Incidental Mutation 'R7036:Dop1b'
ID 546728
Institutional Source Beutler Lab
Gene Symbol Dop1b
Ensembl Gene ENSMUSG00000022946
Gene Name DOP1 leucine zipper like protein B
Synonyms Dopey2, 0610038M01Rik, 2610510B01Rik
MMRRC Submission 045012-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7036 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 93508795-93607476 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93574378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 30 (D30E)
Ref Sequence ENSEMBL: ENSMUSP00000156073 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045004] [ENSMUST00000227156] [ENSMUST00000228261]
AlphaFold Q3UHQ6
Predicted Effect probably benign
Transcript: ENSMUST00000045004
AA Change: D1750E

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000044437
Gene: ENSMUSG00000022946
AA Change: D1750E

DomainStartEndE-ValueType
Pfam:Dopey_N 11 308 3.9e-104 PFAM
low complexity region 651 666 N/A INTRINSIC
low complexity region 709 719 N/A INTRINSIC
low complexity region 747 759 N/A INTRINSIC
low complexity region 1186 1199 N/A INTRINSIC
low complexity region 1436 1451 N/A INTRINSIC
low complexity region 1893 1908 N/A INTRINSIC
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000227156
AA Change: D1632E

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000228261
AA Change: D30E

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T A 10: 100,445,118 (GRCm39) probably null Het
Ahnak2 A G 12: 112,745,216 (GRCm39) probably benign Het
Akt2 T C 7: 27,336,437 (GRCm39) probably null Het
Aldh1a7 A T 19: 20,685,542 (GRCm39) L336Q possibly damaging Het
Ank2 T C 3: 126,740,041 (GRCm39) probably benign Het
Ank3 C T 10: 69,835,209 (GRCm39) T680M probably damaging Het
Apeh T C 9: 107,971,470 (GRCm39) E59G possibly damaging Het
Arl8a G C 1: 135,082,206 (GRCm39) E145Q probably benign Het
Armc8 C T 9: 99,366,018 (GRCm39) probably null Het
Armh3 A G 19: 45,953,688 (GRCm39) I195T probably damaging Het
Arsj T C 3: 126,158,649 (GRCm39) L76P probably damaging Het
Atp2b1 C T 10: 98,823,172 (GRCm39) T244I probably damaging Het
Bcl6 A T 16: 23,793,611 (GRCm39) L112Q probably damaging Het
Bfsp1 T A 2: 143,668,843 (GRCm39) T579S possibly damaging Het
Btaf1 C A 19: 36,981,869 (GRCm39) T1633K probably benign Het
Cacng8 A G 7: 3,463,819 (GRCm39) S324G probably benign Het
Cd2ap A T 17: 43,109,490 (GRCm39) L623Q probably damaging Het
Cerkl T C 2: 79,171,722 (GRCm39) I379V probably benign Het
Cndp2 T A 18: 84,688,070 (GRCm39) H307L possibly damaging Het
Derl1 A G 15: 57,742,443 (GRCm39) probably null Het
Dixdc1 T A 9: 50,593,864 (GRCm39) R254S probably benign Het
Duox2 T G 2: 122,110,934 (GRCm39) H1513P probably damaging Het
Dyrk1a G A 16: 94,487,427 (GRCm39) V546I probably benign Het
E130308A19Rik A C 4: 59,719,991 (GRCm39) K508Q probably damaging Het
Emc8 A T 8: 121,385,790 (GRCm39) V108E probably benign Het
Epb41l1 A G 2: 156,371,322 (GRCm39) T720A probably benign Het
Fcgr4 T A 1: 170,847,657 (GRCm39) M85K probably benign Het
Fem1b T A 9: 62,704,310 (GRCm39) I317F probably damaging Het
Focad A G 4: 88,042,874 (GRCm39) E36G probably benign Het
Fryl C T 5: 73,212,951 (GRCm39) E2275K probably benign Het
Galnt11 T C 5: 25,463,811 (GRCm39) I361T probably damaging Het
Garin3 G A 11: 46,298,235 (GRCm39) S513N Het
Gatad2a A T 8: 70,370,644 (GRCm39) N114K probably damaging Het
Gcnt2 CTAATG C 13: 41,041,032 (GRCm39) probably null Het
Gramd1a A G 7: 30,832,181 (GRCm39) probably null Het
Gsn T A 2: 35,182,611 (GRCm39) W187R probably damaging Het
Hoxc12 G A 15: 102,846,795 (GRCm39) G229D probably damaging Het
Hycc2 T A 1: 58,574,696 (GRCm39) M282L probably benign Het
Ints14 T C 9: 64,871,827 (GRCm39) V55A probably benign Het
Itga9 T C 9: 118,527,433 (GRCm39) L528P probably benign Het
Klf1 C T 8: 85,629,379 (GRCm39) S68F possibly damaging Het
Kmt2e A G 5: 23,683,741 (GRCm39) E333G probably null Het
Krt39 A C 11: 99,412,062 (GRCm39) V8G probably benign Het
Krt71 A G 15: 101,646,772 (GRCm39) I312T probably benign Het
Lrp1b T C 2: 41,002,354 (GRCm39) D2001G possibly damaging Het
Lrrc37 T A 11: 103,506,638 (GRCm39) probably benign Het
Lrrc71 T C 3: 87,655,693 (GRCm39) T27A probably benign Het
Lrrcc1 T C 3: 14,628,069 (GRCm39) V958A possibly damaging Het
Med15 A T 16: 17,516,019 (GRCm39) M1K probably null Het
Mrgpra3 G T 7: 47,239,838 (GRCm39) N29K possibly damaging Het
Myl1 T C 1: 66,969,395 (GRCm39) N79S probably damaging Het
Naip2 A T 13: 100,291,529 (GRCm39) D1136E probably benign Het
Nat10 T C 2: 103,584,453 (GRCm39) N108S probably benign Het
Ncald A T 15: 37,369,122 (GRCm39) S178T probably benign Het
Ndufs2 T C 1: 171,065,877 (GRCm39) D256G probably benign Het
Nek5 T C 8: 22,597,739 (GRCm39) N280S probably benign Het
Or5ak25 A G 2: 85,268,774 (GRCm39) S243P probably damaging Het
Or5d39 T A 2: 87,979,469 (GRCm39) D298V probably damaging Het
Parp1 G T 1: 180,425,817 (GRCm39) K849N possibly damaging Het
Pcdhb4 T A 18: 37,441,835 (GRCm39) C382S possibly damaging Het
Plce1 A G 19: 38,727,801 (GRCm39) N1520S probably damaging Het
Plcg2 G A 8: 118,323,045 (GRCm39) R700H probably benign Het
Popdc2 A T 16: 38,183,173 (GRCm39) Y52F probably damaging Het
Prrx1 T A 1: 163,075,907 (GRCm39) M220L probably benign Het
Pspc1 A C 14: 56,996,085 (GRCm39) probably null Het
Ptchd1 T A X: 154,357,708 (GRCm39) Y499F probably damaging Het
Ptpn20 A G 14: 33,336,392 (GRCm39) *44W probably null Het
Qars1 T A 9: 108,391,976 (GRCm39) V83E probably damaging Het
Rrh T C 3: 129,609,342 (GRCm39) E55G possibly damaging Het
Sash1 C A 10: 8,605,847 (GRCm39) E848* probably null Het
Sds A T 5: 120,618,912 (GRCm39) K125M possibly damaging Het
Serpinf2 A T 11: 75,329,244 (GRCm39) probably benign Het
Sh2b2 G A 5: 136,247,739 (GRCm39) T604I probably benign Het
Smug1 A G 15: 103,064,369 (GRCm39) L184P probably damaging Het
Spatc1 A G 15: 76,168,080 (GRCm39) T180A probably benign Het
Ssr1 A T 13: 38,178,001 (GRCm39) L20Q probably null Het
Supt4a A G 11: 87,634,084 (GRCm39) E100G probably damaging Het
Tbx1 G T 16: 18,405,551 (GRCm39) P38T unknown Het
Tcl1 T C 12: 105,183,860 (GRCm39) probably benign Het
Teddm2 T C 1: 153,726,320 (GRCm39) I132V probably benign Het
Tmem131 C T 1: 36,832,054 (GRCm39) G1861E possibly damaging Het
Tpr A T 1: 150,299,358 (GRCm39) H1186L probably benign Het
Trim34b A T 7: 103,978,743 (GRCm39) probably benign Het
Trpm2 T C 10: 77,748,426 (GRCm39) M1415V probably benign Het
Ttll12 A G 15: 83,471,086 (GRCm39) F264S probably benign Het
Vmn2r59 T C 7: 41,695,644 (GRCm39) E256G probably benign Het
Vmn2r93 A T 17: 18,546,672 (GRCm39) H848L probably benign Het
Vps35l T C 7: 118,372,315 (GRCm39) S290P probably damaging Het
Wdr70 T C 15: 7,913,855 (GRCm39) D598G possibly damaging Het
Ybey T C 10: 76,304,197 (GRCm39) S2G possibly damaging Het
Zfp346 A T 13: 55,280,200 (GRCm39) Q308L probably benign Het
Zfp872 C T 9: 22,111,856 (GRCm39) P445L probably benign Het
Other mutations in Dop1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00476:Dop1b APN 16 93,596,914 (GRCm39) unclassified probably benign
IGL00492:Dop1b APN 16 93,577,670 (GRCm39) missense probably benign 0.00
IGL00753:Dop1b APN 16 93,566,512 (GRCm39) missense probably benign
IGL00832:Dop1b APN 16 93,560,289 (GRCm39) missense probably benign 0.01
IGL00939:Dop1b APN 16 93,570,971 (GRCm39) missense possibly damaging 0.83
IGL01019:Dop1b APN 16 93,607,117 (GRCm39) missense probably benign 0.32
IGL01288:Dop1b APN 16 93,536,181 (GRCm39) missense possibly damaging 0.78
IGL01505:Dop1b APN 16 93,554,004 (GRCm39) missense possibly damaging 0.87
IGL01535:Dop1b APN 16 93,566,846 (GRCm39) nonsense probably null
IGL01696:Dop1b APN 16 93,567,128 (GRCm39) missense probably benign 0.00
IGL02077:Dop1b APN 16 93,577,648 (GRCm39) missense probably damaging 0.96
IGL02163:Dop1b APN 16 93,559,315 (GRCm39) missense possibly damaging 0.48
IGL02234:Dop1b APN 16 93,549,039 (GRCm39) missense probably benign
IGL02302:Dop1b APN 16 93,607,005 (GRCm39) missense probably benign 0.08
IGL02485:Dop1b APN 16 93,567,710 (GRCm39) missense probably damaging 1.00
IGL02563:Dop1b APN 16 93,574,293 (GRCm39) missense probably damaging 0.99
IGL02733:Dop1b APN 16 93,536,079 (GRCm39) missense possibly damaging 0.80
IGL02792:Dop1b APN 16 93,598,460 (GRCm39) missense possibly damaging 0.75
IGL02941:Dop1b APN 16 93,552,361 (GRCm39) missense probably benign 0.09
IGL03143:Dop1b APN 16 93,556,543 (GRCm39) missense probably benign
PIT4519001:Dop1b UTSW 16 93,558,942 (GRCm39) missense probably benign
R0320:Dop1b UTSW 16 93,607,035 (GRCm39) missense probably benign 0.02
R0499:Dop1b UTSW 16 93,567,325 (GRCm39) missense probably benign 0.00
R0501:Dop1b UTSW 16 93,549,750 (GRCm39) missense probably benign 0.00
R0534:Dop1b UTSW 16 93,559,393 (GRCm39) missense probably benign 0.04
R0583:Dop1b UTSW 16 93,552,374 (GRCm39) missense probably benign 0.30
R0626:Dop1b UTSW 16 93,560,844 (GRCm39) missense probably damaging 1.00
R0724:Dop1b UTSW 16 93,559,213 (GRCm39) missense probably benign 0.01
R0907:Dop1b UTSW 16 93,598,481 (GRCm39) missense probably damaging 1.00
R1263:Dop1b UTSW 16 93,574,274 (GRCm39) missense probably benign
R1378:Dop1b UTSW 16 93,567,280 (GRCm39) missense probably benign
R1572:Dop1b UTSW 16 93,567,041 (GRCm39) missense probably damaging 1.00
R1604:Dop1b UTSW 16 93,559,458 (GRCm39) missense probably benign
R1642:Dop1b UTSW 16 93,559,203 (GRCm39) missense probably benign 0.00
R1668:Dop1b UTSW 16 93,562,404 (GRCm39) missense probably damaging 1.00
R1669:Dop1b UTSW 16 93,566,548 (GRCm39) missense probably damaging 1.00
R1702:Dop1b UTSW 16 93,544,509 (GRCm39) missense possibly damaging 0.47
R1711:Dop1b UTSW 16 93,596,814 (GRCm39) missense probably damaging 1.00
R1917:Dop1b UTSW 16 93,513,150 (GRCm39) missense probably damaging 1.00
R1968:Dop1b UTSW 16 93,579,307 (GRCm39) missense probably damaging 1.00
R1988:Dop1b UTSW 16 93,563,061 (GRCm39) missense probably damaging 1.00
R2029:Dop1b UTSW 16 93,566,323 (GRCm39) missense probably benign 0.36
R2139:Dop1b UTSW 16 93,567,895 (GRCm39) missense possibly damaging 0.78
R2355:Dop1b UTSW 16 93,567,565 (GRCm39) missense probably damaging 1.00
R3609:Dop1b UTSW 16 93,536,220 (GRCm39) missense probably damaging 1.00
R3792:Dop1b UTSW 16 93,568,734 (GRCm39) missense possibly damaging 0.54
R4364:Dop1b UTSW 16 93,567,812 (GRCm39) missense probably benign 0.00
R4380:Dop1b UTSW 16 93,513,120 (GRCm39) missense possibly damaging 0.53
R4455:Dop1b UTSW 16 93,563,103 (GRCm39) missense probably damaging 1.00
R4779:Dop1b UTSW 16 93,553,969 (GRCm39) missense probably damaging 1.00
R4820:Dop1b UTSW 16 93,589,978 (GRCm39) missense probably benign 0.00
R4834:Dop1b UTSW 16 93,536,892 (GRCm39) start codon destroyed probably null 0.70
R4866:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R4882:Dop1b UTSW 16 93,549,802 (GRCm39) missense possibly damaging 0.95
R4900:Dop1b UTSW 16 93,560,318 (GRCm39) critical splice donor site probably null
R5153:Dop1b UTSW 16 93,570,891 (GRCm39) missense probably damaging 0.98
R5176:Dop1b UTSW 16 93,536,931 (GRCm39) missense probably damaging 1.00
R5206:Dop1b UTSW 16 93,598,472 (GRCm39) missense probably damaging 1.00
R5320:Dop1b UTSW 16 93,536,874 (GRCm39) missense probably damaging 1.00
R5361:Dop1b UTSW 16 93,567,392 (GRCm39) missense probably damaging 1.00
R5380:Dop1b UTSW 16 93,560,298 (GRCm39) missense probably damaging 0.96
R5476:Dop1b UTSW 16 93,570,801 (GRCm39) splice site probably null
R5502:Dop1b UTSW 16 93,590,114 (GRCm39) missense probably benign 0.00
R5543:Dop1b UTSW 16 93,595,808 (GRCm39) missense probably damaging 0.98
R5557:Dop1b UTSW 16 93,560,819 (GRCm39) missense probably damaging 0.96
R5901:Dop1b UTSW 16 93,566,639 (GRCm39) missense possibly damaging 0.88
R5907:Dop1b UTSW 16 93,598,469 (GRCm39) missense probably damaging 1.00
R6174:Dop1b UTSW 16 93,563,110 (GRCm39) missense probably damaging 1.00
R6256:Dop1b UTSW 16 93,604,102 (GRCm39) missense possibly damaging 0.94
R6383:Dop1b UTSW 16 93,579,136 (GRCm39) missense possibly damaging 0.76
R6525:Dop1b UTSW 16 93,606,304 (GRCm39) missense probably damaging 1.00
R6554:Dop1b UTSW 16 93,557,346 (GRCm39) missense probably benign 0.22
R6823:Dop1b UTSW 16 93,552,373 (GRCm39) missense possibly damaging 0.75
R7058:Dop1b UTSW 16 93,573,878 (GRCm39) missense probably benign 0.00
R7061:Dop1b UTSW 16 93,558,951 (GRCm39) missense probably benign 0.00
R7209:Dop1b UTSW 16 93,566,733 (GRCm39) missense probably benign
R7214:Dop1b UTSW 16 93,607,023 (GRCm39) missense possibly damaging 0.69
R7232:Dop1b UTSW 16 93,557,373 (GRCm39) critical splice donor site probably null
R7255:Dop1b UTSW 16 93,567,034 (GRCm39) missense probably damaging 1.00
R7335:Dop1b UTSW 16 93,544,396 (GRCm39) missense probably benign 0.04
R7535:Dop1b UTSW 16 93,603,249 (GRCm39) missense probably damaging 1.00
R7700:Dop1b UTSW 16 93,595,649 (GRCm39) splice site probably null
R7763:Dop1b UTSW 16 93,552,402 (GRCm39) missense probably benign 0.00
R7814:Dop1b UTSW 16 93,596,859 (GRCm39) missense probably damaging 1.00
R7839:Dop1b UTSW 16 93,560,829 (GRCm39) missense probably damaging 1.00
R7862:Dop1b UTSW 16 93,546,851 (GRCm39) missense probably damaging 1.00
R7894:Dop1b UTSW 16 93,607,092 (GRCm39) missense probably benign 0.01
R7952:Dop1b UTSW 16 93,546,848 (GRCm39) missense possibly damaging 0.93
R7956:Dop1b UTSW 16 93,567,916 (GRCm39) critical splice donor site probably null
R8033:Dop1b UTSW 16 93,566,371 (GRCm39) missense probably benign
R8061:Dop1b UTSW 16 93,546,884 (GRCm39) missense probably damaging 1.00
R8067:Dop1b UTSW 16 93,562,336 (GRCm39) nonsense probably null
R8146:Dop1b UTSW 16 93,546,827 (GRCm39) missense possibly damaging 0.95
R8184:Dop1b UTSW 16 93,573,881 (GRCm39) missense probably benign 0.13
R8221:Dop1b UTSW 16 93,546,847 (GRCm39) missense probably benign 0.01
R8263:Dop1b UTSW 16 93,559,083 (GRCm39) missense possibly damaging 0.87
R8329:Dop1b UTSW 16 93,568,675 (GRCm39) missense probably damaging 1.00
R8555:Dop1b UTSW 16 93,568,698 (GRCm39) missense probably damaging 1.00
R8683:Dop1b UTSW 16 93,570,809 (GRCm39) missense probably benign
R8683:Dop1b UTSW 16 93,568,699 (GRCm39) missense probably damaging 0.98
R8716:Dop1b UTSW 16 93,577,673 (GRCm39) nonsense probably null
R8807:Dop1b UTSW 16 93,558,973 (GRCm39) missense probably benign 0.03
R8840:Dop1b UTSW 16 93,607,005 (GRCm39) missense probably benign 0.08
R8851:Dop1b UTSW 16 93,559,398 (GRCm39) missense probably benign 0.39
R8884:Dop1b UTSW 16 93,556,550 (GRCm39) missense probably benign
R8976:Dop1b UTSW 16 93,558,969 (GRCm39) missense probably benign 0.01
R9219:Dop1b UTSW 16 93,567,184 (GRCm39) missense probably damaging 1.00
R9238:Dop1b UTSW 16 93,546,018 (GRCm39) missense probably benign 0.14
R9284:Dop1b UTSW 16 93,557,196 (GRCm39) missense probably damaging 1.00
R9289:Dop1b UTSW 16 93,568,681 (GRCm39) missense probably damaging 1.00
R9298:Dop1b UTSW 16 93,597,087 (GRCm39) missense probably damaging 0.96
R9338:Dop1b UTSW 16 93,600,448 (GRCm39) missense probably damaging 1.00
R9346:Dop1b UTSW 16 93,577,702 (GRCm39) critical splice donor site probably null
R9444:Dop1b UTSW 16 93,607,127 (GRCm39) missense probably benign 0.00
R9500:Dop1b UTSW 16 93,607,171 (GRCm39) missense probably benign
R9601:Dop1b UTSW 16 93,544,531 (GRCm39) missense possibly damaging 0.87
R9793:Dop1b UTSW 16 93,598,503 (GRCm39) missense probably benign 0.30
Z1088:Dop1b UTSW 16 93,560,214 (GRCm39) missense probably benign 0.00
Z1176:Dop1b UTSW 16 93,604,756 (GRCm39) missense possibly damaging 0.82
Z1176:Dop1b UTSW 16 93,600,434 (GRCm39) missense probably damaging 1.00
Z1176:Dop1b UTSW 16 93,566,469 (GRCm39) missense probably benign 0.00
Z1177:Dop1b UTSW 16 93,560,783 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTCAGCCTTCAAGGAACTC -3'
(R):5'- GCTAAGAGTTGAGCATCAGGC -3'

Sequencing Primer
(F):5'- AAGGAACTCTCTTCTTCTGGGCAG -3'
(R):5'- AGCAGTGCCCAAAGTCTG -3'
Posted On 2019-05-13