Incidental Mutation 'R7020:Olfm2'
ID 545570
Institutional Source Beutler Lab
Gene Symbol Olfm2
Ensembl Gene ENSMUSG00000032172
Gene Name olfactomedin 2
Synonyms A030009A06Rik
MMRRC Submission 045121-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.547) question?
Stock # R7020 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 20578986-20657645 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20579864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 326 (R326W)
Ref Sequence ENSEMBL: ENSMUSP00000151018 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034689] [ENSMUST00000034692] [ENSMUST00000215999] [ENSMUST00000217198]
AlphaFold Q8BM13
Predicted Effect probably benign
Transcript: ENSMUST00000034689
SMART Domains Protein: ENSMUSP00000034689
Gene: ENSMUSG00000032171

DomainStartEndE-ValueType
WW 6 39 3.57e-14 SMART
Pfam:Rotamase_3 45 165 1.6e-23 PFAM
Pfam:Rotamase 61 165 1.4e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000034692
AA Change: R296W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034692
Gene: ENSMUSG00000032172
AA Change: R296W

DomainStartEndE-ValueType
Pfam:Noelin-1 19 118 3.8e-44 PFAM
Blast:OLF 132 177 2e-18 BLAST
OLF 190 440 4.32e-123 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215999
AA Change: R304W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217198
AA Change: R326W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.3038 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 100% (52/52)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate locomotor and anxiety-related behavioral abnormalities, altered visual evoked potential, and reduced compactness of myelin sheaths in the optic nerve. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001K19Rik C T 12: 110,634,975 (GRCm39) G188R probably damaging Het
Abhd3 T C 18: 10,645,127 (GRCm39) Y384C probably damaging Het
Cd209b T A 8: 3,968,783 (GRCm39) E282V probably damaging Het
Cep350 A C 1: 155,804,077 (GRCm39) L1002W probably damaging Het
Clcn1 T C 6: 42,275,754 (GRCm39) V292A probably damaging Het
Clcn7 T C 17: 25,365,325 (GRCm39) I107T possibly damaging Het
Cntrob A G 11: 69,193,918 (GRCm39) probably null Het
Crb1 A T 1: 139,159,341 (GRCm39) S1294T possibly damaging Het
Cst13 T G 2: 148,665,129 (GRCm39) Y41* probably null Het
Gp1ba A G 11: 70,531,139 (GRCm39) probably benign Het
Gucy2e A T 11: 69,123,619 (GRCm39) L427I probably benign Het
Gucy2g A G 19: 55,221,482 (GRCm39) S340P probably damaging Het
Herc1 A G 9: 66,393,360 (GRCm39) T4080A probably benign Het
Iglon5 A T 7: 43,126,319 (GRCm39) C195S probably damaging Het
Itgae A G 11: 73,002,195 (GRCm39) T100A probably damaging Het
Jarid2 C T 13: 45,038,300 (GRCm39) S205L probably damaging Het
Macrod2 A T 2: 142,231,795 (GRCm39) *424C probably null Het
Map2k6 A T 11: 110,397,540 (GRCm39) probably benign Het
Muc4 A T 16: 32,570,628 (GRCm39) K563* probably null Het
Myh7b T C 2: 155,473,671 (GRCm39) I1568T possibly damaging Het
Myo15b G A 11: 115,757,493 (GRCm39) W1114* probably null Het
Mypn T C 10: 63,028,289 (GRCm39) Y258C probably damaging Het
