Incidental Mutation 'R7046:Zfp874a'
ID 547336
Institutional Source Beutler Lab
Gene Symbol Zfp874a
Ensembl Gene ENSMUSG00000069206
Gene Name zinc finger protein 874a
Synonyms C330011K17Rik, Zfp874, Rslcan15
MMRRC Submission 045144-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R7046 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67588550-67599743 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 67590418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 422 (C422F)
Ref Sequence ENSEMBL: ENSMUSP00000074735 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057241] [ENSMUST00000075255] [ENSMUST00000180580] [ENSMUST00000223682] [ENSMUST00000225479]
AlphaFold Q8BX23
Predicted Effect probably benign
Transcript: ENSMUST00000057241
SMART Domains Protein: ENSMUSP00000077307
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000075255
AA Change: C422F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074735
Gene: ENSMUSG00000069206
AA Change: C422F

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
ZnF_C2H2 137 159 9.58e-3 SMART
ZnF_C2H2 165 187 5.99e-4 SMART
ZnF_C2H2 193 215 7.26e-3 SMART
ZnF_C2H2 221 243 2.4e-3 SMART
ZnF_C2H2 249 269 1.88e2 SMART
ZnF_C2H2 277 299 5.21e-4 SMART
ZnF_C2H2 305 327 2.12e-4 SMART
ZnF_C2H2 333 355 2.12e-4 SMART
ZnF_C2H2 361 383 8.47e-4 SMART
ZnF_C2H2 389 411 1.79e-2 SMART
ZnF_C2H2 417 438 2.86e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180580
SMART Domains Protein: ENSMUSP00000137953
Gene: ENSMUSG00000069206

