Incidental Mutation 'R0609:Lrrk1'
| ID |
54524 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
|
| MMRRC Submission |
038798-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0609 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
66226912-66388350 bp(-) (GRCm38) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 66266615 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000015277
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131239
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137181
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167705
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 103 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930596D02Rik |
A |
T |
14: 35,811,461 (GRCm38) |
|
probably null |
Het |
| Abcb4 |
T |
A |
5: 8,947,376 (GRCm38) |
C952S |
probably damaging |
Het |
| Adamtsl2 |
A |
G |
2: 27,089,635 (GRCm38) |
D272G |
probably benign |
Het |
| Aim2 |
G |
A |
1: 173,461,964 (GRCm38) |
D158N |
probably damaging |
Het |
| Aldh3b1 |
C |
T |
19: 3,914,024 (GRCm38) |
R426H |
probably damaging |
Het |
| Apoc2 |
A |
G |
7: 19,673,353 (GRCm38) |
S28P |
probably benign |
Het |
| Arfgef3 |
G |
A |
10: 18,597,431 (GRCm38) |
T1628I |
probably benign |
Het |
| Atp10a |
G |
A |
7: 58,819,740 (GRCm38) |
|
probably null |
Het |
| Bcl2 |
G |
A |
1: 106,712,562 (GRCm38) |
R107C |
probably damaging |
Het |
| Bmp8b |
T |
A |
4: 123,121,899 (GRCm38) |
D226E |
probably benign |
Het |
| Brsk2 |
T |
C |
7: 141,998,492 (GRCm38) |
Y618H |
probably damaging |
Het |
| Casp12 |
T |
A |
9: 5,346,554 (GRCm38) |
F27Y |
probably damaging |
Het |
| Casp8 |
T |
A |
1: 58,844,792 (GRCm38) |
N439K |
probably benign |
Het |
| Ccdc175 |
T |
A |
12: 72,157,507 (GRCm38) |
K253N |
probably benign |
Het |
| Cdc42bpa |
A |
G |
1: 180,040,179 (GRCm38) |
H193R |
probably damaging |
Het |
| Cdk17 |
T |
C |
10: 93,216,472 (GRCm38) |
M105T |
probably benign |
Het |
| Cdon |
C |
A |
9: 35,478,611 (GRCm38) |
P854T |
probably damaging |
Het |
| Cep44 |
A |
G |
8: 56,544,152 (GRCm38) |
M117T |
possibly damaging |
Het |
| Cep89 |
A |
T |
7: 35,435,530 (GRCm38) |
E674D |
probably damaging |
Het |
| Cit |
C |
T |
5: 115,873,943 (GRCm38) |
A203V |
probably damaging |
Het |
| Clstn1 |
C |
A |
4: 149,629,300 (GRCm38) |
|
probably null |
Het |
| Col7a1 |
T |
A |
9: 108,958,147 (GRCm38) |
D565E |
unknown |
Het |
| Cpb1 |
T |
A |
3: 20,262,474 (GRCm38) |
Y304F |
probably damaging |
Het |
| Cps1 |
T |
G |
1: 67,172,802 (GRCm38) |
Y710D |
probably damaging |
Het |
| Creb3l1 |
T |
C |
2: 91,987,053 (GRCm38) |
T372A |
possibly damaging |
Het |
| Dars |
A |
G |
1: 128,405,381 (GRCm38) |
V102A |
probably benign |
Het |
| Dhx35 |
C |
T |
2: 158,817,415 (GRCm38) |
T168I |
possibly damaging |
Het |
| Dnah5 |
T |
C |
15: 28,327,779 (GRCm38) |
S2100P |
probably benign |
Het |
| Dst |
T |
C |
1: 34,266,960 (GRCm38) |
|
probably null |
Het |
| Egflam |
A |
C |
15: 7,253,523 (GRCm38) |
L351R |
possibly damaging |
Het |
| Elp2 |
T |
A |
18: 24,626,156 (GRCm38) |
D523E |
probably benign |
Het |
| Exo5 |
C |
A |
4: 120,921,684 (GRCm38) |
G328V |
probably damaging |
Het |
| Fam208a |
C |
T |
14: 27,461,750 (GRCm38) |
T722I |
probably benign |
Het |
| Fut9 |
A |
G |
4: 25,620,811 (GRCm38) |
M1T |
probably null |
Het |
| Galnt5 |
A |
G |
2: 58,024,625 (GRCm38) |
N584S |
possibly damaging |
Het |
| Gbp3 |
T |
C |
3: 142,567,772 (GRCm38) |
V360A |
probably damaging |
Het |
| Gdf6 |
G |
A |
4: 9,859,977 (GRCm38) |
C353Y |
probably damaging |
Het |
| Gm13089 |
A |
T |
4: 143,698,503 (GRCm38) |
D123E |
probably benign |
Het |
| Hace1 |
A |
G |
10: 45,648,869 (GRCm38) |
T244A |
probably damaging |
Het |
| Hr |
T |
C |
14: 70,559,657 (GRCm38) |
I500T |
probably benign |
Het |
| Ifnl2 |
A |
T |
7: 28,509,282 (GRCm38) |
L115Q |
probably damaging |
Het |
| Iigp1 |
T |
C |
18: 60,389,824 (GRCm38) |
F5L |
probably benign |
Het |
| Inhbb |
A |
G |
1: 119,417,416 (GRCm38) |
L381P |
probably damaging |
Het |
| Irx3 |
A |
T |
8: 91,801,093 (GRCm38) |
S50T |
probably benign |
Het |
| Ivns1abp |
C |
T |
1: 151,360,145 (GRCm38) |
T363I |
probably benign |
Het |
| Izumo1 |
A |
T |
7: 45,622,899 (GRCm38) |
T35S |
probably benign |
Het |
| Kank4 |
A |
G |
4: 98,777,105 (GRCm38) |
S651P |
probably damaging |
Het |
| Kit |
T |
C |
5: 75,610,879 (GRCm38) |
V232A |
probably benign |
Het |
| Klhl11 |
T |
C |
11: 100,463,714 (GRCm38) |
Y427C |
