Incidental Mutation 'R0611:Rgs12'
| ID |
54702 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rgs12
|
| Ensembl Gene |
ENSMUSG00000029101 |
| Gene Name |
regulator of G-protein signaling 12 |
| Synonyms |
4632412M04Rik, 1200016K18Rik |
| MMRRC Submission |
038800-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.247)
|
| Stock # |
R0611 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
35106789-35196988 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 35176804 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Glutamic Acid
at position 65
(A65E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109924
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030984]
[ENSMUST00000087684]
[ENSMUST00000114280]
[ENSMUST00000114281]
[ENSMUST00000114283]
[ENSMUST00000114284]
[ENSMUST00000114285]
[ENSMUST00000225237]
[ENSMUST00000156339]
|
| AlphaFold |
Q8CGE9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030984
AA Change: A713E
PolyPhen 2
Score 0.858 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000030984
Gene: ENSMUSG00000029101
AA Change: A713E
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
low complexity region
|
849 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
868 |
880 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
928 |
N/A |
INTRINSIC |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
low complexity region
|
1259 |
1280 |
N/A |
INTRINSIC |
|
low complexity region
|
1292 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1359 |
1378 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087684
AA Change: A713E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000084970
Gene: ENSMUSG00000029101
AA Change: A713E
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
29 |
98 |
5.25e-18 |
SMART |
|
PTB
|
224 |
373 |
5.05e-28 |
SMART |
|
low complexity region
|
443 |
456 |
N/A |
INTRINSIC |
|
low complexity region
|
643 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
685 |
697 |
N/A |
INTRINSIC |
|
RGS
|
715 |
832 |
2.84e-41 |
SMART |
|
Pfam:RGS12_us1
|
836 |
953 |
4.3e-61 |
PFAM |
|
RBD
|
962 |
1032 |
3.12e-28 |
SMART |
|
RBD
|
1034 |
1104 |
2.44e-21 |
SMART |
|
Pfam:RGS12_us2
|
1106 |
1180 |
2.4e-37 |
PFAM |
|
GoLoco
|
1187 |
1209 |
9.74e-9 |
SMART |
|
Pfam:RGS12_usC
|
1238 |
1379 |
9.2e-49 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114280
AA Change: A55E
PolyPhen 2
Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000109919
Gene: ENSMUSG00000029101
AA Change: A55E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114281
AA Change: A55E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109920
Gene: ENSMUSG00000029101
AA Change: A55E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
701 |
720 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114283
AA Change: A55E
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109922
Gene: ENSMUSG00000029101
AA Change: A55E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
39 |
N/A |
INTRINSIC |
|
RGS
|
57 |
174 |
2.84e-41 |
SMART |
|
low complexity region
|
191 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
210 |
222 |
N/A |
INTRINSIC |
|
low complexity region
|
253 |
270 |
N/A |
INTRINSIC |
|
RBD
|
304 |
374 |
3.12e-28 |
SMART |
|
RBD
|
376 |
446 |
2.44e-21 |
SMART |
|
GoLoco
|
529 |
551 |
9.74e-9 |
SMART |
|
low complexity region
|
601 |
622 |
N/A |
INTRINSIC |
|
low complexity region
|
634 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
729 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114284
AA Change: A65E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000109923
Gene: ENSMUSG00000029101
AA Change: A65E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
730 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114285
AA Change: A65E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109924
Gene: ENSMUSG00000029101
AA Change: A65E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
37 |
49 |
N/A |
INTRINSIC |
|
RGS
|
67 |
184 |
2.84e-41 |
SMART |
|
low complexity region
|
201 |
217 |
N/A |
INTRINSIC |
|
low complexity region
|
220 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
263 |
280 |
N/A |
INTRINSIC |
|
RBD
|
314 |
384 |
3.12e-28 |
SMART |
|
RBD
|
386 |
456 |
2.44e-21 |
SMART |
|
GoLoco
|
539 |
561 |
9.74e-9 |
SMART |
|
low complexity region
|
