Incidental Mutation 'R7026:Ints4'
ID 545957
Institutional Source Beutler Lab
Gene Symbol Ints4
Ensembl Gene ENSMUSG00000025133
Gene Name integrator complex subunit 4
Synonyms 2610034N24Rik
MMRRC Submission 045127-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.960) question?
Stock # R7026 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 97130163-97190602 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 97168361 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 625 (V625D)
Ref Sequence ENSEMBL: ENSMUSP00000026126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026126]
AlphaFold Q8CIM8
Predicted Effect possibly damaging
Transcript: ENSMUST00000026126
AA Change: V625D

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000026126
Gene: ENSMUSG00000025133
AA Change: V625D

DomainStartEndE-ValueType
Pfam:HEAT_2 153 258 9.8e-9 PFAM
Pfam:Cohesin_HEAT 179 219 7.7e-6 PFAM
low complexity region 518 527 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 99% (69/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 A T 19: 43,805,392 (GRCm39) M749L probably benign Het
Abcc2 A G 19: 43,818,974 (GRCm39) N1321S probably benign Het
Acsm2 T A 7: 119,191,450 (GRCm39) V506E probably damaging Het
Add2 G A 6: 86,063,965 (GRCm39) R88Q probably benign Het
Adgra3 A G 5: 50,118,083 (GRCm39) V1155A probably benign Het
Ahsg T A 16: 22,710,963 (GRCm39) D33E probably damaging Het
Alox12b A T 11: 69,048,131 (GRCm39) D20V possibly damaging Het
Alppl2 A G 1: 87,017,420 (GRCm39) probably null Het
Ankfn1 A G 11: 89,530,403 (GRCm39) *49Q probably null Het
Bcl11b T C 12: 107,882,851 (GRCm39) D488G probably damaging Het
Bcl2l10 T A 9: 75,258,364 (GRCm39) F175L probably benign Het
C2cd3 T A 7: 100,081,299 (GRCm39) D127E probably damaging Het
Cacna1c C T 6: 118,614,732 (GRCm39) V1311I probably damaging Het
Cd55b A T 1: 130,316,427 (GRCm39) I374K probably benign Het
Cfap36 T C 11: 29,172,565 (GRCm39) T267A probably benign Het
Cibar2 G A 8: 120,895,324 (GRCm39) H193Y probably damaging Het
Cog1 T C 11: 113,540,415 (GRCm39) L10P probably damaging Het
Dnah7a T A 1: 53,543,448 (GRCm39) M2241L probably benign Het
Dock10 G T 1: 80,479,504 (GRCm39) A1809E probably benign Het
Dock7 A T 4: 98,967,156 (GRCm39) D255E probably benign Het
Exph5 T C 9: 53,251,728 (GRCm39) F123L probably benign Het
Fbxw27 C A 9: 109,617,146 (GRCm39) K118N possibly damaging Het
Fscb C A 12: 64,518,391 (GRCm39) S1025I unknown Het
Get4 C T 5: 139,238,358 (GRCm39) R47W possibly damaging Het
Gm3676 G A 14: 41,366,072 (GRCm39) S81F probably benign Het
Gulp1 C T 1: 44,820,245 (GRCm39) P251S possibly damaging Het
Hhatl T C 9: 121,617,339 (GRCm39) D298G probably benign Het
Hsf2bp T A 17: 32,252,254 (GRCm39) K60N possibly damaging Het
Iqch T A 9: 63,432,421 (GRCm39) K286* probably null Het
Irak1bp1 T A 9: 82,712,084 (GRCm39) S2T possibly damaging Het
Kdm3b G A 18: 34,955,517 (GRCm39) V1135I possibly damaging Het
Lama3 C A 18: 12,649,605 (GRCm39) N181K probably damaging Het
Lrfn2 T G 17: 49,404,005 (GRCm39) S709R probably benign Het
Lrp12 T C 15: 39,743,566 (GRCm39) H123R probably damaging Het
Lrp1b A G 2: 41,159,234 (GRCm39) S1569P probably damaging Het
Lrp2 T G 2: 69,352,131 (GRCm39) Q635P probably damaging Het
Mboat2 T C 12: 24,998,381 (GRCm39) probably null Het
Mctp1 A G 13: 76,954,378 (GRCm39) T596A probably benign Het
Mroh9 T A 1: 162,888,251 (GRCm39) M275L probably benign Het
Ms4a10 A C 19: 10,944,869 (GRCm39) probably null Het
Myo9a C T 9: 59,722,617 (GRCm39) R560C probably damaging Het
Or11h4b A G 14: 50,918,716 (GRCm39) I125T probably damaging Het
Or5b107 A G 19: 13,142,779 (GRCm39) T134A probably benign Het
Or6z1 T A 7: 6,504,820 (GRCm39) H135L probably damaging Het
Ormdl3 A G 11: 98,474,808 (GRCm39) V45A possibly damaging Het
Parp4 T C 14: 56,858,049 (GRCm39) Y894H probably benign Het
Pigo G A 4: 43,023,380 (GRCm39) Q259* probably null Het
Prrc2a G A 17: 35,380,803 (GRCm39) P70S unknown Het
Rab3ip A G 10: 116,773,441 (GRCm39) I124T probably benign Het
Rap1b A G 10: 117,654,384 (GRCm39) I21T probably benign Het
Rasgrf2 T A 13: 92,131,732 (GRCm39) S642C probably damaging Het
Rb1 T C 14: 73,535,539 (GRCm39) E106G probably benign Het
Reps1 C A 10: 17,983,437 (GRCm39) R427S probably damaging Het
Rnf213 A C 11: 119,370,481 (GRCm39) H4760P possibly damaging Het
Rtl1 A G 12: 109,559,595 (GRCm39) I748T probably damaging Het
Sco1 A T 11: 66,944,683 (GRCm39) K102M probably damaging Het
Sec16b T C 1: 157,362,281 (GRCm39) M44T possibly damaging Het
Slc7a10 T C 7: 34,898,139 (GRCm39) M297T probably damaging Het
Smchd1 T C 17: 71,656,662 (GRCm39) H1935R probably benign Het
Sowaha G A 11: 53,370,050 (GRCm39) R229W probably damaging Het
Sptlc3 A T 2: 139,379,608 (GRCm39) M83L probably benign Het
Tbc1d9 T C 8: 83,968,192 (GRCm39) V431A probably benign Het
Tmem98 A G 11: 80,712,214 (GRCm39) E217G possibly damaging Het
Trim13 T A 14: 61,842,562 (GRCm39) L193* probably null Het
Trp53bp2 T C 1: 182,270,300 (GRCm39) S367P probably benign Het
Tsc2 T G 17: 24,845,713 (GRCm39) I202L probably damaging Het
Twf2 T A 9: 106,092,079 (GRCm39) V312E probably damaging Het
Usp34 G T 11: 23,311,622 (GRCm39) L471F probably damaging Het
Vps37c A G 19: 10,683,632 (GRCm39) D18G probably damaging Het
Zfp1010 T A 2: 176,957,361 (GRCm39) I46F probably benign Het
Other mutations in Ints4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00765:Ints4 APN 7 97,184,412 (GRCm39) missense probably damaging 1.00
IGL01736:Ints4 APN 7 97,175,849 (GRCm39) missense probably benign 0.01
IGL01862:Ints4 APN 7 97,190,360 (GRCm39) missense probably damaging 1.00
IGL02277:Ints4 APN 7 97,136,665 (GRCm39) missense probably damaging 1.00
IGL02396:Ints4 APN 7 97,187,107 (GRCm39) missense possibly damaging 0.64
IGL02661:Ints4 APN 7 97,144,912 (GRCm39) missense probably benign
IGL02750:Ints4 APN 7 97,166,964 (GRCm39) critical splice donor site probably null
IGL03108:Ints4 APN 7 97,140,137 (GRCm39) critical splice acceptor site probably null
R0332:Ints4 UTSW 7 97,166,925 (GRCm39) missense probably damaging 1.00
R0449:Ints4 UTSW 7 97,178,430 (GRCm39) missense probably damaging 0.97
R1065:Ints4 UTSW 7 97,157,099 (GRCm39) critical splice donor site probably null
R1722:Ints4 UTSW 7 97,162,786 (GRCm39) missense probably benign 0.24
R2060:Ints4 UTSW 7 97,150,970 (GRCm39) missense possibly damaging 0.93
R2211:Ints4 UTSW 7 97,158,957 (GRCm39) missense possibly damaging 0.63
R3731:Ints4 UTSW 7 97,155,308 (GRCm39) missense probably benign 0.18
R3881:Ints4 UTSW 7 97,165,464 (GRCm39) missense possibly damaging 0.94
R4089:Ints4 UTSW 7 97,178,462 (GRCm39) nonsense probably null
R4192:Ints4 UTSW 7 97,156,940 (GRCm39) missense probably damaging 1.00
R4479:Ints4 UTSW 7 97,134,178 (GRCm39) missense probably damaging 1.00
R4980:Ints4 UTSW 7 97,151,057 (GRCm39) critical splice donor site probably null
R5029:Ints4 UTSW 7 97,158,981 (GRCm39) missense probably benign 0.06
R5306:Ints4 UTSW 7 97,158,885 (GRCm39) missense probably damaging 1.00
R6160:Ints4 UTSW 7 97,158,790 (GRCm39) splice site probably null
R6317:Ints4 UTSW 7 97,178,425 (GRCm39) nonsense probably null
R6961:Ints4 UTSW 7 97,190,397 (GRCm39) makesense probably null
R7156:Ints4 UTSW 7 97,184,493 (GRCm39) critical splice donor site probably null
R7205:Ints4 UTSW 7 97,184,433 (GRCm39) nonsense probably null
R7234:Ints4 UTSW 7 97,179,507 (GRCm39) missense probably benign 0.00
R7418:Ints4 UTSW 7 97,140,179 (GRCm39) missense probably benign 0.03
R7423:Ints4 UTSW 7 97,156,926 (GRCm39) missense probably damaging 1.00
R7462:Ints4 UTSW 7 97,155,335 (GRCm39) missense probably benign 0.11
R7658:Ints4 UTSW 7 97,178,460 (GRCm39) missense possibly damaging 0.90
R7947:Ints4 UTSW 7 97,148,792 (GRCm39) missense probably benign
R8114:Ints4 UTSW 7 97,165,732 (GRCm39) splice site probably null
R8426:Ints4 UTSW 7 97,150,239 (GRCm39) nonsense probably null
R8765:Ints4 UTSW 7 97,151,016 (GRCm39) missense possibly damaging 0.70
R8777:Ints4 UTSW 7 97,134,227 (GRCm39) missense probably damaging 1.00
R8777-TAIL:Ints4 UTSW 7 97,134,227 (GRCm39) missense probably damaging 1.00
R8944:Ints4 UTSW 7 97,183,593 (GRCm39) missense probably benign
R9001:Ints4 UTSW 7 97,190,276 (GRCm39) missense possibly damaging 0.51
R9057:Ints4 UTSW 7 97,158,987 (GRCm39) missense possibly damaging 0.90
R9315:Ints4 UTSW 7 97,156,840 (GRCm39) intron probably benign
Predicted Primers PCR Primer
(F):5'- GGTGGGTCATGCTAGCATTCTC -3'
(R):5'- TGACTCATGAATGCAAACAGC -3'

Sequencing Primer
(F):5'- CTCTGTGCATCTGAGAGAGAG -3'
(R):5'- GCATGAGAGAATGCTAGC -3'
Posted On 2019-05-13