Incidental Mutation 'R7032:Or1p1c'
ID 546400
Institutional Source Beutler Lab
Gene Symbol Or1p1c
Ensembl Gene ENSMUSG00000070375
Gene Name olfactory receptor family 1 subfamily P member 1C
Synonyms Olfr406, MOR133-1, Olfr406-ps, GA_x6K02T2P1NL-4415162-4416133
MMRRC Submission 045133-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # R7032 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 74160217-74161188 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 74160428 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 71 (I71T)
Ref Sequence ENSEMBL: ENSMUSP00000148929 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000133561] [ENSMUST00000214303] [ENSMUST00000217016]
AlphaFold Q7TRX0
Predicted Effect possibly damaging
Transcript: ENSMUST00000133561
AA Change: I71T

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000125963
Gene: ENSMUSG00000070375
AA Change: I71T

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 3.5e-56 PFAM
Pfam:7tm_1 41 292 3e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214303
AA Change: I71T

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217016
AA Change: I71T

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik T A 5: 88,120,438 (GRCm39) D398E possibly damaging Het
Adam34 T C 8: 44,105,303 (GRCm39) Y114C probably damaging Het
Akap9 T A 5: 4,004,896 (GRCm39) D156E probably benign Het
Apba1 T A 19: 23,889,825 (GRCm39) S408T probably benign Het
Asb14 C T 14: 26,625,412 (GRCm39) H256Y probably benign Het
Atf6 A T 1: 170,627,181 (GRCm39) probably null Het
Atp6v1b2 T A 8: 69,541,548 (GRCm39) V35E probably benign Het
Atp8a2 T C 14: 60,255,289 (GRCm39) probably null Het
Ccdc170 C A 10: 4,432,597 (GRCm39) P12Q unknown Het
Cdh23 C T 10: 60,167,567 (GRCm39) E1810K probably damaging Het
Cdo1 A T 18: 46,853,475 (GRCm39) F94L probably damaging Het
Cfap96 T G 8: 46,409,474 (GRCm39) S282R probably damaging Het
Chdh C T 14: 29,758,809 (GRCm39) P585S possibly damaging Het
Clasp2 A G 9: 113,683,391 (GRCm39) N407S probably benign Het
Clca3a1 T A 3: 144,453,329 (GRCm39) S465C probably benign Het
Clip2 C A 5: 134,551,484 (GRCm39) V213L probably damaging Het
Col6a6 A G 9: 105,644,707 (GRCm39) S1194P probably damaging Het
Cyp7a1 T C 4: 6,268,463 (GRCm39) T421A possibly damaging Het
Dhh C T 15: 98,791,907 (GRCm39) G367E possibly damaging Het
Dnah5 A G 15: 28,326,796 (GRCm39) N2002D probably damaging Het
Epn2 T A 11: 61,437,528 (GRCm39) N15Y probably damaging Het
Evi5 A C 5: 107,936,147 (GRCm39) V647G probably benign Het
Eya1 T C 1: 14,353,424 (GRCm39) probably null Het
Fam120a A G 13: 49,102,589 (GRCm39) V222A probably benign Het
Fastkd5 A T 2: 130,457,864 (GRCm39) I242K possibly damaging Het
Hnrnpul1 A G 7: 25,450,319 (GRCm39) M131T probably benign Het
Ice1 T C 13: 70,744,283 (GRCm39) N2100S probably damaging Het
Ifi205 T A 1: 173,855,916 (GRCm39) D38V possibly damaging Het
Klhl9 G A 4: 88,639,843 (GRCm39) Q133* probably null Het
Krt84 T C 15: 101,436,924 (GRCm39) E370G probably benign Het
Lrrc4c T C 2: 97,459,410 (GRCm39) I12T probably benign Het
Lrriq4 T A 3: 30,709,850 (GRCm39) L398* probably null Het
Ltf G A 9: 110,855,198 (GRCm39) probably null Het
Macf1 C T 4: 123,366,101 (GRCm39) V1322I probably benign Het
Mark2 T A 19: 7,264,698 (GRCm39) I112L probably damaging Het
Mettl25b A G 3: 87,831,649 (GRCm39) probably null Het
Mterf2 A T 10: 84,956,527 (GRCm39) C32* probably null Het
Myo3b C T 2: 69,925,608 (GRCm39) T25I probably damaging Het
Nsun7 A C 5: 66,421,378 (GRCm39) I115L probably benign Het
Olfm3 G A 3: 114,883,805 (GRCm39) V36M probably damaging Het
Or5d44 T C 2: 88,141,373 (GRCm39) T256A probably benign Het
Or8b3 A T 9: 38,314,965 (GRCm39) Y262F possibly damaging Het
Or8g18 A T 9: 39,148,983 (GRCm39) S246T possibly damaging Het
Pcdhgb8 A T 18: 37,896,962 (GRCm39) R677S probably benign Het
Prrt4 A C 6: 29,170,538 (GRCm39) L638R possibly damaging Het
Ptk2 G A 15: 73,093,658 (GRCm39) P854S possibly damaging Het
Rab44 T C 17: 29,359,438 (GRCm39) F542S unknown Het
Rhobtb3 T A 13: 76,020,513 (GRCm39) E596D probably benign Het
Rpl36 T C 17: 56,920,944 (GRCm39) I44T probably benign Het
Rptor A G 11: 119,737,762 (GRCm39) I112V probably benign Het
Rxfp2 T C 5: 149,993,813 (GRCm39) I611T probably damaging Het
Slc12a4 G T 8: 106,675,865 (GRCm39) N553K probably damaging Het
Spata31d1d T A 13: 59,876,046 (GRCm39) R496S probably benign Het
Strbp T C 2: 37,493,125 (GRCm39) D387G possibly damaging Het
Tas2r107 A T 6: 131,636,153 (GRCm39) C299S possibly damaging Het
Tbc1d21 A T 9: 58,274,134 (GRCm39) probably null Het
Tdrd12 A T 7: 35,180,471 (GRCm39) Y847* probably null Het
Tlr2 A T 3: 83,745,212 (GRCm39) N290K probably benign Het
Tmppe A G 9: 114,234,858 (GRCm39) T386A probably damaging Het
Tnks1bp1 C A 2: 84,892,297 (GRCm39) H741Q probably benign Het
Trpc6 G A 9: 8,609,951 (GRCm39) V140M probably damaging Het
Ttn T C 2: 76,641,932 (GRCm39) D13427G probably damaging Het
Uba7 C A 9: 107,853,371 (GRCm39) L106I possibly damaging Het
Unc5b T G 10: 60,614,587 (GRCm39) T237P probably damaging Het
Vit A C 17: 78,932,294 (GRCm39) D467A probably damaging Het
Vmn1r103 T C 7: 20,243,780 (GRCm39) Y227C possibly damaging Het
Vmn1r77 T A 7: 11,776,017 (GRCm39) Y196* probably null Het
Zhx3 A G 2: 160,622,898 (GRCm39) V423A probably damaging Het
Other mutations in Or1p1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Or1p1c APN 11 74,160,325 (GRCm39) missense probably benign 0.01
IGL01480:Or1p1c APN 11 74,160,427 (GRCm39) missense possibly damaging 0.64
IGL02138:Or1p1c APN 11 74,160,544 (GRCm39) missense probably benign 0.01
IGL02986:Or1p1c APN 11 74,160,928 (GRCm39) missense possibly damaging 0.82
R0018:Or1p1c UTSW 11 74,160,934 (GRCm39) missense probably benign 0.39
R1822:Or1p1c UTSW 11 74,161,066 (GRCm39) missense probably benign 0.11
R1823:Or1p1c UTSW 11 74,161,043 (GRCm39) missense probably damaging 1.00
R1956:Or1p1c UTSW 11 74,160,670 (GRCm39) missense probably damaging 1.00
R2017:Or1p1c UTSW 11 74,161,159 (GRCm39) missense probably benign
R2879:Or1p1c UTSW 11 74,161,049 (GRCm39) missense probably damaging 1.00
R3854:Or1p1c UTSW 11 74,161,105 (GRCm39) nonsense probably null
R4750:Or1p1c UTSW 11 74,160,246 (GRCm39) missense probably benign 0.00
R6076:Or1p1c UTSW 11 74,161,088 (GRCm39) missense probably damaging 1.00
R6257:Or1p1c UTSW 11 74,160,833 (GRCm39) missense probably damaging 1.00
R6431:Or1p1c UTSW 11 74,160,235 (GRCm39) missense possibly damaging 0.95
R7216:Or1p1c UTSW 11 74,160,550 (GRCm39) missense probably damaging 1.00
R7429:Or1p1c UTSW 11 74,160,579 (GRCm39) missense probably damaging 1.00
R8144:Or1p1c UTSW 11 74,160,384 (GRCm39) missense probably damaging 0.98
R8161:Or1p1c UTSW 11 74,160,544 (GRCm39) missense probably benign 0.01
R8847:Or1p1c UTSW 11 74,160,443 (GRCm39) missense probably damaging 1.00
R8872:Or1p1c UTSW 11 74,160,120 (GRCm39) splice site probably benign
R8977:Or1p1c UTSW 11 74,160,304 (GRCm39) missense probably benign 0.02
R9049:Or1p1c UTSW 11 74,161,115 (GRCm39) missense possibly damaging 0.80
R9336:Or1p1c UTSW 11 74,160,743 (GRCm39) missense probably damaging 0.98
R9596:Or1p1c UTSW 11 74,160,289 (GRCm39) missense probably benign
R9771:Or1p1c UTSW 11 74,160,635 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GACCAGCACCTTTGAGTTCC -3'
(R):5'- GCGTTGGAAGCTCATGATCATC -3'

Sequencing Primer
(F):5'- TGAGTTCCTCCTCTGGGGAC -3'
(R):5'- GCTCATGATCATCCTATAGTGGAGAG -3'
Posted On 2019-05-13