Incidental Mutation 'R7013:Dact2'
ID 545147
Institutional Source Beutler Lab
Gene Symbol Dact2
Ensembl Gene ENSMUSG00000048826
Gene Name dishevelled-binding antagonist of beta-catenin 2
Synonyms 2900084M21Rik, Frd2, Dpr2, dapper2
MMRRC Submission 045114-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7013 (G1)
Quality Score 110.008
Status Not validated
Chromosome 17
Chromosomal Location 14415492-14424595 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 14423796 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 66 (T66A)
Ref Sequence ENSEMBL: ENSMUSP00000051638 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053218]
AlphaFold Q7TN08
Predicted Effect probably benign
Transcript: ENSMUST00000053218
AA Change: T66A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000051638
Gene: ENSMUSG00000048826
AA Change: T66A

DomainStartEndE-ValueType
Pfam:Dapper 19 757 1.8e-231 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (47/47)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele develop normally but display enhanced keratinocyte migration and accelerated re-epithelialization during cutaneous wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,618,345 (GRCm39) I213V probably null Het
Abcc4 A T 14: 118,763,755 (GRCm39) C952S probably benign Het
Adhfe1 T C 1: 9,620,816 (GRCm39) probably benign Het
Apob T A 12: 8,060,080 (GRCm39) L2854* probably null Het
Arhgap5 T A 12: 52,565,109 (GRCm39) N693K probably benign Het
Arid5b A G 10: 67,933,649 (GRCm39) V508A probably damaging Het
Atl1 A G 12: 70,000,214 (GRCm39) E288G probably damaging Het
Bank1 A G 3: 135,806,270 (GRCm39) S455P possibly damaging Het
Ces1c A T 8: 93,857,392 (GRCm39) L63Q probably damaging Het
Crmp1 A T 5: 37,426,036 (GRCm39) probably null Het
Csnka2ip T C 16: 64,298,780 (GRCm39) D528G unknown Het
Dkk2 T C 3: 131,880,760 (GRCm39) L135P probably damaging Het
Drc3 A G 11: 60,278,129 (GRCm39) N381S probably benign Het
Dsg4 T C 18: 20,591,578 (GRCm39) V439A possibly damaging Het
Dysf C T 6: 84,114,340 (GRCm39) P1240S probably damaging Het
Esyt1 A T 10: 128,361,520 (GRCm39) V58E probably damaging Het
Exo1 G T 1: 175,721,338 (GRCm39) A326S probably damaging Het
Fam20b A G 1: 156,518,135 (GRCm39) S220P probably damaging Het
Fmo6 G A 1: 162,745,817 (GRCm39) T402I probably benign Het
Galnt10 A T 11: 57,656,410 (GRCm39) D198V probably benign Het
Gsap A T 5: 21,483,108 (GRCm39) E604D probably benign Het
Il20rb A G 9: 100,343,481 (GRCm39) Y258H probably benign Het
Impg1 A T 9: 80,285,776 (GRCm39) S409R probably damaging Het
Jak3 G T 8: 72,131,425 (GRCm39) V97F possibly damaging Het
Lbhd1 T C 19: 8,861,523 (GRCm39) S52P probably damaging Het
Lman2l A G 1: 36,482,599 (GRCm39) probably benign Het
Lnpep C A 17: 17,788,625 (GRCm39) M493I probably benign Het
Mpp4 T C 1: 59,188,774 (GRCm39) D132G probably damaging Het
Nlrp1a G A 11: 71,014,378 (GRCm39) R291W probably benign Het
Or1e23 G T 11: 73,407,247 (GRCm39) Y259* probably null Het
Or4a79 T A 2: 89,551,730 (GRCm39) I242F probably benign Het
Or4b13 C T 2: 90,082,441 (GRCm39) R297Q possibly damaging Het
Or4f15 G A 2: 111,814,308 (GRCm39) A37V probably benign Het
Or4n4b T A 14: 50,536,656 (GRCm39) I37F probably damaging Het
Orc5 A G 5: 22,738,787 (GRCm39) V158A probably benign Het
Pate8 C A 9: 36,493,854 (GRCm39) W26C unknown Het
Pcdhga3 A G 18: 37,808,674 (GRCm39) N376D probably damaging Het
Ptprr T A 10: 116,072,659 (GRCm39) I207N probably damaging Het
Recql5 A G 11: 115,785,402 (GRCm39) V698A probably benign Het
Rnf212 A T 5: 108,877,826 (GRCm39) M222K probably benign Het
Rsph6a A G 7: 18,788,820 (GRCm39) S51G probably benign Het
Smap2 T C 4: 120,839,365 (GRCm39) K121E probably damaging Het
Syt11 A T 3: 88,655,296 (GRCm39) V335D possibly damaging Het
Terb1 A T 8: 105,215,222 (GRCm39) C251* probably null Het
Tmprss11d C A 5: 86,474,432 (GRCm39) R37L probably damaging Het
Ttbk2 T C 2: 120,576,265 (GRCm39) N904S possibly damaging Het
Vmn1r119 T A 7: 20,745,714 (GRCm39) I223F probably damaging Het
Vmn1r66 T C 7: 10,008,683 (GRCm39) R117G possibly damaging Het
Zfp106 T C 2: 120,362,113 (GRCm39) D1025G probably damaging Het
Other mutations in Dact2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01867:Dact2 APN 17 14,415,932 (GRCm39) missense probably damaging 0.98
R0597:Dact2 UTSW 17 14,417,303 (GRCm39) missense probably benign
R1657:Dact2 UTSW 17 14,418,252 (GRCm39) missense probably benign 0.03
R1717:Dact2 UTSW 17 14,418,175 (GRCm39) missense probably benign 0.11
R1734:Dact2 UTSW 17 14,416,901 (GRCm39) missense probably benign 0.00
R1883:Dact2 UTSW 17 14,418,085 (GRCm39) missense possibly damaging 0.81
R2238:Dact2 UTSW 17 14,417,312 (GRCm39) missense probably damaging 0.99
R2878:Dact2 UTSW 17 14,416,176 (GRCm39) missense probably damaging 1.00
R4290:Dact2 UTSW 17 14,416,833 (GRCm39) missense probably benign 0.00
R4291:Dact2 UTSW 17 14,416,833 (GRCm39) missense probably benign 0.00
R4902:Dact2 UTSW 17 14,416,991 (GRCm39) missense possibly damaging 0.91
R5029:Dact2 UTSW 17 14,416,114 (GRCm39) missense probably benign 0.00
R5084:Dact2 UTSW 17 14,418,214 (GRCm39) missense possibly damaging 0.94
R5436:Dact2 UTSW 17 14,416,010 (GRCm39) missense probably damaging 1.00
R5837:Dact2 UTSW 17 14,416,515 (GRCm39) missense probably damaging 1.00
R5847:Dact2 UTSW 17 14,419,450 (GRCm39) missense probably damaging 0.97
R6048:Dact2 UTSW 17 14,417,567 (GRCm39) missense probably damaging 1.00
R6377:Dact2 UTSW 17 14,419,450 (GRCm39) missense probably damaging 0.97
R7268:Dact2 UTSW 17 14,416,797 (GRCm39) missense probably benign 0.01
R7425:Dact2 UTSW 17 14,416,593 (GRCm39) missense probably damaging 1.00
R8725:Dact2 UTSW 17 14,417,146 (GRCm39) nonsense probably null
R8727:Dact2 UTSW 17 14,417,146 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACAGCCTGTGTCTAGCCAG -3'
(R):5'- TTCCCCGATGAGCTCATAGG -3'

Sequencing Primer
(F):5'- ACCAAGGTTGTGTCCGC -3'
(R):5'- ATGAGCTCATAGGTCCCAGG -3'
Posted On 2019-05-13