Mutagenetix > Incidental Mutation

Incidental Mutation 'R7023:Vmn2r115'

545809

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

EG638102

MMRRC Submission

045124-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

R7023 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23343977-23360128 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23359811 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 753 (Y753H)

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

probably damaging
Transcript: ENSMUST00000168175
AA Change: Y753H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076
AA Change: Y753H

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	A	G	13: 119,473,907	H372R	probably benign	Het
4933405O20Rik	T	C	7: 50,600,253	I345T	probably damaging	Het
4933427D14Rik	A	G	11: 72,178,403		probably null	Het
6430548M08Rik	T	C	8: 120,145,357	V8A	probably damaging	Het
9530053A07Rik	T	A	7: 28,140,038	C425*	probably null	Het
Adam2	A	T	14: 66,043,056	D501E	probably benign	Het
Agbl3	T	C	6: 34,814,769	V602A	probably benign	Het
Akap12	T	C	10: 4,356,895	M1235T	probably benign	Het
Arid5a	G	A	1: 36,317,550		probably benign	Het
Asxl1	T	A	2: 153,400,549	D1006E	probably benign	Het
AY074887	T	C	9: 54,950,865		probably benign	Het
Btbd9	T	A	17: 30,527,572	R93S	probably benign	Het
Cabp2	A	T	19: 4,082,658		probably null	Het
Cacna1e	T	C	1: 154,725,693	D76G	probably null	Het
Cd177	A	G	7: 24,759,762	I74T	probably benign	Het
Chchd1	G	A	14: 20,703,242		probably benign	Het
Col28a1	T	C	6: 8,083,763	R565G	possibly damaging	Het
Cpvl	T	A	6: 53,967,812	I80F	probably benign	Het
Csgalnact1	T	C	8: 68,358,429	T530A	probably benign	Het
Cybrd1	A	G	2: 71,138,578	D265G	probably benign	Het
Cyp2c69	A	T	19: 39,877,542	N202K	probably benign	Het
D1Pas1	A	G	1: 186,968,008	N45D	probably damaging	Het
Dclre1a	A	G	19: 56,540,206	V839A	probably damaging	Het
Degs1	A	T	1: 182,279,065	Y210N	probably damaging	Het
Doc2g	A	G	19: 4,004,778	S220G	probably benign	Het
Epb41l2	T	A	10: 25,512,977	L885Q	probably damaging	Het
Fabp1	A	T	6: 71,203,085		probably null	Het
Fat2	G	A	11: 55,310,502	S582L	probably benign	Het
Fras1	A	G	5: 96,710,084	N2079S	probably benign	Het
Gdf6	T	C	4: 9,860,210	Y431H	probably damaging	Het
Gfra1	A	T	19: 58,454,332	L6Q	probably damaging	Het
Gm45861	T	G	8: 27,581,006	S1305A	unknown	Het
Gse1	T	C	8: 120,230,648		probably benign	Het
Kmt2e	A	G	5: 23,500,487	H1303R	possibly damaging	Het
Lck	T	C	4: 129,548,865	D499G	possibly damaging	Het
Lepr	A	T	4: 101,789,287	Y805F	probably damaging	Het
Lin7a	A	T	10: 107,382,628	Y11F	possibly damaging	Het
Lrrc43	A	G	5: 123,503,763	K559E	probably damaging	Het
Megf6	T	C	4: 154,254,145	L467P	possibly damaging	Het
Mprip	G	A	11: 59,737,389	G221R	probably damaging	Het
Myo5c	T	C	9: 75,301,456	V1683A	probably damaging	Het
Nbeal2	G	A	9: 110,638,618	R501W	probably damaging	Het
Ncf1	G	T	5: 134,225,262	A219E	possibly damaging	Het
Nckap1l	T	C	15: 103,476,066	I616T	probably benign	Het
Nlrp2	A	T	7: 5,328,229	C389*	probably null	Het
Nrg3	T	C	14: 38,376,376	E507G	probably damaging	Het
Olfr1180	A	G	2: 88,412,415	L81P	probably damaging	Het
P4ha2	A	T	11: 54,131,246	T532S	probably benign	Het
Pappa	A	T	4: 65,351,718	H1623L	probably benign	Het
Paqr6	A	G	3: 88,366,046	Y115C	probably damaging	Het
Pcolce2	A	T	9: 95,678,468	Q190L	probably benign	Het
Poll	A	G	19: 45,558,838	I65T	probably benign	Het
Prmt9	T	C	8: 77,549,457		probably benign	Het
Prpf39	T	C	12: 65,053,300	V130A	possibly damaging	Het
Prpf6	A	G	2: 181,620,640	D144G	probably damaging	Het
Rgs6	T	A	12: 83,092,104		probably benign	Het
Rimbp2	A	G	5: 128,802,783		probably null	Het
Ripor2	A	G	13: 24,671,846	T90A	probably benign	Het
Rnf150	T	C	8: 82,864,077	F23S	probably damaging	Het
Rpp40	G	A	13: 35,898,906	R200W	possibly damaging	Het
Rtp3	G	A	9: 110,986,646	S217L	probably benign	Het
Sacs	A	C	14: 61,208,815	K2770T	probably benign	Het
Scn10a	A	T	9: 119,613,544	I1545N	probably damaging	Het
Scn2b	G	T	9: 45,126,140	V162L	probably damaging	Het
Sema6d	A	G	2: 124,664,911	T880A	probably damaging	Het
Slc36a4	A	G	9: 15,719,633	D16G	probably benign	Het
Slc4a8	T	A	15: 100,791,643	I378K	probably benign	Het
Smco2	T	A	6: 146,858,856	L70*	probably null	Het
Sptb	C	T	12: 76,625,088	V364I	probably damaging	Het
Susd4	A	G	1: 182,765,048	H3R	probably damaging	Het
Tbc1d16	T	C	11: 119,158,791	Q293R	probably damaging	Het
Tnfsf9	T	A	17: 57,107,317	M248K	possibly damaging	Het
Toporsl	A	G	4: 52,611,211	N368S	possibly damaging	Het
Trip11	T	C	12: 101,885,867	E361G	probably benign	Het
Trrap	T	A	5: 144,792,154	M626K	possibly damaging	Het
Ttn	A	T	2: 76,942,874	S2395T	probably damaging	Het
Ubqln3	T	C	7: 104,141,423	R487G	probably damaging	Het
Vdac1	A	G	11: 52,374,366	Y22C	probably damaging	Het
Vmn1r59	C	T	7: 5,454,478	M94I	probably benign	Het
Vmn2r10	G	T	5: 109,002,028	D383E	probably damaging	Het
Vmn2r97	G	T	17: 18,914,401	C27F	probably damaging	Het
Wasf1	T	A	10: 40,936,475	V420E	unknown	Het
Zfp94	A	T	7: 24,303,396	L201Q	probably damaging	Het
Zgpat	TGGAGGAGGAGGAGGAGGA	TGGAGGAGGAGGAGGA	2: 181,366,018		probably benign	Het
Zmym4	C	A	4: 126,868,800	R1410L	probably damaging	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23346206	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23346176	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23359349	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23346339	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23346278	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23346161	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23359397	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23346371	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23346372	missense	probably benign	0.30
IGL00990:Vmn2r115	APN	17	23356960	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23346264	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23359779	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23359824	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23348034	nonsense	probably null
IGL01073:Vmn2r115	APN	17	23345997	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23345997	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23359781	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23359781	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23345139	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23359283	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23346278	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23359781	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23345222	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23360100	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23346264	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23359275	missense	probably benign
R0865:Vmn2r115	UTSW	17	23346408	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23346018	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23346018	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23345271	missense	probably benign	0.12
R1645:Vmn2r115	UTSW	17	23346218	missense	possibly damaging	0.69
R1646:Vmn2r115	UTSW	17	23359539	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23347821	missense	probably benign
R1846:Vmn2r115	UTSW	17	23359383	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23346033	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23359414	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23347953	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23359323	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23357024	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23345172	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23359974	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23360043	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23345103	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23346384	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23346384	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23345223	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23345880	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23346399	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23359851	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23360056	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23345333	missense	probably benign
R5821:Vmn2r115	UTSW	17	23347963	missense	probably damaging	0.99
R6120:Vmn2r115	UTSW	17	23346029	missense	probably damaging	1.00
R6193:Vmn2r115	UTSW	17	23357009	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R6290:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23347903	missense	possibly damaging	0.70
R6495:Vmn2r115	UTSW	17	23359598	missense	probably benign	0.02
R6599:Vmn2r115	UTSW	17	23346032	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23346072	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23346015	missense	probably benign	0.23
R7236:Vmn2r115	UTSW	17	23359602	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23345913	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23346397	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23345798	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23344150	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23359556	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23345799	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23359523	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23345829	missense	probably benign
R9114:Vmn2r115	UTSW	17	23345333	missense	probably benign
R9189:Vmn2r115	UTSW	17	23345810	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23359508	missense	probably benign	0.05
R9397:Vmn2r115	UTSW	17	23345178	nonsense	probably null
R9410:Vmn2r115	UTSW	17	23359941	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23359210	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23346227	missense	probably damaging	1.00
V5622:Vmn2r115	UTSW	17	23359359	missense	probably benign
X0023:Vmn2r115	UTSW	17	23359988	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23359988	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- CTAAAACGATTACTGTAGTTCTGGC -3'
(R):5'- CACCATGACCTTGCCTTTGG -3'

Sequencing Primer
(F):5'- GTTCTGGCATTCAAAATCATAGCCTC -3'
(R):5'- CCTTTGGTGCTATGGTAAACAG -3'

Posted On

2019-05-13