DomainStartEndE-ValueType
KRAB 5 65 1.73e-27 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000223682
Predicted Effect probably benign
Transcript: ENSMUST00000225479
Predicted Effect probably benign
Transcript: ENSMUST00000225778
Meta Mutation Damage Score 0.2305 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc8 T C 7: 45,772,364 (GRCm39) Y805C probably damaging Het
Aoc1l3 T A 6: 48,964,512 (GRCm39) D173E probably benign Het
Cabp7 T A 11: 4,688,886 (GRCm39) I195F probably damaging Het
Camsap1 T C 2: 25,835,201 (GRCm39) N317S probably damaging Het
Ccdc127 T G 13: 74,500,994 (GRCm39) L4V probably damaging Het
Ccdc7a T C 8: 129,774,100 (GRCm39) E145G probably damaging Het
Cdh10 T A 15: 19,013,287 (GRCm39) V629D probably damaging Het
Cdh23 A C 10: 60,214,530 (GRCm39) L1497R probably damaging Het
Chsy3 A G 18: 59,542,875 (GRCm39) K671R probably benign Het
Clca4b T C 3: 144,621,367 (GRCm39) Y569C probably damaging Het
Cnga1 T C 5: 72,786,696 (GRCm39) probably benign Het
Cyp51 T A 5: 4,150,188 (GRCm39) E178D probably damaging Het
Defa30 T A 8: 21,625,471 (GRCm39) N78K probably benign Het
Disp1 C A 1: 182,869,030 (GRCm39) R1130L probably damaging Het
Dnah14 G T 1: 181,450,568 (GRCm39) C727F probably benign Het
Egf A T 3: 129,548,607 (GRCm39) W3R unknown Het
Egfem1 G A 3: 29,136,364 (GRCm39) probably null Het
Epb41l1 G T 2: 156,368,812 (GRCm39) V682L possibly damaging Het
Etv1 A G 12: 38,834,369 (GRCm39) probably null Het
Faap100 A G 11: 120,268,200 (GRCm39) F191S possibly damaging Het
Fmo1 T A 1: 162,667,263 (GRCm39) D184V possibly damaging Het
Ghrl A G 6: 113,696,344 (GRCm39) L16P probably damaging Het
Gria4 T A 9: 4,420,278 (GRCm39) L861F probably damaging Het
Gsr T A 8: 34,185,090 (GRCm39) M428K probably damaging Het
Hspa5 C T 2: 34,663,204 (GRCm39) P127L probably damaging Het
Kbtbd12 A G 6: 88,595,497 (GRCm39) M111T possibly damaging Het
Krtap21-1 G T 16: 89,200,623 (GRCm39) Y6* probably null Het
Lin9 A G 1: 180,494,935 (GRCm39) D219G probably damaging Het
Lrrc38 A G 4: 143,076,739 (GRCm39) M1V probably null Het
Macc1 T G 12: 119,410,773 (GRCm39) F514V probably benign Het
Madcam1 C T 10: 79,504,139 (GRCm39) R242C probably benign Het
Mfhas1 T C 8: 36,131,944 (GRCm39) S1037P probably benign Het
Micall2 C T 5: 139,694,699 (GRCm39) probably benign Het
Mtr C A 13: 12,205,095 (GRCm39) A1122S possibly damaging Het
Muc6 T A 7: 141,226,456 (GRCm39) probably benign Het
Myh15 T A 16: 48,929,662 (GRCm39) C529* probably null Het
Napsa T C 7: 44,234,509 (GRCm39) V247A probably damaging Het
Nr2c2 A G 6: 92,135,338 (GRCm39) T309A probably damaging Het
Or1e26 A T 11: 73,480,558 (GRCm39) I2K probably benign Het
Or1q1 T A 2: 36,887,173 (GRCm39) V117E probably benign Het
Or2n1b A T 17: 38,459,691 (GRCm39) M71L probably benign Het
Osgepl1 A T 1: 53,360,710 (GRCm39) I384F possibly damaging Het
Otud4 C T 8: 80,377,671 (GRCm39) L111F possibly damaging Het
Pds5b A G 5: 150,673,385 (GRCm39) Y481C probably damaging Het
Pdzrn4 T A 15: 92,668,303 (GRCm39) Y818* probably null Het
Pin1rt1 T C 2: 104,544,767 (GRCm39) S122G probably benign Het
Pkdcc A T 17: 83,531,687 (GRCm39) Y487F probably damaging Het
Plxna4 C T 6: 32,493,440 (GRCm39) C392Y probably damaging Het
Psd4 T G 2: 24,284,985 (GRCm39) M283R probably benign Het
Ralgds G T 2: 28,430,741 (GRCm39) G68W probably damaging Het
Rmdn2 T A 17: 79,928,808 (GRCm39) I20N probably damaging Het
Sestd1 A G 2: 77,022,910 (GRCm39) V486A probably benign Het
Skic8 T A 9: 54,626,539 (GRCm39) D275V probably damaging Het
Spmap2 G T 10: 79,422,796 (GRCm39) D35E probably benign Het
Tango6 A G 8: 107,533,748 (GRCm39) H958R possibly damaging Het
Taok3 C T 5: 117,411,771 (GRCm39) R857C probably damaging Het
Tasor A T 14: 27,194,392 (GRCm39) L1197F probably damaging Het
Trio T C 15: 27,832,137 (GRCm39) E1245G probably damaging Het
Usp19 C T 9: 108,374,334 (GRCm39) H763Y possibly damaging Het
Vmn1r185 A G 7: 26,310,651 (GRCm39) S285P probably damaging Het
Vmn1r45 T G 6: 89,910,538 (GRCm39) Y144S probably benign Het
Vwa3b G A 1: 37,212,959 (GRCm39) E152K probably benign Het
Xrcc5 G A 1: 72,433,875 (GRCm39) M731I probably benign Het
Zfp619 G A 7: 39,186,787 (GRCm39) S939N possibly damaging Het
Zfp948 A G 17: 21,808,719 (GRCm39) D637G possibly damaging Het
Other mutations in Zfp874a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02490:Zfp874a APN 13 67,590,819 (GRCm39) nonsense probably null
R1052:Zfp874a UTSW 13 67,590,539 (GRCm39) missense possibly damaging 0.89
R1991:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R2085:Zfp874a UTSW 13 67,590,967 (GRCm39) missense probably damaging 1.00
R2103:Zfp874a UTSW 13 67,590,623 (GRCm39) missense probably benign 0.03
R5129:Zfp874a UTSW 13 67,591,100 (GRCm39) missense probably damaging 1.00
R5336:Zfp874a UTSW 13 67,590,799 (GRCm39) missense probably damaging 1.00
R5423:Zfp874a UTSW 13 67,590,473 (GRCm39) missense possibly damaging 0.75
R5713:Zfp874a UTSW 13 67,597,476 (GRCm39) missense probably benign 0.16
R5855:Zfp874a UTSW 13 67,590,812 (GRCm39) missense probably benign 0.03
R6496:Zfp874a UTSW 13 67,590,694 (GRCm39) missense possibly damaging 0.62
R7065:Zfp874a UTSW 13 67,590,401 (GRCm39) missense probably damaging 0.97
R7233:Zfp874a UTSW 13 67,590,776 (GRCm39) missense possibly damaging 0.83
R7271:Zfp874a UTSW 13 67,591,415 (GRCm39) missense probably benign 0.00
R7465:Zfp874a UTSW 13 67,590,376 (GRCm39) missense probably damaging 0.99
R7468:Zfp874a UTSW 13 67,573,723 (GRCm39) splice site probably null
R8108:Zfp874a UTSW 13 67,591,353 (GRCm39) nonsense probably null
R8109:Zfp874a UTSW 13 67,597,563 (GRCm39) missense possibly damaging 0.46
R8843:Zfp874a UTSW 13 67,590,764 (GRCm39) missense probably damaging 1.00
R8859:Zfp874a UTSW 13 67,590,647 (GRCm39) missense probably benign 0.17
R9137:Zfp874a UTSW 13 67,590,841 (GRCm39) missense probably damaging 1.00
R9673:Zfp874a UTSW 13 67,591,156 (GRCm39) missense probably benign 0.03
X0063:Zfp874a UTSW 13 67,591,106 (GRCm39) missense probably damaging 1.00
Z1177:Zfp874a UTSW 13 67,590,781 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCTTTGTGACAGTCTTCAT -3'
(R):5'- TTTGCTATCGTTCATATCTTAGGGA -3'

Sequencing Primer
(F):5'- AGGCTTTGTGACAGTCTTCATATTTG -3'
(R):5'- CTCCCCATGAGTGTGTAGAATGC -3'
Posted On 2019-05-13