Incidental Mutation 'R7019:Ifi202b'
ID545486
Institutional Source Beutler Lab
Gene Symbol Ifi202b
Ensembl Gene ENSMUSG00000026535
Gene Nameinterferon activated gene 202B
Synonymsp202
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #R7019 (G1)
Quality Score225.009
Status Validated
Chromosome1
Chromosomal Location173962568-173982744 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 173963958 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Glycine at position 385 (C385G)
Ref Sequence ENSEMBL: ENSMUSP00000000266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000000266]
PDB Structure
Structural mimicry for functional antagonism [X-RAY DIFFRACTION]
Molecular basis for abrogation of activation of pro-inflammatory cytokines [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 [X-RAY DIFFRACTION]
Crystal structure of p202 HIN1 in complex with 20-mer dsDNA [X-RAY DIFFRACTION]
p202 HIN1 in complex with 12-mer dsDNA [X-RAY DIFFRACTION]
Crystal structure of the tetrameric p202 HIN2 [X-RAY DIFFRACTION]
Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000000266
AA Change: C385G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000000266
Gene: ENSMUSG00000026535
AA Change: C385G

DomainStartEndE-ValueType
Pfam:HIN 58 223 4.1e-68 PFAM
Pfam:HIN 256 421 1.5e-61 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat A T 16: 8,618,531 K414* probably null Het
Aco1 T A 4: 40,186,376 I596N probably damaging Het
Adgre1 A C 17: 57,410,945 D319A probably damaging Het
BC067074 C T 13: 113,351,750 T102I probably benign Het
Birc6 T C 17: 74,609,345 V445A probably benign Het
Btd A C 14: 31,667,105 Q261P probably damaging Het
Btd G T 14: 31,667,106 Q261H possibly damaging Het
C7 T A 15: 5,045,682 Y176F probably benign Het
Ccdc102a T C 8: 94,909,803 S287G probably benign Het
Ccdc178 T A 18: 22,150,438 T12S probably benign Het
Cnga4 G T 7: 105,405,829 A104S probably benign Het
Col10a1 G T 10: 34,394,951 L306F probably damaging Het
Cpne5 T C 17: 29,226,222 D36G probably damaging Het
Csmd2 G A 4: 128,369,063 D681N Het
Cstl1 A G 2: 148,755,303 M75V probably benign Het
Cyp26a1 T C 19: 37,698,812 L149P probably damaging Het
D630045J12Rik T G 6: 38,194,635 E866A probably benign Het
Dlec1 C T 9: 119,112,422 P292L probably benign Het
Dpp3 T G 19: 4,916,789 E402A possibly damaging Het
Egf T C 3: 129,718,064 probably null Het
Epha5 T C 5: 84,416,462 Q15R possibly damaging Het
Esyt3 A G 9: 99,315,285 F831L probably benign Het
Fam50b G A 13: 34,747,101 E187K possibly damaging Het
Fut7 A G 2: 25,425,780 D350G probably benign Het
Gab1 C A 8: 80,784,817 E466D probably damaging Het
Glrp1 A T 1: 88,503,168 M160K unknown Het
Gngt1 T C 6: 3,994,088 probably null Het
Gprc6a A T 10: 51,631,412 V7E possibly damaging Het
Idh3b A T 2: 130,280,966 V301D probably damaging Het
Ilvbl T A 10: 78,579,086 L261Q probably damaging Het
Irx6 T A 8: 92,678,734 L410Q probably damaging Het
Ism2 T C 12: 87,299,663 M15V unknown Het
Itih5 C A 2: 10,190,327 R177S probably damaging Het
Klra3 C T 6: 130,327,124 G202R probably damaging Het
Krt7 T C 15: 101,413,970 V103A probably damaging Het
Lama3 T C 18: 12,528,418 S2145P probably damaging Het
Mlph A G 1: 90,941,706 R477G probably damaging Het
Mybpc1 T A 10: 88,543,719 L653F probably damaging Het
Myrfl A G 10: 116,781,947 probably null Het
Myrip T G 9: 120,422,507 L232R probably damaging Het
Nrd1 A T 4: 109,028,802 H126L probably benign Het
Olfr251 T A 9: 38,378,802 L307Q possibly damaging Het
Olfr469 G T 7: 107,823,158 L104I probably benign Het
Olfr722 A T 14: 49,895,667 I45N probably damaging Het
Pcdhb10 T A 18: 37,413,003 N377K probably damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,499,669 probably null Het
Prkdc A C 16: 15,769,966 I2572L probably benign Het
Ptpro C A 6: 137,380,478 D322E probably benign Het
R3hcc1 A G 14: 69,704,125 I332T probably damaging Het
Rab8a T C 8: 72,161,383 F9L probably damaging Het
Ranbp3l A T 15: 9,057,160 K165N probably damaging Het
Rock2 T A 12: 16,977,740 C1353S probably damaging Het
Rsad2 T A 12: 26,456,419 M1L possibly damaging Het
Tymp A T 15: 89,376,281 probably null Het
Vmn1r104 A G 7: 20,534,566 M244V probably benign Het
Vmn1r232 G A 17: 20,913,285 T351M possibly damaging Het
Vmn2r50 A G 7: 10,050,245 Y101H probably benign Het
Vmn2r57 A G 7: 41,428,665 L123P probably damaging Het
Wdr17 T C 8: 54,681,453 N331D probably damaging Het
Wdr47 C T 3: 108,614,355 Q89* probably null Het
Zcchc4 A T 5: 52,784,033 T57S probably benign Het
Other mutations in Ifi202b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01551:Ifi202b APN 1 173971362 missense probably benign 0.00
IGL02019:Ifi202b APN 1 173974984 missense possibly damaging 0.95
IGL02466:Ifi202b APN 1 173972309 missense possibly damaging 0.71
IGL02508:Ifi202b APN 1 173974772 missense probably benign 0.18
IGL02567:Ifi202b APN 1 173963804 missense possibly damaging 0.84
IGL02644:Ifi202b APN 1 173971714 missense probably benign 0.00
R0282:Ifi202b UTSW 1 173977360 missense probably benign 0.00
R1178:Ifi202b UTSW 1 173972222 missense probably benign 0.02
R3414:Ifi202b UTSW 1 173963913 missense probably benign 0.19
R5739:Ifi202b UTSW 1 173971352 critical splice donor site probably null
R5944:Ifi202b UTSW 1 173963799 missense probably benign 0.00
R6805:Ifi202b UTSW 1 173974989 missense probably damaging 1.00
R7291:Ifi202b UTSW 1 173974815 missense probably benign 0.02
R7555:Ifi202b UTSW 1 173972221 missense probably damaging 0.99
R7825:Ifi202b UTSW 1 173975050 missense probably damaging 1.00
R8151:Ifi202b UTSW 1 173977357 missense probably benign 0.00
R8379:Ifi202b UTSW 1 173974732 critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- GCACATACCTCCATGTAACTGTAC -3'
(R):5'- TTTAAACTGTGAGGTTTGAGGAGAC -3'

Sequencing Primer
(F):5'- GTAACTGTACCTCGTAGATCTCAG -3'
(R):5'- TCAGGCTTGGCTAGATAACTCAG -3'
Posted On2019-05-13