Incidental Mutation 'R7019:Vmn2r50'
ID 545502
Institutional Source Beutler Lab
Gene Symbol Vmn2r50
Ensembl Gene ENSMUSG00000094606
Gene Name vomeronasal 2, receptor 50
Synonyms EG434117
MMRRC Submission 045120-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R7019 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 9771162-9787105 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 9784172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 101 (Y101H)
Ref Sequence ENSEMBL: ENSMUSP00000083478 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074943] [ENSMUST00000086298]
AlphaFold E9PW61
Predicted Effect probably benign
Transcript: ENSMUST00000074943
AA Change: Y101H

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000074476
Gene: ENSMUSG00000094606
AA Change: Y101H

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 1.4e-32 PFAM
Pfam:NCD3G 512 565 2.9e-20 PFAM
Pfam:7tm_3 597 833 1.3e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000086298
AA Change: Y101H

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000083478
Gene: ENSMUSG00000094606
AA Change: Y101H

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 452 7e-31 PFAM
Pfam:NCD3G 496 549 5.3e-19 PFAM
Pfam:7tm_3 579 818 3.9e-78 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat A T 16: 8,436,395 (GRCm39) K414* probably null Het
Aco1 T A 4: 40,186,376 (GRCm39) I596N probably damaging Het
Adgre1 A C 17: 57,717,945 (GRCm39) D319A probably damaging Het
Birc6 T C 17: 74,916,340 (GRCm39) V445A probably benign Het
Btd A C 14: 31,389,062 (GRCm39) Q261P probably damaging Het
Btd G T 14: 31,389,063 (GRCm39) Q261H possibly damaging Het
C7 T A 15: 5,075,164 (GRCm39) Y176F probably benign Het
Ccdc102a T C 8: 95,636,431 (GRCm39) S287G probably benign Het
Ccdc178 T A 18: 22,283,495 (GRCm39) T12S probably benign Het
Cnga4 G T 7: 105,055,036 (GRCm39) A104S probably benign Het
Col10a1 G T 10: 34,270,947 (GRCm39) L306F probably damaging Het
Cpne5 T C 17: 29,445,196 (GRCm39) D36G probably damaging Het
Csmd2 G A 4: 128,262,856 (GRCm39) D681N Het
Cspg4b C T 13: 113,488,284 (GRCm39) T102I probably benign Het
Cstl1 A G 2: 148,597,223 (GRCm39) M75V probably benign Het
Cyp26a1 T C 19: 37,687,260 (GRCm39) L149P probably damaging Het
D630045J12Rik T G 6: 38,171,570 (GRCm39) E866A probably benign Het
Dlec1 C T 9: 118,941,490 (GRCm39) P292L probably benign Het
Dpp3 T G 19: 4,966,817 (GRCm39) E402A possibly damaging Het
Egf T C 3: 129,511,713 (GRCm39) probably null Het
Epha5 T C 5: 84,564,321 (GRCm39) Q15R possibly damaging Het
Esyt3 A G 9: 99,197,338 (GRCm39) F831L probably benign Het
Fam50b G A 13: 34,931,084 (GRCm39) E187K possibly damaging Het
Fut7 A G 2: 25,315,792 (GRCm39) D350G probably benign Het
Gab1 C A 8: 81,511,446 (GRCm39) E466D probably damaging Het
Glrp1 A T 1: 88,430,890 (GRCm39) M160K unknown Het
Gngt1 T C 6: 3,994,088 (GRCm39) probably null Het
Gprc6a A T 10: 51,507,508 (GRCm39) V7E possibly damaging Het
Idh3b A T 2: 130,122,886 (GRCm39) V301D probably damaging Het
Ifi202b A C 1: 173,791,524 (GRCm39) C385G probably benign Het
Ilvbl T A 10: 78,414,920 (GRCm39) L261Q probably damaging Het
Irx6 T A 8: 93,405,362 (GRCm39) L410Q probably damaging Het
Ism2 T C 12: 87,346,437 (GRCm39) M15V unknown Het
Itih5 C A 2: 10,195,138 (GRCm39) R177S probably damaging Het
Klra3 C T 6: 130,304,087 (GRCm39) G202R probably damaging Het
Krt7 T C 15: 101,311,851 (GRCm39) V103A probably damaging Het
Lama3 T C 18: 12,661,475 (GRCm39) S2145P probably damaging Het
Mlph A G 1: 90,869,428 (GRCm39) R477G probably damaging Het
Mybpc1 T A 10: 88,379,581 (GRCm39) L653F probably damaging Het
Myrfl A G 10: 116,617,852 (GRCm39) probably null Het
Myrip T G 9: 120,251,573 (GRCm39) L232R probably damaging Het
Nrdc A T 4: 108,885,999 (GRCm39) H126L probably benign Het
Or4n5 A T 14: 50,133,124 (GRCm39) I45N probably damaging Het
Or5p50 G T 7: 107,422,365 (GRCm39) L104I probably benign Het
Or8c11 T A 9: 38,290,098 (GRCm39) L307Q possibly damaging Het
Pcdhb10 T A 18: 37,546,056 (GRCm39) N377K probably damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Prkdc A C 16: 15,587,830 (GRCm39) I2572L probably benign Het
Ptpro C A 6: 137,357,476 (GRCm39) D322E probably benign Het
R3hcc1 A G 14: 69,941,574 (GRCm39) I332T probably damaging Het
Rab8a T C 8: 72,915,227 (GRCm39) F9L probably damaging Het
Ranbp3l A T 15: 9,057,241 (GRCm39) K165N probably damaging Het
Rock2 T A 12: 17,027,741 (GRCm39) C1353S probably damaging Het
Rsad2 T A 12: 26,506,418 (GRCm39) M1L possibly damaging Het
Tymp A T 15: 89,260,484 (GRCm39) probably null Het
Vmn1r104 A G 7: 20,268,491 (GRCm39) M244V probably benign Het
Vmn1r232 G A 17: 21,133,547 (GRCm39) T351M possibly damaging Het
Vmn2r57 A G 7: 41,078,089 (GRCm39) L123P probably damaging Het
Wdr17 T C 8: 55,134,488 (GRCm39) N331D probably damaging Het
Wdr47 C T 3: 108,521,671 (GRCm39) Q89* probably null Het
Zcchc4 A T 5: 52,941,375 (GRCm39) T57S probably benign Het
Other mutations in Vmn2r50
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Vmn2r50 APN 7 9,771,610 (GRCm39) missense probably damaging 1.00
IGL01739:Vmn2r50 APN 7 9,771,364 (GRCm39) missense probably damaging 1.00
IGL02351:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02358:Vmn2r50 APN 7 9,787,002 (GRCm39) missense probably benign 0.01
IGL02871:Vmn2r50 APN 7 9,781,714 (GRCm39) missense possibly damaging 0.91
IGL02962:Vmn2r50 APN 7 9,784,252 (GRCm39) missense probably damaging 1.00
IGL03187:Vmn2r50 APN 7 9,771,368 (GRCm39) missense probably damaging 1.00
IGL03346:Vmn2r50 APN 7 9,779,929 (GRCm39) missense probably damaging 0.99
PIT4651001:Vmn2r50 UTSW 7 9,771,659 (GRCm39) missense probably benign 0.30
R0530:Vmn2r50 UTSW 7 9,781,644 (GRCm39) missense possibly damaging 0.82
R1291:Vmn2r50 UTSW 7 9,771,404 (GRCm39) missense probably damaging 0.98
R1438:Vmn2r50 UTSW 7 9,784,062 (GRCm39) nonsense probably null
R1713:Vmn2r50 UTSW 7 9,771,731 (GRCm39) missense probably damaging 1.00
R1747:Vmn2r50 UTSW 7 9,781,605 (GRCm39) missense probably benign 0.20
R1750:Vmn2r50 UTSW 7 9,786,915 (GRCm39) missense possibly damaging 0.69
R1918:Vmn2r50 UTSW 7 9,781,610 (GRCm39) missense probably benign 0.03
R2435:Vmn2r50 UTSW 7 9,787,026 (GRCm39) missense probably benign 0.27
R2511:Vmn2r50 UTSW 7 9,781,640 (GRCm39) missense possibly damaging 0.81
R3795:Vmn2r50 UTSW 7 9,771,851 (GRCm39) missense probably benign 0.18
R4156:Vmn2r50 UTSW 7 9,774,309 (GRCm39) missense probably benign 0.12
