Incidental Mutation 'R7018:Or5p66'
ID 545450
Institutional Source Beutler Lab
Gene Symbol Or5p66
Ensembl Gene ENSMUSG00000109884
Gene Name olfactory receptor family 5 subfamily P member 66
Synonyms Olfr490, GA_x6K02T2PBJ9-10617173-10616229, MOR204-17
MMRRC Submission 045119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.164) question?
Stock # R7018 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 107885387-107886331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 107885551 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 261 (I261L)
Ref Sequence ENSEMBL: ENSMUSP00000147922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210114] [ENSMUST00000211345]
AlphaFold Q8VFD2
Predicted Effect probably benign
Transcript: ENSMUST00000210114
AA Change: I261L

PolyPhen 2 Score 0.343 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000211345
AA Change: I261L

PolyPhen 2 Score 0.343 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.1605 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apcdd1 G T 18: 63,070,120 (GRCm39) R129L probably damaging Het
Arhgef28 C T 13: 98,101,943 (GRCm39) V844I probably damaging Het
Arhgef5 T C 6: 43,265,665 (GRCm39) V1569A probably damaging Het
Atr T A 9: 95,748,747 (GRCm39) S431T probably benign Het
Cdh11 T C 8: 103,360,953 (GRCm39) D795G possibly damaging Het
Crygf T C 1: 65,967,130 (GRCm39) S85P probably benign Het
Dip2c T A 13: 9,709,314 (GRCm39) Y1385N probably damaging Het
Dnah14 G A 1: 181,454,509 (GRCm39) V840I possibly damaging Het
Dsg1a T C 18: 20,461,795 (GRCm39) F299L possibly damaging Het
Fgfr4 A T 13: 55,314,013 (GRCm39) S576C probably damaging Het
Frmd8 T C 19: 5,919,546 (GRCm39) D167G probably damaging Het
Gm5105 G A 3: 137,755,319 (GRCm39) T89I unknown Het
Grhl1 C T 12: 24,625,996 (GRCm39) S35L possibly damaging Het
Gsn A G 2: 35,183,518 (GRCm39) E242G probably benign Het
Hcrtr1 A G 4: 130,029,661 (GRCm39) I140T probably damaging Het
Ifnlr1 T C 4: 135,431,135 (GRCm39) Y208H possibly damaging Het
Ighv1-58 T C 12: 115,275,985 (GRCm39) Y51C probably damaging Het
Iqcj T A 3: 67,948,580 (GRCm39) Y21* probably null Het
Kcnc4 T C 3: 107,366,178 (GRCm39) Y10C probably benign Het
Kcnk7 G T 19: 5,756,160 (GRCm39) G129W probably damaging Het
Kcnq2 T A 2: 180,723,517 (GRCm39) R620* probably null Het
Klk13 C A 7: 43,376,126 (GRCm39) P267Q probably benign Het
L3mbtl4 G A 17: 68,793,938 (GRCm39) R314H probably damaging Het
Lamc2 T A 1: 153,012,488 (GRCm39) M729L probably benign Het
Lyst T G 13: 13,918,044 (GRCm39) probably null Het
Med13l G A 5: 118,890,051 (GRCm39) R1909H probably damaging Het
Mstn T A 1: 53,103,243 (GRCm39) L193Q possibly damaging Het
Mylk T C 16: 34,820,796 (GRCm39) V125A possibly damaging Het
Nalcn T A 14: 123,647,233 (GRCm39) M547L probably damaging Het
Nckap5 A G 1: 125,952,785 (GRCm39) S1256P probably damaging Het
Nkain1 T C 4: 130,532,118 (GRCm38) Y189C probably damaging Het
Oosp3 T A 19: 11,676,783 (GRCm39) D47E probably benign Het
Or14j8 A T 17: 38,263,393 (GRCm39) I174N probably damaging Het
Or5d37 T A 2: 87,923,600 (GRCm39) I227F probably benign Het
Or5h25 A G 16: 58,930,970 (GRCm39) M1T probably null Het
Pcdh15 G T 10: 74,302,186 (GRCm39) G942W probably damaging Het
Pcyox1l C A 18: 61,840,625 (GRCm39) probably benign Het
Peg3 T C 7: 6,711,838 (GRCm39) E1128G possibly damaging Het
Plscr1 T A 9: 92,146,715 (GRCm39) V119D probably damaging Het
Prss56 A T 1: 87,113,670 (GRCm39) D258V possibly damaging Het
Ptpn23 T G 9: 110,214,884 (GRCm39) K85Q possibly damaging Het
Ranbp3l C A 15: 9,037,159 (GRCm39) S7Y probably benign Het
Rnf31 T C 14: 55,829,690 (GRCm39) L85P probably damaging Het
Rptn T C 3: 93,305,207 (GRCm39) C847R possibly damaging Het
Six4 T A 12: 73,155,727 (GRCm39) E413D probably benign Het
Slc30a2 G A 4: 134,074,726 (GRCm39) R161Q probably damaging Het
Sned1 T C 1: 93,212,143 (GRCm39) V1115A probably damaging Het
Spen T C 4: 141,220,755 (GRCm39) K401E unknown Het
Srbd1 T A 17: 86,443,843 (GRCm39) R128W possibly damaging Het
Strc A T 2: 121,199,539 (GRCm39) I1300N probably damaging Het
Susd1 T G 4: 59,390,627 (GRCm39) T230P probably benign Het
Thumpd2 G T 17: 81,363,326 (GRCm39) S47* probably null Het
Tmprss11a C T 5: 86,576,429 (GRCm39) V141I probably damaging Het
Tmprss15 T C 16: 78,821,741 (GRCm39) Y438C possibly damaging Het
Tnfrsf1a T C 6: 125,333,914 (GRCm39) S56P probably damaging Het
Ttc39d T C 17: 80,523,610 (GRCm39) W90R probably benign Het
Utp25 A G 1: 192,797,163 (GRCm39) I563T probably benign Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Wdr20rt A T 12: 65,272,536 (GRCm39) probably null Het
Zfp646 C A 7: 127,481,494 (GRCm39) Q1224K probably benign Het
Other mutations in Or5p66
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0395:Or5p66 UTSW 7 107,885,478 (GRCm39) missense probably benign 0.00
R0634:Or5p66 UTSW 7 107,885,503 (GRCm39) missense probably benign 0.00
R0940:Or5p66 UTSW 7 107,886,264 (GRCm39) missense probably benign 0.01
R1990:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R1991:Or5p66 UTSW 7 107,885,566 (GRCm39) nonsense probably null
R2860:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R2861:Or5p66 UTSW 7 107,886,169 (GRCm39) missense probably damaging 0.98
R3712:Or5p66 UTSW 7 107,885,663 (GRCm39) nonsense probably null
R4735:Or5p66 UTSW 7 107,885,520 (GRCm39) missense probably benign
R4895:Or5p66 UTSW 7 107,885,802 (GRCm39) missense probably damaging 0.97
R4976:Or5p66 UTSW 7 107,885,818 (GRCm39) missense probably damaging 1.00
R5686:Or5p66 UTSW 7 107,885,949 (GRCm39) missense probably damaging 1.00
R5719:Or5p66 UTSW 7 107,885,599 (GRCm39) missense probably damaging 0.97
R5883:Or5p66 UTSW 7 107,885,451 (GRCm39) missense probably damaging 1.00
R5911:Or5p66 UTSW 7 107,885,605 (GRCm39) missense probably damaging 1.00
R6452:Or5p66 UTSW 7 107,886,100 (GRCm39) missense probably damaging 1.00
R7233:Or5p66 UTSW 7 107,885,923 (GRCm39) missense probably benign 0.36
R8085:Or5p66 UTSW 7 107,885,620 (GRCm39) missense probably benign 0.01
R8166:Or5p66 UTSW 7 107,885,904 (GRCm39) missense probably benign 0.06
R8919:Or5p66 UTSW 7 107,886,289 (GRCm39) missense probably damaging 1.00
R9209:Or5p66 UTSW 7 107,885,526 (GRCm39) missense probably benign 0.06
R9612:Or5p66 UTSW 7 107,885,487 (GRCm39) missense probably benign
R9789:Or5p66 UTSW 7 107,885,898 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-05-13