Mutagenetix > Incidental Mutation

Incidental Mutation 'R7040:Fpr-rs6'

547023

Institutional Source

Beutler Lab

Gene Symbol

Fpr-rs6

Ensembl Gene

ENSMUSG00000071275

Gene Name

formyl peptide receptor, related sequence 6

Synonyms

MMRRC Submission

045013-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R7040 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

20182078-20183097 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20182934 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 55 (M55T)

Ref Sequence

ENSEMBL: ENSMUSP00000093296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095636]

AlphaFold

Q3SXG2

Predicted Effect

probably damaging
Transcript: ENSMUST00000095636
AA Change: M55T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000093296
Gene: ENSMUSG00000071275
AA Change: M55T

Domain	Start	End	E-Value	Type
Pfam:7tm_1	43	297	5.7e-38	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130023H24Rik	A	G	7: 128,236,725	L232P	possibly damaging	Het
Acaa1a	T	C	9: 119,349,038	V312A	probably damaging	Het
Bmp2	A	G	2: 133,561,684	D385G	probably damaging	Het
C1qtnf9	T	C	14: 60,779,792	V257A	probably damaging	Het
Cd3d	G	A	9: 44,985,693	V122I	probably damaging	Het
Cdc37	T	C	9: 21,142,223	E199G	probably damaging	Het
Crb2	T	A	2: 37,787,684	D326E	probably benign	Het
Cyp2c29	A	C	19: 39,330,337	K420N	possibly damaging	Het
Cyp2g1	A	C	7: 26,820,759	D472A	probably damaging	Het
Dab2	A	C	15: 6,422,251	H116P	probably damaging	Het
Dnah7b	G	C	1: 46,236,809	E2619Q	probably benign	Het
Dsg4	A	T	18: 20,451,852	M208L	probably benign	Het
Eif4enif1	T	G	11: 3,234,040	V521G	probably benign	Het
Fan1	T	A	7: 64,372,486	N340Y	probably damaging	Het
Grhpr	A	G	4: 44,985,362	S101G	probably damaging	Het
Kif15	T	A	9: 123,011,614	D33E	possibly damaging	Het
Krt1	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	15: 101,850,378		probably benign	Het
Lama4	A	G	10: 39,060,162	Q611R	possibly damaging	Het
Lrrc47	T	A	4: 154,020,452	*123R	probably null	Het
Map4k3	A	C	17: 80,680,915	V36G	probably damaging	Het
Mme	T	A	3: 63,368,923	I707N	probably damaging	Het
Muc2	A	G	7: 141,751,457	E166G	unknown	Het
Mucl1	T	A	15: 103,753,578	T108S	possibly damaging	Het
Myo1h	A	T	5: 114,359,744	D53V	possibly damaging	Het
Naa15	T	A	3: 51,472,784	L811Q	possibly damaging	Het
Nalcn	T	C	14: 123,287,855	T1487A	probably benign	Het
Nme8	A	T	13: 19,694,328	L87H	probably damaging	Het
Nr2e1	A	G	10: 42,568,378	V245A	probably damaging	Het
Nt5c2	A	T	19: 46,893,535	F291Y	possibly damaging	Het
Olfr1337	T	C	4: 118,781,986	M200V	probably benign	Het
Olfr1508	T	C	14: 52,463,475	D178G	possibly damaging	Het
Olfr556	A	T	7: 102,670,730	Q270L	probably benign	Het
Olfr668	A	T	7: 104,925,510	C85S	probably benign	Het
Ooep	T	C	9: 78,378,401	N43S	possibly damaging	Het
Ovch2	A	T	7: 107,796,565	I82N	probably damaging	Het
Palb2	A	T	7: 122,114,399	M524K	possibly damaging	Het
Patj	T	C	4: 98,441,080	S524P	probably benign	Het
Patl1	T	A	19: 11,929,954	Y401N	possibly damaging	Het
Pcdhb20	A	T	18: 37,504,717	T99S	probably benign	Het
Plcb4	G	A	2: 135,932,262	A155T	probably benign	Het
Rpap3	A	G	15: 97,679,112	V585A	possibly damaging	Het
Sorbs1	G	C	19: 40,376,800	R180G	probably benign	Het
Spen	T	A	4: 141,494,382	T302S	unknown	Het
Tenm4	G	A	7: 96,553,496	R106H	probably benign	Het
Ube2o	T	C	11: 116,541,860	E760G	probably benign	Het
Uimc1	T	A	13: 55,075,454		probably null	Het
Usp16	C	T	16: 87,480,929	A689V	probably damaging	Het
Vmn2r60	G	A	7: 42,142,242	A530T	probably benign	Het
Vps8	T	A	16: 21,575,022	M1185K	probably damaging	Het
Vwa8	T	C	14: 78,912,205	S136P	probably damaging	Het
Ythdc2	A	G	18: 44,834,462	N175S	probably benign	Het
Zfp160	A	T	17: 21,026,532	H448L	probably damaging	Het
Zfp90	T	A	8: 106,425,009	C451*	probably null	Het
Zfp945	A	G	17: 22,852,290	C212R	probably damaging	Het

Other mutations in Fpr-rs6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02836:Fpr-rs6	APN	17	20183045	missense	probably benign	0.30
IGL03380:Fpr-rs6	APN	17	20182983	missense	possibly damaging	0.66
R0149:Fpr-rs6	UTSW	17	20182213	missense	probably benign	0.29
R0190:Fpr-rs6	UTSW	17	20182479	missense	probably benign	0.07
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1347:Fpr-rs6	UTSW	17	20182749	missense	probably benign	0.23
R1934:Fpr-rs6	UTSW	17	20182890	missense	probably benign	0.36
R1965:Fpr-rs6	UTSW	17	20182656	missense	probably damaging	0.98
R3690:Fpr-rs6	UTSW	17	20182875	missense	probably benign	0.02
R3963:Fpr-rs6	UTSW	17	20182217	missense	probably damaging	1.00
R4564:Fpr-rs6	UTSW	17	20182906	nonsense	probably null
R4574:Fpr-rs6	UTSW	17	20183097	start codon destroyed	probably damaging	1.00
R5015:Fpr-rs6	UTSW	17	20182346	missense	probably damaging	1.00
R5599:Fpr-rs6	UTSW	17	20182113	missense	probably benign	0.05
R6737:Fpr-rs6	UTSW	17	20183077	missense	probably benign	0.08
R6786:Fpr-rs6	UTSW	17	20182838	missense	possibly damaging	0.95
R6908:Fpr-rs6	UTSW	17	20182439	missense	probably damaging	1.00
R7462:Fpr-rs6	UTSW	17	20182223	missense	probably damaging	1.00
R7673:Fpr-rs6	UTSW	17	20182737	missense	probably benign	0.03
R7958:Fpr-rs6	UTSW	17	20182443	missense	probably damaging	0.98
R8103:Fpr-rs6	UTSW	17	20182577	missense	possibly damaging	0.69
R8772:Fpr-rs6	UTSW	17	20182233	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCCCATACTGGATGCAGAAC -3'
(R):5'- TGCTGACAAAATGGAAGCCAAC -3'

Sequencing Primer
(F):5'- CGATCCATGGCAATGAAAGTAATC -3'
(R):5'- CTTCTCCATACCTCAGAATGGATCAG -3'

Posted On

2019-05-13