Incidental Mutation 'R7037:Mrgprb3'
ID 546768
Institutional Source Beutler Lab
Gene Symbol Mrgprb3
Ensembl Gene ENSMUSG00000070546
Gene Name MAS-related GPR, member B3
Synonyms MrgB3
MMRRC Submission 045137-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R7037 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 48292611-48293549 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 48292942 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 203 (L203P)
Ref Sequence ENSEMBL: ENSMUSP00000091945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094383]
AlphaFold Q91ZC1
Predicted Effect probably damaging
Transcript: ENSMUST00000094383
AA Change: L203P

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000091945
Gene: ENSMUSG00000070546
AA Change: L203P

DomainStartEndE-ValueType
SCOP:d1l9ha_ 25 279 4e-13 SMART
low complexity region 301 312 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (70/70)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm3 A T 7: 119,367,266 (GRCm39) N33I probably damaging Het
Ahnak2 A T 12: 112,740,712 (GRCm39) V314D probably damaging Het
Arl14epl T G 18: 47,065,510 (GRCm39) C92G probably benign Het
Atp6v1h T A 1: 5,220,215 (GRCm39) M423K possibly damaging Het
Baiap3 G A 17: 25,462,814 (GRCm39) R1075C probably benign Het
Baz2b C T 2: 59,764,014 (GRCm39) probably null Het
Bicral T C 17: 47,135,560 (GRCm39) H550R probably benign Het
C1rl A G 6: 124,485,598 (GRCm39) Y323C probably damaging Het
Ccr9 T A 9: 123,609,036 (GRCm39) H239Q possibly damaging Het
Cdh16 T A 8: 105,344,267 (GRCm39) R91* probably null Het
Coro1c A G 5: 113,983,457 (GRCm39) F357S possibly damaging Het
Cpsf4 G A 5: 145,112,939 (GRCm39) R141Q possibly damaging Het
Cryzl2 G A 1: 157,298,318 (GRCm39) V236I probably damaging Het
Cttnbp2 T C 6: 18,435,117 (GRCm39) E247G probably damaging Het
Dbr1 T A 9: 99,458,621 (GRCm39) probably null Het
Dclk1 T C 3: 55,370,469 (GRCm39) S23P probably damaging Het
Dpyd A T 3: 118,692,938 (GRCm39) I361F probably benign Het
Elac2 A G 11: 64,874,537 (GRCm39) E218G probably benign Het
Eml4 T A 17: 83,732,756 (GRCm39) D136E probably benign Het
Foxred1 A T 9: 35,118,844 (GRCm39) S223T probably benign Het
Garin5b G T 7: 4,761,584 (GRCm39) probably benign Het
Gask1a G T 9: 121,794,592 (GRCm39) V249L possibly damaging Het
Gm11595 A G 11: 99,663,474 (GRCm39) C69R unknown Het
Gna14 A T 19: 16,511,128 (GRCm39) H59L Het
H2-Ab1 T A 17: 34,486,963 (GRCm39) I239N probably damaging Het
Ints7 T C 1: 191,351,717 (GRCm39) S809P probably benign Het
Itgb4 T A 11: 115,896,391 (GRCm39) Y1379* probably null Het
Kank1 A G 19: 25,407,705 (GRCm39) D1233G probably damaging Het
Kif13a C T 13: 46,905,931 (GRCm39) V671M possibly damaging Het
Lrrc66 A T 5: 73,764,504 (GRCm39) D846E probably benign Het
Lyst A G 13: 13,791,251 (GRCm39) H38R probably damaging Het
Mc3r T C 2: 172,091,554 (GRCm39) F259L probably damaging Het
Med25 A G 7: 44,532,206 (GRCm39) Y384H probably damaging Het
Met A T 6: 17,547,127 (GRCm39) probably benign Het
Mmp16 T C 4: 18,116,148 (GRCm39) V584A possibly damaging Het
Mus81 A G 19: 5,536,108 (GRCm39) L185P probably damaging Het
Naaa A G 5: 92,424,934 (GRCm39) V75A possibly damaging Het
Obscn T A 11: 58,934,755 (GRCm39) T5292S probably damaging Het
Obscn T C 11: 58,943,430 (GRCm39) S4801G probably damaging Het
Or2ag19 T C 7: 106,444,543 (GRCm39) S242P probably damaging Het
Otof T C 5: 30,538,882 (GRCm39) D1112G probably benign Het
Pals1 T A 12: 78,843,973 (GRCm39) I59N probably damaging Het
Pbx4 A G 8: 70,317,525 (GRCm39) R170G probably damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Plce1 A T 19: 38,690,461 (GRCm39) D715V probably damaging Het
Pms1 T C 1: 53,246,770 (GRCm39) T311A possibly damaging Het
Popdc2 A G 16: 38,194,629 (GRCm39) D350G probably damaging Het
Prex1 A G 2: 166,429,100 (GRCm39) V661A probably benign Het
Ptbp2 A G 3: 119,545,557 (GRCm39) Y130H probably damaging Het
Rev3l C T 10: 39,727,971 (GRCm39) R2707W probably damaging Het
Rpl37 G A 15: 5,147,185 (GRCm39) R75K probably null Het
Ryr3 T A 2: 112,779,475 (GRCm39) R259* probably null Het
Scai A T 2: 39,080,633 (GRCm39) S8T probably benign Het
Scn4a C A 11: 106,211,726 (GRCm39) L1430F probably damaging Het
Sema5a A G 15: 32,686,993 (GRCm39) K1035R probably damaging Het
Siah3 A G 14: 75,763,025 (GRCm39) H92R probably benign Het
Smc4 G A 3: 68,925,528 (GRCm39) V342I possibly damaging Het
Spata31d1a C T 13: 59,848,138 (GRCm39) C1330Y possibly damaging Het
St18 C A 1: 6,873,260 (GRCm39) H332N possibly damaging Het
Sycp1 T A 3: 102,806,250 (GRCm39) E480D possibly damaging Het
Tex14 A T 11: 87,388,741 (GRCm39) I323F probably damaging Het
Tm7sf2 A T 19: 6,114,107 (GRCm39) probably null Het
Tmem241 G T 18: 12,246,463 (GRCm39) H62Q probably benign Het
Tmem54 T A 4: 129,004,594 (GRCm39) probably null Het
Tomm34 A G 2: 163,912,398 (GRCm39) L39P probably damaging Het
Triml2 T A 8: 43,646,573 (GRCm39) V354D probably damaging Het
Usp19 T C 9: 108,374,157 (GRCm39) I738T possibly damaging Het
Utp25 A C 1: 192,803,031 (GRCm39) probably null Het
Utrn T A 10: 12,702,514 (GRCm39) probably null Het
Zfp1005 G T 2: 150,108,376 (GRCm39) V46F possibly damaging Het
Other mutations in Mrgprb3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03069:Mrgprb3 APN 7 48,293,198 (GRCm39) missense possibly damaging 0.71
Reserve UTSW 7 48,293,447 (GRCm39) missense probably benign 0.02
starker UTSW 7 48,293,116 (GRCm39) missense probably benign 0.28
IGL03052:Mrgprb3 UTSW 7 48,293,341 (GRCm39) missense possibly damaging 0.93
R0446:Mrgprb3 UTSW 7 48,292,984 (GRCm39) missense probably benign 0.42
R0546:Mrgprb3 UTSW 7 48,293,263 (GRCm39) missense probably damaging 1.00
R0885:Mrgprb3 UTSW 7 48,292,844 (GRCm39) missense probably damaging 1.00
R1764:Mrgprb3 UTSW 7 48,292,771 (GRCm39) missense probably benign 0.01
R2044:Mrgprb3 UTSW 7 48,293,482 (GRCm39) missense possibly damaging 0.92
R2230:Mrgprb3 UTSW 7 48,292,770 (GRCm39) missense probably benign 0.05
R2232:Mrgprb3 UTSW 7 48,292,770 (GRCm39) missense probably benign 0.05
R2240:Mrgprb3 UTSW 7 48,293,389 (GRCm39) missense probably damaging 0.99
R3001:Mrgprb3 UTSW 7 48,293,232 (GRCm39) missense probably benign
R3002:Mrgprb3 UTSW 7 48,293,232 (GRCm39) missense probably benign
R4717:Mrgprb3 UTSW 7 48,293,000 (GRCm39) missense probably benign 0.01
R4805:Mrgprb3 UTSW 7 48,293,054 (GRCm39) missense probably benign 0.01
R5083:Mrgprb3 UTSW 7 48,292,762 (GRCm39) missense probably benign 0.01
R5311:Mrgprb3 UTSW 7 48,293,059 (GRCm39) missense probably damaging 1.00
R5330:Mrgprb3 UTSW 7 48,292,682 (GRCm39) missense possibly damaging 0.90
R5331:Mrgprb3 UTSW 7 48,292,682 (GRCm39) missense possibly damaging 0.90
R5615:Mrgprb3 UTSW 7 48,293,234 (GRCm39) missense probably benign 0.01
R5621:Mrgprb3 UTSW 7 48,293,116 (GRCm39) missense probably benign 0.28
R5697:Mrgprb3 UTSW 7 48,292,673 (GRCm39) missense probably damaging 0.96
R5725:Mrgprb3 UTSW 7 48,293,548 (GRCm39) start codon destroyed probably null 0.02
R5758:Mrgprb3 UTSW 7 48,293,067 (GRCm39) missense probably benign 0.01
R5807:Mrgprb3 UTSW 7 48,293,110 (GRCm39) missense probably benign 0.02
R5908:Mrgprb3 UTSW 7 48,293,366 (GRCm39) missense probably damaging 0.98
R6902:Mrgprb3 UTSW 7 48,293,447 (GRCm39) missense probably benign 0.02
R7288:Mrgprb3 UTSW 7 48,293,059 (GRCm39) missense probably damaging 1.00
R7605:Mrgprb3 UTSW 7 48,292,862 (GRCm39) missense probably benign 0.01
R8246:Mrgprb3 UTSW 7 48,293,268 (GRCm39) missense probably benign 0.02
R8292:Mrgprb3 UTSW 7 48,293,255 (GRCm39) missense probably benign 0.01
R8972:Mrgprb3 UTSW 7 48,293,422 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GCCTAATGGAGCCAACAAGG -3'
(R):5'- CACATCAGCTGTCATTTGTGTC -3'

Sequencing Primer
(F):5'- GTATATGGTAGCATTGACACAGATG -3'
(R):5'- GTCTTGCTTTGGGCTCTATCTCTG -3'
Posted On 2019-05-13