Incidental Mutation 'R7033:Ints2'
ID 546470
Institutional Source Beutler Lab
Gene Symbol Ints2
Ensembl Gene ENSMUSG00000018068
Gene Name integrator complex subunit 2
Synonyms 2810417D08Rik
MMRRC Submission 045134-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7033 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 86210681-86257575 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 86233085 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 626 (G626R)
Ref Sequence ENSEMBL: ENSMUSP00000103674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018212] [ENSMUST00000108039]
AlphaFold Q80UK8
Predicted Effect probably damaging
Transcript: ENSMUST00000018212
AA Change: G626R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000018212
Gene: ENSMUSG00000018068
AA Change: G626R

DomainStartEndE-ValueType
Pfam:INTS2 24 1131 N/A PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000108039
AA Change: G626R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000103674
Gene: ENSMUSG00000018068
AA Change: G626R

DomainStartEndE-ValueType
Pfam:INTS2 24 1132 N/A PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127745
Predicted Effect probably benign
Transcript: ENSMUST00000134828
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134883
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143819
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146421
Meta Mutation Damage Score 0.3327 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 96% (70/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700024B05Rik A G 14: 41,997,417 (GRCm38) Y105C probably damaging Het
2610301B20Rik A G 4: 10,898,014 (GRCm38) T199A probably benign Het
Acr T C 15: 89,569,500 (GRCm38) S81P probably benign Het
Akr1c14 T C 13: 4,079,178 (GRCm38) probably null Het
Ank2 C A 3: 126,944,850 (GRCm38) E2375* probably null Het
Avpi1 A G 19: 42,124,977 (GRCm38) W14R probably damaging Het
Brd4 A G 17: 32,199,015 (GRCm38) V55A probably benign Het
Casp8ap2 A G 4: 32,639,392 (GRCm38) N149D probably damaging Het
Ccl25 A T 8: 4,349,641 (GRCm38) probably benign Het
Celf5 A G 10: 81,462,714 (GRCm38) L299P probably damaging Het
Cfap57 T G 4: 118,613,126 (GRCm38) T186P possibly damaging Het
Chrm4 A G 2: 91,928,347 (GRCm38) M367V probably benign Het
Col1a2 A T 6: 4,516,904 (GRCm38) probably benign Het
Crybg3 G A 16: 59,554,165 (GRCm38) P2242L probably damaging Het
Cspg4 T C 9: 56,888,074 (GRCm38) V1031A probably damaging Het
Dbnl C A 11: 5,798,102 (GRCm38) P313T probably benign Het
Dnah1 A G 14: 31,264,925 (GRCm38) F3637L probably damaging Het
Dnah7a A T 1: 53,479,661 (GRCm38) I2979N probably damaging Het
Dusp10 T C 1: 184,037,605 (GRCm38) V256A possibly damaging Het
Erlin2 T C 8: 27,031,764 (GRCm38) V164A probably benign Het
Fam110a T C 2: 151,970,211 (GRCm38) D213G probably damaging Het
Fkbp1a T C 2: 151,557,500 (GRCm38) probably null Het
Foxg1 G A 12: 49,384,720 (GRCm38) probably benign Het
Gm12185 T C 11: 48,915,999 (GRCm38) S122G probably benign Het
Gm2042 A T 12: 87,960,281 (GRCm38) D456V probably damaging Het
Gm8857 G T 5: 10,950,551 (GRCm38) probably null Het
Grin2b A G 6: 135,923,038 (GRCm38) Y282H probably damaging Het
Gys2 T C 6: 142,472,722 (GRCm38) D27G probably benign Het
H2-DMa T A 17: 34,136,997 (GRCm38) probably null Het
Hectd4 T A 5: 121,364,568 (GRCm38) I4245N possibly damaging Het
Incenp A G 19: 9,893,372 (GRCm38) Y298H unknown Het
Kifc1 A T 17: 33,883,697 (GRCm38) V314E probably damaging Het
Lurap1l C T 4: 80,911,367 (GRCm38) P5S probably benign Het
Mtmr11 A G 3: 96,169,946 (GRCm38) Y540C probably damaging Het
Muc4 C A 16: 32,756,324 (GRCm38) probably benign Het
Myh13 A G 11: 67,369,316 (GRCm38) E1860G possibly damaging Het
Myl10 G C 5: 136,697,971 (GRCm38) V70L probably benign Het
Nbeal1 G A 1: 60,310,947 (GRCm38) G2385D probably damaging Het
Ncaph2 G A 15: 89,371,356 (GRCm38) A578T probably benign Het
Ncr1 T C 7: 4,338,145 (GRCm38) V8A possibly damaging Het
Nutm1 T C 2: 112,256,168 (GRCm38) T73A probably damaging Het
Olfm1 G A 2: 28,229,336 (GRCm38) D313N probably damaging Het
Olfr1196 T A 2: 88,700,820 (GRCm38) N170Y probably damaging Het
Olfr275 A G 4: 52,826,089 (GRCm38) M231V probably benign Het
Olfr749 A G 14: 50,736,707 (GRCm38) F152L possibly damaging Het
Otog T A 7: 46,267,398 (GRCm38) probably null Het
Peak1 G T 9: 56,259,707 (GRCm38) D312E probably damaging Het
Plekhg1 T C 10: 3,940,251 (GRCm38) I331T probably damaging Het
Polr1b T C 2: 129,115,642 (GRCm38) V539A possibly damaging Het
Polr2a A T 11: 69,747,213 (GRCm38) H143Q possibly damaging Het
Ppargc1b G T 18: 61,307,714 (GRCm38) A711D probably damaging Het
Prnd T A 2: 131,953,442 (GRCm38) C161S possibly damaging Het
Prrt4 A G 6: 29,171,148 (GRCm38) L435P possibly damaging Het
Psen2 C T 1: 180,227,520 (GRCm38) probably null Het
Psg23 T C 7: 18,614,744 (GRCm38) E46G possibly damaging Het
Rasgef1b C T 5: 99,232,336 (GRCm38) R350H probably damaging Het
Rfxank G C 8: 70,138,170 (GRCm38) P16A probably benign Het
Sema6a A G 18: 47,248,570 (GRCm38) I944T probably damaging Het
Serpinc1 A G 1: 160,997,521 (GRCm38) T313A probably benign Het
Slc27a4 T C 2: 29,804,271 (GRCm38) S36P possibly damaging Het
Slc36a1 C A 11: 55,223,737 (GRCm38) R214S probably benign Het
Sorl1 C T 9: 42,030,983 (GRCm38) S982N possibly damaging Het
Syt1 A C 10: 108,690,936 (GRCm38) D37E probably benign Het
Tcl1b5 A T 12: 105,176,491 (GRCm38) D26V probably damaging Het
Tenm4 A T 7: 96,895,223 (GRCm38) K2149* probably null Het
Ubc T A 5: 125,388,174 (GRCm38) I30F probably damaging Het
Ugt1a7c A T 1: 88,095,528 (GRCm38) E136D possibly damaging Het
Utp20 A G 10: 88,754,475 (GRCm38) probably null Het
Vmn1r159 C T 7: 22,842,864 (GRCm38) V248I probably damaging Het
Vmn2r105 T C 17: 20,208,612 (GRCm38) H734R probably damaging Het
Wdr60 T C 12: 116,211,891 (GRCm38) M889V probably benign Het
Xrcc2 T G 5: 25,692,709 (GRCm38) I81L possibly damaging Het
Zfat A C 15: 68,181,015 (GRCm38) I310S probably damaging Het
Zfp119a A G 17: 55,866,009 (GRCm38) V278A probably benign Het
Zfp53 A G 17: 21,500,246 (GRCm38) K33E probably benign Het
Zfp866 G T 8: 69,765,841 (GRCm38) H376Q probably damaging Het
Other mutations in Ints2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ints2 APN 11 86,233,135 (GRCm38) missense probably damaging 1.00
IGL02490:Ints2 APN 11 86,233,183 (GRCm38) missense possibly damaging 0.93
IGL02612:Ints2 APN 11 86,215,578 (GRCm38) missense probably damaging 1.00
IGL03396:Ints2 APN 11 86,213,062 (GRCm38) missense probably damaging 0.99
R0015:Ints2 UTSW 11 86,249,287 (GRCm38) missense probably damaging 1.00
R0015:Ints2 UTSW 11 86,249,287 (GRCm38) missense probably damaging 1.00
R0355:Ints2 UTSW 11 86,234,749 (GRCm38) missense probably benign 0.00
R0389:Ints2 UTSW 11 86,248,851 (GRCm38) missense probably damaging 1.00
R0631:Ints2 UTSW 11 86,233,196 (GRCm38) missense probably benign 0.02
R0944:Ints2 UTSW 11 86,244,463 (GRCm38) missense possibly damaging 0.85
R1268:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1269:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1270:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1396:Ints2 UTSW 11 86,249,248 (GRCm38) missense probably damaging 0.98
R1474:Ints2 UTSW 11 86,226,781 (GRCm38) missense probably damaging 0.97
R1503:Ints2 UTSW 11 86,226,781 (GRCm38) missense probably damaging 0.97
R1840:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1987:Ints2 UTSW 11 86,217,800 (GRCm38) missense probably benign 0.03
R1990:Ints2 UTSW 11 86,248,934 (GRCm38) missense possibly damaging 0.58
R1991:Ints2 UTSW 11 86,248,934 (GRCm38) missense possibly damaging 0.58
R3694:Ints2 UTSW 11 86,243,001 (GRCm38) missense probably benign 0.41
R4056:Ints2 UTSW 11 86,242,952 (GRCm38) missense probably damaging 1.00
R4057:Ints2 UTSW 11 86,242,952 (GRCm38) missense probably damaging 1.00
R4569:Ints2 UTSW 11 86,256,198 (GRCm38) missense probably damaging 1.00
R4585:Ints2 UTSW 11 86,249,275 (GRCm38) missense probably damaging 1.00
R4586:Ints2 UTSW 11 86,249,275 (GRCm38) missense probably damaging 1.00
R4806:Ints2 UTSW 11 86,256,209 (GRCm38) missense probably benign 0.10
R4929:Ints2 UTSW 11 86,212,653 (GRCm38) missense possibly damaging 0.56
R5031:Ints2 UTSW 11 86,256,200 (GRCm38) missense probably damaging 1.00
R5064:Ints2 UTSW 11 86,249,274 (GRCm38) missense probably damaging 1.00
R5270:Ints2 UTSW 11 86,215,795 (GRCm38) missense probably damaging 1.00
R5621:Ints2 UTSW 11 86,242,947 (GRCm38) missense probably benign 0.32
R5875:Ints2 UTSW 11 86,238,312 (GRCm38) missense probably benign 0.04
R5908:Ints2 UTSW 11 86,215,545 (GRCm38) critical splice donor site probably null
R5914:Ints2 UTSW 11 86,222,174 (GRCm38) missense probably benign 0.03
R5941:Ints2 UTSW 11 86,250,972 (GRCm38) missense probably benign 0.01
R5975:Ints2 UTSW 11 86,226,748 (GRCm38) missense possibly damaging 0.72
R6003:Ints2 UTSW 11 86,238,468 (GRCm38) missense probably damaging 1.00
R6091:Ints2 UTSW 11 86,236,603 (GRCm38) missense probably damaging 0.96
R6209:Ints2 UTSW 11 86,225,058 (GRCm38) missense probably damaging 1.00
R6567:Ints2 UTSW 11 86,226,661 (GRCm38) missense probably benign 0.42
R6764:Ints2 UTSW 11 86,212,779 (GRCm38) missense probably benign 0.00
R7132:Ints2 UTSW 11 86,217,754 (GRCm38) missense probably benign 0.26
R7337:Ints2 UTSW 11 86,217,842 (GRCm38) missense probably benign 0.00
R7410:Ints2 UTSW 11 86,233,226 (GRCm38) missense probably benign 0.02
R7483:Ints2 UTSW 11 86,215,618 (GRCm38) missense probably damaging 1.00
R7503:Ints2 UTSW 11 86,232,055 (GRCm38) missense probably benign
R7804:Ints2 UTSW 11 86,212,663 (GRCm38) missense possibly damaging 0.92
R7845:Ints2 UTSW 11 86,238,263 (GRCm38) missense possibly damaging 0.93
R7875:Ints2 UTSW 11 86,213,062 (GRCm38) missense probably damaging 0.99
R7918:Ints2 UTSW 11 86,222,217 (GRCm38) missense probably damaging 1.00
R7922:Ints2 UTSW 11 86,244,627 (GRCm38) missense probably benign 0.29
R8058:Ints2 UTSW 11 86,255,353 (GRCm38) missense probably benign 0.05
R8134:Ints2 UTSW 11 86,212,660 (GRCm38) missense probably damaging 1.00
R8189:Ints2 UTSW 11 86,215,570 (GRCm38) missense probably damaging 1.00
R8295:Ints2 UTSW 11 86,225,088 (GRCm38) missense probably damaging 0.97
R8348:Ints2 UTSW 11 86,255,423 (GRCm38) missense probably benign
R8448:Ints2 UTSW 11 86,255,423 (GRCm38) missense probably benign
R8784:Ints2 UTSW 11 86,225,115 (GRCm38) nonsense probably null
R8784:Ints2 UTSW 11 86,222,137 (GRCm38) missense probably damaging 1.00
R8942:Ints2 UTSW 11 86,212,894 (GRCm38) missense probably benign 0.00
R9037:Ints2 UTSW 11 86,215,704 (GRCm38) missense probably benign
R9154:Ints2 UTSW 11 86,234,698 (GRCm38) missense probably damaging 1.00
R9397:Ints2 UTSW 11 86,244,485 (GRCm38) missense probably benign 0.01
R9412:Ints2 UTSW 11 86,226,763 (GRCm38) missense probably damaging 0.99
R9472:Ints2 UTSW 11 86,242,998 (GRCm38) missense
R9476:Ints2 UTSW 11 86,244,509 (GRCm38) missense probably benign
R9510:Ints2 UTSW 11 86,244,509 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGAGGCTTCAAAACAACTCCTTG -3'
(R):5'- ACTGGATTTACAGACAGCTATGTG -3'

Sequencing Primer
(F):5'- ATGAGTTTGCGACTACCCAG -3'
(R):5'- TACAGACAGCTATGTGAAACTTCC -3'
Posted On 2019-05-13