Incidental Mutation 'R7036:Med15'
ID 546724
Institutional Source Beutler Lab
Gene Symbol Med15
Ensembl Gene ENSMUSG00000012114
Gene Name mediator complex subunit 15
Synonyms A230074L19Rik, Pcqap
MMRRC Submission 045012-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R7036 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 17469072-17540811 bp(-) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 17516019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1 (M1K)
Ref Sequence ENSEMBL: ENSMUSP00000156242 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012259] [ENSMUST00000080936] [ENSMUST00000231413] [ENSMUST00000231674] [ENSMUST00000232202] [ENSMUST00000232645] [ENSMUST00000232236] [ENSMUST00000232431]
AlphaFold Q924H2
Predicted Effect probably benign
Transcript: ENSMUST00000012259
SMART Domains Protein: ENSMUSP00000012259
Gene: ENSMUSG00000012114

DomainStartEndE-ValueType
Pfam:Med15 17 789 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080936
SMART Domains Protein: ENSMUSP00000079737
Gene: ENSMUSG00000012114

DomainStartEndE-ValueType
Pfam:Med15 17 749 1.2e-276 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231413
Predicted Effect probably benign
Transcript: ENSMUST00000231674
Predicted Effect probably benign
Transcript: ENSMUST00000232163
Predicted Effect probably benign
Transcript: ENSMUST00000232202
Predicted Effect probably null
Transcript: ENSMUST00000232645
AA Change: M1K
Predicted Effect probably benign
Transcript: ENSMUST00000232236
Predicted Effect probably benign
Transcript: ENSMUST00000232431
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T A 10: 100,445,118 (GRCm39) probably null Het
Ahnak2 A G 12: 112,745,216 (GRCm39) probably benign Het
Akt2 T C 7: 27,336,437 (GRCm39) probably null Het
Aldh1a7 A T 19: 20,685,542 (GRCm39) L336Q possibly damaging Het
Ank2 T C 3: 126,740,041 (GRCm39) probably benign Het
Ank3 C T 10: 69,835,209 (GRCm39) T680M probably damaging Het
Apeh T C 9: 107,971,470 (GRCm39) E59G possibly damaging Het
Arl8a G C 1: 135,082,206 (GRCm39) E145Q probably benign Het
Armc8 C T 9: 99,366,018 (GRCm39) probably null Het
Armh3 A G 19: 45,953,688 (GRCm39) I195T probably damaging Het
Arsj T C 3: 126,158,649 (GRCm39) L76P probably damaging Het
Atp2b1 C T 10: 98,823,172 (GRCm39) T244I probably damaging Het
Bcl6 A T 16: 23,793,611 (GRCm39) L112Q probably damaging Het
Bfsp1 T A 2: 143,668,843 (GRCm39) T579S possibly damaging Het
Btaf1 C A 19: 36,981,869 (GRCm39) T1633K probably benign Het
Cacng8 A G 7: 3,463,819 (GRCm39) S324G probably benign Het
Cd2ap A T 17: 43,109,490 (GRCm39) L623Q probably damaging Het
Cerkl T C 2: 79,171,722 (GRCm39) I379V probably benign Het
Cndp2 T A 18: 84,688,070 (GRCm39) H307L possibly damaging Het
Derl1 A G 15: 57,742,443 (GRCm39) probably null Het
Dixdc1 T A 9: 50,593,864 (GRCm39) R254S probably benign Het
Dop1b T A 16: 93,574,378 (GRCm39) D30E probably benign Het
Duox2 T G 2: 122,110,934 (GRCm39) H1513P probably damaging Het
Dyrk1a G A 16: 94,487,427 (GRCm39) V546I probably benign Het
E130308A19Rik A C 4: 59,719,991 (GRCm39) K508Q probably damaging Het
Emc8 A T 8: 121,385,790 (GRCm39) V108E probably benign Het
Epb41l1 A G 2: 156,371,322 (GRCm39) T720A probably benign Het
Fcgr4 T A 1: 170,847,657 (GRCm39) M85K probably benign Het
Fem1b T A 9: 62,704,310 (GRCm39) I317F probably damaging Het
Focad A G 4: 88,042,874 (GRCm39) E36G probably benign Het
Fryl C T 5: 73,212,951 (GRCm39) E2275K probably benign Het
Galnt11 T C 5: 25,463,811 (GRCm39) I361T probably damaging Het
Garin3 G A 11: 46,298,235 (GRCm39) S513N Het
Gatad2a A T 8: 70,370,644 (GRCm39) N114K probably damaging Het
Gcnt2 CTAATG C 13: 41,041,032 (GRCm39) probably null Het
Gramd1a A G 7: 30,832,181 (GRCm39) probably null Het
Gsn T A 2: 35,182,611 (GRCm39) W187R probably damaging Het
Hoxc12 G A 15: 102,846,795 (GRCm39) G229D probably damaging Het
Hycc2 T A 1: 58,574,696 (GRCm39) M282L probably benign Het
Ints14 T C 9: 64,871,827 (GRCm39) V55A probably benign Het
Itga9 T C 9: 118,527,433 (GRCm39) L528P probably benign Het
Klf1 C T 8: 85,629,379 (GRCm39) S68F possibly damaging Het
Kmt2e A G 5: 23,683,741 (GRCm39) E333G probably null Het
Krt39 A C 11: 99,412,062 (GRCm39) V8G probably benign Het
Krt71 A G 15: 101,646,772 (GRCm39) I312T probably benign Het
Lrp1b T C 2: 41,002,354 (GRCm39) D2001G possibly damaging Het
Lrrc37 T A 11: 103,506,638 (GRCm39) probably benign Het
Lrrc71 T C 3: 87,655,693 (GRCm39) T27A probably benign Het
Lrrcc1 T C 3: 14,628,069 (GRCm39) V958A possibly damaging Het
Mrgpra3 G T 7: 47,239,838 (GRCm39) N29K possibly damaging Het
Myl1 T C 1: 66,969,395 (GRCm39) N79S probably damaging Het
Naip2 A T 13: 100,291,529 (GRCm39) D1136E probably benign Het
Nat10 T C 2: 103,584,453 (GRCm39) N108S probably benign Het
Ncald A T 15: 37,369,122 (GRCm39) S178T probably benign Het
Ndufs2 T C 1: 171,065,877 (GRCm39) D256G probably benign Het
Nek5 T C 8: 22,597,739 (GRCm39) N280S probably benign Het
Or5ak25 A G 2: 85,268,774 (GRCm39) S243P probably damaging Het
Or5d39 T A 2: 87,979,469 (GRCm39) D298V probably damaging Het
Parp1 G T 1: 180,425,817 (GRCm39) K849N possibly damaging Het
Pcdhb4 T A 18: 37,441,835 (GRCm39) C382S possibly damaging Het
Plce1 A G 19: 38,727,801 (GRCm39) N1520S probably damaging Het
Plcg2 G A 8: 118,323,045 (GRCm39) R700H probably benign Het
Popdc2 A T 16: 38,183,173 (GRCm39) Y52F probably damaging Het
Prrx1 T A 1: 163,075,907 (GRCm39) M220L probably benign Het
Pspc1 A C 14: 56,996,085 (GRCm39) probably null Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Ptpn20 A G 14: 33,336,392 (GRCm39) *44W probably null Het
Qars1 T A 9: 108,391,976 (GRCm39) V83E probably damaging Het
Rrh T C 3: 129,609,342 (GRCm39) E55G possibly damaging Het
Sash1 C A 10: 8,605,847 (GRCm39) E848* probably null Het
Sds A T 5: 120,618,912 (GRCm39) K125M possibly damaging Het
Serpinf2 A T 11: 75,329,244 (GRCm39) probably benign Het
Sh2b2 G A 5: 136,247,739 (GRCm39) T604I probably benign Het
Smug1 A G 15: 103,064,369 (GRCm39) L184P probably damaging Het
Spatc1 A G 15: 76,168,080 (GRCm39) T180A probably benign Het
Ssr1 A T 13: 38,178,001 (GRCm39) L20Q probably null Het
Supt4a A G 11: 87,634,084 (GRCm39) E100G probably damaging Het
Tbx1 G T 16: 18,405,551 (GRCm39) P38T unknown Het
Tcl1 T C 12: 105,183,860 (GRCm39) probably benign Het
Teddm2 T C 1: 153,726,320 (GRCm39) I132V probably benign Het
Tmem131 C T 1: 36,832,054 (GRCm39) G1861E possibly damaging Het
Tpr A T 1: 150,299,358 (GRCm39) H1186L probably benign Het
Trim34b A T 7: 103,978,743 (GRCm39) probably benign Het
Trpm2 T C 10: 77,748,426 (GRCm39) M1415V probably benign Het
Ttll12 A G 15: 83,471,086 (GRCm39) F264S probably benign Het
Vmn2r59 T C 7: 41,695,644 (GRCm39) E256G probably benign Het
Vmn2r93 A T 17: 18,546,672 (GRCm39) H848L probably benign Het
Vps35l T C 7: 118,372,315 (GRCm39) S290P probably damaging Het
Wdr70 T C 15: 7,913,855 (GRCm39) D598G possibly damaging Het
Ybey T C 10: 76,304,197 (GRCm39) S2G possibly damaging Het
Zfp346 A T 13: 55,280,200 (GRCm39) Q308L probably benign Het
Zfp872 C T 9: 22,111,856 (GRCm39) P445L probably benign Het
Other mutations in Med15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00235:Med15 APN 16 17,498,590 (GRCm39) missense probably damaging 0.96
IGL00780:Med15 APN 16 17,471,351 (GRCm39) missense probably damaging 1.00
IGL02365:Med15 APN 16 17,489,470 (GRCm39) intron probably benign
R0324:Med15 UTSW 16 17,515,476 (GRCm39) missense probably damaging 0.98
R1225:Med15 UTSW 16 17,540,652 (GRCm39) missense probably damaging 1.00
R1695:Med15 UTSW 16 17,540,644 (GRCm39) missense probably damaging 0.96
R1745:Med15 UTSW 16 17,473,570 (GRCm39) unclassified probably benign
R1801:Med15 UTSW 16 17,498,599 (GRCm39) missense possibly damaging 0.66
R1838:Med15 UTSW 16 17,471,426 (GRCm39) missense probably benign 0.11
R1901:Med15 UTSW 16 17,491,018 (GRCm39) unclassified probably benign
R2153:Med15 UTSW 16 17,503,315 (GRCm39) critical splice donor site probably null
R2974:Med15 UTSW 16 17,470,575 (GRCm39) missense probably damaging 1.00
R3808:Med15 UTSW 16 17,473,598 (GRCm39) unclassified probably benign
R3809:Med15 UTSW 16 17,473,598 (GRCm39) unclassified probably benign
R4240:Med15 UTSW 16 17,473,358 (GRCm39) missense probably damaging 1.00
R4483:Med15 UTSW 16 17,489,428 (GRCm39) intron probably benign
R4484:Med15 UTSW 16 17,489,428 (GRCm39) intron probably benign
R4577:Med15 UTSW 16 17,492,379 (GRCm39) nonsense probably null
R5652:Med15 UTSW 16 17,473,055 (GRCm39) missense probably damaging 1.00
R6244:Med15 UTSW 16 17,470,609 (GRCm39) nonsense probably null
R6701:Med15 UTSW 16 17,489,447 (GRCm39) intron probably benign
R6793:Med15 UTSW 16 17,470,567 (GRCm39) unclassified probably benign
R7038:Med15 UTSW 16 17,470,591 (GRCm39) missense possibly damaging 0.90
R7211:Med15 UTSW 16 17,515,977 (GRCm39) missense unknown
R7317:Med15 UTSW 16 17,489,507 (GRCm39) missense unknown
R7390:Med15 UTSW 16 17,540,626 (GRCm39) missense unknown
R7471:Med15 UTSW 16 17,540,729 (GRCm39) missense probably benign 0.03
R7726:Med15 UTSW 16 17,473,038 (GRCm39) missense possibly damaging 0.87
R8872:Med15 UTSW 16 17,470,605 (GRCm39) missense probably damaging 1.00
R9043:Med15 UTSW 16 17,470,582 (GRCm39) missense probably benign 0.07
R9084:Med15 UTSW 16 17,471,072 (GRCm39) missense probably damaging 0.99
R9089:Med15 UTSW 16 17,473,421 (GRCm39) missense unknown
R9363:Med15 UTSW 16 17,489,414 (GRCm39) missense unknown
Z1177:Med15 UTSW 16 17,471,096 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- GACTGTCCCAAGAGATTGCTC -3'
(R):5'- ATAGCTCTTTCCCCTGGAGTG -3'

Sequencing Primer
(F):5'- CAGCACTATTGATTAGGTCAGTG -3'
(R):5'- TTCCCCTGGAGTGTGAAAAGGATATC -3'
Posted On 2019-05-13