611 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
644 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
707 |
739 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153972
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175356
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135403
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128161
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141562
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000225237
AA Change: A68E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156339
|
| SMART Domains |
Protein: ENSMUSP00000115064
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:RGS
|
1 |
30 |
1.3e-7 |
PFAM |
|
low complexity region
|
48 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000201936
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156819
|
| SMART Domains |
Protein: ENSMUSP00000116913
Gene: ENSMUSG00000029101
| Domain | Start | End | E-Value | Type |
|---|
|
RBD
|
21 |
91 |
3.12e-28 |
SMART |
|
RBD
|
93 |
163 |
2.44e-21 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.5%
- 20x: 94.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca14 |
T |
A |
7: 119,851,479 (GRCm39) |
M819K |
possibly damaging |
Het |
| Adamtsl3 |
T |
G |
7: 82,178,120 (GRCm39) |
C528G |
probably damaging |
Het |
| Akap9 |
A |
G |
5: 4,004,870 (GRCm39) |
K148E |
probably benign |
Het |
| Akr1b1 |
A |
T |
6: 34,286,577 (GRCm39) |
D225E |
probably benign |
Het |
| Alms1 |
C |
A |
6: 85,655,653 (GRCm39) |
Q2931K |
possibly damaging |
Het |
| Ano3 |
T |
C |
2: 110,715,346 (GRCm39) |
K31E |
possibly damaging |
Het |
| Cdc37 |
A |
G |
9: 21,053,537 (GRCm39) |
I242T |
probably damaging |
Het |
| Celsr1 |
T |
A |
15: 85,816,524 (GRCm39) |
K1806N |
possibly damaging |
Het |
| Clpb |
T |
A |
7: 101,436,956 (GRCm39) |
I707N |
possibly damaging |
Het |
| Cntnap2 |
A |
T |
6: 47,072,483 (GRCm39) |
Y1017F |
possibly damaging |
Het |
| Creb3l2 |
A |
T |
6: 37,311,416 (GRCm39) |
S458T |
probably benign |
Het |
| Ctnnd2 |
C |
A |
15: 31,009,230 (GRCm39) |
T1109K |
possibly damaging |
Het |
| Dcaf10 |
T |
A |
4: 45,373,011 (GRCm39) |
L425Q |
probably damaging |
Het |
| Dlec1 |
A |
G |
9: 118,941,167 (GRCm39) |
E239G |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,390,020 (GRCm39) |
K742E |
probably damaging |
Het |
| Dsp |
A |
T |
13: 38,371,717 (GRCm39) |
R889S |
probably damaging |
Het |
| Dync1h1 |
T |
A |
12: 110,599,222 (GRCm39) |
M1859K |
probably damaging |
Het |
| Efcab7 |
T |
A |
4: 99,758,886 (GRCm39) |
N361K |
probably damaging |
Het |
| Eps8l2 |
T |
C |
7: 140,935,646 (GRCm39) |
V139A |
probably damaging |
Het |
| Fads3 |
T |
G |
19: 10,019,200 (GRCm39) |
H35Q |
probably damaging |
Het |
| Fam163b |
C |
A |
2: 27,003,583 (GRCm39) |
V24F |
probably damaging |
Het |
| Gm14496 |
A |
T |
2: 181,636,904 (GRCm39) |
T121S |
probably benign |
Het |
| Gm4799 |
C |
T |
10: 82,790,563 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7168 |
A |
T |
17: 14,169,797 (GRCm39) |
D388V |
probably benign |
Het |
| Gmeb1 |
A |
T |
4: 131,953,386 (GRCm39) |
L460* |
probably null |
Het |
| Gpc6 |
T |
G |
14: 118,212,430 (GRCm39) |
F534V |
probably null |
Het |
| Hectd3 |
A |
G |
4: 116,853,241 (GRCm39) |
D156G |
possibly damaging |
Het |
| Itga6 |
T |
C |
2: 71,650,404 (GRCm39) |
I150T |
possibly damaging |
Het |
| Kansl1 |
A |
G |
11: 104,229,012 (GRCm39) |
M863T |
probably benign |
Het |
| Kcnb2 |
A |
T |
1: 15,780,664 (GRCm39) |
Y512F |
probably benign |
Het |
| Klhdc2 |
A |
T |
12: 69,347,053 (GRCm39) |
M73L |
probably benign |
Het |
| Ktn1 |
A |
G |
14: 47,932,073 (GRCm39) |
T667A |
probably benign |
Het |
| Lgsn |
A |
C |
1: 31,242,736 (GRCm39) |
I273L |
probably benign |
Het |
| Lilra5 |
A |
G |
7: 4,245,232 (GRCm39) |
D292G |
probably benign |
Het |
| Mrps27 |
C |
T |
13: 99,541,582 (GRCm39) |
R229C |
probably damaging |
Het |
| Muc5b |
T |
G |
7: 141,416,173 (GRCm39) |
S3040A |
probably benign |
Het |
| Nat14 |
T |
C |
7: 4,926,275 (GRCm39) |
S7P |
probably damaging |
Het |
| Nfia |
A |
G |
4: 97,671,694 (GRCm39) |
I135V |
possibly damaging |
Het |
| Nkd1 |
G |
A |
8: 89,248,944 (GRCm39) |
A30T |
probably damaging |
Het |
| Nup205 |
A |
G |
6: 35,202,903 (GRCm39) |
D1370G |
probably null |
Het |
| Or1j15 |
C |
G |
2: 36,459,568 (GRCm39) |
|
probably null |
Het |
| Or4k15c |
G |
A |
14: 50,321,310 (GRCm39) |
T276I |
probably damaging |
Het |
| Or51k2 |
T |
C |
7: 103,596,400 (GRCm39) |
L209P |
probably damaging |
Het |
| Or5p79 |
T |
A |
7: 108,221,494 (GRCm39) |
N158K |
possibly damaging |
Het |
| Or8s10 |
T |
C |
15: 98,336,168 (GRCm39) |
S273P |
possibly damaging |
Het |
| Orc1 |
C |
T |
4: 108,459,229 (GRCm39) |
A466V |
probably benign |
Het |
| Otud7a |
T |
A |
7: 63,385,638 (GRCm39) |
D367E |
possibly damaging |
Het |
| Pcdhb4 |
A |
G |
18: 37,441,263 (GRCm39) |
Y191C |
probably damaging |
Het |
| Pclo |
T |
C |
5: 14,762,828 (GRCm39) |
V3767A |
unknown |
Het |
| Pclo |
T |
C |
5: 14,728,789 (GRCm39) |
|
probably benign |
Het |
| Prmt1 |
A |
T |
7: 44,628,225 (GRCm39) |
|
probably null |
Het |
| Ralgapa1 |
A |
G |
12: 55,842,483 (GRCm39) |
F62S |
probably damaging |
Het |
| Rangrf |
T |
C |
11: 68,863,518 (GRCm39) |
S163G |
probably benign |
Het |
| Rrbp1 |
T |
C |
2: 143,830,436 (GRCm39) |
N577S |
probably damaging |
Het |
| Septin11 |
A |
G |
5: 93,315,393 (GRCm39) |
H374R |
probably damaging |
Het |
| Serpina5 |
T |
G |
12: 104,070,046 (GRCm39) |
N314K |
probably benign |
Het |
| Sgce |
T |
C |
6: 4,689,621 (GRCm39) |
D395G |
probably damaging |
Het |
| Slc26a9 |
A |
T |
1: 131,690,499 (GRCm39) |
N501I |
probably damaging |
Het |
| Slc9c1 |
A |
G |
16: 45,401,965 (GRCm39) |
D784G |
possibly damaging |
Het |
| Snapc2 |
A |
G |
8: 4,305,676 (GRCm39) |
D207G |
probably benign |
Het |
| Stard9 |
G |
T |
2: 120,529,738 (GRCm39) |
M1998I |
probably benign |
Het |
| Stk38 |
A |
C |
17: 29,194,907 (GRCm39) |
F280V |
possibly damaging |
Het |
| Tas2r126 |
A |
G |
6: 42,412,025 (GRCm39) |
K186R |
probably damaging |
Het |
| Tdp1 |
A |
C |
12: 99,875,970 (GRCm39) |
D307A |
probably benign |
Het |
| Tead2 |
A |
G |
7: 44,866,674 (GRCm39) |
D11G |
probably damaging |
Het |
| Tmco4 |
C |
A |
4: 138,747,383 (GRCm39) |
L211I |
probably damaging |
Het |
| Tmem183a |
A |
G |
1: 134,280,115 (GRCm39) |
F255S |
probably damaging |
Het |
| Tmem87a |
C |
T |
2: 120,205,929 (GRCm39) |
G349S |
possibly damaging |
Het |
| Tpte |
G |
A |
8: 22,826,549 (GRCm39) |
E377K |
possibly damaging |
Het |
| Trim32 |
T |
C |
4: 65,531,893 (GRCm39) |
F150S |
possibly damaging |
Het |
| Trpc7 |
T |
A |
13: 57,035,636 (GRCm39) |
K99M |
probably damaging |
Het |
| Ttc22 |
A |
G |
4: 106,491,381 (GRCm39) |
K195E |
probably damaging |
Het |
| Txn2 |
G |
A |
15: 77,811,917 (GRCm39) |
P7S |
probably damaging |
Het |
| Ubxn2a |
G |
A |
12: 4,930,700 (GRCm39) |
T220I |
probably damaging |
Het |
| Ufd1 |
A |
G |
16: 18,633,626 (GRCm39) |
N17S |
possibly damaging |
Het |
| Unc13a |
A |
G |
8: 72,102,509 (GRCm39) |
S958P |
probably damaging |
Het |
| Vmn1r202 |
T |
A |
13: 22,685,824 (GRCm39) |
M198L |
probably damaging |
Het |
| Vmn2r84 |
G |
A |
10: 130,221,991 (GRCm39) |
A743V |
probably damaging |
Het |
| Washc5 |
A |
G |
15: 59,213,007 (GRCm39) |
F891S |
probably damaging |
Het |
| Zfp708 |
T |
C |
13: 67,218,375 (GRCm39) |
T495A |
probably benign |
Het |
| Zfp81 |
A |
G |
17: 33,553,593 (GRCm39) |
I407T |
probably benign |
Het |
| Zswim5 |
T |
C |
4: 116,843,874 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Rgs12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01443:Rgs12
|
APN |
5 |
35,132,563 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02296:Rgs12
|
APN |
5 |
35,123,464 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02337:Rgs12
|
APN |
5 |
35,177,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02483:Rgs12
|
APN |
5 |
35,187,861 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02869:Rgs12
|
APN |
5 |
35,183,227 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02989:Rgs12
|
APN |
5 |
35,122,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0015:Rgs12
|
UTSW |
5 |
35,180,120 (GRCm39) |
unclassified |
probably benign |
|
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0046:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0106:Rgs12
|
UTSW |
5 |
35,124,008 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Rgs12
|
UTSW |
5 |
35,187,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0245:Rgs12
|
UTSW |
5 |
35,187,424 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0704:Rgs12
|
UTSW |
5 |
35,180,466 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0723:Rgs12
|
UTSW |
5 |
35,181,710 (GRCm39) |
unclassified |
probably benign |
|
|
R1174:Rgs12
|
UTSW |
5 |
35,123,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1538:Rgs12
|
UTSW |
5 |
35,178,511 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1556:Rgs12
|
UTSW |
5 |
35,196,626 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1774:Rgs12
|
UTSW |
5 |
35,123,747 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1791:Rgs12
|
UTSW |
5 |
35,123,456 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1866:Rgs12
|
UTSW |
5 |
35,123,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1872:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1923:Rgs12
|
UTSW |
5 |
35,189,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Rgs12
|
UTSW |
5 |
35,187,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2107:Rgs12
|
UTSW |
5 |
35,124,079 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3730:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3731:Rgs12
|
UTSW |
5 |
35,189,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Rgs12
|
UTSW |
5 |
35,189,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3827:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3829:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3830:Rgs12
|
UTSW |
5 |
35,123,359 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4392:Rgs12
|
UTSW |
5 |
35,189,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4617:Rgs12
|
UTSW |
5 |
35,177,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5132:Rgs12
|
UTSW |
5 |
35,147,156 (GRCm39) |
intron |
probably benign |
|
|
R5213:Rgs12
|
UTSW |
5 |
35,122,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Rgs12
|
UTSW |
5 |
35,178,448 (GRCm39) |
unclassified |
probably benign |
|
|
R5480:Rgs12
|
UTSW |
5 |
35,123,455 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5510:Rgs12
|
UTSW |
5 |
35,123,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5708:Rgs12
|
UTSW |
5 |
35,123,696 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5987:Rgs12
|
UTSW |
5 |
35,177,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6053:Rgs12
|
UTSW |
5 |
35,123,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6113:Rgs12
|
UTSW |
5 |
35,177,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6401:Rgs12
|
UTSW |
5 |
35,177,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6736:Rgs12
|
UTSW |
5 |
35,180,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6807:Rgs12
|
UTSW |
5 |
35,180,515 (GRCm39) |
missense |
probably null |
0.27 |
|
R6857:Rgs12
|
UTSW |
5 |
35,187,366 (GRCm39) |
nonsense |
probably null |
|
|
R7082:Rgs12
|
UTSW |
5 |
35,124,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7250:Rgs12
|
UTSW |
5 |
35,122,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7276:Rgs12
|
UTSW |
5 |
35,183,715 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7444:Rgs12
|
UTSW |
5 |
35,183,287 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7632:Rgs12
|
UTSW |
5 |
35,122,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Rgs12
|
UTSW |
5 |
35,183,374 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8089:Rgs12
|
UTSW |
5 |
35,177,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8241:Rgs12
|
UTSW |
5 |
35,123,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8797:Rgs12
|
UTSW |
5 |
35,186,915 (GRCm39) |
missense |
|
|
|
R8927:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8928:Rgs12
|
UTSW |
5 |
35,123,633 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9073:Rgs12
|
UTSW |
5 |
35,177,753 (GRCm39) |
unclassified |
probably benign |
|
|
R9211:Rgs12
|
UTSW |
5 |
35,123,165 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9485:Rgs12
|
UTSW |
5 |
35,189,614 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9550:Rgs12
|
UTSW |
5 |
35,196,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Rgs12
|
UTSW |
5 |
35,123,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,183,696 (GRCm39) |
missense |
probably benign |
0.44 |
|
Z1177:Rgs12
|
UTSW |
5 |
35,122,198 (GRCm39) |
start gained |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTCAGCCCTGGGAAGTTGAGATG -3'
(R):5'- CGACCACACCTCTAACAAGGTGATG -3'
Sequencing Primer
(F):5'- GCAGTACATGTTGCTCAGTGAAC -3'
(R):5'- CTCTAACAAGGTGATGCCCAGG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation