Incidental Mutation 'R7013:Dact2'
ID 545147
Institutional Source Beutler Lab
Gene Symbol Dact2
Ensembl Gene ENSMUSG00000048826
Gene Name dishevelled-binding antagonist of beta-catenin 2
Synonyms dapper2, Dpr2, Frd2, 2900084M21Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7013 (G1)
Quality Score 110.008
Status Not validated
Chromosome 17
Chromosomal Location 14195231-14203831 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 14203534 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 66 (T66A)
Ref Sequence ENSEMBL: ENSMUSP00000051638 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053218]
AlphaFold Q7TN08
Predicted Effect probably benign
Transcript: ENSMUST00000053218
AA Change: T66A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000051638
Gene: ENSMUSG00000048826
AA Change: T66A

DomainStartEndE-ValueType
Pfam:Dapper 19 757 1.8e-231 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (47/47)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele develop normally but display enhanced keratinocyte migration and accelerated re-epithelialization during cutaneous wound healing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,641,386 I213V probably null Het
Abcc4 A T 14: 118,526,343 C952S probably benign Het
Adhfe1 T C 1: 9,550,591 probably benign Het
Apob T A 12: 8,010,080 L2854* probably null Het
Arhgap5 T A 12: 52,518,326 N693K probably benign Het
Arid5b A G 10: 68,097,819 V508A probably damaging Het
Atl1 A G 12: 69,953,440 E288G probably damaging Het
Bank1 A G 3: 136,100,509 S455P possibly damaging Het
Ces1c A T 8: 93,130,764 L63Q probably damaging Het
Crmp1 A T 5: 37,268,692 probably null Het
Csnka2ip T C 16: 64,478,417 D528G unknown Het
Dkk2 T C 3: 132,174,999 L135P probably damaging Het
Drc3 A G 11: 60,387,303 N381S probably benign Het
Dsg4 T C 18: 20,458,521 V439A possibly damaging Het
Dysf C T 6: 84,137,358 P1240S probably damaging Het
Esyt1 A T 10: 128,525,651 V58E probably damaging Het
Exo1 G T 1: 175,893,772 A326S probably damaging Het
Fam20b A G 1: 156,690,565 S220P probably damaging Het
Fmo6 G A 1: 162,918,248 T402I probably benign Het
Galnt10 A T 11: 57,765,584 D198V probably benign Het
Gm17689 C A 9: 36,582,558 W26C unknown Het
Gsap A T 5: 21,278,110 E604D probably benign Het
Il20rb A G 9: 100,461,428 Y258H probably benign Het
Impg1 A T 9: 80,378,494 S409R probably damaging Het
Jak3 G T 8: 71,678,781 V97F possibly damaging Het
Lbhd1 T C 19: 8,884,159 S52P probably damaging Het
Lman2l A G 1: 36,443,518 probably benign Het
Lnpep C A 17: 17,568,363 M493I probably benign Het
Mpp4 T C 1: 59,149,615 D132G probably damaging Het
Nlrp1a G A 11: 71,123,552 R291W probably benign Het
Olfr1252 T A 2: 89,721,386 I242F probably benign Het
Olfr1309 G A 2: 111,983,963 A37V probably benign Het
Olfr142 C T 2: 90,252,097 R297Q possibly damaging Het
Olfr382 G T 11: 73,516,421 Y259* probably null Het
Olfr733 T A 14: 50,299,199 I37F probably damaging Het
Orc5 A G 5: 22,533,789 V158A probably benign Het
Pcdhga3 A G 18: 37,675,621 N376D probably damaging Het
Ptprr T A 10: 116,236,754 I207N probably damaging Het
Recql5 A G 11: 115,894,576 V698A probably benign Het
Rnf212 A T 5: 108,729,960 M222K probably benign Het
Rsph6a A G 7: 19,054,895 S51G probably benign Het
Smap2 T C 4: 120,982,168 K121E probably damaging Het
Syt11 A T 3: 88,747,989 V335D possibly damaging Het
Terb1 A T 8: 104,488,590 C251* probably null Het
Tmprss11d C A 5: 86,326,573 R37L probably damaging Het
Ttbk2 T C 2: 120,745,784 N904S possibly damaging Het
Vmn1r119 T A 7: 21,011,789 I223F probably damaging Het
Vmn1r66 T C 7: 10,274,756 R117G possibly damaging Het
Zfp106 T C 2: 120,531,632 D1025G probably damaging Het
Other mutations in Dact2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01867:Dact2 APN 17 14195670 missense probably damaging 0.98
R0597:Dact2 UTSW 17 14197041 missense probably benign
R1657:Dact2 UTSW 17 14197990 missense probably benign 0.03
R1717:Dact2 UTSW 17 14197913 missense probably benign 0.11
R1734:Dact2 UTSW 17 14196639 missense probably benign 0.00
R1883:Dact2 UTSW 17 14197823 missense possibly damaging 0.81
R2238:Dact2 UTSW 17 14197050 missense probably damaging 0.99
R2878:Dact2 UTSW 17 14195914 missense probably damaging 1.00
R4290:Dact2 UTSW 17 14196571 missense probably benign 0.00
R4291:Dact2 UTSW 17 14196571 missense probably benign 0.00
R4902:Dact2 UTSW 17 14196729 missense possibly damaging 0.91
R5029:Dact2 UTSW 17 14195852 missense probably benign 0.00
R5084:Dact2 UTSW 17 14197952 missense possibly damaging 0.94
R5436:Dact2 UTSW 17 14195748 missense probably damaging 1.00
R5837:Dact2 UTSW 17 14196253 missense probably damaging 1.00
R5847:Dact2 UTSW 17 14199188 missense probably damaging 0.97
R6048:Dact2 UTSW 17 14197305 missense probably damaging 1.00
R6377:Dact2 UTSW 17 14199188 missense probably damaging 0.97
R7268:Dact2 UTSW 17 14196535 missense probably benign 0.01
R7425:Dact2 UTSW 17 14196331 missense probably damaging 1.00
R8725:Dact2 UTSW 17 14196884 nonsense probably null
R8727:Dact2 UTSW 17 14196884 nonsense probably null
Predicted Primers PCR Primer
(F):5'- AACAGCCTGTGTCTAGCCAG -3'
(R):5'- TTCCCCGATGAGCTCATAGG -3'

Sequencing Primer
(F):5'- ACCAAGGTTGTGTCCGC -3'
(R):5'- ATGAGCTCATAGGTCCCAGG -3'
Posted On 2019-05-13