Incidental Mutation 'R7033:Sema6a'
| ID |
546489 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sema6a
|
| Ensembl Gene |
ENSMUSG00000019647 |
| Gene Name |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A |
| Synonyms |
VIa, Semaq, Sema6A-1, sema, A730020P05Rik |
| MMRRC Submission |
045134-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7033 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
18 |
| Chromosomal Location |
47378321-47504267 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 47381637 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 944
(I944T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000111109
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019791]
[ENSMUST00000076043]
[ENSMUST00000115449]
[ENSMUST00000135790]
[ENSMUST00000156422]
|
| AlphaFold |
O35464 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000019791
AA Change: I970T
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000019791
Gene: ENSMUSG00000019647
AA Change: I970T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000076043
AA Change: I915T
PolyPhen 2
Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000075420
Gene: ENSMUSG00000019647
AA Change: I915T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
593 |
615 |
N/A |
INTRINSIC |
|
low complexity region
|
877 |
896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115449
AA Change: I944T
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000111109
Gene: ENSMUSG00000019647
AA Change: I944T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
461 |
1.24e-168 |
SMART |
|
PSI
|
488 |
543 |
9.57e-1 |
SMART |
|
transmembrane domain
|
622 |
644 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
925 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123228
|
| SMART Domains |
Protein: ENSMUSP00000120249
Gene: ENSMUSG00000019647
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:PSI
|
2 |
45 |
4e-26 |
BLAST |
|
PDB:3OKY|B
|
2 |
47 |
2e-26 |
PDB |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000135790
AA Change: I987T
PolyPhen 2
Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000120011
Gene: ENSMUSG00000019647
AA Change: I987T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
665 |
687 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
968 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000156422
AA Change: I970T
PolyPhen 2
Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000121442
Gene: ENSMUSG00000019647
AA Change: I970T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Sema
|
56 |
487 |
1.06e-185 |
SMART |
|
PSI
|
514 |
569 |
9.57e-1 |
SMART |
|
transmembrane domain
|
648 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
932 |
951 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0741 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
96% (70/73) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit defects in lamina-specific neurite stratification of specific retinal neuron subtypes and disruption of the dendritic plexus organization of On but not Off starburst amacrine cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700024B05Rik |
A |
G |
14: 41,819,374 (GRCm39) |
Y105C |
probably damaging |
Het |
| Acr |
T |
C |
15: 89,453,703 (GRCm39) |
S81P |
probably benign |
Het |
| Akr1c14 |
T |
C |
13: 4,129,178 (GRCm39) |
|
probably null |
Het |
| Ank2 |
C |
A |
3: 126,738,499 (GRCm39) |
E2375* |
probably null |
Het |
| Avpi1 |
A |
G |
19: 42,113,416 (GRCm39) |
W14R |
probably damaging |
Het |
| Brd4 |
A |
G |
17: 32,417,989 (GRCm39) |
V55A |
probably benign |
Het |
| Casp8ap2 |
A |
G |
4: 32,639,392 (GRCm39) |
N149D |
probably damaging |
Het |
| Ccl25 |
A |
T |
8: 4,399,641 (GRCm39) |
|
probably benign |
Het |
| Celf5 |
A |
G |
10: 81,298,548 (GRCm39) |
L299P |
probably damaging |
Het |
| Cfap418 |
A |
G |
4: 10,898,014 (GRCm39) |
T199A |
probably benign |
Het |
| Cfap57 |
T |
G |
4: 118,470,323 (GRCm39) |
T186P |
possibly damaging |
Het |
| Chrm4 |
A |
G |
2: 91,758,692 (GRCm39) |
M367V |
probably benign |
Het |
| Col1a2 |
A |
T |
6: 4,516,904 (GRCm39) |
|
probably benign |
Het |
| Crybg3 |
G |
A |
16: 59,374,528 (GRCm39) |
P2242L |
probably damaging |
Het |
| Cspg4 |
T |
C |
9: 56,795,358 (GRCm39) |
V1031A |
probably damaging |
Het |
| Dbnl |
C |
A |
11: 5,748,102 (GRCm39) |
P313T |
probably benign |
Het |
| Dnah1 |
A |
G |
14: 30,986,882 (GRCm39) |
F3637L |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,518,820 (GRCm39) |
I2979N |
probably damaging |
Het |
| Dusp10 |
T |
C |
1: 183,769,802 (GRCm39) |
V256A |
possibly damaging |
Het |
| Dync2i1 |
T |
C |
12: 116,175,511 (GRCm39) |
M889V |
probably benign |
Het |
| Erlin2 |
T |
C |
8: 27,521,792 (GRCm39) |
V164A |
probably benign |
Het |
| Fam110a |
T |
C |
2: 151,812,131 (GRCm39) |
D213G |
probably damaging |
Het |
| Fkbp1a |
T |
C |
2: 151,399,420 (GRCm39) |
|
probably null |
Het |
| Foxg1 |
G |
A |
12: 49,431,503 (GRCm39) |
|
probably benign |
Het |
| Gm12185 |
T |
C |
11: 48,806,826 (GRCm39) |
S122G |
probably benign |
Het |
| Gm2042 |
A |
T |
12: 87,927,051 (GRCm39) |
D456V |
probably damaging |
Het |
| Grin2b |
A |
G |
6: 135,900,036 (GRCm39) |
Y282H |
probably damaging |
Het |
| Gys2 |
T |
C |
6: 142,418,448 (GRCm39) |
D27G |
probably benign |
Het |
| H2-DMa |
T |
A |
17: 34,355,971 (GRCm39) |
|
probably null |
Het |
| Hectd4 |
T |
A |
5: 121,502,631 (GRCm39) |
I4245N |
possibly damaging |
Het |
| Incenp |
A |
G |
19: 9,870,736 (GRCm39) |
Y298H |
unknown |
Het |
| Ints2 |
C |
T |
11: 86,123,911 (GRCm39) |
G626R |
probably damaging |
Het |
| Kifc1 |
A |
T |
17: 34,102,671 (GRCm39) |
V314E |
probably damaging |
Het |
| Lurap1l |
C |
T |
4: 80,829,604 (GRCm39) |
P5S |
probably benign |
Het |
| Mtmr11 |
A |
G |
3: 96,077,262 (GRCm39) |
Y540C |
probably damaging |
Het |
| Muc4 |
C |
A |
16: 32,576,698 (GRCm39) |
|
probably benign |
Het |
| Myh13 |
A |
G |
11: 67,260,142 (GRCm39) |
E1860G |
possibly damaging |
Het |
| Myl10 |
G |
C |
5: 136,726,825 (GRCm39) |
V70L |
probably benign |
Het |
| Nbeal1 |
G |
A |
1: 60,350,106 (GRCm39) |
G2385D |
probably damaging |
Het |
| Ncaph2 |
G |
A |
15: 89,255,559 (GRCm39) |
A578T |
probably benign |
Het |
| Ncr1 |
T |
C |
7: 4,341,144 (GRCm39) |
V8A |
possibly damaging |
Het |
| Nutm1 |
T |
C |
2: 112,086,513 (GRCm39) |
T73A |
probably damaging |
Het |
| Olfm1 |
G |
A |
2: 28,119,348 (GRCm39) |
D313N |
probably damaging |
Het |
| Or11h4 |
A |
G |
14: 50,974,164 (GRCm39) |
F152L |
possibly damaging |
Het |
| Or13f5 |
A |
G |
4: 52,826,089 (GRCm39) |
M231V |
probably benign |
Het |
| Or4a66 |
T |
A |
2: 88,531,164 (GRCm39) |
N170Y |
probably damaging |
Het |
| Otog |
T |
A |
7: 45,916,822 (GRCm39) |
|
probably null |
Het |
| Peak1 |
G |
T |
9: 56,166,991 (GRCm39) |
D312E |
probably damaging |
Het |
| Plekhg1 |
T |
C |
10: 3,890,251 (GRCm39) |
I331T |
probably damaging |
Het |
| Polr1b |
T |
C |
2: 128,957,562 (GRCm39) |
V539A |
possibly damaging |
Het |
| Polr2a |
A |
T |
11: 69,638,039 (GRCm39) |
H143Q |
possibly damaging |
Het |
| Ppargc1b |
G |
T |
18: 61,440,785 (GRCm39) |
A711D |
probably damaging |
Het |
| Prnd |
T |
A |
2: 131,795,362 (GRCm39) |
C161S |
possibly damaging |
Het |
| Prrt4 |
A |
G |
6: 29,171,147 (GRCm39) |
L435P |
possibly damaging |
Het |
| Psen2 |
C |
T |
1: 180,055,085 (GRCm39) |
|
probably null |
Het |
| Psg23 |
T |
C |
7: 18,348,669 (GRCm39) |
E46G |
possibly damaging |
Het |
| Rasgef1b |
C |
T |
5: 99,380,195 (GRCm39) |
R350H |
probably damaging |
Het |
| Rfxank |
G |
C |
8: 70,590,820 (GRCm39) |
P16A |
probably benign |
Het |
| Serpinc1 |
A |
G |
1: 160,825,091 (GRCm39) |
T313A |
probably benign |
Het |
| Slc27a4 |
T |
C |
2: 29,694,283 (GRCm39) |
S36P |
possibly damaging |
Het |
| Slc36a1 |
C |
A |
11: 55,114,563 (GRCm39) |
R214S |
probably benign |
Het |
| Sorl1 |
C |
T |
9: 41,942,279 (GRCm39) |
S982N |
possibly damaging |
Het |
| Speer1k |
G |
T |
5: 11,000,518 (GRCm39) |
|
probably null |
Het |
| Syt1 |
A |
C |
10: 108,526,797 (GRCm39) |
D37E |
probably benign |
Het |
| Tcl1b5 |
A |
T |
12: 105,142,750 (GRCm39) |
D26V |
probably damaging |
Het |
| Tenm4 |
A |
T |
7: 96,544,430 (GRCm39) |
K2149* |
probably null |
Het |
| Ubc |
T |
A |
5: 125,465,238 (GRCm39) |
I30F |
probably damaging |
Het |
| Ugt1a7c |
A |
T |
1: 88,023,250 (GRCm39) |
E136D |
possibly damaging |
Het |
| Utp20 |
A |
G |
10: 88,590,337 (GRCm39) |
|
probably null |
Het |
| Vmn1r159 |
C |
T |
7: 22,542,289 (GRCm39) |
V248I |
probably damaging |
Het |
| Vmn2r105 |
T |
C |
17: 20,428,874 (GRCm39) |
H734R |
probably damaging |
Het |
| Xrcc2 |
T |
G |
5: 25,897,707 (GRCm39) |
I81L |
possibly damaging |
Het |
| Zfat |
A |
C |
15: 68,052,864 (GRCm39) |
I310S |
probably damaging |
Het |
| Zfp119a |
A |
G |
17: 56,173,009 (GRCm39) |
V278A |
probably benign |
Het |
| Zfp53 |
A |
G |
17: 21,720,508 (GRCm39) |
K33E |
probably benign |
Het |
| Zfp866 |
G |
T |
8: 70,218,491 (GRCm39) |
H376Q |
probably damaging |
Het |
|
| Other mutations in Sema6a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Sema6a
|
APN |
18 |
47,423,042 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01351:Sema6a
|
APN |
18 |
47,414,369 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01594:Sema6a
|
APN |
18 |
47,381,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01953:Sema6a
|
APN |
18 |
47,423,187 (GRCm39) |
nonsense |
probably null |
|
|
IGL02077:Sema6a
|
APN |
18 |
47,416,465 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02632:Sema6a
|
APN |
18 |
47,423,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02957:Sema6a
|
APN |
18 |
47,382,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03013:Sema6a
|
APN |
18 |
47,381,461 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03279:Sema6a
|
APN |
18 |
47,433,157 (GRCm39) |
nonsense |
probably null |
|
|
saphire
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
IGL02988:Sema6a
|
UTSW |
18 |
47,431,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0114:Sema6a
|
UTSW |
18 |
47,423,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0312:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0347:Sema6a
|
UTSW |
18 |
47,424,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0350:Sema6a
|
UTSW |
18 |
47,403,785 (GRCm39) |
missense |
probably benign |
|
|
R0366:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0368:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0391:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0403:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0466:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0515:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0517:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0542:Sema6a
|
UTSW |
18 |
47,381,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0557:Sema6a
|
UTSW |
18 |
47,382,567 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0569:Sema6a
|
UTSW |
18 |
47,403,872 (GRCm39) |
splice site |
probably null |
|
|
R0650:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0689:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0694:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0726:Sema6a
|
UTSW |
18 |
47,425,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0821:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0824:Sema6a
|
UTSW |
18 |
47,423,112 (GRCm39) |
splice site |
probably null |
|
|
R0924:Sema6a
|
UTSW |
18 |
47,381,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1108:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1255:Sema6a
|
UTSW |
18 |
47,382,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Sema6a
|
UTSW |
18 |
47,439,498 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1531:Sema6a
|
UTSW |
18 |
47,382,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1707:Sema6a
|
UTSW |
18 |
47,416,512 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1746:Sema6a
|
UTSW |
18 |
47,439,416 (GRCm39) |
splice site |
probably benign |
|
|
R1807:Sema6a
|
UTSW |
18 |
47,409,491 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1974:Sema6a
|
UTSW |
18 |
47,403,696 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1987:Sema6a
|
UTSW |
18 |
47,433,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2044:Sema6a
|
UTSW |
18 |
47,439,496 (GRCm39) |
nonsense |
probably null |
|
|
R3719:Sema6a
|
UTSW |
18 |
47,382,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4491:Sema6a
|
UTSW |
18 |
47,439,524 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R4552:Sema6a
|
UTSW |
18 |
47,424,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Sema6a
|
UTSW |
18 |
47,381,779 (GRCm39) |
missense |
probably benign |
0.43 |
|
R4710:Sema6a
|
UTSW |
18 |
47,403,750 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4713:Sema6a
|
UTSW |
18 |
47,382,363 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4963:Sema6a
|
UTSW |
18 |
47,431,318 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5088:Sema6a
|
UTSW |
18 |
47,382,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5133:Sema6a
|
UTSW |
18 |
47,433,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Sema6a
|
UTSW |
18 |
47,424,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5141:Sema6a
|
UTSW |
18 |
47,381,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5277:Sema6a
|
UTSW |
18 |
47,409,611 (GRCm39) |
intron |
probably benign |
|
|
R5551:Sema6a
|
UTSW |
18 |
47,381,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5618:Sema6a
|
UTSW |
18 |
47,415,015 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5717:Sema6a
|
UTSW |
18 |
47,382,330 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5729:Sema6a
|
UTSW |
18 |
47,414,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5779:Sema6a
|
UTSW |
18 |
47,381,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5917:Sema6a
|
UTSW |
18 |
47,414,405 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6054:Sema6a
|
UTSW |
18 |
47,416,470 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6142:Sema6a
|
UTSW |
18 |
47,414,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6209:Sema6a
|
UTSW |
18 |
47,431,369 (GRCm39) |
splice site |
probably null |
|
|
R6307:Sema6a
|
UTSW |
18 |
47,382,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6734:Sema6a
|
UTSW |
18 |
47,412,236 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7014:Sema6a
|
UTSW |
18 |
47,431,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Sema6a
|
UTSW |
18 |
47,424,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8054:Sema6a
|
UTSW |
18 |
47,424,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8250:Sema6a
|
UTSW |
18 |
47,423,182 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8408:Sema6a
|
UTSW |
18 |
47,381,958 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8411:Sema6a
|
UTSW |
18 |
47,382,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8900:Sema6a
|
UTSW |
18 |
47,424,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9140:Sema6a
|
UTSW |
18 |
47,415,009 (GRCm39) |
missense |
probably benign |
|
|
R9158:Sema6a
|
UTSW |
18 |
47,431,330 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9488:Sema6a
|
UTSW |
18 |
47,437,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Sema6a
|
UTSW |
18 |
47,382,594 (GRCm39) |
missense |
probably null |
1.00 |
|
R9652:Sema6a
|
UTSW |
18 |
47,382,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9732:Sema6a
|
UTSW |
18 |
47,381,925 (GRCm39) |
missense |
probably damaging |
0.96 |
|
X0065:Sema6a
|
UTSW |
18 |
47,416,386 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATCGGATGCTTCAACTCCTGG -3'
(R):5'- TCCTATGGGCTCGAATATAAGAGG -3'
Sequencing Primer
(F):5'- AACCCCTGGGATTATGTACATGC -3'
(R):5'- GCTCGAATATAAGAGGAGCTACCC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation