Incidental Mutation 'R0609:Lrrk1'
| ID |
54524 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
038798-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0609 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 65916363 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000015277
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131239
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137181
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167705
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930596D02Rik |
A |
T |
14: 35,533,418 (GRCm39) |
|
probably null |
Het |
| Abcb4 |
T |
A |
5: 8,997,376 (GRCm39) |
C952S |
probably damaging |
Het |
| Adamtsl2 |
A |
G |
2: 26,979,647 (GRCm39) |
D272G |
probably benign |
Het |
| Aim2 |
G |
A |
1: 173,289,530 (GRCm39) |
D158N |
probably damaging |
Het |
| Aldh3b1 |
C |
T |
19: 3,964,024 (GRCm39) |
R426H |
probably damaging |
Het |
| Apoc2 |
A |
G |
7: 19,407,278 (GRCm39) |
S28P |
probably benign |
Het |
| Arfgef3 |
G |
A |
10: 18,473,179 (GRCm39) |
T1628I |
probably benign |
Het |
| Atp10a |
G |
A |
7: 58,469,488 (GRCm39) |
|
probably null |
Het |
| Bcl2 |
G |
A |
1: 106,640,292 (GRCm39) |
R107C |
probably damaging |
Het |
| Bmp8b |
T |
A |
4: 123,015,692 (GRCm39) |
D226E |
probably benign |
Het |
| Brsk2 |
T |
C |
7: 141,552,229 (GRCm39) |
Y618H |
probably damaging |
Het |
| Casp12 |
T |
A |
9: 5,346,554 (GRCm39) |
F27Y |
probably damaging |
Het |
| Casp8 |
T |
A |
1: 58,883,951 (GRCm39) |
N439K |
probably benign |
Het |
| Ccdc175 |
T |
A |
12: 72,204,281 (GRCm39) |
K253N |
probably benign |
Het |
| Cdc42bpa |
A |
G |
1: 179,867,744 (GRCm39) |
H193R |
probably damaging |
Het |
| Cdk17 |
T |
C |
10: 93,052,334 (GRCm39) |
M105T |
probably benign |
Het |
| Cdon |
C |
A |
9: 35,389,907 (GRCm39) |
P854T |
probably damaging |
Het |
| Cep44 |
A |
G |
8: 56,997,187 (GRCm39) |
M117T |
possibly damaging |
Het |
| Cep89 |
A |
T |
7: 35,134,955 (GRCm39) |
E674D |
probably damaging |
Het |
| Cit |
C |
T |
5: 116,012,002 (GRCm39) |
A203V |
probably damaging |
Het |
| Clstn1 |
C |
A |
4: 149,713,757 (GRCm39) |
|
probably null |
Het |
| Col7a1 |
T |
A |
9: 108,787,215 (GRCm39) |
D565E |
unknown |
Het |
| Cpb1 |
T |
A |
3: 20,316,638 (GRCm39) |
Y304F |
probably damaging |
Het |
| Cps1 |
T |
G |
1: 67,211,961 (GRCm39) |
Y710D |
probably damaging |
Het |
| Creb3l1 |
T |
C |
2: 91,817,398 (GRCm39) |
T372A |
possibly damaging |
Het |
| Dars1 |
A |
G |
1: 128,333,118 (GRCm39) |
V102A |
probably benign |
Het |
| Dhx35 |
C |
T |
2: 158,659,335 (GRCm39) |
T168I |
possibly damaging |
Het |
| Dnah5 |
T |
C |
15: 28,327,925 (GRCm39) |
S2100P |
probably benign |
Het |
| Dst |
T |
C |
1: 34,306,041 (GRCm39) |
|
probably null |
Het |
| Egflam |
A |
C |
15: 7,283,004 (GRCm39) |
L351R |
possibly damaging |
Het |
| Elp2 |
T |
A |
18: 24,759,213 (GRCm39) |
D523E |
probably benign |
Het |
| Exo5 |
