Incidental Mutation 'R7018:Olfr490'
ID 545450
Institutional Source Beutler Lab
Gene Symbol Olfr490
Ensembl Gene ENSMUSG00000109884
Gene Name olfactory receptor 490
Synonyms MOR204-17, GA_x6K02T2PBJ9-10617173-10616229
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.113) question?
Stock # R7018 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108285893-108288934 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to G at 108286344 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 261 (I261L)
Ref Sequence ENSEMBL: ENSMUSP00000147922 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210114] [ENSMUST00000211345]
AlphaFold Q8VFD2
Predicted Effect probably benign
Transcript: ENSMUST00000210114
AA Change: I261L

PolyPhen 2 Score 0.343 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000211345
AA Change: I261L

PolyPhen 2 Score 0.343 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.1605 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apcdd1 G T 18: 62,937,049 R129L probably damaging Het
Arhgef28 C T 13: 97,965,435 V844I probably damaging Het
Arhgef5 T C 6: 43,288,731 V1569A probably damaging Het
Atr T A 9: 95,866,694 S431T probably benign Het
Cdh11 T C 8: 102,634,321 D795G possibly damaging Het
Crygf T C 1: 65,927,971 S85P probably benign Het
Diexf A G 1: 193,114,855 I563T probably benign Het
Dip2c T A 13: 9,659,278 Y1385N probably damaging Het
Dnah14 G A 1: 181,626,944 V840I possibly damaging Het
Dsg1a T C 18: 20,328,738 F299L possibly damaging Het
Fgfr4 A T 13: 55,166,200 S576C probably damaging Het
Frmd8 T C 19: 5,869,518 D167G probably damaging Het
Gm5105 G A 3: 138,049,558 T89I unknown Het
Grhl1 C T 12: 24,575,997 S35L possibly damaging Het
Gsn A G 2: 35,293,506 E242G probably benign Het
Hcrtr1 A G 4: 130,135,868 I140T probably damaging Het
Ifnlr1 T C 4: 135,703,824 Y208H possibly damaging Het
Ighv1-58 T C 12: 115,312,365 Y51C probably damaging Het
Iqcj T A 3: 68,041,247 Y21* probably null Het
Kcnc4 T C 3: 107,458,862 Y10C probably benign Het
Kcnk7 G T 19: 5,706,132 G129W probably damaging Het
Kcnq2 T A 2: 181,081,724 R620* probably null Het
Klk13 C A 7: 43,726,702 P267Q probably benign Het
Krt1 AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC 15: 101,850,378 probably benign Het
L3mbtl4 G A 17: 68,486,943 R314H probably damaging Het
Lamc2 T A 1: 153,136,742 M729L probably benign Het
Lyst T G 13: 13,743,459 probably null Het
Med13l G A 5: 118,751,986 R1909H probably damaging Het
Mstn T A 1: 53,064,084 L193Q possibly damaging Het
Mylk T C 16: 35,000,426 V125A possibly damaging Het
Nalcn T A 14: 123,409,821 M547L probably damaging Het
Nckap5 A G 1: 126,025,048 S1256P probably damaging Het
Nkain1 T C 4: 130,532,118 Y189C probably damaging Het
Olfr1164 T A 2: 88,093,256 I227F probably benign Het
Olfr193 A G 16: 59,110,607 M1T probably null Het
Olfr761 A T 17: 37,952,502 I174N probably damaging Het
Oosp3 T A 19: 11,699,419 D47E probably benign Het
Pcdh15 G T 10: 74,466,354 G942W probably damaging Het
Pcyox1l C A 18: 61,707,554 probably benign Het
Peg3 T C 7: 6,708,839 E1128G possibly damaging Het
Pkd1l3 GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA 8: 109,624,195 probably benign Het
Plscr1 T A 9: 92,264,662 V119D probably damaging Het
Prss56 A T 1: 87,185,948 D258V possibly damaging Het
Ptpn23 T G 9: 110,385,816 K85Q possibly damaging Het
Ranbp3l C A 15: 9,007,285 S7Y probably benign Het
Rnf31 T C 14: 55,592,233 L85P probably damaging Het
Rptn T C 3: 93,397,900 C847R possibly damaging Het
Six4 T A 12: 73,108,953 E413D probably benign Het
Slc30a2 G A 4: 134,347,415 R161Q probably damaging Het
Sned1 T C 1: 93,284,421 V1115A probably damaging Het
Spen T C 4: 141,493,444 K401E unknown Het
Srbd1 T A 17: 86,136,415 R128W possibly damaging Het
Strc A T 2: 121,369,058 I1300N probably damaging Het
Susd1 T G 4: 59,390,627 T230P probably benign Het
Thumpd2 G T 17: 81,055,897 S47* probably null Het
Tmprss11a C T 5: 86,428,570 V141I probably damaging Het
Tmprss15 T C 16: 79,024,853 Y438C possibly damaging Het
Tnfrsf1a T C 6: 125,356,951 S56P probably damaging Het
Ttc39d T C 17: 80,216,181 W90R probably benign Het
Vmn2r111 T C 17: 22,559,051 N549S possibly damaging Het
Wdr20rt A T 12: 65,225,762 probably null Het
Zfp646 C A 7: 127,882,322 Q1224K probably benign Het
Other mutations in Olfr490
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0395:Olfr490 UTSW 7 108286271 missense probably benign 0.00
R0634:Olfr490 UTSW 7 108286296 missense probably benign 0.00
R0940:Olfr490 UTSW 7 108287057 missense probably benign 0.01
R1990:Olfr490 UTSW 7 108286359 nonsense probably null
R1991:Olfr490 UTSW 7 108286359 nonsense probably null
R2860:Olfr490 UTSW 7 108286962 missense probably damaging 0.98
R2861:Olfr490 UTSW 7 108286962 missense probably damaging 0.98
R3712:Olfr490 UTSW 7 108286456 nonsense probably null
R4735:Olfr490 UTSW 7 108286313 missense probably benign
R4895:Olfr490 UTSW 7 108286595 missense probably damaging 0.97
R4976:Olfr490 UTSW 7 108286611 missense probably damaging 1.00
R5686:Olfr490 UTSW 7 108286742 missense probably damaging 1.00
R5719:Olfr490 UTSW 7 108286392 missense probably damaging 0.97
R5883:Olfr490 UTSW 7 108286244 missense probably damaging 1.00
R5911:Olfr490 UTSW 7 108286398 missense probably damaging 1.00
R6452:Olfr490 UTSW 7 108286893 missense probably damaging 1.00
R7233:Olfr490 UTSW 7 108286716 missense probably benign 0.36
R8085:Olfr490 UTSW 7 108286413 missense probably benign 0.01
R8166:Olfr490 UTSW 7 108286697 missense probably benign 0.06
R8919:Olfr490 UTSW 7 108287082 missense probably damaging 1.00
R9209:Olfr490 UTSW 7 108286319 missense probably benign 0.06
R9612:Olfr490 UTSW 7 108286280 missense probably benign
R9789:Olfr490 UTSW 7 108286691 missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTCAAAGCCTGGTTAAATTTGGATC -3'
(R):5'- AGCTCTCGTGTTCTGATGTCAG -3'

Sequencing Primer
(F):5'- TGGATCATAACATGTATCCCCC -3'
(R):5'- GTTGTTATTTCATTTTCTGCTGGCAC -3'
Posted On 2019-05-13