Incidental Mutation 'R7032:Clasp2'
ID 546393
Institutional Source Beutler Lab
Gene Symbol Clasp2
Ensembl Gene ENSMUSG00000033392
Gene Name CLIP associating protein 2
Synonyms CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik
MMRRC Submission 045133-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7032 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 113570541-113748750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 113683391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 407 (N407S)
Ref Sequence ENSEMBL: ENSMUSP00000128460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111838] [ENSMUST00000163895] [ENSMUST00000166734] [ENSMUST00000213663] [ENSMUST00000214522] [ENSMUST00000215022]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000111838
AA Change: N407S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000107469
Gene: ENSMUSG00000033392
AA Change: N407S

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 877 2.03e-1 SMART
low complexity region 995 1009 N/A INTRINSIC
TOG 1043 1274 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163895
AA Change: N407S

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392
AA Change: N407S

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166734
AA Change: N407S

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392
AA Change: N407S

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213663
Predicted Effect probably benign
Transcript: ENSMUST00000214522
AA Change: N407S

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000215022
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (67/67)
MGI Phenotype PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik T A 5: 88,120,438 (GRCm39) D398E possibly damaging Het
Adam34 T C 8: 44,105,303 (GRCm39) Y114C probably damaging Het
Akap9 T A 5: 4,004,896 (GRCm39) D156E probably benign Het
Apba1 T A 19: 23,889,825 (GRCm39) S408T probably benign Het
Asb14 C T 14: 26,625,412 (GRCm39) H256Y probably benign Het
Atf6 A T 1: 170,627,181 (GRCm39) probably null Het
Atp6v1b2 T A 8: 69,541,548 (GRCm39) V35E probably benign Het
Atp8a2 T C 14: 60,255,289 (GRCm39) probably null Het
Ccdc170 C A 10: 4,432,597 (GRCm39) P12Q unknown Het
Cdh23 C T 10: 60,167,567 (GRCm39) E1810K probably damaging Het
Cdo1 A T 18: 46,853,475 (GRCm39) F94L probably damaging Het
Cfap96 T G 8: 46,409,474 (GRCm39) S282R probably damaging Het
Chdh C T 14: 29,758,809 (GRCm39) P585S possibly damaging Het
Clca3a1 T A 3: 144,453,329 (GRCm39) S465C probably benign Het
Clip2 C A 5: 134,551,484 (GRCm39) V213L probably damaging Het
Col6a6 A G 9: 105,644,707 (GRCm39) S1194P probably damaging Het
Cyp7a1 T C 4: 6,268,463 (GRCm39) T421A possibly damaging Het
Dhh C T 15: 98,791,907 (GRCm39) G367E possibly damaging Het
Dnah5 A G 15: 28,326,796 (GRCm39) N2002D probably damaging Het
Epn2 T A 11: 61,437,528 (GRCm39) N15Y probably damaging Het
Evi5 A C 5: 107,936,147 (GRCm39) V647G probably benign Het
Eya1 T C 1: 14,353,424 (GRCm39) probably null Het
Fam120a A G 13: 49,102,589 (GRCm39) V222A probably benign Het
Fastkd5 A T 2: 130,457,864 (GRCm39) I242K possibly damaging Het
Hnrnpul1 A G 7: 25,450,319 (GRCm39) M131T probably benign Het
Ice1 T C 13: 70,744,283 (GRCm39) N2100S probably damaging Het
Ifi205 T A 1: 173,855,916 (GRCm39) D38V possibly damaging Het
Klhl9 G A 4: 88,639,843 (GRCm39) Q133* probably null Het
Krt84 T C 15: 101,436,924 (GRCm39) E370G probably benign Het
Lrrc4c T C 2: 97,459,410 (GRCm39) I12T probably benign Het
Lrriq4 T A 3: 30,709,850 (GRCm39) L398* probably null Het
Ltf G A 9: 110,855,198 (GRCm39) probably null Het
Macf1 C T 4: 123,366,101 (GRCm39) V1322I probably benign Het
Mark2 T A 19: 7,264,698 (GRCm39) I112L probably damaging Het
Mettl25b A G 3: 87,831,649 (GRCm39) probably null Het
Mterf2 A T 10: 84,956,527 (GRCm39) C32* probably null Het
Myo3b C T 2: 69,925,608 (GRCm39) T25I probably damaging Het
Nsun7 A C 5: 66,421,378 (GRCm39) I115L probably benign Het
Olfm3 G A 3: 114,883,805 (GRCm39) V36M probably damaging Het
Or1p1c T C 11: 74,160,428 (GRCm39) I71T possibly damaging Het
Or5d44 T C 2: 88,141,373 (GRCm39) T256A probably benign Het
Or8b3 A T 9: 38,314,965 (GRCm39) Y262F possibly damaging Het
Or8g18 A T 9: 39,148,983 (GRCm39) S246T possibly damaging Het
Pcdhgb8 A T 18: 37,896,962 (GRCm39) R677S probably benign Het
Prrt4 A C 6: 29,170,538 (GRCm39) L638R possibly damaging Het
Ptk2 G A 15: 73,093,658 (GRCm39) P854S possibly damaging Het
Rab44 T C 17: 29,359,438 (GRCm39) F542S unknown Het
Rhobtb3 T A 13: 76,020,513 (GRCm39) E596D probably benign Het
Rpl36 T C 17: 56,920,944 (GRCm39) I44T probably benign Het
Rptor A G 11: 119,737,762 (GRCm39) I112V probably benign Het
Rxfp2 T C 5: 149,993,813 (GRCm39) I611T probably damaging Het
Slc12a4 G T 8: 106,675,865 (GRCm39) N553K probably damaging Het
Spata31d1d T A 13: 59,876,046 (GRCm39) R496S probably benign Het
Strbp T C 2: 37,493,125 (GRCm39) D387G possibly damaging Het
Tas2r107 A T 6: 131,636,153 (GRCm39) C299S possibly damaging Het
Tbc1d21 A T 9: 58,274,134 (GRCm39) probably null Het
Tdrd12 A T 7: 35,180,471 (GRCm39) Y847* probably null Het
Tlr2 A T 3: 83,745,212 (GRCm39) N290K probably benign Het
Tmppe A G 9: 114,234,858 (GRCm39) T386A probably damaging Het
Tnks1bp1 C A 2: 84,892,297 (GRCm39) H741Q probably benign Het
Trpc6 G A 9: 8,609,951 (GRCm39) V140M probably damaging Het
Ttn T C 2: 76,641,932 (GRCm39) D13427G probably damaging Het
Uba7 C A 9: 107,853,371 (GRCm39) L106I possibly damaging Het
Unc5b T G 10: 60,614,587 (GRCm39) T237P probably damaging Het
Vit A C 17: 78,932,294 (GRCm39) D467A probably damaging Het
Vmn1r103 T C 7: 20,243,780 (GRCm39) Y227C possibly damaging Het
Vmn1r77 T A 7: 11,776,017 (GRCm39) Y196* probably null Het
Zhx3 A G 2: 160,622,898 (GRCm39) V423A probably damaging Het
Other mutations in Clasp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00772:Clasp2 APN 9 113,735,060 (GRCm39) splice site probably benign
IGL00885:Clasp2 APN 9 113,740,484 (GRCm39) missense probably damaging 1.00
IGL01314:Clasp2 APN 9 113,735,195 (GRCm39) missense possibly damaging 0.89
IGL01344:Clasp2 APN 9 113,642,360 (GRCm39) splice site probably null
IGL01567:Clasp2 APN 9 113,709,164 (GRCm39) missense probably damaging 1.00
IGL02238:Clasp2 APN 9 113,709,088 (GRCm39) missense probably damaging 1.00
IGL02299:Clasp2 APN 9 113,709,057 (GRCm39) missense probably damaging 1.00
IGL02323:Clasp2 APN 9 113,697,794 (GRCm39) splice site probably benign
IGL02635:Clasp2 APN 9 113,737,910 (GRCm39) missense probably damaging 0.98
IGL02645:Clasp2 APN 9 113,719,129 (GRCm39) missense probably damaging 1.00
IGL02976:Clasp2 APN 9 113,735,204 (GRCm39) missense probably damaging 1.00
IGL03190:Clasp2 APN 9 113,673,208 (GRCm39) nonsense probably null
IGL03219:Clasp2 APN 9 113,677,545 (GRCm39) splice site probably benign
PIT4810001:Clasp2 UTSW 9 113,735,135 (GRCm39) missense probably damaging 1.00
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0421:Clasp2 UTSW 9 113,683,370 (GRCm39) missense probably benign 0.02
R0432:Clasp2 UTSW 9 113,738,487 (GRCm39) missense probably benign 0.00
R0458:Clasp2 UTSW 9 113,735,292 (GRCm39) splice site probably null
R0865:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R0972:Clasp2 UTSW 9 113,676,773 (GRCm39) missense possibly damaging 0.58
R1037:Clasp2 UTSW 9 113,725,702 (GRCm39) splice site probably benign
R1925:Clasp2 UTSW 9 113,735,265 (GRCm39) missense possibly damaging 0.88
R2015:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R2066:Clasp2 UTSW 9 113,735,225 (GRCm39) missense possibly damaging 0.86
R2330:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 1.00
R2568:Clasp2 UTSW 9 113,707,832 (GRCm39) missense probably benign
R3011:Clasp2 UTSW 9 113,730,581 (GRCm39) missense probably damaging 1.00
R3879:Clasp2 UTSW 9 113,719,029 (GRCm39) missense probably damaging 0.98
R3915:Clasp2 UTSW 9 113,737,805 (GRCm39) missense probably damaging 0.99
R3928:Clasp2 UTSW 9 113,735,173 (GRCm39) missense probably benign 0.28
R4323:Clasp2 UTSW 9 113,719,027 (GRCm39) missense possibly damaging 0.91
R4571:Clasp2 UTSW 9 113,676,789 (GRCm39) missense probably damaging 1.00
R4975:Clasp2 UTSW 9 113,732,984 (GRCm39) missense probably damaging 1.00
R5445:Clasp2 UTSW 9 113,733,014 (GRCm39) missense probably damaging 1.00
R5564:Clasp2 UTSW 9 113,641,836 (GRCm39) critical splice donor site probably null
R5697:Clasp2 UTSW 9 113,689,190 (GRCm39) missense probably benign 0.01
R5780:Clasp2 UTSW 9 113,679,220 (GRCm39) missense probably damaging 0.99
R5787:Clasp2 UTSW 9 113,691,310 (GRCm39) missense probably damaging 1.00
R6011:Clasp2 UTSW 9 113,705,315 (GRCm39) missense probably benign 0.07
R6026:Clasp2 UTSW 9 113,740,646 (GRCm39) missense probably benign 0.13
R6090:Clasp2 UTSW 9 113,681,803 (GRCm39) missense probably benign 0.06
R6262:Clasp2 UTSW 9 113,705,420 (GRCm39) critical splice donor site probably null
R6427:Clasp2 UTSW 9 113,721,512 (GRCm39) missense probably damaging 1.00
R6464:Clasp2 UTSW 9 113,602,785 (GRCm39) missense probably damaging 1.00
R6586:Clasp2 UTSW 9 113,642,332 (GRCm39) missense probably damaging 1.00
R6628:Clasp2 UTSW 9 113,725,788 (GRCm39) missense probably damaging 1.00
R6745:Clasp2 UTSW 9 113,704,338 (GRCm39) nonsense probably null
R7165:Clasp2 UTSW 9 113,615,467 (GRCm39) splice site probably null
R7221:Clasp2 UTSW 9 113,681,825 (GRCm39) missense probably damaging 0.99
R7336:Clasp2 UTSW 9 113,705,421 (GRCm39) splice site probably null
R7583:Clasp2 UTSW 9 113,737,755 (GRCm39) missense probably benign 0.02
R7774:Clasp2 UTSW 9 113,677,804 (GRCm39) splice site probably null
R7895:Clasp2 UTSW 9 113,733,016 (GRCm39) missense probably benign 0.03
R8084:Clasp2 UTSW 9 113,676,823 (GRCm39) missense probably benign 0.16
R8109:Clasp2 UTSW 9 113,740,588 (GRCm39) missense probably damaging 1.00
R8171:Clasp2 UTSW 9 113,732,974 (GRCm39) missense possibly damaging 0.88
R8230:Clasp2 UTSW 9 113,721,482 (GRCm39) missense possibly damaging 0.73
R8810:Clasp2 UTSW 9 113,728,649 (GRCm39) missense probably damaging 1.00
R8879:Clasp2 UTSW 9 113,602,773 (GRCm39) missense probably benign 0.39
R8888:Clasp2 UTSW 9 113,732,936 (GRCm39) missense possibly damaging 0.54
R8889:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8892:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8922:Clasp2 UTSW 9 113,725,728 (GRCm39) nonsense probably null
R9042:Clasp2 UTSW 9 113,735,065 (GRCm39) missense probably benign
R9195:Clasp2 UTSW 9 113,671,045 (GRCm39) missense probably benign 0.06
R9355:Clasp2 UTSW 9 113,664,309 (GRCm39) missense probably damaging 1.00
R9481:Clasp2 UTSW 9 113,670,669 (GRCm39) missense probably damaging 1.00
R9502:Clasp2 UTSW 9 113,737,866 (GRCm39) missense probably benign 0.01
R9523:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 0.98
R9525:Clasp2 UTSW 9 113,740,677 (GRCm39) missense probably damaging 1.00
R9653:Clasp2 UTSW 9 113,670,993 (GRCm39) missense probably benign 0.01
R9699:Clasp2 UTSW 9 113,738,614 (GRCm39) critical splice donor site probably null
R9738:Clasp2 UTSW 9 113,590,665 (GRCm39) nonsense probably null
R9775:Clasp2 UTSW 9 113,725,740 (GRCm39) missense probably benign
X0022:Clasp2 UTSW 9 113,681,740 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,599,289 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,737,863 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGTTGCCACAGATGACGAG -3'
(R):5'- CATGGGATCAAGAACAGTATGTC -3'

Sequencing Primer
(F):5'- TGCCACAGATGACGAGTTTATG -3'
(R):5'- TGGGATCAAGAACAGTATGTCTGATC -3'
Posted On 2019-05-13