Incidental Mutation 'R7035:Armh4'
ID 546632
Institutional Source Beutler Lab
Gene Symbol Armh4
Ensembl Gene ENSMUSG00000036242
Gene Name armadillo-like helical domain containing 4
Synonyms 3632451O06Rik
MMRRC Submission 045136-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7035 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 49919017-50020843 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50010507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 400 (H400L)
Ref Sequence ENSEMBL: ENSMUSP00000113609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036972] [ENSMUST00000118129]
AlphaFold Q8BT18
Predicted Effect probably benign
Transcript: ENSMUST00000036972
AA Change: H400L

PolyPhen 2 Score 0.279 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000036220
Gene: ENSMUSG00000036242
AA Change: H400L

DomainStartEndE-ValueType
Pfam:DUF4696 48 609 3.8e-224 PFAM
transmembrane domain 714 736 N/A INTRINSIC
low complexity region 741 753 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000118129
AA Change: H400L

PolyPhen 2 Score 0.769 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000113609
Gene: ENSMUSG00000036242
AA Change: H400L

DomainStartEndE-ValueType
coiled coil region 603 644 N/A INTRINSIC
transmembrane domain 714 736 N/A INTRINSIC
low complexity region 741 754 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110032F04Rik T A 3: 68,777,272 (GRCm39) F78I probably benign Het
1700102P08Rik A T 9: 108,272,510 (GRCm39) D140V possibly damaging Het
6430548M08Rik A T 8: 120,879,225 (GRCm39) S208C probably damaging Het
Abcd4 G T 12: 84,662,123 (GRCm39) T41K probably damaging Het
Acaca C T 11: 84,129,769 (GRCm39) R375C probably damaging Het
Acad11 T A 9: 103,990,694 (GRCm39) V433D probably damaging Het
Adal T A 2: 120,985,942 (GRCm39) C226S probably benign Het
Aldh3b2 A T 19: 4,028,142 (GRCm39) M95L probably benign Het
Ano4 A G 10: 88,790,573 (GRCm39) F842S probably damaging Het
Ap5s1 T C 2: 131,054,732 (GRCm39) F181S probably damaging Het
Apba1 G A 19: 23,894,931 (GRCm39) D456N possibly damaging Het
Atp6v0a1 A C 11: 100,918,183 (GRCm39) Q199H probably damaging Het
Atp8a1 C G 5: 67,938,373 (GRCm39) G161A probably benign Het
Atxn2 C T 5: 121,949,530 (GRCm39) Q61* probably null Het
Cacna2d1 T A 5: 16,451,670 (GRCm39) I178K probably damaging Het
Catsperb A C 12: 101,381,593 (GRCm39) T92P probably damaging Het
Ccdc175 A G 12: 72,202,419 (GRCm39) I292T probably benign Het
Cep290 T A 10: 100,334,933 (GRCm39) S318T probably benign Het
Cfb T A 17: 35,079,007 (GRCm39) Y826F possibly damaging Het
Cntn1 C A 15: 92,212,392 (GRCm39) D851E probably benign Het
Coq6 A G 12: 84,415,415 (GRCm39) D146G probably damaging Het
Crem G A 18: 3,327,503 (GRCm39) T12I probably damaging Het
Dennd4c G A 4: 86,730,574 (GRCm39) V824I probably damaging Het
Dnase2b C T 3: 146,288,096 (GRCm39) C333Y probably damaging Het
Dop1a T A 9: 86,406,355 (GRCm39) F365I possibly damaging Het
Dysf A T 6: 84,163,374 (GRCm39) I1570F probably benign Het
Eml1 T A 12: 108,475,493 (GRCm39) C275S probably damaging Het
Fam135b A C 15: 71,334,102 (GRCm39) S1031A possibly damaging Het
Gga2 T C 7: 121,588,939 (GRCm39) D596G probably damaging Het
Gin1 A C 1: 97,720,100 (GRCm39) Y365S possibly damaging Het
Gipr T A 7: 18,896,809 (GRCm39) I154F probably damaging Het
Gm5478 A T 15: 101,553,632 (GRCm39) I284N possibly damaging Het
Gnat1 A T 9: 107,553,827 (GRCm39) probably benign Het
Gsdmc A T 15: 63,650,569 (GRCm39) probably null Het
Lama1 T A 17: 68,088,044 (GRCm39) I1554N Het
Mycbp2 T A 14: 103,412,417 (GRCm39) T2519S probably benign Het
Mylk G A 16: 34,797,352 (GRCm39) V1604M possibly damaging Het
Mypop C T 7: 18,725,922 (GRCm39) probably benign Het
Nol6 A T 4: 41,118,479 (GRCm39) V774E probably benign Het
Nol8 T C 13: 49,814,678 (GRCm39) V262A probably benign Het
Npepps A T 11: 97,113,965 (GRCm39) V637D probably damaging Het
Or1e16 T C 11: 73,286,544 (GRCm39) I101M probably benign Het
Or4f52 A G 2: 111,061,784 (GRCm39) M118T probably damaging Het
Or5p52 T C 7: 107,502,140 (GRCm39) V72A probably benign Het
Pcdhgb8 A T 18: 37,896,201 (GRCm39) I424F possibly damaging Het
Phf7 A C 14: 30,961,183 (GRCm39) W231G probably damaging Het
Plagl1 A G 10: 13,003,977 (GRCm39) probably benign Het
Plat A T 8: 23,262,327 (GRCm39) D117V probably benign Het
Prkag2 T C 5: 25,152,564 (GRCm39) Y180C probably damaging Het
Prpf8 T C 11: 75,395,654 (GRCm39) I1927T possibly damaging Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Rad17 T A 13: 100,764,133 (GRCm39) D446V possibly damaging Het
Ralgapa2 G T 2: 146,353,777 (GRCm39) Q15K probably damaging Het
Ret A G 6: 118,140,247 (GRCm39) Y982H probably damaging Het
Rnf145 T A 11: 44,452,583 (GRCm39) S521T probably damaging Het
Samd4 G A 14: 47,326,620 (GRCm39) silent Het
Sardh T C 2: 27,120,854 (GRCm39) D390G probably damaging Het
Saxo1 T C 4: 86,363,359 (GRCm39) T375A probably damaging Het
Scly A G 1: 91,236,125 (GRCm39) T126A probably damaging Het
Slc6a16 T A 7: 44,910,251 (GRCm39) V307D probably damaging Het
Sned1 T C 1: 93,189,852 (GRCm39) C320R probably damaging Het
Sspo G A 6: 48,426,147 (GRCm39) probably null Het
Sycp2l C T 13: 41,310,973 (GRCm39) T645I unknown Het
Tpmt T C 13: 47,193,584 (GRCm39) K72E probably damaging Het
Tsbp1 C T 17: 34,679,305 (GRCm39) probably benign Het
Ube2q2l G A 6: 136,378,347 (GRCm39) T161M possibly damaging Het
Vmn1r51 A T 6: 90,106,207 (GRCm39) H41L probably benign Het
Wdfy3 A T 5: 102,003,415 (GRCm39) I2900N probably damaging Het
Zfp663 A G 2: 165,195,023 (GRCm39) S399P probably benign Het
Zfp692 T C 11: 58,200,268 (GRCm39) probably null Het
Other mutations in Armh4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00470:Armh4 APN 14 50,010,460 (GRCm39) missense probably damaging 1.00
IGL00981:Armh4 APN 14 50,010,447 (GRCm39) missense probably damaging 1.00
IGL01447:Armh4 APN 14 50,005,923 (GRCm39) missense probably damaging 0.99
IGL01645:Armh4 APN 14 50,011,011 (GRCm39) missense probably damaging 1.00
IGL02135:Armh4 APN 14 50,011,386 (GRCm39) missense probably damaging 0.99
IGL02154:Armh4 APN 14 50,010,399 (GRCm39) missense possibly damaging 0.58
IGL02163:Armh4 APN 14 50,011,614 (GRCm39) missense possibly damaging 0.61
IGL03234:Armh4 APN 14 50,005,973 (GRCm39) missense probably damaging 1.00
P0014:Armh4 UTSW 14 49,989,116 (GRCm39) missense probably damaging 1.00
R0165:Armh4 UTSW 14 50,011,243 (GRCm39) missense probably benign
R0240:Armh4 UTSW 14 50,005,859 (GRCm39) splice site probably benign
R0553:Armh4 UTSW 14 49,920,143 (GRCm39) missense probably damaging 0.99
R0616:Armh4 UTSW 14 50,011,113 (GRCm39) missense possibly damaging 0.74
R0635:Armh4 UTSW 14 50,010,600 (GRCm39) missense probably benign 0.00
R1423:Armh4 UTSW 14 49,988,896 (GRCm39) missense probably damaging 1.00
R1547:Armh4 UTSW 14 50,010,953 (GRCm39) missense probably benign 0.01
R1642:Armh4 UTSW 14 50,005,867 (GRCm39) splice site probably null
R1657:Armh4 UTSW 14 50,011,017 (GRCm39) missense probably damaging 0.99
R1717:Armh4 UTSW 14 49,989,121 (GRCm39) missense probably damaging 0.99
R1875:Armh4 UTSW 14 49,919,815 (GRCm39) missense probably damaging 1.00
R1900:Armh4 UTSW 14 50,008,040 (GRCm39) missense probably damaging 1.00
R1916:Armh4 UTSW 14 50,005,932 (GRCm39) missense probably damaging 1.00
R1945:Armh4 UTSW 14 50,005,940 (GRCm39) missense probably damaging 1.00
R2102:Armh4 UTSW 14 50,011,459 (GRCm39) missense probably damaging 0.98
R2147:Armh4 UTSW 14 49,989,028 (GRCm39) missense probably benign 0.31
R2149:Armh4 UTSW 14 49,989,028 (GRCm39) missense probably benign 0.31
R3921:Armh4 UTSW 14 50,011,659 (GRCm39) missense probably benign 0.13
R4063:Armh4 UTSW 14 50,011,444 (GRCm39) missense probably benign 0.02
R4373:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4374:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4377:Armh4 UTSW 14 50,007,893 (GRCm39) missense probably damaging 1.00
R4589:Armh4 UTSW 14 50,011,039 (GRCm39) missense probably damaging 1.00
R4940:Armh4 UTSW 14 50,010,939 (GRCm39) missense probably benign 0.15
R4986:Armh4 UTSW 14 49,989,111 (GRCm39) missense probably damaging 0.97
R5047:Armh4 UTSW 14 50,007,895 (GRCm39) missense probably damaging 1.00
R5104:Armh4 UTSW 14 50,010,929 (GRCm39) missense possibly damaging 0.77
R5682:Armh4 UTSW 14 49,989,043 (GRCm39) missense probably damaging 1.00
R6357:Armh4 UTSW 14 50,010,769 (GRCm39) missense probably benign 0.10
R6478:Armh4 UTSW 14 50,010,789 (GRCm39) missense possibly damaging 0.61
R6673:Armh4 UTSW 14 50,008,049 (GRCm39) missense probably benign 0.00
R7054:Armh4 UTSW 14 50,011,155 (GRCm39) missense probably damaging 1.00
R7458:Armh4 UTSW 14 49,920,196 (GRCm39) missense probably damaging 1.00
R7536:Armh4 UTSW 14 50,011,703 (GRCm39) splice site probably null
R7944:Armh4 UTSW 14 50,010,670 (GRCm39) missense probably benign 0.25
R7945:Armh4 UTSW 14 50,010,670 (GRCm39) missense probably benign 0.25
R8049:Armh4 UTSW 14 50,010,993 (GRCm39) missense probably damaging 0.97
R8066:Armh4 UTSW 14 50,005,980 (GRCm39) missense possibly damaging 0.83
R8519:Armh4 UTSW 14 50,010,693 (GRCm39) missense probably damaging 1.00
R8765:Armh4 UTSW 14 49,920,100 (GRCm39) missense probably damaging 1.00
R8766:Armh4 UTSW 14 50,011,497 (GRCm39) missense probably damaging 1.00
R8833:Armh4 UTSW 14 50,011,318 (GRCm39) missense probably benign 0.17
R8936:Armh4 UTSW 14 50,008,024 (GRCm39) missense probably damaging 0.98
R9007:Armh4 UTSW 14 50,011,695 (GRCm39) missense probably damaging 0.99
R9122:Armh4 UTSW 14 50,011,459 (GRCm39) missense possibly damaging 0.64
R9406:Armh4 UTSW 14 50,010,945 (GRCm39) missense possibly damaging 0.93
R9741:Armh4 UTSW 14 50,008,081 (GRCm39) missense probably benign 0.06
X0026:Armh4 UTSW 14 49,920,193 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACAAAGCTTGGGGATGTTTTG -3'
(R):5'- CCAGGAGACAATGCAGAGACTC -3'

Sequencing Primer
(F):5'- AACACATTTCCTGCTTCCTGCTG -3'
(R):5'- CAATGCAGAGACTCAAATGAGAAC -3'
Posted On 2019-05-13