Incidental Mutation 'R7035:Zfp663'
ID 546586
Institutional Source Beutler Lab
Gene Symbol Zfp663
Ensembl Gene ENSMUSG00000056824
Gene Name zinc finger protein 663
Synonyms LOC381405, Gm1008
MMRRC Submission 045136-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R7035 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 165193217-165210649 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 165195023 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 399 (S399P)
Ref Sequence ENSEMBL: ENSMUSP00000099374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073062] [ENSMUST00000103085] [ENSMUST00000141140]
AlphaFold Q6NXM6
Predicted Effect probably benign
Transcript: ENSMUST00000073062
AA Change: S399P

PolyPhen 2 Score 0.361 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000072813
Gene: ENSMUSG00000056824
AA Change: S399P

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103085
AA Change: S399P

PolyPhen 2 Score 0.361 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000099374
Gene: ENSMUSG00000056824
AA Change: S399P

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000141140
SMART Domains Protein: ENSMUSP00000115254
Gene: ENSMUSG00000056824

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T A 3: 68,777,272 (GRCm39) F78I probably benign Het
1700102P08Rik A T 9: 108,272,510 (GRCm39) D140V possibly damaging Het
6430548M08Rik A T 8: 120,879,225 (GRCm39) S208C probably damaging Het
Abcd4 G T 12: 84,662,123 (GRCm39) T41K probably damaging Het
Acaca C T 11: 84,129,769 (GRCm39) R375C probably damaging Het
Acad11 T A 9: 103,990,694 (GRCm39) V433D probably damaging Het
Adal T A 2: 120,985,942 (GRCm39) C226S probably benign Het
Aldh3b2 A T 19: 4,028,142 (GRCm39) M95L probably benign Het
Ano4 A G 10: 88,790,573 (GRCm39) F842S probably damaging Het
Ap5s1 T C 2: 131,054,732 (GRCm39) F181S probably damaging Het
Apba1 G A 19: 23,894,931 (GRCm39) D456N possibly damaging Het
Armh4 T A 14: 50,010,507 (GRCm39) H400L possibly damaging Het
Atp6v0a1 A C 11: 100,918,183 (GRCm39) Q199H probably damaging Het
Atp8a1 C G 5: 67,938,373 (GRCm39) G161A probably benign Het
Atxn2 C T 5: 121,949,530 (GRCm39) Q61* probably null Het
Cacna2d1 T A 5: 16,451,670 (GRCm39) I178K probably damaging Het
Catsperb A C 12: 101,381,593 (GRCm39) T92P probably damaging Het
Ccdc175 A G 12: 72,202,419 (GRCm39) I292T probably benign Het
Cep290 T A 10: 100,334,933 (GRCm39) S318T probably benign Het
Cfb T A 17: 35,079,007 (GRCm39) Y826F possibly damaging Het
Cntn1 C A 15: 92,212,392 (GRCm39) D851E probably benign Het
Coq6 A G 12: 84,415,415 (GRCm39) D146G probably damaging Het
Crem G A 18: 3,327,503 (GRCm39) T12I probably damaging Het
Dennd4c G A 4: 86,730,574 (GRCm39) V824I probably damaging Het
Dnase2b C T 3: 146,288,096 (GRCm39) C333Y probably damaging Het
Dop1a T A 9: 86,406,355 (GRCm39) F365I possibly damaging Het
Dysf A T 6: 84,163,374 (GRCm39) I1570F probably benign Het
Eml1 T A 12: 108,475,493 (GRCm39) C275S probably damaging Het
Fam135b A C 15: 71,334,102 (GRCm39) S1031A possibly damaging Het
Gga2 T C 7: 121,588,939 (GRCm39) D596G probably damaging Het
Gin1 A C 1: 97,720,100 (GRCm39) Y365S possibly damaging Het
Gipr T A 7: 18,896,809 (GRCm39) I154F probably damaging Het
Gm5478 A T 15: 101,553,632 (GRCm39) I284N possibly damaging Het
Gnat1 A T 9: 107,553,827 (GRCm39) probably benign Het
Gsdmc A T 15: 63,650,569 (GRCm39) probably null Het
Lama1 T A 17: 68,088,044 (GRCm39) I1554N Het
Mycbp2 T A 14: 103,412,417 (GRCm39) T2519S probably benign Het
Mylk G A 16: 34,797,352 (GRCm39) V1604M possibly damaging Het
Mypop C T 7: 18,725,922 (GRCm39) probably benign Het
Nol6 A T 4: 41,118,479 (GRCm39) V774E probably benign Het
Nol8 T C 13: 49,814,678 (GRCm39) V262A probably benign Het
Npepps A T 11: 97,113,965 (GRCm39) V637D probably damaging Het
Or1e16 T C 11: 73,286,544 (GRCm39) I101M probably benign Het
Or4f52 A G 2: 111,061,784 (GRCm39) M118T probably damaging Het
Or5p52 T C 7: 107,502,140 (GRCm39) V72A probably benign Het
Pcdhgb8 A T 18: 37,896,201 (GRCm39) I424F possibly damaging Het
Phf7 A C 14: 30,961,183 (GRCm39) W231G probably damaging Het
Plagl1 A G 10: 13,003,977 (GRCm39) probably benign Het
Plat A T 8: 23,262,327 (GRCm39) D117V probably benign Het
Prkag2 T C 5: 25,152,564 (GRCm39) Y180C probably damaging Het
Prpf8 T C 11: 75,395,654 (GRCm39) I1927T possibly damaging Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Rad17 T A 13: 100,764,133 (GRCm39) D446V possibly damaging Het
Ralgapa2 G T 2: 146,353,777 (GRCm39) Q15K probably damaging Het
Ret A G 6: 118,140,247 (GRCm39) Y982H probably damaging Het
Rnf145 T A 11: 44,452,583 (GRCm39) S521T probably damaging Het
Samd4 G A 14: 47,326,620 (GRCm39) silent Het
Sardh T C 2: 27,120,854 (GRCm39) D390G probably damaging Het
Saxo1 T C 4: 86,363,359 (GRCm39) T375A probably damaging Het
Scly A G 1: 91,236,125 (GRCm39) T126A probably damaging Het
Slc6a16 T A 7: 44,910,251 (GRCm39) V307D probably damaging Het
Sned1 T C 1: 93,189,852 (GRCm39) C320R probably damaging Het
Sspo G A 6: 48,426,147 (GRCm39) probably null Het
Sycp2l C T 13: 41,310,973 (GRCm39) T645I unknown Het
Tpmt T C 13: 47,193,584 (GRCm39) K72E probably damaging Het
Tsbp1 C T 17: 34,679,305 (GRCm39) probably benign Het
Ube2q2l G A 6: 136,378,347 (GRCm39) T161M possibly damaging Het
Vmn1r51 A T 6: 90,106,207 (GRCm39) H41L probably benign Het
Wdfy3 A T 5: 102,003,415 (GRCm39) I2900N probably damaging Het
Zfp692 T C 11: 58,200,268 (GRCm39) probably null Het
Other mutations in Zfp663
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Zfp663 APN 2 165,194,525 (GRCm39) missense probably damaging 1.00
IGL01382:Zfp663 APN 2 165,200,935 (GRCm39) missense probably damaging 1.00
IGL02007:Zfp663 APN 2 165,200,993 (GRCm39) missense probably benign 0.12
IGL02164:Zfp663 APN 2 165,200,968 (GRCm39) nonsense probably null
IGL02506:Zfp663 APN 2 165,195,871 (GRCm39) missense probably benign 0.35
IGL03173:Zfp663 APN 2 165,194,419 (GRCm39) missense probably damaging 0.99
R0735:Zfp663 UTSW 2 165,200,995 (GRCm39) missense probably damaging 0.97
R1395:Zfp663 UTSW 2 165,194,492 (GRCm39) missense probably damaging 1.00
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1503:Zfp663 UTSW 2 165,194,573 (GRCm39) missense probably damaging 0.99
R1587:Zfp663 UTSW 2 165,195,437 (GRCm39) missense probably benign
R1854:Zfp663 UTSW 2 165,195,211 (GRCm39) missense probably benign 0.18
R1867:Zfp663 UTSW 2 165,194,651 (GRCm39) missense possibly damaging 0.74
R3031:Zfp663 UTSW 2 165,195,616 (GRCm39) nonsense probably null
R4643:Zfp663 UTSW 2 165,194,925 (GRCm39) missense probably benign 0.24
R4691:Zfp663 UTSW 2 165,201,050 (GRCm39) intron probably benign
R4977:Zfp663 UTSW 2 165,195,731 (GRCm39) missense probably damaging 0.97
R5135:Zfp663 UTSW 2 165,195,590 (GRCm39) missense possibly damaging 0.95
R5151:Zfp663 UTSW 2 165,195,113 (GRCm39) missense probably benign 0.00
R5639:Zfp663 UTSW 2 165,194,929 (GRCm39) missense probably benign 0.03
R5763:Zfp663 UTSW 2 165,200,355 (GRCm39) nonsense probably null
R6776:Zfp663 UTSW 2 165,200,935 (GRCm39) missense probably damaging 1.00
R6929:Zfp663 UTSW 2 165,195,178 (GRCm39) missense probably benign
R6998:Zfp663 UTSW 2 165,195,922 (GRCm39) missense possibly damaging 0.74
R7169:Zfp663 UTSW 2 165,194,359 (GRCm39) missense probably benign 0.00
R7529:Zfp663 UTSW 2 165,194,728 (GRCm39) missense probably damaging 1.00
R7790:Zfp663 UTSW 2 165,194,453 (GRCm39) missense probably damaging 1.00
R8087:Zfp663 UTSW 2 165,195,679 (GRCm39) missense probably benign 0.20
R8715:Zfp663 UTSW 2 165,194,644 (GRCm39) missense probably damaging 1.00
R8934:Zfp663 UTSW 2 165,194,714 (GRCm39) missense probably damaging 1.00
R8966:Zfp663 UTSW 2 165,194,958 (GRCm39) missense probably damaging 1.00
R9257:Zfp663 UTSW 2 165,195,974 (GRCm39) missense probably benign 0.00
R9278:Zfp663 UTSW 2 165,202,010 (GRCm39) critical splice acceptor site probably null
R9524:Zfp663 UTSW 2 165,195,607 (GRCm39) missense probably damaging 0.99
RF004:Zfp663 UTSW 2 165,200,363 (GRCm39) missense probably benign 0.00
Z1177:Zfp663 UTSW 2 165,195,033 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AAGGCTTGCAGTCTTGGGAC -3'
(R):5'- CTCCAAAATGAGGAACTTCATGTGG -3'

Sequencing Primer
(F):5'- AGTCTTGGGACAGCCTTCC -3'
(R):5'- CTTCATGTGGGAGAGAAAATCTGTGC -3'
Posted On 2019-05-13