Mutagenetix > Incidental Mutations

Incidental Mutation 'R7024:Vmn2r111'

545866

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r111

Ensembl Gene

ENSMUSG00000095093

Gene Name

vomeronasal 2, receptor 111

Synonyms

EG210876

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

R7024 (G1)

Quality Score

202.009

Status

Validated

Chromosome

Chromosomal Location

22547941-22573273 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22559051 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 549 (N549S)

Ref Sequence

ENSEMBL: ENSMUSP00000090148 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092491]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092491
AA Change: N549S

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000090148
Gene: ENSMUSG00000095093
AA Change: N549S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.5e-29	PFAM
Pfam:NCD3G	512	565	1.1e-20	PFAM
Pfam:7tm_3	595	833	5.6e-54	PFAM

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.9%

Validation Efficiency

97% (61/63)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310079G19Rik	A	G	16: 88,627,220	S128P	probably damaging	Het
Abcc1	G	C	16: 14,413,383		probably null	Het
Armc4	A	C	18: 7,211,593	D760E	probably benign	Het
Atg2a	G	A	19: 6,250,219	G686S	possibly damaging	Het
Atrnl1	A	T	19: 57,638,450		probably null	Het
Brd4	T	C	17: 32,221,910		probably benign	Het
C77080	T	A	4: 129,225,408	E173V	probably null	Het
Camsap3	A	G	8: 3,608,242	E688G	probably damaging	Het
Cc2d2a	T	A	5: 43,733,929	S1402R	probably benign	Het
Ccnb1	A	G	13: 100,786,380		probably null	Het
Cdc42bpb	G	A	12: 111,326,085	H339Y	probably damaging	Het
Ciart	T	A	3: 95,879,080	T94S	probably benign	Het
Col6a5	T	A	9: 105,912,475	K1540*	probably null	Het
Csmd3	A	T	15: 47,710,991	V1969E	probably damaging	Het
Dgka	T	G	10: 128,720,487	N710T	probably damaging	Het
Dock6	A	G	9: 21,820,370	V1212A	probably benign	Het
En1	C	T	1: 120,603,322	P97L	unknown	Het
Esd	T	A	14: 74,744,662	F172L	probably damaging	Het
Gfer	C	A	17: 24,695,968	D34Y	probably damaging	Het
Gm2832	G	A	14: 41,279,739	M68I		Het
Hmgcr	A	G	13: 96,658,910	S384P	probably benign	Het
Hsp90aa1	T	C	12: 110,694,112	T299A	possibly damaging	Het
Igsf10	A	G	3: 59,331,701	M353T	probably benign	Het
Ino80b	T	C	6: 83,122,325	T211A	probably benign	Het
Lamb2	C	A	9: 108,489,488	T1607K	probably benign	Het
Lhfpl5	A	G	17: 28,582,983	E218G	probably benign	Het
Lpo	C	A	11: 87,816,443	C248F	probably damaging	Het
Lrrc3	C	T	10: 77,900,991	D204N	probably damaging	Het
Mavs	C	A	2: 131,243,131	L160I	probably benign	Het
Morn4	C	T	19: 42,078,044	D35N	possibly damaging	Het
Mroh8	G	A	2: 157,221,263	H813Y	probably benign	Het
Myf6	T	C	10: 107,494,529	E59G	probably damaging	Het
Nlrp10	T	A	7: 108,925,198	E358D	possibly damaging	Het
Olfr1009	T	A	2: 85,721,608	F68I	probably damaging	Het
Olfr107	T	C	17: 37,406,204	F219L	probably benign	Het
Olfr1120	A	G	2: 87,357,722	T93A	probably benign	Het
Olfr396-ps1	T	A	11: 73,928,506	L94*	probably null	Het
Olfr525	T	C	7: 140,322,846	I49T	possibly damaging	Het
Olfr846	T	C	9: 19,361,283	E24G	possibly damaging	Het
Optn	T	C	2: 5,052,837		probably null	Het
Plxna4	T	A	6: 32,192,269	H1331L	probably damaging	Het
Poli	A	T	18: 70,516,849	M357K	possibly damaging	Het
Psd4	T	G	2: 24,394,543	C140G	possibly damaging	Het
Rab3gap1	T	A	1: 127,891,098		probably null	Het
Rasa3	T	C	8: 13,631,826	N41S	probably benign	Het
Rps6kc1	A	G	1: 190,800,210	S532P	probably benign	Het
S100a3	T	A	3: 90,602,440		probably null	Het
Sfrp5	T	C	19: 42,201,765	K83E	possibly damaging	Het
Slco1a4	T	C	6: 141,834,708	I119V	probably benign	Het
Snx15	T	A	19: 6,120,596	Q271L	probably damaging	Het
Sorcs2	C	A	5: 36,021,261	S1128I	probably damaging	Het
Tbc1d7	A	T	13: 43,154,735	F85I	probably damaging	Het
Thoc7	A	G	14: 13,953,528	Y46H	probably damaging	Het
Top1mt	T	A	15: 75,667,448	Y366F	probably damaging	Het
Trpv2	C	A	11: 62,584,461	S233R	probably benign	Het
Vav1	C	A	17: 57,279,268	T24N	probably damaging	Het
Wdfy4	G	T	14: 32,964,626		probably null	Het
Wdr3	A	G	3: 100,154,997	S201P	probably benign	Het
Wdr34	A	G	2: 30,038,266	V116A	possibly damaging	Het
Wfs1	C	T	5: 36,966,950	D866N	probably damaging	Het
Wnk1	A	T	6: 119,965,726		probably benign	Het
Xpot	G	T	10: 121,602,399	Q762K	probably benign	Het
Zfp287	A	T	11: 62,714,938	L370H	possibly damaging	Het

