Mutagenetix > Incidental Mutations

Incidental Mutation 'R7045:Olfr319'

547265

Institutional Source

Beutler Lab

Gene Symbol

Olfr319

Ensembl Gene

ENSMUSG00000064044

Gene Name

olfactory receptor 319

Synonyms

MOR285-2, GA_x6K02T2NKPP-708319-707399

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

R7045 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

58699162-58703472 bp(+) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

A to T at 58701669 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000150883 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076965] [ENSMUST00000215962]

Predicted Effect

probably benign
Transcript: ENSMUST00000076965

SMART Domains

Protein: ENSMUSP00000076232
Gene: ENSMUSG00000064044

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	306	3.8e-46	PFAM
Pfam:7tm_1	41	290	1.4e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215962

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akt1	A	T	12: 112,662,301	Y18*	probably null	Het
Ank2	C	A	3: 127,012,744	A583S	probably damaging	Het
Atp8b4	T	C	2: 126,372,195	N706S	probably benign	Het
Bace2	A	G	16: 97,399,665	N111S	probably damaging	Het
Cnp	A	T	11: 100,580,358	R275S	probably benign	Het
Cs	T	A	10: 128,352,717	M104K	probably benign	Het
Ctcfl	G	A	2: 173,112,374	T310I	probably damaging	Het
Cyp2d40	T	C	15: 82,761,562	I81V	probably benign	Het
Ddx19a	A	G	8: 110,993,074	V30A	probably benign	Het
Disp1	C	A	1: 183,087,466	R1130L	probably damaging	Het
Dock6	G	A	9: 21,821,811	A1062V	probably damaging	Het
Dpysl2	T	C	14: 66,829,946	D172G	probably benign	Het
Eml2	A	G	7: 19,201,579	D638G	probably damaging	Het
Epb41l4b	C	A	4: 57,103,522	A105S	possibly damaging	Het
Fam198a	T	C	9: 121,965,641	L287P	probably damaging	Het
Fat4	A	G	3: 38,888,601	I548V	probably benign	Het
Gabrb2	G	A	11: 42,593,931	A272T	probably damaging	Het
Hcn1	C	T	13: 117,975,462	P654L	unknown	Het
Hjurp	TCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCTGCT	TCT	1: 88,266,278		probably benign	Het
Hk1	C	A	10: 62,286,570	G477C	probably damaging	Het
Hspa5	C	T	2: 34,773,192	P127L	probably damaging	Het
Kiss1r	A	G	10: 79,919,425		probably null	Het
L3mbtl4	G	T	17: 68,461,566	R223L	probably benign	Het
Loxl4	G	T	19: 42,606,635	N200K	probably damaging	Het
Lrba	T	C	3: 86,285,091	V104A	probably benign	Het
Lyst	T	A	13: 13,634,900	V385D	probably benign	Het
Lyst	T	A	13: 13,637,708	C902S	probably damaging	Het
Mrpl28	T	C	17: 26,126,287	F227S	probably benign	Het
Mtmr3	A	T	11: 4,498,896	V289E	possibly damaging	Het
Ndst3	A	G	3: 123,672,083	V80A	probably damaging	Het
Nid2	C	T	14: 19,779,681	A680V	possibly damaging	Het
Nudcd1	T	C	15: 44,405,830	N145D	probably benign	Het
Nup210	A	T	6: 91,054,451	I812N	probably damaging	Het
Olfr1008	A	G	2: 85,689,911	S161G	possibly damaging	Het
Olfr130	C	T	17: 38,067,971	H267Y	probably benign	Het
Olfr1390	A	T	11: 49,340,930	T133S	probably damaging	Het
Olfr1468-ps1	C	A	19: 13,374,972	N3K	probably damaging	Het
Olfr251	T	A	9: 38,378,433	M184K	probably damaging	Het
Olfr503	A	G	7: 108,545,245	K238R	probably damaging	Het
Pcdhb6	A	C	18: 37,336,276	Q750P	possibly damaging	Het
Plppr4	T	C	3: 117,360,034	Y72C	probably damaging	Het
Rasgrf2	G	T	13: 92,022,592		probably benign	Het
Sbk2	A	G	7: 4,958,906	I127T	probably damaging	Het
Smchd1	A	C	17: 71,415,044	S817A	probably benign	Het
Speer4b	A	T	5: 27,500,125	N83K	probably damaging	Het
Strc	A	T	2: 121,370,726	L1296Q	probably damaging	Het
Svs1	T	C	6: 48,988,612	V518A	possibly damaging	Het
Thap11	C	A	8: 105,855,583	R75S	possibly damaging	Het
Unc13a	A	C	8: 71,658,763	L268R	possibly damaging	Het
Zfp39	A	T	11: 58,890,443	C498S	unknown	Het
Zfp507	T	C	7: 35,795,553	T22A	possibly damaging	Het
Zfp85	T	C	13: 67,749,593	Y120C	probably benign	Het
Zfp882	G	A	8: 71,913,249		probably null	Het

Other mutations in Olfr319

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01398:Olfr319	APN	11	58701767	missense	probably benign
IGL01955:Olfr319	APN	11	58702129	missense	probably damaging	0.97
IGL02145:Olfr319	APN	11	58702060	missense	probably damaging	0.99
IGL02283:Olfr319	APN	11	58702276	missense	probably damaging	0.96
R0468:Olfr319	UTSW	11	58701793	missense	probably damaging	1.00
R0499:Olfr319	UTSW	11	58702243	missense	probably benign	0.01
R0815:Olfr319	UTSW	11	58702609	missense	possibly damaging	0.84
R0885:Olfr319	UTSW	11	58702087	missense	possibly damaging	0.93
R1081:Olfr319	UTSW	11	58702498	missense	probably damaging	1.00
R1603:Olfr319	UTSW	11	58702460	missense	probably benign	0.00
R1935:Olfr319	UTSW	11	58702346	missense	probably damaging	1.00
R1936:Olfr319	UTSW	11	58702346	missense	probably damaging	1.00
R1938:Olfr319	UTSW	11	58702623	makesense	probably null
R2436:Olfr319	UTSW	11	58702126	missense	probably damaging	0.97
R4243:Olfr319	UTSW	11	58702451	missense	probably damaging	1.00
R4244:Olfr319	UTSW	11	58702451	missense	probably damaging	1.00
R4742:Olfr319	UTSW	11	58701859	missense	probably benign
R4801:Olfr319	UTSW	11	58701791	missense	probably benign
R4802:Olfr319	UTSW	11	58701791	missense	probably benign
R4927:Olfr319	UTSW	11	58701807	missense	probably damaging	1.00
R5259:Olfr319	UTSW	11	58701952	missense	probably benign	0.07
R5259:Olfr319	UTSW	11	58701953	missense	possibly damaging	0.83
R5393:Olfr319	UTSW	11	58702500	missense	probably damaging	0.97
R5471:Olfr319	UTSW	11	58702325	missense	probably damaging	0.98
R5571:Olfr319	UTSW	11	58702051	missense	probably damaging	1.00
R6746:Olfr319	UTSW	11	58702543	missense	probably benign
X0065:Olfr319	UTSW	11	58702489	missense	probably benign	0.02
Z1177:Olfr319	UTSW	11	58702113	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GAGATCCCATGACTTAATGCATGC -3'
(R):5'- GAGGACCAGTGTGATGTTGC -3'

Sequencing Primer
(F):5'- ACATAAGCCTGACATTAGCATGTG -3'
(R):5'- ATGTTGCCTATGAGAGCCAC -3'

Posted On

2019-05-13