probably damaging |
Het |
| Laptm4b |
T |
A |
15: 34,258,689 (GRCm38) |
N36K |
probably damaging |
Het |
| Mamdc4 |
G |
T |
2: 25,564,193 (GRCm38) |
Q1042K |
probably benign |
Het |
| Mical2 |
A |
G |
7: 112,321,440 (GRCm38) |
|
probably null |
Het |
| Ms4a3 |
C |
A |
19: 11,631,361 (GRCm38) |
V176F |
possibly damaging |
Het |
| Myo3a |
A |
C |
2: 22,396,299 (GRCm38) |
E626D |
possibly damaging |
Het |
| Myo3a |
T |
C |
2: 22,333,513 (GRCm38) |
V427A |
probably benign |
Het |
| Nckap5 |
A |
T |
1: 126,027,288 (GRCm38) |
L509* |
probably null |
Het |
| Ndufa5 |
A |
T |
6: 24,519,249 (GRCm38) |
D64E |
possibly damaging |
Het |
| Nedd4l |
T |
C |
18: 65,208,461 (GRCm38) |
Y753H |
probably damaging |
Het |
| Nynrin |
T |
C |
14: 55,872,761 (GRCm38) |
V1775A |
probably damaging |
Het |
| Olfr141 |
A |
G |
2: 86,806,861 (GRCm38) |
L46S |
probably damaging |
Het |
| Olfr292 |
T |
C |
7: 86,694,876 (GRCm38) |
V140A |
possibly damaging |
Het |
| Olfr694 |
A |
T |
7: 106,688,998 (GRCm38) |
H244Q |
probably damaging |
Het |
| Olfr735 |
T |
C |
14: 50,345,926 (GRCm38) |
Y141C |
probably damaging |
Het |
| Olfr823 |
G |
A |
10: 130,112,580 (GRCm38) |
S70F |
probably damaging |
Het |
| Oplah |
A |
G |
15: 76,302,992 (GRCm38) |
S570P |
probably benign |
Het |
| Osbpl11 |
C |
A |
16: 33,234,444 (GRCm38) |
Y632* |
probably null |
Het |
| Osbpl5 |
A |
T |
7: 143,694,821 (GRCm38) |
L644Q |
probably damaging |
Het |
| Pcdhb19 |
T |
C |
18: 37,497,952 (GRCm38) |
W267R |
probably benign |
Het |
| Pkhd1l1 |
A |
C |
15: 44,467,424 (GRCm38) |
S132R |
possibly damaging |
Het |
| Ptpn13 |
T |
A |
5: 103,556,145 (GRCm38) |
S1348T |
probably benign |
Het |
| Rc3h1 |
T |
A |
1: 160,930,135 (GRCm38) |
W8R |
probably damaging |
Het |
| Rgs3 |
T |
G |
4: 62,625,936 (GRCm38) |
V315G |
probably damaging |
Het |
| Rora |
T |
A |
9: 69,361,869 (GRCm38) |
M82K |
probably damaging |
Het |
| Rph3al |
T |
C |
11: 75,908,969 (GRCm38) |
I55V |
probably benign |
Het |
| Sag |
T |
C |
1: 87,812,991 (GRCm38) |
V45A |
probably damaging |
Het |
| Scn3a |
T |
C |
2: 65,536,510 (GRCm38) |
E56G |
probably damaging |
Het |
| Sec24c |
T |
G |
14: 20,686,948 (GRCm38) |
V324G |
probably damaging |
Het |
| Sptbn1 |
A |
G |
11: 30,138,979 (GRCm38) |
L748S |
probably damaging |
Het |
| Stard9 |
A |
T |
2: 120,706,306 (GRCm38) |
D4186V |
probably damaging |
Het |
| Stk39 |
T |
C |
2: 68,366,167 (GRCm38) |
E306G |
probably damaging |
Het |
| Sycp1 |
C |
A |
3: 102,898,849 (GRCm38) |
|
probably null |
Het |
| Taf2 |
A |
C |
15: 55,060,050 (GRCm38) |
L277R |
probably damaging |
Het |
| Tbc1d23 |
T |
A |
16: 57,173,106 (GRCm38) |
I566F |
possibly damaging |
Het |
| Tekt5 |
T |
C |
16: 10,361,304 (GRCm38) |
T400A |
possibly damaging |
Het |
| Tgfbrap1 |
T |
C |
1: 43,060,141 (GRCm38) |
H401R |
probably benign |
Het |
| Tie1 |
T |
A |
4: 118,476,147 (GRCm38) |
I841L |
possibly damaging |
Het |
| Tln1 |
T |
G |
4: 43,544,645 (GRCm38) |
T1095P |
possibly damaging |
Het |
| Tmem147 |
A |
G |
7: 30,728,102 (GRCm38) |
Y72H |
probably benign |
Het |
| Tnfaip2 |
A |
G |
12: 111,453,507 (GRCm38) |
N691S |
probably benign |
Het |
| Trim24 |
G |
A |
6: 37,957,783 (GRCm38) |
C811Y |
probably damaging |
Het |
| Trim30b |
T |
A |
7: 104,357,976 (GRCm38) |
|
probably benign |
Het |
| Trpc4 |
T |
G |
3: 54,194,768 (GRCm38) |
L29R |
probably damaging |
Het |
| Trpm6 |
A |
T |
19: 18,825,862 (GRCm38) |
I890F |
probably damaging |
Het |
| Ttc23l |
C |
T |
15: 10,504,536 (GRCm38) |
E442K |
probably benign |
Het |
| Uggt2 |
A |
G |
14: 119,095,336 (GRCm38) |
V62A |
probably damaging |
Het |
| Ugt1a6a |
C |
A |
1: 88,138,884 (GRCm38) |
S137R |
probably benign |
Het |
| Unc13a |
A |
G |
8: 71,658,467 (GRCm38) |
Y367H |
probably damaging |
Het |
| Vmn2r49 |
A |
G |
7: 9,976,306 (GRCm38) |
I833T |
probably benign |
Het |
| Vmn2r7 |
T |
C |
3: 64,716,479 (GRCm38) |
D231G |
probably benign |
Het |
| Ythdc2 |
A |
T |
18: 44,864,357 (GRCm38) |
M994L |
probably benign |
Het |
| Zcchc6 |
A |
T |
13: 59,799,782 (GRCm38) |
C506* |
probably null |
Het |
| Zfp804a |
G |
A |
2: 82,257,588 (GRCm38) |
S587N |
probably damaging |
Het |
| Zswim2 |
A |
G |
2: 83,923,659 (GRCm38) |
I219T |
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
66,287,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
66,265,450 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
66,279,416 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
66,308,659 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
66,274,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
66,330,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
66,262,563 (GRCm38) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
66,262,890 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
66,259,959 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
66,306,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
66,296,263 (GRCm38) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
66,290,908 (GRCm38) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
66,292,336 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
66,262,283 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
66,273,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
66,302,671 (GRCm38) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,381,538 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
66,262,437 (GRCm38) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
66,279,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
66,281,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
66,279,282 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
66,330,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
66,296,163 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
66,285,411 (GRCm38) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
66,292,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
66,294,903 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
66,330,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
66,262,293 (GRCm38) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
66,306,873 (GRCm38) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
66,295,454 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
66,332,363 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
66,307,107 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
66,270,797 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
66,330,670 (GRCm38) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
66,307,215 (GRCm38) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
66,287,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
66,262,133 (GRCm38) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
66,307,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
66,306,839 (GRCm38) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
66,302,728 (GRCm38) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
66,342,779 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
66,292,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
66,287,443 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
66,285,279 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
66,270,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
66,332,386 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
66,262,155 (GRCm38) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
66,290,854 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
66,262,562 (GRCm38) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
66,262,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
66,300,729 (GRCm38) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
66,262,454 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
66,285,341 (GRCm38) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
66,342,782 (GRCm38) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
66,262,623 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
66,292,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
66,278,684 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
66,282,327 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
66,262,596 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
66,302,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
66,269,825 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
66,278,609 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
66,278,583 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
66,259,918 (GRCm38) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
66,274,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,381,502 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTACCCTGAATCCTAGCTTCCAGC -3'
(R):5'- ATCCAGACTCACTGTGTCCAGTCC -3'
Sequencing Primer
(F):5'- CAGGGACAAGTTGATCTTGACATC -3'
(R):5'- gagaaggtggggagggag -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation