Incidental Mutation 'R7022:Pik3c2g'
| ID |
545690 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
045123-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.087)
|
| Stock # |
R7022 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
139587221-139969284 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 139622063 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 59
(E59G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141141
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032353]
[ENSMUST00000185968]
[ENSMUST00000187618]
[ENSMUST00000188066]
[ENSMUST00000190962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032353
AA Change: E59G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000032353
Gene: ENSMUSG00000030228
AA Change: E59G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000185968
AA Change: E59G
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000140368
Gene: ENSMUSG00000030228
AA Change: E59G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
371 |
2e-42 |
SMART |
|
Blast:PI3K_rbd
|
272 |
371 |
2e-64 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000187618
AA Change: E59G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000141025
Gene: ENSMUSG00000030228
AA Change: E59G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188066
AA Change: E59G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190962
AA Change: E59G
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000141141
Gene: ENSMUSG00000030228
AA Change: E59G
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (75/75) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
T |
11: 110,083,500 (GRCm38) |
S203T |
probably damaging |
Het |
| Adat1 |
A |
T |
8: 111,989,862 (GRCm38) |
M76K |
probably damaging |
Het |
| Ankrd33 |
G |
C |
15: 101,116,899 (GRCm38) |
V56L |
probably benign |
Het |
| Ascc3 |
T |
A |
10: 50,716,629 (GRCm38) |
L1134I |
possibly damaging |
Het |
| C3 |
T |
G |
17: 57,217,286 (GRCm38) |
D948A |
probably damaging |
Het |
| Ccdc121rt3 |
A |
C |
5: 112,355,529 (GRCm38) |
M103R |
probably benign |
Het |
| Ccdc40 |
A |
G |
11: 119,231,786 (GRCm38) |
E138G |
possibly damaging |
Het |
| Cd80 |
A |
G |
16: 38,486,504 (GRCm38) |
|
probably null |
Het |
| Cdca7 |
T |
A |
2: 72,479,529 (GRCm38) |
|
probably null |
Het |
| Chit1 |
A |
G |
1: 134,151,292 (GRCm38) |
S447G |
probably benign |
Het |
| Cmya5 |
C |
T |
13: 93,069,278 (GRCm38) |
|
probably null |
Het |
| Cnnm2 |
T |
A |
19: 46,858,940 (GRCm38) |
|
probably null |
Het |
| Cnnm2 |
A |
T |
19: 46,762,550 (GRCm38) |
I260F |
probably damaging |
Het |
| Col1a2 |
T |
C |
6: 4,534,639 (GRCm38) |
L881P |
unknown |
Het |
| Crebbp |
A |
T |
16: 4,117,323 (GRCm38) |
S901T |
probably damaging |
Het |
| Dcun1d2 |
T |
C |
8: 13,271,637 (GRCm38) |
Y158C |
probably damaging |
Het |
| Dnhd1 |
C |
T |
7: 105,720,798 (GRCm38) |
P4477S |
probably benign |
Het |
| Donson |
A |
G |
16: 91,681,330 (GRCm38) |
Y428H |
probably damaging |
Het |
| Dsp |
G |
T |
13: 38,191,740 (GRCm38) |
W1167L |
probably benign |
Het |
| Elmo2 |
C |
T |
2: 165,295,041 (GRCm38) |
V592M |
probably damaging |
Het |
| Enpp3 |
T |
A |
10: 24,826,195 (GRCm38) |
E60D |
probably damaging |
Het |
| Erfl |
A |
T |
7: 24,931,664 (GRCm38) |
|
probably null |
Het |
| Fam83b |
TAAGA |
T |
9: 76,502,112 (GRCm38) |
|
probably null |
Het |
| Fbxo38 |
A |
G |
18: 62,536,224 (GRCm38) |
C52R |
probably damaging |
Het |
| Gm10912 |
T |
C |
2: 104,066,710 (GRCm38) |
W65R |
probably damaging |
Het |
| Gm43518 |
A |
T |
5: 123,936,427 (GRCm38) |
M44L |
probably benign |
Het |
| Gnb1 |
T |
A |
4: 155,553,456 (GRCm38) |
D212E |
probably damaging |
Het |
| Gnl1 |
A |
G |
17: 35,988,728 (GRCm38) |
N597S |
probably damaging |
Het |
| Gprin1 |
T |
G |
13: 54,739,042 (GRCm38) |
E473A |
probably benign |
Het |
| Ighv1-69 |
T |
A |
12: 115,623,214 (GRCm38) |
M100L |
probably benign |
Het |
| Igkv14-100 |
T |
C |
6: 68,519,209 (GRCm38) |
S29P |
probably damaging |
Het |
| Ints6 |
A |
G |
14: 62,714,337 (GRCm38) |
V232A |
probably damaging |
Het |
| Jup |
A |
G |
11: 100,379,553 (GRCm38) |
L376P |
probably damaging |
Het |
| Kdr |
A |
T |
5: 75,972,260 (GRCm38) |
Y119* |
probably null |
Het |
| Kif1a |
T |
G |
1: 93,066,098 (GRCm38) |
T377P |
probably benign |
Het |
| Lama5 |
C |
A |
2: 180,180,731 (GRCm38) |
V2850L |
probably damaging |
Het |
| Lrp2 |
T |
C |
2: 69,483,208 (GRCm38) |
Y2393C |
probably damaging |
Het |
| Mfsd13a |
C |
T |
19: 46,368,324 (GRCm38) |
Q255* |
probably null |
Het |
| Msh3 |
A |
C |
13: 92,235,588 (GRCm38) |
D891E |
probably damaging |
Het |
| Msl2 |
A |
G |
9: 101,075,282 (GRCm38) |
N2D |
possibly damaging |
Het |
| Myo19 |
T |
C |
11: 84,900,547 (GRCm38) |
L476P |
probably damaging |
Het |
| Nbeal2 |
G |
A |
9: 110,638,618 (GRCm38) |
R501W |
probably damaging |
Het |
| Nfasc |
C |
A |
1: 132,621,049 (GRCm38) |
K293N |
probably damaging |
Het |
| Npbwr1 |
A |
T |
1: 5,917,100 (GRCm38) |
L65Q |
probably damaging |
Het |
| Nrbp1 |
T |
A |
5: 31,244,481 (GRCm38) |
D34E |
probably damaging |
Het |
| Nup205 |
T |
A |
6: 35,243,936 (GRCm38) |
V1891D |
probably benign |
Het |
| Or51g2 |
T |
A |
7: 102,973,968 (GRCm38) |
N8I |
possibly damaging |
Het |
| Or5g29 |
T |
A |
2: 85,590,598 (GRCm38) |
D19E |
probably benign |
Het |
| Or5k1b |
T |
C |
16: 58,761,119 (GRCm38) |
N19S |
probably benign |
Het |
| Or8g22 |
G |
T |
9: 39,047,083 (GRCm38) |
C156* |
probably null |
Het |
| Oscp1 |
G |
A |
4: 126,082,990 (GRCm38) |
|
probably null |
Het |
| Pcdhgb7 |
A |
G |
18: 37,753,033 (GRCm38) |
T419A |
probably damaging |
Het |
| Pdzph1 |
T |
C |
17: 58,974,126 (GRCm38) |
D387G |
probably benign |
Het |
| Phc1 |
A |
G |
6: 122,335,031 (GRCm38) |
F56S |
probably damaging |
Het |
| Prickle1 |
G |
T |
15: 93,500,871 (GRCm38) |
T692K |
possibly damaging |
Het |
| Rbm45 |
T |
A |
2: 76,376,394 (GRCm38) |
L250Q |
probably damaging |
Het |
| Ror1 |
T |
A |
4: 100,407,911 (GRCm38) |
M194K |
probably damaging |
Het |
| Rrbp1 |
T |
A |
2: 143,957,802 (GRCm38) |
|
probably null |
Het |
| Rundc3b |
T |
C |
5: 8,512,348 (GRCm38) |
K340R |
probably null |
Het |
| Scn1a |
T |
A |
2: 66,317,899 (GRCm38) |
T1101S |
probably damaging |
Het |
| Sdk1 |
C |
G |
5: 142,094,657 (GRCm38) |
|
probably null |
Het |
| Skic2 |
A |
G |
17: 34,845,207 (GRCm38) |
F501S |
possibly damaging |
Het |
| Slc20a1 |
T |
A |
2: 129,200,059 (GRCm38) |
M114K |
probably damaging |
Het |
| Sorl1 |
A |
C |
9: 41,969,751 (GRCm38) |
I2158S |
probably benign |
Het |
| Strip1 |
A |
T |
3: 107,626,795 (GRCm38) |
F174L |
probably benign |
Het |
| Sucnr1 |
A |
T |
3: 60,086,278 (GRCm38) |
I76L |
probably benign |
Het |
| Syt17 |
C |
T |
7: 118,408,019 (GRCm38) |
V412I |
probably benign |
Het |
| Tie1 |
T |
A |
4: 118,489,653 (GRCm38) |
H18L |
probably benign |
Het |
| Tpp1 |
T |
G |
7: 105,748,922 (GRCm38) |
K345Q |
probably damaging |
Het |
| Trcg1 |
G |
A |
9: 57,241,569 (GRCm38) |
M141I |
possibly damaging |
Het |
| Trpc4ap |
T |
C |
2: 155,657,822 (GRCm38) |
N260S |
probably benign |
Het |
| Vps41 |
C |
A |
13: 18,842,268 (GRCm38) |
T512K |
possibly damaging |
Het |
| Vps52 |
A |
T |
17: 33,959,319 (GRCm38) |
M147L |
probably benign |
Het |
| Ywhaq |
A |
G |
12: 21,391,751 (GRCm38) |
|
probably benign |
Het |
| Zfp619 |
A |
G |
7: 39,534,963 (GRCm38) |
N139S |
probably benign |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,896,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,852,857 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,622,516 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,754,741 (GRCm38) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,622,409 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,860,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,918,004 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,852,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,736,973 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,967,828 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,772,407 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,635,656 (GRCm38) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,635,654 (GRCm38) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,626,564 (GRCm38) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,859,370 (GRCm38) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,768,745 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,957,793 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,662,443 (GRCm38) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,629,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,957,699 (GRCm38) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,896,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,772,428 (GRCm38) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,844,070 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,748,178 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,635,636 (GRCm38) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,844,042 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1970:Pik3c2g
|
UTSW |
6 |
139,900,386 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,622,548 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,855,286 (GRCm38) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,852,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,622,387 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,855,292 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,852,863 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,635,610 (GRCm38) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,730,370 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,841,681 (GRCm38) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,633,751 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,720,006 (GRCm38) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,720,018 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,935,985 (GRCm38) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,768,779 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,967,802 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,843,931 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,896,202 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,720,147 (GRCm38) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,635,625 (GRCm38) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,622,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,896,257 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,622,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,720,082 (GRCm38) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,736,943 (GRCm38) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,715,855 (GRCm38) |
splice site |
probably null |
|
|
R5580:Pik3c2g
|
UTSW |
6 |
139,626,533 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5664:Pik3c2g
|
UTSW |
6 |
139,737,007 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,622,479 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,896,792 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,622,139 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,626,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,719,998 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,730,469 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,896,173 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,957,776 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,629,870 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,860,264 (GRCm38) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,754,863 (GRCm38) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,896,255 (GRCm38) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,967,894 (GRCm38) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,855,353 (GRCm38) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,967,917 (GRCm38) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,622,072 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,896,744 (GRCm38) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,633,793 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,882,060 (GRCm38) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,622,069 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,936,056 (GRCm38) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,967,893 (GRCm38) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,768,700 (GRCm38) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,768,710 (GRCm38) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,730,366 (GRCm38) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,875,367 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,622,403 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,875,435 (GRCm38) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,882,016 (GRCm38) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,629,770 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,896,200 (GRCm38) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,622,239 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,967,791 (GRCm38) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,629,867 (GRCm38) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,896,184 (GRCm38) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,754,771 (GRCm38) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,635,658 (GRCm38) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,860,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATACAGTTGGCAAACAGAGC -3'
(R):5'- TCGATGCCATGATATTTTCCACTG -3'
Sequencing Primer
(F):5'- GAGCCAAATCGCACTGAAC -3'
(R):5'- TCCACTGGGATTTCTCCAGGAAG -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation