Incidental Mutation 'R7040:Olfr1337'
ID 546987
Institutional Source Beutler Lab
Gene Symbol Olfr1337
Ensembl Gene ENSMUSG00000111159
Gene Name olfactory receptor 1337
Synonyms GA_x6K02T2QD9B-18767132-18768073, Olfr219-ps1, GA_x6K02SYWGW3-414-3, MOR259-10
MMRRC Submission 045013-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.239) question?
Stock # R7040 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 118781636-118782586 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118781986 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 200 (M200V)
Ref Sequence ENSEMBL: ENSMUSP00000076483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077247]
AlphaFold A2ACY8
Predicted Effect probably benign
Transcript: ENSMUST00000077247
AA Change: M200V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000076483
Gene: ENSMUSG00000111159
AA Change: M200V

Pfam:7tm_4 34 310 7.8e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 308 8.5e-7 PFAM
Pfam:7tm_1 44 293 8.3e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A G 7: 128,236,725 (GRCm38) L232P possibly damaging Het
Acaa1a T C 9: 119,349,038 (GRCm38) V312A probably damaging Het
Bmp2 A G 2: 133,561,684 (GRCm38) D385G probably damaging Het
C1qtnf9 T C 14: 60,779,792 (GRCm38) V257A probably damaging Het
Cd3d G A 9: 44,985,693 (GRCm38) V122I probably damaging Het
Cdc37 T C 9: 21,142,223 (GRCm38) E199G probably damaging Het
Crb2 T A 2: 37,787,684 (GRCm38) D326E probably benign Het
Cyp2c29 A C 19: 39,330,337 (GRCm38) K420N possibly damaging Het
Cyp2g1 A C 7: 26,820,759 (GRCm38) D472A probably damaging Het
Dab2 A C 15: 6,422,251 (GRCm38) H116P probably damaging Het
Dnah7b G C 1: 46,236,809 (GRCm38) E2619Q probably benign Het
Dsg4 A T 18: 20,451,852 (GRCm38) M208L probably benign Het
Eif4enif1 T G 11: 3,234,040 (GRCm38) V521G probably benign Het
Fan1 T A 7: 64,372,486 (GRCm38) N340Y probably damaging Het
Fpr-rs6 A G 17: 20,182,934 (GRCm38) M55T probably damaging Het
Grhpr A G 4: 44,985,362 (GRCm38) S101G probably damaging Het
Kif15 T A 9: 123,011,614 (GRCm38) D33E possibly damaging Het
Lama4 A G 10: 39,060,162 (GRCm38) Q611R possibly damaging Het
Lrrc47 T A 4: 154,020,452 (GRCm38) *123R probably null Het
Map4k3 A C 17: 80,680,915 (GRCm38) V36G probably damaging Het
Mme T A 3: 63,368,923 (GRCm38) I707N probably damaging Het
Muc2 A G 7: 141,751,457 (GRCm38) E166G unknown Het
Mucl1 T A 15: 103,753,578 (GRCm38) T108S possibly damaging Het
Myo1h A T 5: 114,359,744 (GRCm38) D53V possibly damaging Het
Naa15 T A 3: 51,472,784 (GRCm38) L811Q possibly damaging Het
Nalcn T C 14: 123,287,855 (GRCm38) T1487A probably benign Het
Nme8 A T 13: 19,694,328 (GRCm38) L87H probably damaging Het
Nr2e1 A G 10: 42,568,378 (GRCm38) V245A probably damaging Het
Nt5c2 A T 19: 46,893,535 (GRCm38) F291Y possibly damaging Het
Olfr1508 T C 14: 52,463,475 (GRCm38) D178G possibly damaging Het
Olfr556 A T 7: 102,670,730 (GRCm38) Q270L probably benign Het
Olfr668 A T 7: 104,925,510 (GRCm38) C85S probably benign Het
Ooep T C 9: 78,378,401 (GRCm38) N43S possibly damaging Het
Ovch2 A T 7: 107,796,565 (GRCm38) I82N probably damaging Het
Palb2 A T 7: 122,114,399 (GRCm38) M524K possibly damaging Het
Patj T C 4: 98,441,080 (GRCm38) S524P probably benign Het
Patl1 T A 19: 11,929,954 (GRCm38) Y401N possibly damaging Het
Pcdhb20 A T 18: 37,504,717 (GRCm38) T99S probably benign Het
Plcb4 G A 2: 135,932,262 (GRCm38) A155T probably benign Het
Rpap3 A G 15: 97,679,112 (GRCm38) V585A possibly damaging Het
Sorbs1 G C 19: 40,376,800 (GRCm38) R180G probably benign Het
Spen T A 4: 141,494,382 (GRCm38) T302S unknown Het
Tenm4 G A 7: 96,553,496 (GRCm38) R106H probably benign Het
Ube2o T C 11: 116,541,860 (GRCm38) E760G probably benign Het
Uimc1 T A 13: 55,075,454 (GRCm38) probably null Het
Usp16 C T 16: 87,480,929 (GRCm38) A689V probably damaging Het
Vmn2r60 G A 7: 42,142,242 (GRCm38) A530T probably benign Het
Vps8 T A 16: 21,575,022 (GRCm38) M1185K probably damaging Het
Vwa8 T C 14: 78,912,205 (GRCm38) S136P probably damaging Het
Ythdc2 A G 18: 44,834,462 (GRCm38) N175S probably benign Het
Zfp160 A T 17: 21,026,532 (GRCm38) H448L probably damaging Het
Zfp90 T A 8: 106,425,009 (GRCm38) C451* probably null Het
Zfp945 A G 17: 22,852,290 (GRCm38) C212R probably damaging Het
Other mutations in Olfr1337
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02203:Olfr1337 APN 4 118,782,429 (GRCm38) missense possibly damaging 0.95
IGL02626:Olfr1337 APN 4 118,782,334 (GRCm38) missense probably damaging 0.98
IGL02699:Olfr1337 APN 4 118,782,152 (GRCm38) nonsense probably null
IGL02754:Olfr1337 APN 4 118,781,920 (GRCm38) missense possibly damaging 0.90
IGL03287:Olfr1337 APN 4 118,782,354 (GRCm38) missense possibly damaging 0.64
R1341:Olfr1337 UTSW 4 118,782,382 (GRCm38) missense probably benign 0.01
R4894:Olfr1337 UTSW 4 118,782,286 (GRCm38) missense probably damaging 1.00
R6124:Olfr1337 UTSW 4 118,782,195 (GRCm38) missense probably damaging 1.00
R6515:Olfr1337 UTSW 4 118,782,270 (GRCm38) missense probably benign 0.13
R6529:Olfr1337 UTSW 4 118,781,710 (GRCm38) missense probably benign 0.15
R7398:Olfr1337 UTSW 4 118,781,699 (GRCm38) missense possibly damaging 0.80
R7684:Olfr1337 UTSW 4 118,782,274 (GRCm38) missense probably benign 0.40
R8377:Olfr1337 UTSW 4 118,782,006 (GRCm38) missense probably benign 0.22
R8717:Olfr1337 UTSW 4 118,781,799 (GRCm38) missense probably damaging 1.00
R9369:Olfr1337 UTSW 4 118,781,880 (GRCm38) missense probably benign 0.31
R9594:Olfr1337 UTSW 4 118,781,755 (GRCm38) missense probably benign
Z1189:Olfr1337 UTSW 4 118,782,087 (GRCm38) missense possibly damaging 0.85
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-05-13