39) I477V probably benign Het
Fhad1 CGG CG 4: 141,645,602 (GRCm39) probably null Het
Git1 T C 11: 77,390,606 (GRCm39) L114P probably damaging Het
Greb1l G T 18: 10,529,707 (GRCm39) probably null Het
Itih4 A G 14: 30,612,706 (GRCm39) N244S probably benign Het
Lin28a A G 4: 133,746,040 (GRCm39) S5P probably damaging Het
Lipt1 T C 1: 37,915,060 (GRCm39) I372T probably benign Het
Lysmd4 A G 7: 66,875,765 (GRCm39) T143A probably benign Het
Muc16 T C 9: 18,406,914 (GRCm39) probably null Het
Or13c9 A G 4: 52,936,193 (GRCm39) L30P probably damaging Het
Or5t16 A T 2: 86,819,051 (GRCm39) H156Q possibly damaging Het
Or6e1 A G 14: 54,519,674 (GRCm39) I226T possibly damaging Het
Pclo G A 5: 14,800,493 (GRCm39) G4438D unknown Het
Phlpp2 T A 8: 110,603,486 (GRCm39) F51I possibly damaging Het
Rab5c G A 11: 100,610,789 (GRCm39) R40C probably damaging Het
Rxfp2 T C 5: 150,004,659 (GRCm39) V711A probably benign Het
Sbno2 A T 10: 79,905,352 (GRCm39) probably benign Het
Setd2 T A 9: 110,376,751 (GRCm39) S189T probably damaging Het
Sez6 A G 11: 77,868,621 (GRCm39) N965S probably benign Het
Sh3d19 A G 3: 85,992,320 (GRCm39) N116S probably benign Het
Slc43a3 T C 2: 84,777,313 (GRCm39) Y221H probably damaging Het
Slco1a6 T C 6: 142,032,287 (GRCm39) I613V probably benign Het
Stag3 T A 5: 138,295,871 (GRCm39) probably null Het
Ston1 T C 17: 88,943,413 (GRCm39) M273T probably damaging Het
Tbc1d32 A T 10: 56,100,820 (GRCm39) Y53N probably damaging Het
Tmem132b T A 5: 125,775,654 (GRCm39) L376Q probably damaging Het
Trim60 A G 8: 65,453,043 (GRCm39) V402A possibly damaging Het
Tssk5 A C 15: 76,257,745 (GRCm39) N178K probably damaging Het
Ttll9 T C 2: 152,844,982 (GRCm39) I450T possibly damaging Het
Tyw1 T G 5: 130,306,571 (GRCm39) probably null Het
Usp16 T C 16: 87,255,632 (GRCm39) probably null Het
Vmn2r97 T C 17: 19,167,756 (GRCm39) V670A probably damaging Het
Vmn2r98 A G 17: 19,286,530 (GRCm39) N343D probably benign Het
Zfp472 T G 17: 33,196,220 (GRCm39) N98K probably benign Het
Other mutations in Or2y1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Or2y1g APN 11 49,171,314 (GRCm39) missense possibly damaging 0.94
IGL02291:Or2y1g APN 11 49,171,812 (GRCm39) missense probably damaging 1.00
IGL03127:Or2y1g APN 11 49,171,599 (GRCm39) missense possibly damaging 0.88
R0580:Or2y1g UTSW 11 49,171,449 (GRCm39) missense probably damaging 0.97
R1985:Or2y1g UTSW 11 49,171,110 (GRCm39) missense probably damaging 1.00
R4812:Or2y1g UTSW 11 49,171,284 (GRCm39) missense possibly damaging 0.94
R5190:Or2y1g UTSW 11 49,171,209 (GRCm39) missense probably damaging 0.99
R6694:Or2y1g UTSW 11 49,171,379 (GRCm39) missense probably benign 0.01
R6911:Or2y1g UTSW 11 49,171,634 (GRCm39) missense probably benign 0.22
R7159:Or2y1g UTSW 11 49,171,185 (GRCm39) missense probably damaging 1.00
R7541:Or2y1g UTSW 11 49,171,160 (GRCm39) missense probably damaging 1.00
R7759:Or2y1g UTSW 11 49,171,463 (GRCm39) missense probably benign 0.00
R8767:Or2y1g UTSW 11 49,171,227 (GRCm39) missense possibly damaging 0.87
R9069:Or2y1g UTSW 11 49,171,247 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AGGCTCCTATGCACAGATTG -3'
(R):5'- ATGGACAGCTTCATGCATGTAC -3'

Sequencing Primer
(F):5'- CACAGATTGCTAGGGCGGTG -3'
(R):5'- GGACAGCTTCATGCATGTACATAAC -3'
Posted On 2019-05-13