Notch1 T C 2: 26,371,586 (GRCm39) T288A possibly damaging Het
Npc1 C T 18: 12,331,594 (GRCm39) G859R probably damaging Het
Or2a7 T C 6: 43,151,096 (GRCm39) Y59H possibly damaging Het
Or5al7 A G 2: 85,992,363 (GRCm39) I310T probably benign Het
Or5g23 A G 2: 85,438,976 (GRCm39) S93P probably benign Het
Ovol1 G A 19: 5,610,261 (GRCm39) P23L probably damaging Het
Pappa2 C A 1: 158,675,579 (GRCm39) V1056F probably damaging Het
Pik3ca T C 3: 32,490,428 (GRCm39) L25S probably damaging Het
Pla2r1 T C 2: 60,277,743 (GRCm39) H860R possibly damaging Het
Pms1 A T 1: 53,228,541 (GRCm39) H902Q probably damaging Het
Ptgs1 T G 2: 36,141,041 (GRCm39) L496R probably damaging Het
Ralgapa2 A T 2: 146,188,638 (GRCm39) Y1381* probably null Het
Rtl1 T C 12: 109,558,749 (GRCm39) Q1030R possibly damaging Het
Ryr3 T A 2: 112,583,423 (GRCm39) Y2816F probably benign Het
Sh2b2 T C 5: 136,253,153 (GRCm39) T340A possibly damaging Het
Slc30a5 T A 13: 100,961,421 (GRCm39) probably null Het
Spta1 T C 1: 174,036,918 (GRCm39) L1143P probably damaging Het
St8sia5 T C 18: 77,333,876 (GRCm39) I178T probably damaging Het
Tap2 A G 17: 34,433,388 (GRCm39) N517S possibly damaging Het
Tcp11 A G 17: 28,290,679 (GRCm39) Y227H possibly damaging Het
Usp34 A G 11: 23,343,954 (GRCm39) D1411G probably benign Het
Vmn2r105 A G 17: 20,429,336 (GRCm39) L580P probably damaging Het
Wdr19 A G 5: 65,413,657 (GRCm39) E1200G probably damaging Het
Xirp2 T C 2: 67,355,913 (GRCm39) V3558A probably benign Het
Xpo7 T C 14: 70,903,463 (GRCm39) N1082S probably benign Het
Zbtb49 A T 5: 38,370,711 (GRCm39) L390* probably null Het
Zfp639 C A 3: 32,574,261 (GRCm39) D295E probably damaging Het
Other mutations in Olfm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02105:Olfm2 APN 9 20,583,476 (GRCm39) missense probably damaging 1.00
IGL03276:Olfm2 APN 9 20,580,083 (GRCm39) splice site probably benign
IGL03352:Olfm2 APN 9 20,580,019 (GRCm39) missense probably damaging 1.00
R0015:Olfm2 UTSW 9 20,580,037 (GRCm39) missense probably damaging 1.00
R0847:Olfm2 UTSW 9 20,579,953 (GRCm39) missense probably damaging 1.00
R1051:Olfm2 UTSW 9 20,579,759 (GRCm39) missense probably damaging 1.00
R3730:Olfm2 UTSW 9 20,584,063 (GRCm39) missense probably damaging 1.00
R5366:Olfm2 UTSW 9 20,579,708 (GRCm39) missense probably benign 0.04
R5665:Olfm2 UTSW 9 20,579,840 (GRCm39) splice site probably null
R5986:Olfm2 UTSW 9 20,586,946 (GRCm39) missense probably damaging 1.00
R6046:Olfm2 UTSW 9 20,579,824 (GRCm39) missense probably damaging 1.00
R6709:Olfm2 UTSW 9 20,584,009 (GRCm39) missense probably damaging 1.00
R7636:Olfm2 UTSW 9 20,579,593 (GRCm39) missense possibly damaging 0.72
R8341:Olfm2 UTSW 9 20,583,918 (GRCm39) splice site probably null
R8782:Olfm2 UTSW 9 20,579,501 (GRCm39) missense probably damaging 1.00
R9743:Olfm2 UTSW 9 20,579,785 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACCGCAGATCATGAAGGC -3'
(R):5'- TTCCGTACTCTGGGAGACTTC -3'

Sequencing Primer
(F):5'- TGTCCCAGGATCTCACGAC -3'
(R):5'- CGTACTCTGGGAGACTTCATCAAAG -3'
Posted On 2019-05-13