Other mutations in Vmn2r111

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Vmn2r111	APN	17	22548753	missense	probably benign	0.00
IGL01306:Vmn2r111	APN	17	22568984	missense	probably damaging	0.99
IGL01309:Vmn2r111	APN	17	22569016	missense	possibly damaging	0.51
IGL01457:Vmn2r111	APN	17	22571985	nonsense	probably null
IGL01465:Vmn2r111	APN	17	22548737	missense	probably benign	0.00
IGL01505:Vmn2r111	APN	17	22548572	missense	probably benign	0.00
IGL01571:Vmn2r111	APN	17	22571392	missense	probably damaging	0.99
IGL01715:Vmn2r111	APN	17	22569073	splice site	probably benign
IGL01962:Vmn2r111	APN	17	22548284	missense	possibly damaging	0.90
IGL02190:Vmn2r111	APN	17	22570773	missense	probably benign	0.00
IGL02496:Vmn2r111	APN	17	22568856	missense	probably benign
IGL02519:Vmn2r111	APN	17	22548339	missense	possibly damaging	0.80
IGL02616:Vmn2r111	APN	17	22571050	missense	possibly damaging	0.67
IGL02641:Vmn2r111	APN	17	22573224	missense	possibly damaging	0.82
IGL02690:Vmn2r111	APN	17	22559042	critical splice donor site	probably null
IGL02698:Vmn2r111	APN	17	22571245	missense	probably damaging	1.00
IGL03017:Vmn2r111	APN	17	22570858	missense	probably damaging	1.00
R0046:Vmn2r111	UTSW	17	22548009	missense	probably benign
R0064:Vmn2r111	UTSW	17	22572072	missense	probably benign	0.00
R0519:Vmn2r111	UTSW	17	22573121	missense	probably benign	0.02
R1439:Vmn2r111	UTSW	17	22571116	missense	probably benign	0.00
R1467:Vmn2r111	UTSW	17	22571047	missense	probably damaging	0.99
R1467:Vmn2r111	UTSW	17	22571047	missense	probably damaging	0.99
R1636:Vmn2r111	UTSW	17	22571399	missense	probably damaging	1.00
R1647:Vmn2r111	UTSW	17	22569061	missense	probably benign	0.03
R1648:Vmn2r111	UTSW	17	22569061	missense	probably benign	0.03
R1697:Vmn2r111	UTSW	17	22548060	missense	probably benign	0.26
R1996:Vmn2r111	UTSW	17	22548081	missense	probably benign	0.21
R2040:Vmn2r111	UTSW	17	22548414	missense	probably damaging	1.00
R2075:Vmn2r111	UTSW	17	22559062	missense	probably damaging	1.00
R2134:Vmn2r111	UTSW	17	22573104	missense	possibly damaging	0.68
R2357:Vmn2r111	UTSW	17	22559170	splice site	probably benign
R3700:Vmn2r111	UTSW	17	22571161	nonsense	probably null
R3782:Vmn2r111	UTSW	17	22571320	missense	possibly damaging	0.89
R4085:Vmn2r111	UTSW	17	22559115	missense	probably benign	0.00
R4323:Vmn2r111	UTSW	17	22573178	missense	probably benign	0.02
R4900:Vmn2r111	UTSW	17	22548656	missense	possibly damaging	0.94
R5072:Vmn2r111	UTSW	17	22548041	missense	probably damaging	0.99
R5123:Vmn2r111	UTSW	17	22571143	missense	possibly damaging	0.82
R5181:Vmn2r111	UTSW	17	22571020	missense	possibly damaging	0.56
R5357:Vmn2r111	UTSW	17	22548102	nonsense	probably null
R5398:Vmn2r111	UTSW	17	22573271	start codon destroyed	probably null	0.88
R5434:Vmn2r111	UTSW	17	22548489	missense	probably damaging	0.99
R5462:Vmn2r111	UTSW	17	22548257	missense	probably damaging	1.00
R6149:Vmn2r111	UTSW	17	22548815	missense	probably benign	0.00
R6149:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6207:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6281:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6282:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6283:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6307:Vmn2r111	UTSW	17	22573089	missense	probably benign	0.00
R6323:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6325:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6367:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6368:Vmn2r111	UTSW	17	22571908	missense	probably benign	0.38
R6369:Vmn2r111	UTSW	17	22548602	missense	probably damaging	1.00
R6489:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6490:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6546:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6547:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6557:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6654:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6655:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6657:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6659:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6660:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6664:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6798:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6799:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6801:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6893:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6895:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6897:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6922:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6923:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6944:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R6945:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7017:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7018:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7031:Vmn2r111	UTSW	17	22571245	missense	probably damaging	1.00
R7039:Vmn2r111	UTSW	17	22548184	missense	probably damaging	1.00
R7053:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7054:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7055:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7056:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7145:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7146:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7246:Vmn2r111	UTSW	17	22548714	missense	probably damaging	1.00
R7259:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7260:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7327:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7401:Vmn2r111	UTSW	17	22571086	missense	possibly damaging	0.93
R7514:Vmn2r111	UTSW	17	22548399	missense	probably benign	0.05
R7651:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7781:Vmn2r111	UTSW	17	22570733	missense	probably benign	0.17
R7816:Vmn2r111	UTSW	17	22573102	missense	probably damaging	0.97
R7821:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7838:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R7921:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R8078:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R8080:Vmn2r111	UTSW	17	22559051	missense	possibly damaging	0.50
R8117:Vmn2r111	UTSW	17	22571488	missense	probably benign	0.12
X0026:Vmn2r111	UTSW	17	22548695	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CAAGGTGTAAAAGATGCAGCCC -3'
(R):5'- TCAAGGAGTTGGGAAACAATTCAAC -3'

Sequencing Primer
(F):5'- GGTGTAAAAGATGCAGCCCAATTTC -3'
(R):5'- ACAATGCACTAAATAAGGTCTGC -3'

Posted On

2019-05-13