C |
A |
4: 120,778,881 (GRCm39) |
G328V |
probably damaging |
Het |
| Fut9 |
A |
G |
4: 25,620,811 (GRCm39) |
M1T |
probably null |
Het |
| Galnt5 |
A |
G |
2: 57,914,637 (GRCm39) |
N584S |
possibly damaging |
Het |
| Gbp3 |
T |
C |
3: 142,273,533 (GRCm39) |
V360A |
probably damaging |
Het |
| Gdf6 |
G |
A |
4: 9,859,977 (GRCm39) |
C353Y |
probably damaging |
Het |
| Hace1 |
A |
G |
10: 45,524,965 (GRCm39) |
T244A |
probably damaging |
Het |
| Hr |
T |
C |
14: 70,797,097 (GRCm39) |
I500T |
probably benign |
Het |
| Ifnl2 |
A |
T |
7: 28,208,707 (GRCm39) |
L115Q |
probably damaging |
Het |
| Iigp1 |
T |
C |
18: 60,522,896 (GRCm39) |
F5L |
probably benign |
Het |
| Inhbb |
A |
G |
1: 119,345,146 (GRCm39) |
L381P |
probably damaging |
Het |
| Irx3 |
A |
T |
8: 92,527,721 (GRCm39) |
S50T |
probably benign |
Het |
| Ivns1abp |
C |
T |
1: 151,235,896 (GRCm39) |
T363I |
probably benign |
Het |
| Izumo1 |
A |
T |
7: 45,272,323 (GRCm39) |
T35S |
probably benign |
Het |
| Kank4 |
A |
G |
4: 98,665,342 (GRCm39) |
S651P |
probably damaging |
Het |
| Kit |
T |
C |
5: 75,771,539 (GRCm39) |
V232A |
probably benign |
Het |
| Klhl11 |
T |
C |
11: 100,354,540 (GRCm39) |
Y427C |
probably damaging |
Het |
| Laptm4b |
T |
A |
15: 34,258,835 (GRCm39) |
N36K |
probably damaging |
Het |
| Mamdc4 |
G |
T |
2: 25,454,205 (GRCm39) |
Q1042K |
probably benign |
Het |
| Mical2 |
A |
G |
7: 111,920,647 (GRCm39) |
|
probably null |
Het |
| Ms4a3 |
C |
A |
19: 11,608,725 (GRCm39) |
V176F |
possibly damaging |
Het |
| Myo3a |
T |
C |
2: 22,338,324 (GRCm39) |
V427A |
probably benign |
Het |
| Myo3a |
A |
C |
2: 22,401,110 (GRCm39) |
E626D |
possibly damaging |
Het |
| Nckap5 |
A |
T |
1: 125,955,025 (GRCm39) |
L509* |
probably null |
Het |
| Ndufa5 |
A |
T |
6: 24,519,248 (GRCm39) |
D64E |
possibly damaging |
Het |
| Nedd4l |
T |
C |
18: 65,341,532 (GRCm39) |
Y753H |
probably damaging |
Het |
| Nynrin |
T |
C |
14: 56,110,218 (GRCm39) |
V1775A |
probably damaging |
Het |
| Oplah |
A |
G |
15: 76,187,192 (GRCm39) |
S570P |
probably benign |
Het |
| Or14c39 |
T |
C |
7: 86,344,084 (GRCm39) |
V140A |
possibly damaging |
Het |
| Or2ag1b |
A |
T |
7: 106,288,205 (GRCm39) |
H244Q |
probably damaging |
Het |
| Or4q3 |
T |
C |
14: 50,583,383 (GRCm39) |
Y141C |
probably damaging |
Het |
| Or5t18 |
A |
G |
2: 86,637,205 (GRCm39) |
L46S |
probably damaging |
Het |
| Or9r3 |
G |
A |
10: 129,948,449 (GRCm39) |
S70F |
probably damaging |
Het |
| Osbpl11 |
C |
A |
16: 33,054,814 (GRCm39) |
Y632* |
probably null |
Het |
| Osbpl5 |
A |
T |
7: 143,248,558 (GRCm39) |
L644Q |
probably damaging |
Het |
| Pcdhb19 |
T |
C |
18: 37,631,005 (GRCm39) |
W267R |
probably benign |
Het |
| Pkhd1l1 |
A |
C |
15: 44,330,820 (GRCm39) |
S132R |
possibly damaging |
Het |
| Pramel23 |
A |
T |
4: 143,425,073 (GRCm39) |
D123E |
probably benign |
Het |
| Ptpn13 |
T |
A |
5: 103,704,011 (GRCm39) |
S1348T |
probably benign |
Het |
| Rc3h1 |
T |
A |
1: 160,757,705 (GRCm39) |
W8R |
probably damaging |
Het |
| Rgs3 |
T |
G |
4: 62,544,173 (GRCm39) |
V315G |
probably damaging |
Het |
| Rora |
T |
A |
9: 69,269,151 (GRCm39) |
M82K |
probably damaging |
Het |
| Rph3al |
T |
C |
11: 75,799,795 (GRCm39) |
I55V |
probably benign |
Het |
| Sag |
T |
C |
1: 87,740,713 (GRCm39) |
V45A |
probably damaging |
Het |
| Scn3a |
T |
C |
2: 65,366,854 (GRCm39) |
E56G |
probably damaging |
Het |
| Sec24c |
T |
G |
14: 20,737,016 (GRCm39) |
V324G |
probably damaging |
Het |
| Sptbn1 |
A |
G |
11: 30,088,979 (GRCm39) |
L748S |
probably damaging |
Het |
| Stard9 |
A |
T |
2: 120,536,787 (GRCm39) |
D4186V |
probably damaging |
Het |
| Stk39 |
T |
C |
2: 68,196,511 (GRCm39) |
E306G |
probably damaging |
Het |
| Sycp1 |
C |
A |
3: 102,806,165 (GRCm39) |
|
probably null |
Het |
| Taf2 |
A |
C |
15: 54,923,446 (GRCm39) |
L277R |
probably damaging |
Het |
| Tasor |
C |
T |
14: 27,183,707 (GRCm39) |
T722I |
probably benign |
Het |
| Tbc1d23 |
T |
A |
16: 56,993,469 (GRCm39) |
I566F |
possibly damaging |
Het |
| Tekt5 |
T |
C |
16: 10,179,168 (GRCm39) |
T400A |
possibly damaging |
Het |
| Tgfbrap1 |
T |
C |
1: 43,099,301 (GRCm39) |
H401R |
probably benign |
Het |
| Tie1 |
T |
A |
4: 118,333,344 (GRCm39) |
I841L |
possibly damaging |
Het |
| Tln1 |
T |
G |
4: 43,544,645 (GRCm39) |
T1095P |
possibly damaging |
Het |
| Tmem147 |
A |
G |
7: 30,427,527 (GRCm39) |
Y72H |
probably benign |
Het |
| Tnfaip2 |
A |
G |
12: 111,419,941 (GRCm39) |
N691S |
probably benign |
Het |
| Trim24 |
G |
A |
6: 37,934,718 (GRCm39) |
C811Y |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,007,183 (GRCm39) |
|
probably benign |
Het |
| Trpc4 |
T |
G |
3: 54,102,189 (GRCm39) |
L29R |
probably damaging |
Het |
| Trpm6 |
A |
T |
19: 18,803,226 (GRCm39) |
I890F |
probably damaging |
Het |
| Ttc23l |
C |
T |
15: 10,504,622 (GRCm39) |
E442K |
probably benign |
Het |
| Tut7 |
A |
T |
13: 59,947,596 (GRCm39) |
C506* |
probably null |
Het |
| Uggt2 |
A |
G |
14: 119,332,748 (GRCm39) |
V62A |
probably damaging |
Het |
| Ugt1a6a |
C |
A |
1: 88,066,606 (GRCm39) |
S137R |
probably benign |
Het |
| Unc13a |
A |
G |
8: 72,111,111 (GRCm39) |
Y367H |
probably damaging |
Het |
| Vmn2r49 |
A |
G |
7: 9,710,233 (GRCm39) |
I833T |
probably benign |
Het |
| Vmn2r7 |
T |
C |
3: 64,623,900 (GRCm39) |
D231G |
probably benign |
Het |
| Ythdc2 |
A |
T |
18: 44,997,424 (GRCm39) |
M994L |
probably benign |
Het |
| Zfp804a |
G |
A |
2: 82,087,932 (GRCm39) |
S587N |
probably damaging |
Het |
| Zswim2 |
A |
G |
2: 83,754,003 (GRCm39) |
I219T |
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTACCCTGAATCCTAGCTTCCAGC -3'
(R):5'- ATCCAGACTCACTGTGTCCAGTCC -3'
Sequencing Primer
(F):5'- CAGGGACAAGTTGATCTTGACATC -3'
(R):5'- gagaaggtggggagggag -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation