Incidental Mutation 'R7034:Vmn2r93'
| ID |
546572 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r93
|
| Ensembl Gene |
ENSMUSG00000079698 |
| Gene Name |
vomeronasal 2, receptor 93 |
| Synonyms |
EG627132 |
| MMRRC Submission |
045135-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.084)
|
| Stock # |
R7034 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
18518543-18546703 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 18546672 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 848
(H848L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078200
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079206]
[ENSMUST00000231879]
[ENSMUST00000231938]
|
| AlphaFold |
L7N1Z9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079206
AA Change: H848L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000078200
Gene: ENSMUSG00000079698
AA Change: H848L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
453 |
5.9e-40 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
2.6e-21 |
PFAM |
|
Pfam:7tm_3
|
594 |
830 |
1.5e-50 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231879
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231938
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017N19Rik |
T |
A |
10: 100,445,118 (GRCm39) |
|
probably null |
Het |
| Adamts1 |
T |
A |
16: 85,599,634 (GRCm39) |
|
probably benign |
Het |
| Aff4 |
A |
G |
11: 53,299,236 (GRCm39) |
K979E |
probably damaging |
Het |
| Aftph |
A |
T |
11: 20,642,498 (GRCm39) |
M845K |
probably damaging |
Het |
| Akt2 |
T |
C |
7: 27,336,437 (GRCm39) |
|
probably null |
Het |
| Aldh1a7 |
A |
T |
19: 20,685,542 (GRCm39) |
L336Q |
possibly damaging |
Het |
| Ank3 |
C |
T |
10: 69,835,209 (GRCm39) |
T680M |
probably damaging |
Het |
| Apeh |
T |
C |
9: 107,971,470 (GRCm39) |
E59G |
possibly damaging |
Het |
| Armc8 |
C |
T |
9: 99,366,018 (GRCm39) |
|
probably null |
Het |
| Armh3 |
A |
G |
19: 45,953,688 (GRCm39) |
I195T |
probably damaging |
Het |
| Atp2b1 |
C |
T |
10: 98,823,172 (GRCm39) |
T244I |
probably damaging |
Het |
| Btaf1 |
C |
A |
19: 36,981,869 (GRCm39) |
T1633K |
probably benign |
Het |
| Cacng8 |
A |
G |
7: 3,463,819 (GRCm39) |
S324G |
probably benign |
Het |
| Calcr |
T |
A |
6: 3,692,543 (GRCm39) |
Q400L |
probably damaging |
Het |
| Caprin2 |
G |
A |
6: 148,749,703 (GRCm39) |
P536S |
possibly damaging |
Het |
| Ccdc54 |
A |
T |
16: 50,410,951 (GRCm39) |
M105K |
probably benign |
Het |
| Ccna1 |
T |
C |
3: 54,953,460 (GRCm39) |
E381G |
possibly damaging |
Het |
| Cd2ap |
A |
T |
17: 43,109,490 (GRCm39) |
L623Q |
probably damaging |
Het |
| Cdkl3 |
A |
G |
11: 51,918,042 (GRCm39) |
E415G |
probably benign |
Het |
| Chd5 |
C |
A |
4: 152,445,398 (GRCm39) |
L430I |
possibly damaging |
Het |
| Clspn |
G |
A |
4: 126,474,775 (GRCm39) |
E975K |
possibly damaging |
Het |
| Cobl |
C |
A |
11: 12,204,177 (GRCm39) |
V835F |
probably damaging |
Het |
| D430041D05Rik |
C |
A |
2: 104,022,883 (GRCm39) |
R1037L |
probably damaging |
Het |
| Derl1 |
A |
G |
15: 57,742,443 (GRCm39) |
|
probably null |
Het |
| Dhrs9 |
T |
G |
2: 69,223,520 (GRCm39) |
N89K |
probably benign |
Het |
| Erich1 |
A |
G |
8: 14,114,330 (GRCm39) |
I60T |
probably benign |
Het |
| Fam184a |
A |
T |
10: 53,570,910 (GRCm39) |
S408T |
possibly damaging |
Het |
| Fcgr4 |
T |
A |
1: 170,847,657 (GRCm39) |
M85K |
probably benign |
Het |
| Foxj3 |
A |
G |
4: 119,476,497 (GRCm39) |
E259G |
probably damaging |
Het |
| Galnt11 |
T |
C |
5: 25,463,811 (GRCm39) |
I361T |
probably damaging |
Het |
| Gck |
A |
G |
11: 5,851,747 (GRCm39) |
S441P |
probably damaging |
Het |
| Gdap1l1 |
G |
T |
2: 163,288,065 (GRCm39) |
V98F |
probably damaging |
Het |
| Gramd1a |
A |
G |
7: 30,832,181 (GRCm39) |
|
probably null |
Het |
| H2ac21 |
C |
T |
3: 96,127,304 (GRCm39) |
Q25* |
probably null |
Het |
| Herc3 |
A |
T |
6: 58,853,840 (GRCm39) |
M629L |
probably benign |
Het |
| Hoxc12 |
G |
A |
15: 102,846,795 (GRCm39) |
G229D |
probably damaging |
Het |
| Hycc2 |
T |
A |
1: 58,574,696 (GRCm39) |
M282L |
probably benign |
Het |
| Itga9 |
T |
C |
9: 118,527,433 (GRCm39) |
L528P |
probably benign |
Het |
| Krt39 |
A |
C |
11: 99,412,062 (GRCm39) |
V8G |
probably benign |
Het |
| Krt71 |
A |
G |
15: 101,646,772 (GRCm39) |
I312T |
probably benign |
Het |
| Lrrc37 |
T |
A |
11: 103,506,638 (GRCm39) |
|
probably benign |
Het |
| Mllt11 |
A |
G |
3: 95,127,744 (GRCm39) |
Y9H |
probably damaging |
Het |
| Mrgpra3 |
G |
T |
7: 47,239,838 (GRCm39) |
N29K |
possibly damaging |
Het |
| Mug1 |
A |
G |
6: 121,850,603 (GRCm39) |
T700A |
probably benign |
Het |
| Myl1 |
T |
C |
1: 66,969,395 (GRCm39) |
N79S |
probably damaging |
Het |
| Myo18b |
G |
A |
5: 112,871,770 (GRCm39) |
Q2104* |
probably null |
Het |
| Nalf1 |
G |
A |
8: 9,820,589 (GRCm39) |
P144S |
possibly damaging |
Het |
| Ndufs2 |
T |
C |
1: 171,065,877 (GRCm39) |
D256G |
probably benign |
Het |
| Nek5 |
T |
C |
8: 22,597,739 (GRCm39) |
N280S |
probably benign |
Het |
| Nwd2 |
A |
T |
5: 63,962,258 (GRCm39) |
N614I |
probably damaging |
Het |
| Or6c88 |
G |
A |
10: 129,406,941 (GRCm39) |
C139Y |
possibly damaging |
Het |
| Parp1 |
G |
T |
1: 180,425,817 (GRCm39) |
K849N |
possibly damaging |
Het |
| Pcnx2 |
T |
C |
8: 126,512,041 (GRCm39) |
T1422A |
probably damaging |
Het |
| Plce1 |
A |
G |
19: 38,727,801 (GRCm39) |
N1520S |
probably damaging |
Het |
| Ppcdc |
T |
C |
9: 57,322,453 (GRCm39) |
T149A |
probably damaging |
Het |
| Ppl |
A |
G |
16: 4,905,366 (GRCm39) |
V1643A |
probably benign |
Het |
| Pramel23 |
A |
T |
4: 143,423,898 (GRCm39) |
I297N |
probably damaging |
Het |
| Prrx1 |
T |
A |
1: 163,075,907 (GRCm39) |
M220L |
probably benign |
Het |
| Pspc1 |
A |
C |
14: 56,996,085 (GRCm39) |
|
probably null |
Het |
| Ptpn20 |
A |
G |
14: 33,336,392 (GRCm39) |
*44W |
probably null |
Het |
| Qars1 |
T |
A |
9: 108,391,976 (GRCm39) |
V83E |
probably damaging |
Het |
| Rbm33 |
T |
C |
5: 28,599,496 (GRCm39) |
M956T |
unknown |
Het |
| Sash1 |
C |
A |
10: 8,605,847 (GRCm39) |
E848* |
probably null |
Het |
| Scai |
T |
A |
2: 39,011,147 (GRCm39) |
Y163F |
probably damaging |
Het |
| Serpinf2 |
A |
T |
11: 75,329,244 (GRCm39) |
|
probably benign |
Het |
| Sgo2b |
T |
A |
8: 64,379,868 (GRCm39) |
H988L |
probably benign |
Het |
| Sh2b2 |
G |
A |
5: 136,247,739 (GRCm39) |
T604I |
probably benign |
Het |
| Skint4 |
A |
T |
4: 112,015,281 (GRCm39) |
I449F |
possibly damaging |
Het |
| Slc30a2 |
A |
G |
4: 134,074,653 (GRCm39) |
I88V |
possibly damaging |
Het |
| Smug1 |
A |
G |
15: 103,064,369 (GRCm39) |
L184P |
probably damaging |
Het |
| Spatc1 |
A |
G |
15: 76,168,080 (GRCm39) |
T180A |
probably benign |
Het |
| Ssr1 |
A |
T |
13: 38,178,001 (GRCm39) |
L20Q |
probably null |
Het |
| Supt4a |
A |
G |
11: 87,634,084 (GRCm39) |
E100G |
probably damaging |
Het |
| Teddm2 |
T |
C |
1: 153,726,320 (GRCm39) |
I132V |
probably benign |
Het |
| Tmem131 |
C |
T |
1: 36,832,054 (GRCm39) |
G1861E |
possibly damaging |
Het |
| Tpr |
A |
T |
1: 150,299,358 (GRCm39) |
H1186L |
probably benign |
Het |
| Trim34b |
A |
T |
7: 103,978,743 (GRCm39) |
|
probably benign |
Het |
| Trpm2 |
T |
C |
10: 77,748,426 (GRCm39) |
M1415V |
probably benign |
Het |
| Ttll12 |
A |
G |
15: 83,471,086 (GRCm39) |
F264S |
probably benign |
Het |
| Vmn2r59 |
T |
C |
7: 41,695,644 (GRCm39) |
E256G |
probably benign |
Het |
| Vps35l |
T |
C |
7: 118,372,315 (GRCm39) |
S290P |
probably damaging |
Het |
| Wdfy3 |
G |
A |
5: 102,055,384 (GRCm39) |
T1562I |
probably damaging |
Het |
| Ybey |
T |
C |
10: 76,304,197 (GRCm39) |
S2G |
possibly damaging |
Het |
| Zfp346 |
A |
T |
13: 55,280,200 (GRCm39) |
Q308L |
probably benign |
Het |
|
| Other mutations in Vmn2r93 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00743:Vmn2r93
|
APN |
17 |
18,546,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01326:Vmn2r93
|
APN |
17 |
18,536,906 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01328:Vmn2r93
|
APN |
17 |
18,545,819 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01360:Vmn2r93
|
APN |
17 |
18,525,510 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01382:Vmn2r93
|
APN |
17 |
18,533,578 (GRCm39) |
nonsense |
probably null |
|
|
IGL01463:Vmn2r93
|
APN |
17 |
18,525,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02057:Vmn2r93
|
APN |
17 |
18,546,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02257:Vmn2r93
|
APN |
17 |
18,545,770 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02686:Vmn2r93
|
APN |
17 |
18,533,526 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02720:Vmn2r93
|
APN |
17 |
18,525,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03328:Vmn2r93
|
APN |
17 |
18,525,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4576001:Vmn2r93
|
UTSW |
17 |
18,533,473 (GRCm39) |
missense |
probably benign |
|
|
R0067:Vmn2r93
|
UTSW |
17 |
18,546,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0067:Vmn2r93
|
UTSW |
17 |
18,546,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0240:Vmn2r93
|
UTSW |
17 |
18,525,061 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0240:Vmn2r93
|
UTSW |
17 |
18,525,061 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0488:Vmn2r93
|
UTSW |
17 |
18,546,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0667:Vmn2r93
|
UTSW |
17 |
18,546,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0668:Vmn2r93
|
UTSW |
17 |
18,518,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0850:Vmn2r93
|
UTSW |
17 |
18,525,279 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0924:Vmn2r93
|
UTSW |
17 |
18,524,443 (GRCm39) |
missense |
probably benign |
|
|
R0947:Vmn2r93
|
UTSW |
17 |
18,524,343 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1124:Vmn2r93
|
UTSW |
17 |
18,518,710 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1584:Vmn2r93
|
UTSW |
17 |
18,525,413 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1943:Vmn2r93
|
UTSW |
17 |
18,546,063 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2012:Vmn2r93
|
UTSW |
17 |
18,536,840 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2018:Vmn2r93
|
UTSW |
17 |
18,546,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2196:Vmn2r93
|
UTSW |
17 |
18,525,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Vmn2r93
|
UTSW |
17 |
18,518,665 (GRCm39) |
missense |
probably benign |
|
|
R2864:Vmn2r93
|
UTSW |
17 |
18,546,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4276:Vmn2r93
|
UTSW |
17 |
18,525,092 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4446:Vmn2r93
|
UTSW |
17 |
18,524,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4537:Vmn2r93
|
UTSW |
17 |
18,525,194 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4674:Vmn2r93
|
UTSW |
17 |
18,525,255 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4726:Vmn2r93
|
UTSW |
17 |
18,536,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4936:Vmn2r93
|
UTSW |
17 |
18,524,327 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4984:Vmn2r93
|
UTSW |
17 |
18,533,389 (GRCm39) |
splice site |
probably null |
|
|
R5111:Vmn2r93
|
UTSW |
17 |
18,546,326 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5749:Vmn2r93
|
UTSW |
17 |
18,518,546 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5918:Vmn2r93
|
UTSW |
17 |
18,546,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5921:Vmn2r93
|
UTSW |
17 |
18,546,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6091:Vmn2r93
|
UTSW |
17 |
18,545,958 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6283:Vmn2r93
|
UTSW |
17 |
18,524,366 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6680:Vmn2r93
|
UTSW |
17 |
18,536,920 (GRCm39) |
nonsense |
probably null |
|
|
R6876:Vmn2r93
|
UTSW |
17 |
18,525,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6963:Vmn2r93
|
UTSW |
17 |
18,536,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6996:Vmn2r93
|
UTSW |
17 |
18,524,903 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Vmn2r93
|
UTSW |
17 |
18,533,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7036:Vmn2r93
|
UTSW |
17 |
18,546,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7246:Vmn2r93
|
UTSW |
17 |
18,546,012 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7258:Vmn2r93
|
UTSW |
17 |
18,525,403 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7323:Vmn2r93
|
UTSW |
17 |
18,533,497 (GRCm39) |
nonsense |
probably null |
|
|
R7325:Vmn2r93
|
UTSW |
17 |
18,524,249 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7390:Vmn2r93
|
UTSW |
17 |
18,525,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Vmn2r93
|
UTSW |
17 |
18,546,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7428:Vmn2r93
|
UTSW |
17 |
18,546,672 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Vmn2r93
|
UTSW |
17 |
18,546,248 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7453:Vmn2r93
|
UTSW |
17 |
18,533,580 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7562:Vmn2r93
|
UTSW |
17 |
18,518,731 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7662:Vmn2r93
|
UTSW |
17 |
18,525,631 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7682:Vmn2r93
|
UTSW |
17 |
18,525,583 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7704:Vmn2r93
|
UTSW |
17 |
18,536,910 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7772:Vmn2r93
|
UTSW |
17 |
18,533,482 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7957:Vmn2r93
|
UTSW |
17 |
18,545,954 (GRCm39) |
nonsense |
probably null |
|
|
R8276:Vmn2r93
|
UTSW |
17 |
18,525,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8290:Vmn2r93
|
UTSW |
17 |
18,524,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8362:Vmn2r93
|
UTSW |
17 |
18,546,353 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8376:Vmn2r93
|
UTSW |
17 |
18,525,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8870:Vmn2r93
|
UTSW |
17 |
18,525,320 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8925:Vmn2r93
|
UTSW |
17 |
18,546,500 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8927:Vmn2r93
|
UTSW |
17 |
18,546,500 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8954:Vmn2r93
|
UTSW |
17 |
18,546,252 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9038:Vmn2r93
|
UTSW |
17 |
18,524,471 (GRCm39) |
missense |
probably benign |
|
|
R9131:Vmn2r93
|
UTSW |
17 |
18,546,143 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9205:Vmn2r93
|
UTSW |
17 |
18,524,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9530:Vmn2r93
|
UTSW |
17 |
18,518,562 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1088:Vmn2r93
|
UTSW |
17 |
18,546,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r93
|
UTSW |
17 |
18,525,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCGGGAGTTATACCATGGCC -3'
(R):5'- AGCTGAATCACCAGAGCAAATG -3'
Sequencing Primer
(F):5'- TTGCCTGATACATTCAACGAATCC -3'
(R):5'- TCACCAGAGCAAATGTAGTGATC -3'
|
| Posted On |
2019-05-13 |
Incidental Mutation