Mutagenetix > Incidental Mutation

Incidental Mutation 'R7025:Or6c63-ps1'

545918

Institutional Source

Beutler Lab

Gene Symbol

Or6c63-ps1

Ensembl Gene

ENSMUSG00000107748

Gene Name

olfactory receptor family 6 subfamily C member 63, pseudogene 1

Synonyms

Olfr766, GA_x6K02T2PULF-10749079-10748573, EG546487, MOR115-2, EG544748, Olfr766-ps1

MMRRC Submission

045126-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R7025 (G1)

Quality Score

122.008

Status

Not validated

Chromosome

Chromosomal Location

128898897-128899835 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to A at 128900544 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 1 (M1L)

Ref Sequence

ENSEMBL: ENSMUSP00000154204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000204515]

AlphaFold

A0A2I3BQH9

Predicted Effect

probably benign
Transcript: ENSMUST00000204515
AA Change: M1L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.6%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acbd4	T	A	11: 102,995,364 (GRCm39)	L90M	probably damaging	Het
Acot7	T	C	4: 152,262,646 (GRCm39)	S7P	unknown	Het
Ahcyl2	T	C	6: 29,908,420 (GRCm39)	Y388H	probably damaging	Het
Atp1a2	T	A	1: 172,112,117 (GRCm39)	R593*	probably null	Het
Bicral	T	C	17: 47,112,594 (GRCm39)	T869A	probably benign	Het
Brca2	C	T	5: 150,463,943 (GRCm39)	P1236S	probably benign	Het
Cacna2d1	C	T	5: 16,557,666 (GRCm39)	Q699*	probably null	Het
Ccser2	T	C	14: 36,661,964 (GRCm39)	N407D	probably damaging	Het
Cd300lg	A	G	11: 101,933,900 (GRCm39)	Y49C	probably damaging	Het
Cdh12	C	A	15: 21,358,900 (GRCm39)	T108K	probably damaging	Het
Ctnnd1	A	T	2: 84,440,950 (GRCm39)	I715K	possibly damaging	Het
Cyp17a1	T	A	19: 46,659,419 (GRCm39)	D137V	probably damaging	Het
Dbr1	A	G	9: 99,458,036 (GRCm39)	T19A	probably damaging	Het
Dnah3	C	T	7: 119,629,233 (GRCm39)	A1441T	possibly damaging	Het
Dpt	G	A	1: 164,624,508 (GRCm39)	D70N	probably damaging	Het
Elk4	C	A	1: 131,947,107 (GRCm39)	P366Q	probably damaging	Het
Eml4	A	C	17: 83,732,740 (GRCm39)	D131A	probably benign	Het
Faap24	A	G	7: 35,092,296 (GRCm39)	I207T	possibly damaging	Het
Fam219a	T	C	4: 41,521,925 (GRCm39)	S41G	probably benign	Het
Gask1b	T	C	3: 79,793,855 (GRCm39)	Y108H	probably damaging	Het
Ifi203	T	C	1: 173,755,951 (GRCm39)		probably benign	Het
Inpp4a	T	C	1: 37,408,504 (GRCm39)	V295A	probably benign	Het
Kif2a	A	G	13: 107,119,102 (GRCm39)	Y267H	probably damaging	Het
Kprp	T	A	3: 92,732,504 (GRCm39)	Q182L	probably benign	Het
Krt90	T	C	15: 101,465,610 (GRCm39)	K337R	possibly damaging	Het
Lrp2	T	A	2: 69,313,372 (GRCm39)	Y2453F	possibly damaging	Het
Magel2	A	C	7: 62,029,535 (GRCm39)	Y813S	unknown	Het
Myh7	C	A	14: 55,212,101 (GRCm39)	E1548*	probably null	Het
Myh8	A	G	11: 67,188,365 (GRCm39)	T1009A	probably benign	Het
Nab2	T	A	10: 127,502,377 (GRCm39)		probably benign	Het
Neb	T	C	2: 52,186,285 (GRCm39)	D929G	possibly damaging	Het
Nelfb	A	C	2: 25,100,505 (GRCm39)	V155G	probably damaging	Het
Nmur1	C	A	1: 86,315,570 (GRCm39)	M65I	possibly damaging	Het
Nop56	C	T	2: 130,119,801 (GRCm39)	R81*	probably null	Het
Npnt	C	T	3: 132,614,157 (GRCm39)	C47Y	probably damaging	Het
Nrp1	G	T	8: 129,207,435 (GRCm39)	C610F	probably damaging	Het
Or4a71	T	A	2: 89,357,948 (GRCm39)	I269F	probably damaging	Het
Or5d45	T	C	2: 88,153,606 (GRCm39)	K148E	probably damaging	Het
Pax5	G	A	4: 44,679,501 (GRCm39)	Q93*	probably null	Het
Pcnt	G	T	10: 76,239,669 (GRCm39)	Q1273K	probably damaging	Het
Pde4dip	G	A	3: 97,631,499 (GRCm39)	Q1137*	probably null	Het
Pfas	A	T	11: 68,881,586 (GRCm39)	D959E	probably benign	Het
Pira13	T	A	7: 3,824,261 (GRCm39)	K629*	probably null	Het
Prex1	TCCGACCCC	TCCGACCCCGACCCC	2: 166,455,107 (GRCm39)		probably benign	Het
Prpf40b	C	T	15: 99,204,281 (GRCm39)	Q182*	probably null	Het
Ptk2	G	A	15: 73,093,658 (GRCm39)	P854S	possibly damaging	Het
Rpe65	A	C	3: 159,328,322 (GRCm39)	E406A	probably damaging	Het
Serpina3k	A	T	12: 104,307,401 (GRCm39)	Y211F	probably benign	Het
Shkbp1	T	C	7: 27,054,706 (GRCm39)	I65V	possibly damaging	Het
Slc22a29	G	A	19: 8,137,944 (GRCm39)	P544S	probably benign	Het
Stab2	T	C	10: 86,686,701 (GRCm39)	D2281G	probably damaging	Het
Tjp2	A	G	19: 24,110,052 (GRCm39)	M64T	probably benign	Het
Tnfrsf8	C	T	4: 145,000,973 (GRCm39)	V378I	possibly damaging	Het
Trpm1	A	T	7: 63,876,462 (GRCm39)		probably null	Het
Ubqln3	A	G	7: 103,790,482 (GRCm39)	I536T	probably benign	Het
Vmn1r44	A	G	6: 89,870,736 (GRCm39)	T161A	possibly damaging	Het
Vmn2r108	T	A	17: 20,691,345 (GRCm39)	I393F	possibly damaging	Het

Other mutations in Or6c63-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7167:Or6c63-ps1	UTSW	10	128,899,141 (GRCm39)	missense	probably damaging	1.00
R8142:Or6c63-ps1	UTSW	10	128,900,519 (GRCm39)	missense	probably benign
R9131:Or6c63-ps1	UTSW	10	128,899,097 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- ACTATTCATTGGAGACTGGTGAGG -3'
(R):5'- AGCTGATTCCTCAAGTTCTCAAAG -3'

Sequencing Primer
(F):5'- GAGTACACAATAGAAGCATCCTTG -3'
(R):5'- TTTTGTTTTCTAGCCACAATAAAACC -3'

Posted On

2019-05-13