R4332:Vmn2r50 UTSW 7 9,786,922 (GRCm39) missense probably benign 0.32
R4399:Vmn2r50 UTSW 7 9,781,834 (GRCm39) missense possibly damaging 0.81
R4411:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4412:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4413:Vmn2r50 UTSW 7 9,784,235 (GRCm39) missense probably damaging 0.99
R4645:Vmn2r50 UTSW 7 9,771,162 (GRCm39) makesense probably null
R5151:Vmn2r50 UTSW 7 9,786,970 (GRCm39) missense probably benign 0.00
R5175:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R5291:Vmn2r50 UTSW 7 9,781,752 (GRCm39) missense probably damaging 1.00
R5457:Vmn2r50 UTSW 7 9,781,873 (GRCm39) missense probably damaging 0.98
R5559:Vmn2r50 UTSW 7 9,771,253 (GRCm39) missense probably damaging 1.00
R5579:Vmn2r50 UTSW 7 9,784,016 (GRCm39) missense probably benign 0.00
R5711:Vmn2r50 UTSW 7 9,774,299 (GRCm39) missense possibly damaging 0.81
R5759:Vmn2r50 UTSW 7 9,781,905 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r50 UTSW 7 9,783,986 (GRCm39) missense probably benign 0.00
R6394:Vmn2r50 UTSW 7 9,774,253 (GRCm39) missense probably damaging 1.00
R6488:Vmn2r50 UTSW 7 9,771,644 (GRCm39) missense probably damaging 1.00
R6762:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R6995:Vmn2r50 UTSW 7 9,779,964 (GRCm39) nonsense probably null
R6998:Vmn2r50 UTSW 7 9,771,684 (GRCm39) missense probably benign 0.03
R7027:Vmn2r50 UTSW 7 9,781,539 (GRCm39) missense probably damaging 1.00
R7231:Vmn2r50 UTSW 7 9,787,010 (GRCm39) missense probably benign 0.04
R7343:Vmn2r50 UTSW 7 9,784,277 (GRCm39) critical splice acceptor site probably null
R7554:Vmn2r50 UTSW 7 9,784,066 (GRCm39) missense probably null 0.00
R7704:Vmn2r50 UTSW 7 9,781,665 (GRCm39) missense probably benign 0.05
R7768:Vmn2r50 UTSW 7 9,771,298 (GRCm39) missense probably damaging 0.99
R7773:Vmn2r50 UTSW 7 9,771,562 (GRCm39) missense possibly damaging 0.70
R7975:Vmn2r50 UTSW 7 9,771,272 (GRCm39) missense probably benign 0.39
R7987:Vmn2r50 UTSW 7 9,772,016 (GRCm39) missense probably benign 0.14
R7996:Vmn2r50 UTSW 7 9,781,795 (GRCm39) missense probably damaging 0.99
R8062:Vmn2r50 UTSW 7 9,774,240 (GRCm39) critical splice donor site probably null
R8396:Vmn2r50 UTSW 7 9,781,639 (GRCm39) nonsense probably null
R8466:Vmn2r50 UTSW 7 9,783,997 (GRCm39) missense probably damaging 0.97
R8985:Vmn2r50 UTSW 7 9,779,974 (GRCm39) missense probably damaging 1.00
R9068:Vmn2r50 UTSW 7 9,772,061 (GRCm39) missense possibly damaging 0.46
R9155:Vmn2r50 UTSW 7 9,781,571 (GRCm39) missense probably damaging 1.00
R9238:Vmn2r50 UTSW 7 9,781,503 (GRCm39) missense probably benign 0.01
R9576:Vmn2r50 UTSW 7 9,771,190 (GRCm39) missense probably benign
R9626:Vmn2r50 UTSW 7 9,771,960 (GRCm39) nonsense probably null
R9631:Vmn2r50 UTSW 7 9,786,990 (GRCm39) nonsense probably null
X0067:Vmn2r50 UTSW 7 9,786,954 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r50 UTSW 7 9,780,086 (GRCm39) missense probably benign 0.01
Z1088:Vmn2r50 UTSW 7 9,771,427 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- TGTCCAGGAAGTTCCAGAAAC -3'
(R):5'- TGGGACCAACACCATCATG -3'

Sequencing Primer
(F):5'- GAAACTTAAAGATACCTCCCAATTGG -3'
(R):5'- TCCAGTATAGCATAGAACTTCCACTG -3'
Posted On 2019-05-13